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This document summarizes the effects of various enzymes on blood antigens. It notes that the M and N antigens are easily destroyed by common blood bank enzymes like ficin, papain and bromelin. The S and s antigens are also degraded by these enzymes but to a lesser extent and depending on enzyme strength. Fy a and Fy b antigens are destroyed by proteolytic enzymes like ficin, papain, bromelin and chymotrypsin. In contrast, treatment with ficin and papain enhances the reactivity of I and i antigens with antibodies. While the P1 antigen is resistant to enzyme treatment, the reactivity of antibodies can be enhanced against enzyme-treated cells. Similarly, papain and fic
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This document discusses a study aiming to elucidate the mechanism by which the HDAC inhibitor Apicidin induces expression of the drug efflux pump P-glycoprotein (P-gp), which may lead to multidrug resistance. The study found that Apicidin treatment activated the PI3K pathway, leading to phosphorylation of the transcription factor SP1. Phosphorylated SP1 then signals chromatin remodeling and activation of the P-gp promoter. This occurred independently of changes in DNA methylation and required the Y-box and GC box regions of the promoter. Blocking the PI3K pathway prevented Apicidin-induced P-gp expression.
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Gabapentin is used to treat partial seizures, postherpetic neuralgia, and neuralgia. It is administered orally in tablet, capsule, and liquid forms at dosages ranging from 300mg to 3600mg per day depending on the condition. Common side effects occurring in over 10% of patients include ataxia, dizziness, drowsiness, fatigue, and somnolence. Less common side effects between 1-10% include diplopia and tremor. Rare side effects under 1% include Stevens-Johnson syndrome, elevated liver enzymes, and rhabdomyolysis. It has drug interactions with aluminum hydroxide, calcium carbonate, and hypnotic agents.
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The document summarizes the Easycure mobile healthcare app, which aims to connect doctors and patients anytime, anywhere in India. The app allows patients to get medical advice and consult doctors remotely, while also allowing doctors to help more patients. It functions like an online marketplace by connecting users to qualified doctors, medical stores, diagnostic centers, and ambulance services. Users can book appointments, consult doctors by phone/video, order medicines for delivery, and more. The document outlines Easycure's value proposition, features, pricing, management team, processes, growth strategy, and disclaimer.
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ーーーーーーーーーーーーーーーーーーーーーーー
schoo WEB-campusは「WEBに誕生した、学校の新しいカタチ」。
ＷＥＢ生放送の授業を無料で配信しています。
▼こちらから授業に参加すると、先生への質問や、ユーザーとのチャット、資料の拡大表示等が可能です。
https://schoo.jp/class/245/room
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El documento clasifica los instrumentos musicales en cuatro familias principales: cordófonos, aerófonos, idiófonos y membranófonos. Dentro de los cordófonos describe los de cuerda pulsada, cuerda percutida y cuerda flotada. Luego describe las subcategorías de aerófonos de viento madera y viento metal, e idiófonos de sonido afinado y no afinado. El documento provee una clasificación detallada de los diferentes tipos de instrumentos musicales.
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Nehmen Sie an diesem Webinar teil, bei dem HCL-Ambassador Marc Thomas und Gastredner Franz Walder Ihnen diese neue Welt näherbringen. Es vermittelt Ihnen die Tools und das Know-how, um den Überblick zu bewahren. Sie werden in der Lage sein, Ihre Kosten durch eine optimierte Domino-Konfiguration zu reduzieren und auch in Zukunft gering zu halten.
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Chapter 8, objective
- 1. Chapter 8, objective # 17 List the antigens that are denatured by routine blood bank enzymes and antigens whose reactivity with antibody is enhanced with enzymes?
- 2. Antigens denatured activity by enzymes M and N antigens Easily destroyed by the routine blood bank enzymes ficin, papain, and bromelin. Less common enzymes are trypsin and pronase. S and s antigen Less easily degraded by Ficin, papain, bromelin, pronase, and chymotrypsin can destroy S and s activity, but the amount of degradation may depend on the strength of the enzyme solution.
- 3. Fya and Fyb antigen Antigens are destroyed by proteolytic enzymes such as ficin, papain, bromelin, and chymotrypsin, and by ZZAP. Neuramidase may reduce the molecular weight of Fya and Fyb antigen, but it does not destroy antigenic activity and neither does purified trypsin.
- 4. Antigens enhanced activity by enzymes I and i antigen Treatment of RBCs with ficin and papain enhances reactivity of I and I antigens with their respective antibodies. The I and i antigens are resistant to treatment with DTT and glycine- acid EDTA. P1 It is resistant to different enzymes treatment. Reactivity of the antibodies can be greatly enhanced by testing with enzyme-treated RBCs.
- 5. Jka and Jk b antigen Kidd antigens are not denatured by papain or ficin; treatment of RBCs with enzymes generally enhances reactivity with Kidd antibodies.