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This document summarizes a study that characterized mutations causing Glanzmann's thrombasthenia (GT) in Iranian patients. The study identified 3 novel mutations in 20 GT patients by analyzing their ITGA2B and ITGB3 genes encoding the platelet glycoprotein IIb/IIIa complex. Sequence analysis revealed frameshift mutations causing premature termination, as well as missense and synonymous polymorphisms. The various mutations were found to impair glycoprotein expression and function, thereby causing the impaired platelet aggregation that is characteristic of GT.
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tasneem GT.pptx
This document summarizes a study that characterized mutations causing Glanzmann's thrombasthenia (GT) in Iranian patients. The study identified 3 novel mutations in the genes encoding platelet glycoprotein IIb/IIIa (GPIIb/IIIa) from DNA analysis of 20 GT patients. The mutations included 2 frameshift mutations resulting in premature protein termination or splice site alterations, and a substitution mutation disrupting the GPIIb/IIIa structure and preventing platelet aggregation. The study contributes to understanding the genetic basis of GT and its variable clinical manifestations.
Kinetika trombosit
1. The document discusses trombopiesis and megakariopoiesis, the production of platelets from megakaryocytes in the bone marrow.
2. Key steps include megakaryocyte maturation through endomitosis and proplatelet formation, which release platelet fragments into circulation.
3. Platelets are the smallest blood cells and function in hemostasis and thrombosis through adhesion, secretion of granule contents, and aggregation.
Uk glanzmann
1) Glanzmann thrombasthenia is a rare bleeding disorder caused by a deficiency in the platelet integrin αIIbβ3, which normally allows platelets to aggregate and form blood clots.
2) Patients experience mucocutaneous bleeding such as purpura, epistaxis, and menorrhagia. The severity of bleeding varies between patients.
3) The disorder is inherited in an autosomal recessive pattern and is caused by mutations in the genes encoding the αIIb and β3 subunits of the integrin. Over 100 mutations have been identified.
Platelet Aggregation
A patient has a history of recurrent gum bleeding since childhood. While platelet counts and coagulation tests are normal, an inherited platelet disorder is suspected. The doctor's diagnostic approach would include a detailed bleeding history, physical exam looking for bruises/petechiae, and first-line screening tests like a bleeding time and platelet function analyzer. Further specific tests may include light transmission aggregometry to assess platelet aggregation in response to various agonists and help identify potential defects in adhesion, activation, secretion or aggregation. Interpreting the different waveforms is important to determine abnormalities consistent with disorders like Glanzmann's thrombasthenia or storage pool disease.
Poster
1) The study investigated the prevalence of Y chromosome microdeletions in infertile males from South West Iran using standard methods.
2) They found a 1.2% prevalence of complete AZFc deletions and 6.25% prevalence of partial AZFc deletions, including 5% gr/gr deletions and 1.25% b2/b3 deletions.
3) Interestingly, 4% of the control group also showed gr/gr deletions, suggesting this deletion may not be involved in spermatogenic failure in the studied population. However, the 1.25% prevalence of b2/b3 deletions only in patients warrants further investigation in a larger group.
Factor 3 and 7
Factor 3 (tissue factor) and Factor 7 work together in the extrinsic pathway of the coagulation cascade. Factor 3 is a cell surface glycoprotein found on tissues and leukocytes that activates Factor 7. Once bound, Factor 7 is activated to Factor 7a, which activates Factor 10 to 10a and prothrombin to thrombin, ultimately resulting in fibrin clot formation. A deficiency in either Factor 3 or Factor 7 can cause a bleeding disorder.
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tasneem GT.pptx
This document summarizes a study that characterized mutations causing Glanzmann's thrombasthenia (GT) in Iranian patients. The study identified 3 novel mutations in the genes encoding platelet glycoprotein IIb/IIIa (GPIIb/IIIa) from DNA analysis of 20 GT patients. The mutations included 2 frameshift mutations resulting in premature protein termination or splice site alterations, and a substitution mutation disrupting the GPIIb/IIIa structure and preventing platelet aggregation. The study contributes to understanding the genetic basis of GT and its variable clinical manifestations.
