Bob, a 79-year-old man with end-stage liver disease from a history of alcoholism, was hospitalized for GI bleeding likely caused by esophageal varices. Upon examining Bob, the advance practice nurse noticed asterixis, a sign of hepatic encephalopathy indicating worsening of his liver condition. Common emergencies in end-stage liver failure include GI bleeding, spontaneous bacterial peritonitis, hepatic coma, and renal failure. Assessment for alcohol-related cirrhosis involves checking for stigmata of liver disease and a history of alcohol use.