1) Cone-beam computed tomography (CBCT) is not the imaging technique of choice for comprehensive orthodontic assessment according to current evidence and guidelines.
2) While CBCT provides some benefits over conventional radiographs for certain conditions, it also exposes patients to higher radiation doses. There is little evidence that the additional information provided by CBCT significantly improves treatment outcomes.
3) Existing guidelines from organizations like SEDENTEXCT recommend that CBCT not be used routinely for orthodontic cases and only be used when information cannot be obtained by lower dose conventional radiographs. Overall, the risks of higher radiation exposure from CBCT do not outweigh the limited benefits for most orthodontic patients based on current
Towards best practice in interventional radiologyNHS Improvement
Towards best practice in interventional radiology draws together the findings from visits to interventional radiology (IR) services at proposed major trauma centres in England during 2011/12. This record of their major findings provides a definitive read for trust chief executives and commissioners to help better inform IR service reviews. (June 2012)
Towards best practice in interventional radiologyNHS Improvement
Towards best practice in interventional radiology draws together the findings from visits to interventional radiology (IR) services at proposed major trauma centres in England during 2011/12. This record of their major findings provides a definitive read for trust chief executives and commissioners to help better inform IR service reviews. (June 2012)
Estimation of tertiary dentin thickness on pulp capping treatment with digita...IJECEIAES
Dentists usually observe the tertiary dentin formation after pulp capping treatment by comparing periapical radiograph before and after treatment visually. However many dentists find difficulties to observe tertiary dentin and also they can‟t measure exactly the thickness of the tertiary dentin. The aims of this study is to assist the dentists to measure the area of tertiary dentin and calculate the dentin formation using b-spline image processing. The dental radiograph of 38 patients of pulp capping in the Dental Hospital Universitas Muhammadiyah Yogyakarta, Indonesia. Each of patient visited dental hospital 3 times. First, the patient got an application of pulp capping material. Second, after one-week treatment and temporary restoration and the third, after more than one month with the composite as the final restoration. Every visited the patient take a radiograph. Dentist placed the dot from the patient's radiograph. The dots were combined and processed with digital image processing. The b-spline method changed the dot to one area. After the calculation, the dentist can see whether there was dentin formation which means it is one of the treatment success indicators. Dentist has the better view to measure the dentin formation by providing area value of its tertiary dentin thickness calculation. We compare the result to the program calculation using the b-spline method and visual observation from the dentist. This study indicated the thickness of tertiary dentin can be measured by this program with an accuracy of 94.2%. Therefore, dentist can make tertiary dentin thickness prediction from patient‟s radiograph.
Recent advances in radiographic technique /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
USE OF PET – HEALTH CARE POLICY PERSPECTIVESRuby Med Plus
POSITRON EMISSION TOMOGRAPHY (PET) USE BY TERTIARY HEALTH CARE CENT RES AND ITS ACCESSIBILITY TO POPULATION: A POLICY PERSPECTIVE. a BRIEF Cost-Benefit analysis.
Co-relation of multidetector CT scan based preoperative staging with intra-op...Apollo Hospitals
To assess the accuracy of CT scan in preoperative staging, to correlate preoperative findings with operative findings and with post-operative histopathological findings of colorectal carcinoma.
The study had two specific goals: 1) Determine the impact of a simulated reduced dose rendering on the detection of skeletal fractures in children, and 2) Evaluate the effect of enhanced skeletal processing on the same detection task. The methodology and results of this study were on display at RSNA 2015. Read the blog at http://www.carestream.com/blog/2016/04/12/carestream-pediatric-fracture-detection-study-and-potential-dose-reduction/#more-7700 or visit www.carestream.com/medical
Adult orthodontics /certified fixed orthodontic courses by Indian dental acad...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Estimation of tertiary dentin thickness on pulp capping treatment with digita...IJECEIAES
Dentists usually observe the tertiary dentin formation after pulp capping treatment by comparing periapical radiograph before and after treatment visually. However many dentists find difficulties to observe tertiary dentin and also they can‟t measure exactly the thickness of the tertiary dentin. The aims of this study is to assist the dentists to measure the area of tertiary dentin and calculate the dentin formation using b-spline image processing. The dental radiograph of 38 patients of pulp capping in the Dental Hospital Universitas Muhammadiyah Yogyakarta, Indonesia. Each of patient visited dental hospital 3 times. First, the patient got an application of pulp capping material. Second, after one-week treatment and temporary restoration and the third, after more than one month with the composite as the final restoration. Every visited the patient take a radiograph. Dentist placed the dot from the patient's radiograph. The dots were combined and processed with digital image processing. The b-spline method changed the dot to one area. After the calculation, the dentist can see whether there was dentin formation which means it is one of the treatment success indicators. Dentist has the better view to measure the dentin formation by providing area value of its tertiary dentin thickness calculation. We compare the result to the program calculation using the b-spline method and visual observation from the dentist. This study indicated the thickness of tertiary dentin can be measured by this program with an accuracy of 94.2%. Therefore, dentist can make tertiary dentin thickness prediction from patient‟s radiograph.
