This document summarizes the current understanding of long-term sequelae, or post-COVID conditions, among children and adolescents. It finds that post-COVID conditions can occur in children and adolescents regardless of the severity of their initial COVID-19 infection. Symptoms are wide-ranging and can include fatigue, respiratory difficulties, brain fog, and mood changes. While most studies have limitations, prevalence estimates suggest 5-30% of children may experience post-COVID conditions. Risk may be higher in adolescents, those hospitalized for COVID-19, and those with multisystem inflammatory syndrome. Many questions remain about associated factors, duration, and impact on daily life. Vaccination against COVID-19 may help reduce risks of long-term
CME Lecture on "COVID-19 Presentation and Diagnosis"
Presented at the Scientific Seminar of Philippine American Medical Association in Chicago on March 6th, 2021.
• Much is still unknown regarding the markers of disease and recovery process for SARS-CoV-2, including if and what immunity arises and which tests or markers can be useful in assessing immunity status
• A multi-phased plan is required to reopen the economy post-COVID-19, with significantly daily testing capacity (millions) required at all stages
o Challenges with scientific validation, regulatory, manufacturing, and ongoing logistics must be overcome to successfully ramp up testing capacities in the US
o Hundreds of molecular and serology tests are now available, but many have limited accuracy (high false positive/negative rates) due to the rapid development and lack of validation of these tests
• In this edition of Demystifying COVID-19 Testing, we highlight what is required now and in the future to move to a “new normal” and why it is challenging to get this testing up and running at volumes needed in the US
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
Webinar Series on COVID-19 vaccine: Jointly organized by Malaysian Society of Infection Control and Infectious Diseases (MyICID) & Institute for Clinical Research (ICR), NIH
Speaker: Dr. Rizah Mazzuin Razali, the head of Geriatric Unit and Internal Medicine Physician working in Kuala Lumpur Hospital, Ministry of Health Malaysia.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
CME Lecture on "COVID-19 Presentation and Diagnosis"
Presented at the Scientific Seminar of Philippine American Medical Association in Chicago on March 6th, 2021.
• Much is still unknown regarding the markers of disease and recovery process for SARS-CoV-2, including if and what immunity arises and which tests or markers can be useful in assessing immunity status
• A multi-phased plan is required to reopen the economy post-COVID-19, with significantly daily testing capacity (millions) required at all stages
o Challenges with scientific validation, regulatory, manufacturing, and ongoing logistics must be overcome to successfully ramp up testing capacities in the US
o Hundreds of molecular and serology tests are now available, but many have limited accuracy (high false positive/negative rates) due to the rapid development and lack of validation of these tests
• In this edition of Demystifying COVID-19 Testing, we highlight what is required now and in the future to move to a “new normal” and why it is challenging to get this testing up and running at volumes needed in the US
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
Webinar Series on COVID-19 vaccine: Jointly organized by Malaysian Society of Infection Control and Infectious Diseases (MyICID) & Institute for Clinical Research (ICR), NIH
Speaker: Dr. Rizah Mazzuin Razali, the head of Geriatric Unit and Internal Medicine Physician working in Kuala Lumpur Hospital, Ministry of Health Malaysia.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
cdc_118584_DS1.pdf
1. cdc.gov/coronavirus
Burden, Prevalence, and
Trends of Long-Term Sequelae
of SARS-CoV-2
Sharon Saydah
National Center for Immunization and Respiratory Diseases
Centers for Disease Control and Prevention
ACIP
June 23, 2022
2. 2
There are many terms used to refer to these conditions
Long COVID
– Commonly used
Post-COVID Condition(s)
– CDC and WHO
Post-Acute Sequelae of SARS-CoV-2 (PASC)
– NIH
3. 3
A general framework for post-COVID conditions
Umbrella term for the
wide range of physical
and mental health
consequences, present
for four weeks and
beyond after SARS-CoV-
2 infection, including for
patients who had initial
mild or asymptomatic
acute infection. Conditions frequently overlap
Patients may experience any combination
*ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Framework for Variety of Conditions
Following SARS-CoV-2 Infection
General consequences of illness
and hospitalization
Post acute consequences of
SARS-CoV-2 infection
• Post ICU syndrome
• Other complications of
treatment or illness
• System specific pathology
(e.g. lung fibrosis, stroke)
• Clinically significant
symptoms with unclear
pathology (e.g. ME/CFS*-
like, dysautonomia)
• On-going symptoms
following MIS-C
4. 4
Multiple proposed potential mechanisms for
post-COVID conditions
Proposed mechanisms could
include viral persistence, systemic
and tissue specific inflammation,
auto immunity, microvascular
dysfunction
Whether potential mechanisms