Kinetika trombosit
1. The document discusses trombopiesis and megakariopoiesis, the production of platelets from megakaryocytes in the bone marrow.
2. Key steps include megakaryocyte maturation through endomitosis and proplatelet formation, which release platelet fragments into circulation.
3. Platelets are the smallest blood cells and function in hemostasis and thrombosis through adhesion, secretion of granule contents, and aggregation.
Uk glanzmann
1) Glanzmann thrombasthenia is a rare bleeding disorder caused by a deficiency in the platelet integrin αIIbβ3, which normally allows platelets to aggregate and form blood clots.
2) Patients experience mucocutaneous bleeding such as purpura, epistaxis, and menorrhagia. The severity of bleeding varies between patients.
3) The disorder is inherited in an autosomal recessive pattern and is caused by mutations in the genes encoding the αIIb and β3 subunits of the integrin. Over 100 mutations have been identified.
Platelet Aggregation
A patient has a history of recurrent gum bleeding since childhood. While platelet counts and coagulation tests are normal, an inherited platelet disorder is suspected. The doctor's diagnostic approach would include a detailed bleeding history, physical exam looking for bruises/petechiae, and first-line screening tests like a bleeding time and platelet function analyzer. Further specific tests may include light transmission aggregometry to assess platelet aggregation in response to various agonists and help identify potential defects in adhesion, activation, secretion or aggregation. Interpreting the different waveforms is important to determine abnormalities consistent with disorders like Glanzmann's thrombasthenia or storage pool disease.
Poster
1) The study investigated the prevalence of Y chromosome microdeletions in infertile males from South West Iran using standard methods.
2) They found a 1.2% prevalence of complete AZFc deletions and 6.25% prevalence of partial AZFc deletions, including 5% gr/gr deletions and 1.25% b2/b3 deletions.
3) Interestingly, 4% of the control group also showed gr/gr deletions, suggesting this deletion may not be involved in spermatogenic failure in the studied population. However, the 1.25% prevalence of b2/b3 deletions only in patients warrants further investigation in a larger group.
Factor 3 and 7
Factor 3 (tissue factor) and Factor 7 work together in the extrinsic pathway of the coagulation cascade. Factor 3 is a cell surface glycoprotein found on tissues and leukocytes that activates Factor 7. Once bound, Factor 7 is activated to Factor 7a, which activates Factor 10 to 10a and prothrombin to thrombin, ultimately resulting in fibrin clot formation. A deficiency in either Factor 3 or Factor 7 can cause a bleeding disorder.
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collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
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because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
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s
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Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
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EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
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Cytokines and their role in immune regulation.pptx
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3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
Nucleic Acid-its structural and functional complexity.
Nucleic Acid-its structural and functional complexity.
Featured
2024 State of Marketing Report – by Hubspot
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
Everything You Need To Know About ChatGPT
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage Engineerings
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental Health
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdf
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Skeleton Culture Code
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
Social Media Marketing Trends 2024 // The Global Indie Insights
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summary
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
Getting into the tech field. what next
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search Intent
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
How to have difficult conversations
Stop putting off having difficult conversations. Seven practical tips to ensure your next difficult conversation go smoothly.
Introduction to Data Science
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best Practices
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project management
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
A presentation for absolute beginners who have never touched TikTok and may be a bit scared of it!