Recent advances in radiographic technique /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
USE OF PET – HEALTH CARE POLICY PERSPECTIVESRuby Med Plus
POSITRON EMISSION TOMOGRAPHY (PET) USE BY TERTIARY HEALTH CARE CENT RES AND ITS ACCESSIBILITY TO POPULATION: A POLICY PERSPECTIVE. a BRIEF Cost-Benefit analysis.
Co-relation of multidetector CT scan based preoperative staging with intra-op...Apollo Hospitals
To assess the accuracy of CT scan in preoperative staging, to correlate preoperative findings with operative findings and with post-operative histopathological findings of colorectal carcinoma.
The study had two specific goals: 1) Determine the impact of a simulated reduced dose rendering on the detection of skeletal fractures in children, and 2) Evaluate the effect of enhanced skeletal processing on the same detection task. The methodology and results of this study were on display at RSNA 2015. Read the blog at http://www.carestream.com/blog/2016/04/12/carestream-pediatric-fracture-detection-study-and-potential-dose-reduction/#more-7700 or visit www.carestream.com/medical
Adult orthodontics /certified fixed orthodontic courses by Indian dental acad...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Adult orthodontics /certified fixed orthodontic courses by Indian dental aca...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all
aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Orthodontic Treatment Modalities Done by: Dr. Mohamad Ghazi Kassem
2. Orthodontic Treatment Modalities Preventive orthodontics: Interceptive orthodontics Corrective orthodontics • Removable appliances • Fixed appliances Orthognathic Surgery “Jaw Surgery”
3. Preventive orthodontics Preventive Orthodontics is the action taken to preserve the integrity of what appears to be normal at a specific time. Any procedure that attempt to ward off untoward environmental attacks or anything that would change the normal course of events, e.g. 1. Early connection of proximal caries that might change the arch length 2. Early recognition and elimination of oral habits that might interfere with the normal development of the teeth and jaws 3. Placing of a space maintainer to maintain proper position of contiguous teeth It is defined as the action taken to preserve the integrity of what appears to be a normal occlusion at a specific time.
4. 1960 : Kesling stated that “some case should be referred as early as 3 or 4 years of age and all cases by the age of 8 or 9 years” there by lying the foundation of preventive and interceptive orthodontics. 1977: Begg stated that “proper time to begin the treatment is as the beginning of the variation from the normal, in the process of development of dental apparatus, as possible” 1980: Profit and Ackermann has defined it as a prevention of potential interference with occlusal development.
5. Various Preventive procedures are : 1. Pre-dental procedures 2. Care of deciduous dentition 3. Patient and parents education programs 4. Supernumerary teeth 5. Early loss of deciduous teeth 6. Proximal caries 7. Oral habits 8. Space maintainers
6. 1. Pre-dental procedures: • Proper nutrition of the child. • Proper nursing care of the infant. • Bottle feeding should be discouraged.
7. 2. Care of deciduous dentition: 3. Patient and parent’s education programs: Need of maintaining good oral hygiene should be explained to the patient and the parents. Demonstration of brushing methods and diet counseling etc are also important.
8. 4. Supernumerary teeth: Supernumerary teeth and supplemental teeth can interfere with the eruption of nearby teeth. Presence of mesiodens prevents the two maxillary central incisors from approximating each other. They should be removed at appropriate time.
9. 5.Oral habits: Abnormal oral habits should be recognized and patient should be helped by motivation or by fitting a suitable habit breaking appliance.