differ for children is unknown
Peluso and Deeks. Early clues regarding the pathogenesis of long-COVID:
Trends in Immunology (cell.com) 2022
5. 5
Symptoms of post-COVID conditions are similar
among children and adults
Dyspnea or increased respiratory effort
Fatigue
Anosmia or dysgeusia
Chest pain
Headache
Lightheadedness
Palpitations and/or tachycardia
Arthralgia
Myalgia
Paresthesia
Cough
Abdominal pain
Diarrhea
Insomnia and other sleep difficulties
Fever
Impaired daily function and mobility
Pain
Rash (e.g., urticaria)
Mood changes
Menstrual cycle irregularities
Post-exertional malaise and/or poor
endurance
“Brain fog,” cognitive impairment
https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html
Borch L et al. Long COVID symptoms and duration children. European Journal Pediatrics 2022
6. 6
There is a wide range in the reported prevalence of
post-COVID conditions among adults
Self-report of symptoms on surveys range from 13.3% at ≥ 1 month to 2.5% at ≥ 3
months
Based on electronic health record data
– Of non-hospitalized adults with COVID-19, 7.7% experienced one or more of 10
identified late-onset conditions 1 to 4 months post infection2
– Burden of at least one symptom at 6 months differs by severity of acute
COVID:3
– Overall: 73.4/1,000 patients
• Non-hospitalized: 44.5/1,000 patients
• Hospitalized: 217.1/1,000 patients
– ICU 360.5/1,000 patients 1. Sudre CH et al Nature Medicine 27, 626-631 (2021)
2. Chevinsky JR et al. Clinical Infectious Diseases 73 (S1) 2021
3. Xie Y et al. Nature Communications 12, 6571 (2021)
7. 7
Duration of post-COVID conditions can vary among
adults
Most patients report no acute
symptoms at 4 weeks and the
proportion reporting on-going
symptoms decreases 4-12 weeks
Improvement slows around 12
weeks after infection
Women and men follow same
pattern, but more women
report symptoms
Technical article, figure 2. Office for National Statistics (ons.gov.uk)
UK Coronavirus Infection Survey: Report of symptoms
lasting 4 or more weeks- April 2020 – August 2021
%
with
symptoms
8. 8
Children present unique challenges in understanding
post-COVID conditions
Difficulties assessing symptoms in young children include
– Inability of younger children to describe symptoms
– Inconsistent manifestation of symptoms
– Assessments of conditions may be dependent on expected
developmental milestones
Limitations of current research
– Varying time points from infection for assessments
– Lack of control groups
– Small sample sizes in most reports
9. 9
Similar to adults there is a wide range in prevalence of
post-COVID conditions among children
Symptoms lasting 4 weeks or longer following SARS-CoV-2 infection are
common among children and adolescents.
The most common symptoms include:
– Headache or respiratory symptoms (~7%)
– Sleep disorders (~8%)
– Fatigue (9%)
– Mood disorders (~16%)
Zimmermann et al. The Challenge of Studying Long COVID: An Updated Review : The Pediatric Infectious Disease
Journal (lww.com)
Lopez-Leon et al. Long-COVID in Children and Adolescents: A Systematic Review and Meta-analyses | medRxiv
10. 10
Non-hospitalized children also experience post-COVID
conditions
Survey of school age
children and parents
in the UK (n = 4,530)
Weighted to ages 5 -
18 years, UK
population
Occurrence higher
among adolescents
16-18 years
0
5
10
15
20
25
30
35
Had a positive test
for SARS-CoV-2
Had ongoing
symptoms for 12 or
more weeks
Daily life affected by
ongoing COVID-19
symptoms
Fulfil all criteria for
Long Covid
Percent
(%)
Primary school (aged 5 to 11 years) Year 7 to 11 (aged 11 to 16 years)
Year 12 to 13 (aged 16 to 18 years)
5 to 11 years 1 %
11 to 16 years 2.5%
16 to 18 years 4.4%
COVID-19 Schools Infection Survey, England - Office for National Statistics, accessed March 2022
11. 11
Risk factors of post-COVID conditions in children
previously hospitalized for COVID-19
Risk factors include older age
and allergic disease
Symptoms decrease over time
Osmanov et al. Risk factors for long COVID in previously hospitalized children. European Respiratory Journal
2021
12. 12
New symptoms 31-150 days after testing positive for
SARS-CoV-2
Children, adolescents,
and young adults who
tested positive for
COVID-19 were more
likely than patients
who tested negative to
have shortness of
breath and heart rate
abnormalities
Hernandez-Romieu AC et al. JAMA Netw Open. 2022
Prevalence ratio is the proportion with symptom & COVID-19 + divided
by the proportion with the symptom & COVID-19 -
13. 13
New conditions 31-150 days after testing positive for
SARS-CoV-2
Children,
adolescents, and
young adults who
tested positive for
COVID-19 were
more likely than
patients who tested
negative to have
new type 2
diabetes
Hernandez-Romieu AC et al. JAMA Netw Open. 2022; 5(2)
Prevalence ratio is the proportion with symptom & COVID-19 + divided
by the proportion with the symptom & COVID-19 -
14. 14
Retrospective cohorts constructed
using IQVIA healthcare claims data
from March 1, 2020, through
February 26, 2021
Incidence of new diabetes diagnosis
among COVID-19 patients, matched
by age and sex, was higher
compared to no COVID-19 diagnosis
and to pre-pandemic non-COVID
acute respiratory infection (ARI)
Hazard ratio of 2.66 overall
Barrett CE, et al. MMWR Morb Mortal Wkly Rep 2022;71:59–65.
