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Three Dimensional Cerebral Cavernous
Malformation Organoids to Advance Drug Discovery
for CCM.
Tasneem Joulani
Bushra Barghothi
Vascular Endothelial Cells
Single layer of cells
Formed from embryonic
mesoderm
Provide a barrier between the
blood and body’s tissues
Endothelial Cells Junctions
In BBB
Cerebral Cavernous Malformation
* The aim of our study to develop CCM spheroid to CCM
organoids which help others in explore proper treatment
and apply drugs on it.
How to develop the CCM spheroids to organoids?
Methodology
Isolated ECs
Matrigel
Methodology

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CCM Organoids.pptx