10. digit sucking Methods to prevent tongue thrusting Mouth breathing
11. 6.Space maintainers: Premature loss of deciduous teeth can cause drifting of the adjacent teeth into the space. Space maintainers must be inserted in appropriate cases after the loss of teeth, particularly after the loss of deciduous molars in inadequate arches. Fixed Space Maintainers Removable space maintainers
12. Interceptive orthodontics Richardson (1982)
Radiology in orthodontics /certified fixed orthodontic courses by Indian dent...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Orthodontic diagnosis deals with recognition of the various characteristics of the malocclusion. It involves collection of pertinent data in a systemic manner to help in the identifying the nature and cause of the problem.
Computed tomography (CT scan) is a medical imaging procedure that uses computer-processed X-rays to produce tomographic images or 'slices' of specific areas of the body. These cross-sectional images are used for diagnostic and therapeutic purposes in various medical disciplines.
Financial Implications for Integrating Carestream OnSight 3D Extremity System...Carestream
Carestream Health commissioned a working group of surgeons and administrators from four leading orthopedic practices to
evaluate the clinical application and economic impact of the OnSight 3D Extremity System. This paper outlines the results of that working group’s findings, including specific economic models for practices of various sizes and throughputs.
My review on application of an effective tool available to an emerging branch of dentistry. For queries and references please contact on dr.mathewthomasm@gmail.com.
43.Merlyn Elizabeth Monsy et al. ROLE OF CBCT IN ORAL AND MAXILLOFACIAL SURGERY – A REVIEW. International Journal of Psychosocial Rehabilitation, Vol. 24, Issue 04, 2020: 10302-10310
Osteoporosis Detection Using Deep LearningIJMTST Journal
Osteoporosis is a bone disorder which occurs due to low bone mass, degradation of bone micro-architecture
and high susceptibility to fracture. It is a major health concern across the world, especially in elderly people.
Osteoporosis can cause spinal or hip fractures that may lead to socio-economic burden and high morbidity.
Therefore, there is a need for the early diagnosis of osteoporosis and predicting the presence of the fracture.
We introduce a Convolutional Neural Network model to effectively diagnose osteoporosis in bone radiography
data. Automated diagnosis from digital radiographs is very challenging since the scans of healthy and
osteoporotic subjects show little or no visual differences. In this paper, we have proposed a model to separate
healthy from osteoporotic subjects using high dimensional textural feature representations computed from
radiography images. CNN can help us bring the use of structural MRI measurements of bone quality into
clinical practice for the detection of Osteoporosis as it gives high accuracy.
Explain the non safe or harm aspects of CT scan on the patient,, particularly after multiple CT scans done for one patient. mentioned essentially the risk of cancer in later life, which reach 1/2000.
Also, mentioned the organs, age group, and gender which affected more by CT radiation
Finally , stressing on eliminating CT scan as possible
Similar to Cbct is not the imaging technique of choice for comprehensive orthodontic assesment (20)
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Cbct is not the imaging technique of choice for comprehensive orthodontic assesment
1. POINT/COUNTERPOINT 403
Cone-beam computed tomography
is not the imaging technique of choice
for comprehensive orthodontic assessment
Demetrios J. Halazonetis
Kifissia, Greece
I
t was a pleasure to see that Dr Larson did not take A similar conclusion was adopted by the Ameri-
the extreme view of proposing cone-beam com- can Association of Orthodontists in 2010: “the
puted tomography (CBCT) as a routine diagnostic AAO recognizes that while there may be clinical sit-
modality—ie, for every patient, irrespective of maloc- uations where a cone-beam computed tomography
clusion or other patient-specific factors—as some or- (CBCT) radiograph may be of value, the use of
thodontic postgraduate programs in the United States such technology is not routinely required for ortho-
seem to do.1 Even so, he does recommend CBCT as dontic radiography.”4
the standard procedure, stating in his conclusions If guidelines already exist, what is the purpose of
that “CBCT has replaced conventional lateral cephalo- this debate? First, it is an opportunity to make these
grams and panoramic images as the most commonly guidelines well known to the orthodontic community
ordered imaging for comprehensive orthodontic pa- at a time when CBCT use is increasing. The SEDEN-
tients.” In my Counterpoint, I will try to present argu- TEXCT guidelines are based on a systematic review of
ments against CBCT as the imaging technique of choice the literature, thus representing current evidence-
for comprehensive orthodontic assessment. based knowledge at a confidence level much higher
Assuming that use for every patient is not advo- than this debate can achieve.2 Most importantly, how-
cated, what are the patient selection criteria? The an- ever, is that these guidelines are not compulsory. The
swer should stem from a comprehensive assessment use of ionizing radiation is governed by law in most
of the benefits and burdens to each patient. This as- countries, but all the law requires is clinical justifica-
sessment cannot be completely objective, but our deci- tion. The guidelines are designed to assist the clinician
sion making should be based on current evidence, in the justification process.3 I hope that this debate will
which could also serve as the basis to develop general convince clinicians to follow the guidelines’ recom-
guidelines. Such guidelines already exist. The SEDEN- mendations.