Featured (20)
Product Design Trends in 2024 | Teenage Engineerings
Product Design Trends in 2024 | Teenage Engineerings
How Race, Age and Gender Shape Attitudes Towards Mental Health
How Race, Age and Gender Shape Attitudes Towards Mental Health
AI Trends in Creative Operations 2024 by Artwork Flow.pdf
AI Trends in Creative Operations 2024 by Artwork Flow.pdf
Content Methodology: A Best Practices Report (Webinar)
Content Methodology: A Best Practices Report (Webinar)
How to Prepare For a Successful Job Search for 2024
How to Prepare For a Successful Job Search for 2024
Social Media Marketing Trends 2024 // The Global Indie Insights
Social Media Marketing Trends 2024 // The Global Indie Insights
Trends In Paid Search: Navigating The Digital Landscape In 2024
Trends In Paid Search: Navigating The Digital Landscape In 2024
5 Public speaking tips from TED - Visualized summary
5 Public speaking tips from TED - Visualized summary
Google's Just Not That Into You: Understanding Core Updates & Search Intent
Google's Just Not That Into You: Understanding Core Updates & Search Intent
The six step guide to practical project management
The six step guide to practical project management
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
tasneem GT.pptx
- 1. Molecular Characterization of Glazmann’s Thrombasthenia in Iran: identification of three novel mutations Prepared By: Tasneem Joulani Supervisor: Dr. Mahmoud Srour
- 2. Platelets and Hemostasis Glanzmann’s Thrombansina Methods Results and Discussion Conclusion Content
- 3. Platelets (Thrombocytes) Produced in BM No nucleus Hemostasis Resting Plt Activated Plt
- 7. Glanzmann’s Thrombasthenia (GT) - Autosomal recessive coagulation disorder (bleeding disorder)
- 8. Glanzmann’s Thrombasthenia (GT) - Men and women affected equally - Genetic defect located on chromosome 17 - Impaired platelet aggregation is the hallmark of GT
- 9. Glanzmann’s Thrombasthenia (GT) - Quantitative and/or qualitative defect of platelet glycoprotein IIb/IIIa (GPIIb/IIIa)
- 10. Glanzmann’s Thrombasthenia (GT) - Nonsense and missense mutations
- 11. Glanzmann’s Thrombasthenia Symptoms Petechia Epistaxis Gum bleeds
- 12. Methods 20 patients (GT) Blood sampling, DNA extraction, and analysis by spectrophotometer Amplification by touch-down PCR Conformation Sensitive Gel Electrophoresis heteroduplex PCR DNA Sequencing
- 13. Results and Discussion Mutation Identification 1
- 14. Glanzmann’s Thrombasthenia (GT) Types 2
- 15. Results and Discussion Mutation Identification
- 16. Results and Discussion Mutation Identification
- 17. Results and Discussion Mutation Identification * Point mutations and polymorphism in GPIIb/IIIa complex * Missense and nonsense mutations cause premature termination or splice site defects. * Ligand binding activity, rate of the complex expression, and the receptor activation impaired depending on the site of mutation
- 18. Discussion * 3 novel mutations and 2 novel polymorphisms were recognized during the examination of entire coding regions of ITGA2B and ITGB3 genes. * Frameshift mutations resulted in premature termination or splice site alteration. - The beginning of exon 9 of ITGB3 and exon 1 of ITGA2B. - The middle of exon 12 of ITGB3
- 19. Discussion * 2 novel synonymous polymorphisms (silent mutation) - exon 10 of IGTB3 no effect on plt (aggregation or adhesion) * Substitution mutation on exon 5 of IGTB3 disrupt GPIIb/IIIa structure and LBA prevents plts aggregation * Type I GT no GPIIb/IIIa expression on their plts. * Another polymorphism (missense gene alteration) in the extracellular domain of B3
- 20. Conclusion * The platelet membrane glycoprotein IIb/IIIa complex mutations lead to Glanzmann's thrombasthenia. A large variety of mutations and polymorphisms are responsible for the aberrant expression and defective activity of this heterodimeric complex. * Mutation screening was analyzed using conformation-sensitive gel electrophoresis heteroduplex PCR, and DNA sequencing.
- 21. Thank You