The document discusses skeletal muscle contraction and the neuromuscular junction. It describes how a motor neuron impulse stimulates a muscle fiber, causing the release of acetylcholine at the neuromuscular junction. This triggers an action potential in the muscle fiber membrane and the subsequent release of calcium ions from the sarcoplasmic reticulum, activating muscle contraction. It also summarizes the steps involved in muscle tension generation and lists several clinical conditions that can affect skeletal muscle function such as polio, tetanus, botulism, and myasthenia gravis.
Molecular basis of Skeletal Muscle ContractionArulSood2
The ppt aims to explain the molecular basis of skeletal muscle contraction and certain applied aspects of the same. Sources include Guyton and Hall's Textbook of Physiology (South-Asia edition, Vol. 2) and C.L. Ghai's Textbook for Practical Physiology.
Striated muscle contracts to move limbs and maintain posture. The contraction of skeletal muscles is an energy-requiring process. In order to perform the mechanical work of contraction, actin and myosin utilize the chemical energy of the molecule adenosine triphosphate (ATP).Muscle contraction results from a chain of events that begins with a nerve impulse traveling in the upper motor neuron from the cerebral cortex in the brain to the spinal cord.When the signal to contract is sent along a nerve to the muscle, the actin and myosin are activated. Myosin works as a motor, hydrolyzing adenosine triphosphate (ATP) to release energy in such a way that a myosin filament moves along an actin…
Excitation–Contraction Coupling
Excitation–contraction coupling is the link (transduction) between the action potential generated in the sarcolemma and the start of a muscle contraction.
Sliding Filament Model of Contraction
For a muscle cell to contract, the sarcomere must shorten. However, thick and thin filaments—the components of sarcomeres—do not shorten. Instead, they slide by one another, causing the sarcomere to shorten while the filaments remain the same length. The sliding filament theory of muscle contraction was developed to fit the differences observed in the named bands on the sarcomere at different degrees of muscle contraction and relaxation. The mechanism of contraction is the binding of myosin to actin, forming cross-bridges that generate filament movement
Molecular basis of Skeletal Muscle ContractionArulSood2
The ppt aims to explain the molecular basis of skeletal muscle contraction and certain applied aspects of the same. Sources include Guyton and Hall's Textbook of Physiology (South-Asia edition, Vol. 2) and C.L. Ghai's Textbook for Practical Physiology.
Striated muscle contracts to move limbs and maintain posture. The contraction of skeletal muscles is an energy-requiring process. In order to perform the mechanical work of contraction, actin and myosin utilize the chemical energy of the molecule adenosine triphosphate (ATP).Muscle contraction results from a chain of events that begins with a nerve impulse traveling in the upper motor neuron from the cerebral cortex in the brain to the spinal cord.When the signal to contract is sent along a nerve to the muscle, the actin and myosin are activated. Myosin works as a motor, hydrolyzing adenosine triphosphate (ATP) to release energy in such a way that a myosin filament moves along an actin…
Excitation–Contraction Coupling
Excitation–contraction coupling is the link (transduction) between the action potential generated in the sarcolemma and the start of a muscle contraction.
Sliding Filament Model of Contraction
For a muscle cell to contract, the sarcomere must shorten. However, thick and thin filaments—the components of sarcomeres—do not shorten. Instead, they slide by one another, causing the sarcomere to shorten while the filaments remain the same length. The sliding filament theory of muscle contraction was developed to fit the differences observed in the named bands on the sarcomere at different degrees of muscle contraction and relaxation. The mechanism of contraction is the binding of myosin to actin, forming cross-bridges that generate filament movement
This file is all about Skeletal Muscle contraction with reference to skeletal muscle Fibers, its structure, contraction, role of Ca++ in Contraction and types of Contraction.
This file is all about Skeletal Muscle contraction with reference to skeletal muscle Fibers, its structure, contraction, role of Ca++ in Contraction and types of Contraction.
It includes the basic anatomy physiology of skeletal muscles, the thorough working of the muscles, at superficial level to molecular level, the energy input, smooth muscle-cardiac-skeletal muscles differences, smooth muscle anatomy physiology.
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Anatomy and Physiology 2e is developed to meet the scope and sequence for a two-semester human anatomy and physiology course for life science and allied health majors. This chapter will examine the structure and function of the three types of muscle tissues.
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3. 3
Muscle contraction begins when a motor neuron
impulse stimulates an impulse in a muscle fiber.
Nerve impulse is generated and sent as an electrical
current (action potential) along sarcolemma
The neuromuscular junction is the region where the
motor neuron comes into close proximity to the muscle
fiber.
The neuromuscular junction (NMJ)
Special intercellular connection between the
nervous system and skeletal muscle fiber
Controls calcium ion release into the sarcoplasm
18. 18
Summary of Steps from Stimulation of the Nerve to
the Production of Tension
1. A stimulus is propagated down the alpha motor
neuron.
2. Acetylcholine (Ach) is released from the
endplate and crosses the synapse.