TEXCT project of the European Union had as its pri-
mary goal “to acquire key information necessary for RADIATION BURDEN
sound and scientifically based clinical use of CBCT”
and “to use this information to develop evidence- The effects of ionizing radiation are considered sto-
based guidelines dealing with justification, optimiza- chastic events. This signifies that the risk, not the sever-
tion and referral criteria for users of dental CBCT.”2 ity, of the condition (eg, cancer) depends on the dose.
The guidelines section dealing with orthodontic diag- Using a low-dosage vs a high-dosage CBCT machine
nosis concludes that “large volume CBCT should not will not result in cancers that are easier to treat, only
be used routinely for orthodontic diagnosis.” fewer of them. The probability of an important sto-
The British Orthodontic Society guidelines give chastic effect (cancer and severe hereditary effect) is
a similar recommendation: “routine use of CBCT even 7.3 3 10À2 Sv.5 For patients aged 10 to 20 years,
for most cases of impaction of teeth . . . cannot yet this doubles to approximately 0.15 Sv. Since a large
be recommended.”3 field-of-view CBCT will provide a dose of 68 to 368
mSv6 compared with approximately 30 mSv for the
cephalometric and panoramic combination, this trans-
Associate professor, School of Dentistry, University of Athens, Athens, Greece.
Reprint requests to: Demetrios J. Halazonetis, 6 Menandrou St, Kifissia GR-145
lates to a risk of about 1 in 170,000 to 1 in 20,000
61, Greece; e-mail, dhal@dhal.com. above the current customary procedure.5 In the United
Am J Orthod Dentofacial Orthop 2012;141:402-11 States, more than 1.6 million orthodontic patients start
0889-5406/$36.00
Copyright Ó 2012 by the American Association of Orthodontists.
treatment every year.7 If each patient had 1 CBCT im-
doi:10.1016/j.ajodo.2012.02.010 age, this would result in 10 to 80 additional cancer
American Journal of Orthodontics and Dentofacial Orthopedics April 2012 Vol 141 Issue 4
2. Counterpoint 405
cases per year. Is this a risk worth taking? This is not anmeasurements. Due to the relatively large voxel size,
easy question and depends mainly on the benefit to the thin structures are difficult to detect, and alveolar
patient.8 What significant improvements in patient bone covering the incisors might be underestimated,
outcomes does CBCT offer? To answer, we should although the results are conflicting.14,15 Errors in mea-
not confuse the benefits to the patient with the techni- suring bone thickness can exceed 1.4 mm for a 0.4-mm
cal capabilities of CBCT technology. The fact that CBCT voxel size.15 Fenestrations and dehiscences are overes-
images are 3-dimensional is not directly relevant. Jus- timated to a large degree.15,16
tification for CBCT images can only be considered At present, there are no diagnostic accuracy studies
when the treatment outcome will not only be better be- regarding the localization of impacted canines, and
cause of them, but also significantly better to outweigh none are expected because this question is not seriously
the above risks. debated.2,17 Regarding resorption of adjacent teeth,
CBCT images show improved sensitivity and specificity
over panoramic radiography.18 CBCT has been shown
EFFICACY to have increased diagnostic accuracy over posteroante-
The following terms are used to evaluate the effi- rior cephalograms in patients with skeletal asymmetry.19
9
cacy of diagnostic imaging procedures : technical effi- Concerning periodontal assessment, although it has
cacy, diagnostic accuracy efficacy, diagnostic thinking a definite 3-dimensional advantage, CBCT comple-
efficacy, therapeutic efficacy, ments but cannot replace in-
patient outcome efficacy,
and societal efficacy. These
Assuming that use for every patient traoral radiography, resolu-
because of reduced
mainly
efficacies constitute a hierar- is not advocated, what are the pa- tion.20 Studies on skull mate-
chy of levels of increasing im- tient selection criteria? The answer rial have shown that CBCT
portance. The top 2 levels should stem from a comprehensive images provide better diag-
evaluate whether the imaging nostic information,21 but
method produces a net bene-
assessment of the benefits and there is no consensus regard-
fit to the patient and society burdens to each patient. ing the accuracy of these
in general, and should dictate measurements.20,22 The SED-