15. 15
Children and adolescents who had COVID-19 have an increased risk of a wide range
of new conditions and symptoms ≥ 4 weeks following COVID-19 compared to
children and adolescents without COVID-19
US Commercial Medical Claims Data, March 1, 2019–September, 2021. Unpublished CDC data.
Hazard Ratio (95% CI of bolded hazard ratio does not include 1)*
New outcome Overall 2–4 years 5–11 years 12–17 years
Symptom
Smell and taste disturbances 1.17 1.22 0.94 1.23
Circulatory signs and symptoms 1.07 1.17 1.11 1.04
Malaise and fatigue 1.05 1.13 1.08 1.03
Musculoskeletal pain 1.02 1.16 1.06 1.00
Condition
Acute pulmonary embolism 2.01 —† —† 2.03
Myocarditis and cardiomyopathy 1.99 2.39 2.84 1.66
Venous thromboembolic event 1.87 —† 2.69 1.52
Acute and unspecified renal failure 1.32 1.52 1.38 1.27
Type 1 diabetes 1.23 1.01 1.31 1.20
Coagulation and hemorrhagic disorders 1.18 1.47 1.28 1.10
Type 2 diabetes 1.17 1.24 1.14 1.18
Cerebrovascular disease 1.16 1.66 1.14 1.18
Asthma 1.07 1.12 1.02 0.96
†: <10 events
16. 16
Children with Multisystem Inflammatory Syndrome (MIS-C) appear to have
higher risk of ongoing symptoms following MIS-C
Continued difficulties at 6 months were reported by 35% of children and
21% of the children’s parents
Specific system involvement decreased by 6 months
Penner J. et al. 6 month follow-up MIS-C. Lancet Pediatric 2021
17. 17
Post-COVID conditions may be less likely to occur after
vaccine breakthrough
While most studies on post-COVID conditions occurring after vaccine breakthrough
have focused on adults, two included adolescents: 1,2
– Less likely to have symptoms between 12 and 20 weeks after infection
compared to persons unvaccinated (OR 0.22, 95% 0.20, 0.25)
– Lower the occurrence of post-COVID conditions in persons with infection
after vaccination (who tend to have milder infections) than infections in
persons who are unvaccinated
1. Simon et al. Reduced Incidence of Long-COVID Symptoms | medRxiv 2022
2. Tarquet et al. Six-month sequelae of post-vaccination SARS-CoV-2 infection| medRxiv 2022
18. 18
Summary of post-COVID conditions among children and
adolescents and unanswered questions
Post-COVID conditions occur among children and adolescents with COVID-19
regardless of acute illness severity, but at higher frequency among:
– Hospitalized or those who had more severe illness
– Adolescents
Remaining areas of uncertainty:
– Frequency, severity, and duration of post-COVID conditions
– Groups disproportionately impacted by post-COVID conditions
– Association of SARS-CoV-2 variants with the incidence of post-COVID
conditions
– Impact on daily activities and participation in school
19. For more information, contact CDC
1-800-CDC-INFO (232-4636)
TTY: 1-888-232-6348 www.cdc.gov
The findings and conclusions in this report are those of the authors and do not necessarily represent the
official position of the Centers for Disease Control and Prevention.
For more information:
Sharon Saydah, PhD, MHS zle0@cdc.gov
COVID-19 Response, Epi Task Force, Post COVID Conditions Team eocevent513@cdc.gov