3. Ach causes Na+ and K+ channels to open up on
the sarcolemma.
4. Na+ flows into the cell and K+ flow out of the
cell, generating a muscle fiber action potential.
5. Na+ spreads downward into the T-tubule
system causing Ca++ to be released from the
sarcoplasmic reticulum.
6. Ca++ binds with troponin, a change in
configuration of actin that exposes the actin
binding site.
7. A cross-bridge is formed between actin and
myosin.
8. The ATP in the myosin head is downgraded to
ADP + Pi.
9. Once the Pi is released the myosin head is
tightly bound to actin.
10. The myosin arm does work on actin and
tension is generated.
21. Tension = pulling force
• Tension Production by Muscles Fibers
• As a whole, a muscle fiber is either contracted or relaxed
The all–or–none principal: as a whole, a muscle fiber is
either contracted or relaxed
Amount of tension in a muscle is determined by the
following:
Resting length of the sarcomere at the time of
stimulation (how much overlap)
Frequency of stimulation….which impacts the
concentration of calcium ions
45. While creatine phosphate can sustain contraction
longer than the ATP reserves, long-term
contraction requires breakdown of glycogen (what
is glycogen?)
55. Figure 10-22
• individual cells (NOT fused into
fibers)
• connected by intercalated discs
• striated, with single central nucleus
• short, broad T tubules encircle Z
lines
• no terminal cisternae in SR
• rich in mitochondria and
myoglobin
• totally dependent on aerobic
metabolism-functional syncitium
Figure 9.4.1 A skeletal muscle fiber contracts when stimulated by a motor neuron
Figure 9.4.8 A skeletal muscle fiber contracts when stimulated by a motor neuron
ATP Provides Energy for Muscle Contraction
Sustained muscle contraction uses a lot of ATP energy
Muscles store enough energy to start contraction
Muscle fibers must manufacture more ATP as needed
ATP Generation
Cells produce ATP in two ways
Aerobic metabolism of fatty acids in the mitochondria
Anaerobic glycolysis in the cytoplasm
Energy demands:
ATP consumption: trillions of molecules per second per fiber
sustained contraction requires continuous regeneration of ATP
Production of ATP for muscle contraction. (a) Creatine phosphate, formed from ATP while the muscle is relaxed, transfers a high-energy phosphate group to ADP, forming ATP during muscle contraction. (b) Breakdown of muscle glycogen into glucose and production of pyruvic acid from glucose via glycolysis produce both ATP and lactic acid. Because no oxygen is needed, this is an anaerobic pathway. (c) Within mitochondria, pyruvic acid, fatty acids, and amino acids are used to produce ATP via aerobic respiration, an oxygen-requiring set of reactions.
Figure 9.10.3 Muscles are subject to fatigue and may require an extended recovery period
Skeletal muscle fibers are not all alike in composition and function. For example, muscle fibers vary in their content of myoglobin, the red-colored protein that binds oxygen in muscle fibers. Skeletal muscle fibers that have a high myoglobin content are termed red muscle fibers and appear darker (the dark meat in chicken legs and thighs); those that have a low content of myoglobin are called white muscle fibers and appear lighter (the white meat in chicken breasts). Red muscle fibers also contain more mitochondria and are supplied by more blood capillaries.
Skeletal muscle fibers also contract and relax at different speeds, and vary in which metabolic reactions they use to generate ATP and in how quickly they fatigue. For example, a fiber is categorized as either slow or fast depending on how rapidly the ATPase in its myosin heads hydrolyzes ATP. Based on all these structural and functional characteristics, skeletal muscle fibers are classified into three main types: (1) slow oxidative fibers, (2) fast oxidative–glycolytic fibers, and (3) fast glycolytic fibers.
Within a particular motor unit, all of the skeletal muscle fibers are of the same type. The different motor units in a muscle are recruited in a specific order, depending on need. For example, if weak contractions suffice to perform a task, only SO motor units are activated. If more force is needed, the motor units of FOG fibers are also recruited. Finally, if maximal force is required, motor units of FG fibers are also called into action with the other two types. Activation of various motor units is controlled by the brain and spinal cord.
The relative ratio of fast glycolytic (FG) and slow oxidative (SO) fibers in each muscle is genetically determined and helps account for individual differences in physical performance. For example, people with a higher proportion of FG fibers (see Table 10.4) often excel in activities that require periods of intense activity, such as weight lifting or sprinting. People with higher percentages of SO fibers are better at activities that require endurance, such as long-distance running.
Although the total number of skeletal muscle fibers usually does not increase with exercise, the characteristics of those present can change to some extent. Various types of exercises can induce changes in the fibers in a skeletal muscle. Endurance-type (aerobic) exercises, such as running or swimming, cause a gradual transformation of some FG fibers into fast oxidative–glycolytic (FOG) fibers. The transformed muscle fibers show slight increases in diameter, number of mitochondria, blood supply, and strength. Endurance exercises also result in cardiovascular and respiratory changes that cause skeletal muscles to receive better supplies of oxygen and nutrients but do not increase muscle mass. By contrast, exercises that require great strength for short periods produce an increase in the size and strength of FG fibers. The increase in size is due to increased synthesis of thick and thin filaments. The overall result is muscle enlargement (hypertrophy), as evidenced by the bulging muscles of body builders.