our imaging policy. Regarding CBCT and its use in or- ENTEXCT guidelines conclude that “CBCT is not indi-
thodontics, no such studies have been conducted. We cated as a routine method of imaging periodontal
will consider the relevant evidence for each of the lower bone support,” although it might be indicated in se-
4 levels, focusing on large field-of-view protocols, lected patients, but preferably not with a large field of
since only these can provide reconstructed lateral ceph- view.2 The American Board of Orthodontics includes
alometric and panoramic views, similar to conventional CBCT images as an option to document periodontal sta-
radiographs. tus but does not consider radiographic images, in gen-
Technical efficacy is related to the quality of the im- eral, as compulsory data and gives priority to clinical
age. The dimensional accuracy of CBCT images has been examination and conventional radiography.23
10
well established. Voxel size is typically 0.3 to 0.4 mm, Diagnostic thinking efficacy evaluates whether the
corresponding to a lower resolution than that of conven- imaging method changes the diagnosis from the pre-
tional intraoral radiographic imaging. Artefacts and noise test situation. Therapeutic efficacy assesses whether
are higher than those observed in multi-slice computed the test produces changes to the treatment plan. These
tomography, making it difficult, if not impossible, to efficacies have been evaluated for impacted third
obtain consistent density values and resulting in low molars24 and impacted canines.25-27 CBCT images
10-12
contrast and poor depiction of soft tissues. Segmen- are perceived to be more useful than traditional radio-
tation is problematic, and even high-contrast objects, graphs for such cases26 and might change the
such as teeth, are measured with errors that can exceed recommended treatment plan in approximately
1 mm, limiting clinical usefulness.13 30% of them.25,27 However, no patient outcome effi-
Diagnostic accuracy efficacy measures the accuracy cacy studies have been conducted, and CBCT is recom-
of diagnosis by using CBCT in comparison with a refer- mended only when “the information cannot be
ence standard—in our case, a cephalogram or pano- obtained adequately by lower dose conventional (tradi-
ramic radiograph. Alveolar bone thickness and height, tional) radiography.”2 Dr Larson referred to the study of
and the presence of fenestrations and dehiscences, Becker et al28 of 28 failed cases of impacted canines,
have been compared between CBCT images and direct but the main reason for failure was inadequate
American Journal of Orthodontics and Dentofacial Orthopedics April 2012 Vol 141 Issue 4
3. Counterpoint 407
anchorage rather than improper localization. The au- serves as an adjunctive tool and has been shown to
thors acknowledged that the initial clinical and radio- be superfluous in some circumstances, affecting
graphic signs were sometimes sufficient to diagnose treatment-planning decisions in some patients and to
properly but were misinterpreted by the clinician. There a limited degree.34,35
are numerous cases when an impacted maxillary canine
can be clearly localized based on conventional radio- INCIDENTAL FINDINGS
graphs and clinical examination (eg, palpation, posi-
tion, and inclination of adjacent teeth), and no Incidental findings are no justification for radio-
further imaging is justified.3 graphic exposure. The European guidelines on radia-
Regarding resorption of adjacent teeth, diagnostic tion protection state that “‘Routine’ radiography is
thinking efficacy and therapeutic efficacy studies unacceptable practice” and define a ‘routine’ or
showed that resorption defects can be identified better ‘screening’ examination as “one in which a radiograph
with CBCT images, but these studies mostly used a me- is taken regardless of the presence or absence of clinical
dium or small field of view.25,26,29 signs and symptoms.”5 If we put this recommendation
Dr Larson also referred to the temporomandibular to the side for a moment, CBCT undoubtedly provides
joint, but asymptomatic patients surely do not need many findings, although incidence varies.36,37 Price
temporomandibular joint imaging. Condylar position et al37 reported that 90% of all CBCT images examined
in the fossa can certainly be seen on CBCT images, had at least 1 finding, and 16.1% of the findings re-
but this information should not affect our diagnosis quired further investigation. In contrast, incidental
