Gabapentin is used to treat partial seizures, postherpetic neuralgia, and neuralgia. It is administered orally in tablet, capsule, and liquid forms at dosages ranging from 300mg to 3600mg per day depending on the condition. Common side effects occurring in over 10% of patients include ataxia, dizziness, drowsiness, fatigue, and somnolence. Less common side effects between 1-10% include diplopia and tremor. Rare side effects under 1% include Stevens-Johnson syndrome, elevated liver enzymes, and rhabdomyolysis. It has drug interactions with aluminum hydroxide, calcium carbonate, and hypnotic agents.

1. {
Jessadaporn K. B5560332

2. Generic name : Gabapentin,Pregabalin
Trade name : Neurontin®
C9H17NO2
Bioavailability 60 % increase with high fat meal
Half life 6 hr
Excretion Renal
Mechanism Unclear
increases GABA synthesis,
activating descending inhibitory noradrenergic pathways

3. Tablet
300mg
600mg
800mg
Administration & Dosage
Capsule
100mg
300mg
400mg
Oral solution
250mg/5mL
โรงพยาบาลบุรีรัมย์
300 mg cap
10 tab 300 Baht

4. Partial seizure
 Adjunctive therapy for partial seizures with or
without secondary generalization
 Initial: 300 mg PO q8hr
 Max dose 3600 mg/day
Postherpetic neuralgia
 Day 1: 300 mg PO qDay
 Day 2: 300 mg PO q12hr
 Day 3: 300 mg PO q8hr
 Day 4: 600 mg PO q8hr
 Keep maintenance >1800 mg/day
Neuralgia
 300 mg PO q8hr
 Max dose 3600 mg/day
Indication
Off-label
Restless legs syndrome
Cocaine withdrawal
Insomnia
Tremors in multiple sclerosis
Hot flashes-cancer related
Orphan
Amyotrophic Lateral Sclerosis

5. Adverse Drug Reaction
Interaction
Aluminum Hydroxide
Calcium Carbonate
Hypnotic agent
Side effect
>10%
Ataxia (1-13%)
Dizziness (16-20%)
Drowsiness (5-21%)
Fatigue (11-15%)
Somnolence (16-20%)
1-10%
Diplopia (6-10%)
Tremor (6-10%)
Constipation (1-5%)
Depression (1-5%)
<1%
SJS
Elevate LFTs
Rhabdomyolysis
Contraindication
Drug allergy
Pregnancy Cat C