Marginal bone loss around mini-implants used to stabilize complete dentures was evaluated over a mean observation period of 2.3 years. On average, bone loss was higher in the maxilla than mandible but remained below 1.5 mm in both arches. A previous smoking habit and implants with low insertion torque that were delayed in loading showed greater bone loss compared to immediately loaded implants with high insertion torque. While panoramic radiographs have limitations, mean bone loss was comparable to standard-diameter implants and remained clinically insignificant.