and treatment plan.30 The value of temporomandibular findings from conventional orthodontic radiographs
joint imaging even for patients with temporomandibu- seem much lower, although no direct comparison has
lar disorders is a debatable subject, and there is no ev- been made.38 By far, the most common pathologic
idence to show that CBCT images will provide better findings seen in CBCT images that could require inter-
treatment.31 vention were carotid artery calcification and periapical
It seems, therefore, that CBCT might benefit some osteitis.37 These are not outside the detection capabil-
patients with the conditions mentioned above, but no ities of the panoramic radiograph.39 Therefore, one
evidence exists for the remaining majority of our should consider that a significant number of incidental
patients. The application of 3-dimensional cephalo- findings in CBCT images (1) represent normal anatomic
metrics, or increased measurement accuracy, could be variants or are benign and do not require further inter-
an indication. However, currently, there are no estab- vention, (2) might already be known to the patient, (3)
lished 3-dimensional cephalometric analyses and no can be detected on traditional radiographic images, or
3-dimensional normative data. CBCT images are (4) might be false-positive findings. In the absence of
used to simulate old technology—ie, reconstruct any signs or symptoms, the taking of CBCT images
2-dimensional lateral cephalometric views. In this tran- just in case an occult pathologic finding appears is
sitory, backward step, we should not carry with us the not justified.
misconceptions of the early cephalometric era: strict
adherence to cephalometric standards and blind faith COMPREHENSIVE EVALUATION
in numbers. Dr Larson seems to base his recommendations on
Cephalometric analyses have significant, well- the premise that a comprehensive imaging modality
recognized deficiencies, and increased accuracy of will prove useful on any occasion, so, why not take
measurements does not address them.32 There is, as it from the start? After all, a CBCT image includes
yet, no evidence that increased accuracy from CBCT a cephalogram and a panoramic image for orthodon-
contributes to a change of treatment plan or better tic assessment, and additional images for any poten-
treatment. Even though such a notion might seem tial periodontal evaluation, temporomandibular joint
self-evident, one should consider that our treatment evaluation, temporary anchorage device placement,
modalities are not so fine tuned to specific craniofacial and airway analysis, plus the benefit of any incidental
patterns that a conventional cephalometric radiograph findings. More extensive diagnostic knowledge is as-
is inadequate to serve. Furthermore, identifying land- sumed to lead to better treatment. This proposition
marks on CBCT images introduces significant errors is alluring but precarious and biased for several rea-
that might mitigate the advantage of increased accu- sons. First, most of our patients are known not to
racy.33 Lastly, most of our diagnostic information is have any of the problems listed, so extra radiation is
gained from clinical evaluations. The cephalogram used just to rule out additional incidental findings,
American Journal of Orthodontics and Dentofacial Orthopedics April 2012 Vol 141 Issue 4
4. Counterpoint 409
over those that would be found with a cephalogram 2. SEDENTEXCT project. Radiation protection: cone beam CT for den-
and a panoramic radiograph. Second, if more diag- tal and maxillofacial radiology. Evidence based guidelines 2011.
Available at: http://www.sedentexct.eu/files/guidelines_final.pdf.
nostic information is the goal, why stop at a CBCT?
Accessed on January 20, 2012.
Why, to take it to the extreme, not perform a full- 3. Isaacson K, Thom A, Horner K, Whaites E. Guidelines for the use
body computed tomography scan instead? Have we of radiographs in clinical orthodontics. London, United King-
determined that a CBCT is the optimum choice in dom: British Orthodontic Society; 2008.
the risk-benefit balance? Third, in our quest for 4. American Association of Orthodontists. Statement on the role
of CBCT in orthodontics (26-10 H). eBulletin; May 7, 2010. Avail-
more information, why not perform other diagnostic
able at: www.aaomembers.org/Resources/Publications/ebulletin-
tests that might be more relevant and do not incur 05-06-10.cfm. Accessed on January 20, 2012.
