CASE Study : There are different clinical forms of plague, though the most common are bubonic, pneumonic and septicemic, according Links to an external site.to the Centers for Disease Control and Prevention. The Black Death, also referred to as the Pestilence, was a bubonic plague pandemic. Symptoms included skin tissue darkened by gangrene and swelling of lymph nodes, or buboes the source of the term bubonic. DNA evidence reveals where the Black Death beganLinks to an external site. The plague strain eventually evolved into a less-dangerous variety, and todayLinks to an external site. the protective variant is present in about 45 percent of British people, according to the 1000 Genomes database, Science Magazine reported in a write-up of the studyLinks to an external site.. Deadly plague outbreaks remain a threat in some areas, but prevention and treatment methods have improved drastically, especially through the use of antibiotics. Bubonic plague was so deadly an English village quarantined itself to save othersLinks to an external site. The findings have raised the question: Will the coronavirusLinks to an external site. pandemic have a big impact on human evolution? Fortune magazine reported that Barreiro is not convincedLinks to an external site.. The Black Death was far deadlier, he said, killing on scale orders of magnitude beyond the effects of covid-19, and had a more devastating effect on the young, killing people before they could pass on their genes..