A certain degree of elasticity is an important attribute of skeletal muscles and their connective tissue attachments. Greater elasticity contributes to a greater degree of flexibility, increasing the range of motion of a joint. When a relaxed muscle is physically stretched, its ability to lengthen is limited by connective tissue structures, such as fasciae. Regular stretching gradually lengthens these structures, but the process occurs very slowly. To see an improvement in flexibility, stretching exercises must be performed regularly—daily, if possible—for many weeks.
Between the layers of cardiac muscle fibers, the contractile cells of the heart, are sheets of connective tissue that contain blood vessels, nerves, and the conduction system
of the heart. Cardiac muscle fibers have the same arrangement of actin and myosin and the same bands, zones, and Z discs as skeletal muscle fibers. However, intercalated discs (in-TER-ka-lāt-ed; intercal- = to insert between) are unique to cardiac muscle fibers. These microscopic structures are irregular transverse thickenings of the sarcolemma that connect the ends of cardiac muscle fibers to one another. The discs contain desmosomes, which hold the fibers together, and gap junctions, which allow muscle action potentials to spread from one cardiac muscle fiber to another. Cardiac muscle tissue has an endomysium and perimysium, but lacks an epimysium.
Cardiac muscle cells (cardiocytes):
individual cells (NOT fused into fibers)
connected by intercalated discs
striated, with single central nucleus
short, broad T tubules encircle Z lines
no terminal cisternae in SR
rich in mitochondria and myoglobin
totally dependent on aerobic metabolism
In response to a single action potential, cardiac muscle tissue remains contracted 10 to 15 times longer than skeletal muscle tissue. The long contraction is due to prolonged delivery of Ca2+ into the sarcoplasm. In cardiac muscle fibers, Ca2+ enters the sarcoplasm both from the sarcoplasmic reticulum (as in skeletal muscle fibers) and from the interstitial fluid that bathes the fibers. Because the channels that allow inflow of Ca2+ from interstitial fluid stay open for a relatively long time, a cardiac muscle contraction lasts much longer than a skeletal muscle twitch.
Intercalated Discs
Are specialized contact points between cardiocytes
Join cell membranes of adjacent cardiocytes (gap junctions, desmosomes)
Functions of intercalated discs
Maintain structure
Enhance molecular and electrical connections
Conduct action potentials
Coordination of cardiocytes
Because intercalated discs link heart cells mechanically, chemically, and electrically, the heart functions like a single, fused mass of cells
We have seen that skeletal muscle tissue contracts only when stimulated by acetylcholine released by a nerve impulse in a motor neuron. In contrast, cardiac muscle tissue contracts when stimulated by its own autorhythmic muscle fibers. Under normal resting conditions, cardiac muscle tissue contracts and relaxes about 75 times a minute. This continuous, rhythmic activity is a major physiological difference between cardiac and skeletal muscle tissue. The mitochondria in cardiac muscle fibers are larger and more numerous than in skeletal muscle fibers. This structural feature correctly suggests that cardiac muscle depends largely on aerobic respiration to generate ATP, and thus requires a constant supply of oxygen. Cardiac muscle fibers can also use lactic acid produced by skeletal muscle fibers to make ATP, a benefit during exercise. Like skeletal muscle, cardiac muscle fibers can undergo hypertrophy in response to an increased workload. This is called a physiological enlarged heart and it is why many athletes have enlarged hearts. By contrast, a pathological enlarged heart is related to significant heart disease.
Action potentials:
long duration compared to skeletal muscle
slow calcium channels delay repolarization (return to a relaxed state)
long refractory period during which these cells cannot be stimulated (NO wave summation or tetany)
spindle-shaped, non-striated
single, central nucleus
no T tubules; SR forms a loose network
filaments NOT arranged in sarcomeres
thin filaments attach to dense bodies
Like cardiac muscle tissue, smooth muscle tissue is usually activated involuntarily. Of the two types of smooth muscle tissue, the more common type is visceral (single-unit) smooth muscle tissue (Figure 10.16a). It is found in the skin and in tubular arrangements that form part of the walls of small arteries and veins and of hollow organs such as the stomach, intestines, uterus, and urinary bladder. Like cardiac muscle, visceral smooth muscle is autorhythmic. The fibers connect to one another by gap junctions, forming a network through which muscle action potentials can spread. When a neurotransmitter, hormone, or autorhythmic signal stimulates one fiber, the muscle action potential is transmitted to neighboring fibers, which then contract in unison, as a single unit.
Figure 9.12.3 Many factors can result in muscle hypertrophy, atrophy, or paralysis