cellular unit

1. Cellular unit in health
disease
Dr.T.Arivazhagan
Department of pathology

2. Introduction
• Viability & activity of the cell depends on a variety of fundamental
housekeeping function
1. Production from environment
2. Provide nutrients
3. Communication
4. Movement
5. Renewal
6. Molecular catabolism

3. Cytosol – metabolism
Mitochondria – Energy
generation
RER- protein synthesis
SER- steroid synthesis
Golgi – protein modification
Nucleus – cell regulation
Lysosomes- cellular catabolism

5. Cytoskeleton
Ability of the cells to adopt a particular shape,
maintain polarity, organize the relationship of
intercellular organelles and move about depends on
the intra cellular scaffolding of proteins called
cytoskeleton.

6. 1. Actin filaments
2. Intermediate filaments
3. Micro tubules

8. Cell-Cell interactions
1. Tight junction
2. Gap junction
3. Anchoring junction

10. Growth factors & receptors
• Growth factor is to stimulate the activity of the genes that are
required for cell growth and cell division.
1. Promote the entry of cell in to cell cycle
2. Relive the blocks
3. Prevent apoptosis

12. 1. EGF
2. HGF
3. PDGF
4. FGF
5. KGF
6. TGF

13. Cell cycle
• Sequence of the events that results in cell division
• It is fundamental to development ,maintance of the steady
state tissue hemostasis and replacement of the dead or
damaged cells
• Tightly regulated by activators and inhibitors

15. Stem cells
• Stem cells are cells that can differentiate into other
types of cells
1. Self renewal
2. Asymmetric division