a radiation burden? Such tests could include evalua- 5. European Commission. Radiation Protection 136. European
tion of thyroid and growth hormone levels, magnetic guidelines on radiation protection in dental radiology. Luxem-
resonance imaging examination of the head (to assess bourg: Office for Official Publications of the European Commu-
nities; 2004:Available at: http://ec.europa.eu/energy/nuclear/
temporomandibular joint disc position, measure the
radioprotection/publication/doc/136_en.pdf:Accessed on Janu-
sizes of the muscles of mastication, examine the pitu- ary 20, 2012.
itary gland for adenomas, and evaluate the airway), 6. Pauwels R, Beinsberger J, Collaert B, Theodorakou C, Rogers J,
nasal endoscopy or rhinomanometry, and bite-force Walker A, et al., The SEDENTEXCT Project Consortium. Effective
measurement. Have we specifically selected large dose range for dental cone beam computed tomography scan-
ners. Eur J Radiol 2012;81:267-71.
field-of-view CBCT based on evidence that it will re-
7. American Association of Orthodontists. 2010 AAO member and
sult in better patient outcome than these other tests, patient census study. Final report; June 23, 2011.
or are we just using it because it is convenient? 8. Kokich VG. Cone-beam computed tomography: have we identi-
Fourth, with each diagnostic test comes more knowl- fied the orthodontic benefits? Am J Orthod Dentofacial Orthop
edge but also more false-positive findings that can 2010;137(4 Suppl):S16.
9. Fryback DG, Thornbury JR. The efficacy of diagnostic imaging.
lead to increased patient anxiety, unnecessary
Med Decis Making 1991;11:88-94.
follow-ups, and further tests. Diagnostic evaluations 10. Ballrick JW, Palomo JM, Ruch E, Amberman BD, Hans MG. Image
should be focused and designed to answer specific distortion and spatial resolution of a commercially available
questions, not be a fishing expedition. cone-beam computed tomography machine. Am J Orthod Den-
tofacial Orthop 2008;134:573-82.
11. Nackaerts O, Maes F, Yan H, Couto Souza P, Pauwels R, Jacobs R.
CONCLUSIONS
Analysis of intensity variability in multislice and cone beam com-
As more research is conducted, and with continual puted tomography. Clin Oral Implants Res 2011;22:873-9.
improvements in technology, CBCT might prove valu- 12. Schulze R, Heil U, Gross D, Bruellmann DD, Dranischnikow E,
Schwanecke U, et al. Artefacts in CBCT: a review. Dentomaxillo-
able for all of our patients in the future. However, at
fac Radiol 2011;40:265-73.
the present time, evidence for the efficacy of CBCT im- 13. Nguyen E, Boychuk D, Orellana M. Accuracy of cone-beam com-
aging is lacking. Except for certain patients, replacing puted tomography in predicting the diameter of unerupted teeth.
the conventional cephalometric and panoramic radio- Am J Orthod Dentofacial Orthop 2011;140:e59-66.
graphs with a large field-of-view CBCT is simply over- 14. Timock A, Cook V, McDonald T, Leo MC, Crowe J,
Benninger B, et al. Accuracy and reliability of buccal bone
kill, potentially leading to a public health problem.40 It
height and thickness measurements from cone-beam computed
is the responsibility of the clinician to carefully select tomography imaging. Am J Orthod Dentofacial Orthop 2011;
patients when CBCT imaging will provide a tangible 140:734-44.
benefit and resist the lure of technology for technol- 15. Patcas R, M₠ ller L, Ullrich L, Peltom₠ki T. Accuracy of cone-beam
u a
ogy’s sake. computed tomography at different resolutions assessed on the
bony covering of the mandibular anterior teeth. Am J Orthod
In response to the Steiner quotation: “Today, just
Dentofacial Orthop 2012;141:41-50.
like orthodontic radiography in the early 1900s, CBCT 16. Leung CC, Palomo L, Griffith R, Hans MG. Accuracy and re-
for orthodontic therapy is advocated by experts, with- liability of cone-beam computed tomography for measuring
out reliable evidence that the diagnostic technology alveolar bone height and detecting bony dehiscences and
is associated with improved patient outcomes.” 40 fenestrations. Am J Orthod Dentofacial Orthop 2010;137(4
Suppl):S109-19.
17. Benn DK. Diagnostic accuracy studies needed for cone beam
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American Journal of Orthodontics and Dentofacial Orthopedics April 2012 Vol 141 Issue 4