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Life style and cellular changes
What is the story?
Dr. S. Mohammadpour
Lifestyle modification involves altering long-term habits, typically of eating or physical activity,
and maintaining the new behavior for months or years. Lifestyle modification can be used to treat
a range of diseases,
The term lifestyle can denote the interests, opinions, behaviors, and behavioral
orientations of an individual, group, or culture and may include views on politics,
religion, health, intimacy, and more
A lifestyle typically reflects an individual's attitudes, way of life, values, or world view.
lifestyle definition
S.Mohammadpour Sep 2018
Most of the stories have three parts:
Villain
Hero
battle
S.Mohammadpour Sep 2018
Diseases are bad guys: like cancers
S.Mohammadpour Sep 2018
The role of genes and environment in the development of cancer
S.Mohammadpour Sep 2018
Emotions
The mind sends signals, the brain releases chemicals, and these messages are sent to our
cells.
someone that is in love, they are producing huge amounts of the feel-good hormones,
dopamine and oxytocin. These hormones alter our brain chemistry to fulfill the growth potential
of cells.
Fear, releases a different set of chemicals (mainly stress hormones and inflammatory
agents), which signals the cells to stop growing.
nocebo effect= negative thought
placebo effect= positive thoughts
S.Mohammadpour Sep 2018
Grandma’s behaviors Leave a Mark on Your Genes
Your ancestors' lousy childhoods or excellent adventures might change your personality, bequeathing anxiety
or resilience by altering the epigenetic expressions of genes in the brain.
•Positive beliefs
•Yoga
•Spirituality
•Prayers
•Positive Images and visualizations
•Electromagnetic shifts
•Optimism
•Intention
•Energy Medicine
•Energy Psychology
•Positive Thinking
•Nurturing
•Gratitude
•Happy Social Networks
•Acts of Kindness
•Meditation
•CompassionS.Mohammadpour Sep 2018
how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually
everything that occurs during the life-span
S.Mohammadpour Sep 2018
Characteristics common to many cancers:
S.Mohammadpour Sep 2018
S.Mohammadpour Sep 2018
S.Mohammadpour Sep 2018
Epigenetic changes:
S.Mohammadpour Sep 2018
Epigenetic changes: how the genome learns from experience
you can hack your environment to change your gene expression by epigenetic changes
Epigenetics doesn’t change the genetic code, it changes how that’s read.
S.Mohammadpour Sep 2018
S.Mohammadpour Sep 2018
Telomeres ‐ non‐coding repeat sequences of DNA; cap and protect chromosomes
– Telomeres shorten with cell division and DNA damage
– Critically short telomeres can lead to
• Cellular senescence
• Genomic instability
– Implications for disease risk
Lifestyle and Environmental Factors Associated with Telomere Length
S.Mohammadpour Sep 2018
Your body is made up of 50 trillion cells. Every second your body produces 25 million new cells.
This cell represents any cell of the body a brain cell, skin cell, liver cell etc.
All cells need to be in close proximity to normal circulation or blood flow so they can continue to function properly.
Happy Cells vs. Unhappy Cells
“The Happy Cell”
S.Mohammadpour Sep 2018
“The Unhappy Cell”
When food is digested the
nutrients are first processed by
the liver and are then released
into the circulation or blood
stream to feed the cells of our
bodies.
When circulation is
blocked or partially
blocked the required
nutrients can not reach
the cell. We call that cell
“The Unhappy Cell”
Happy Cells vs. Unhappy Cells
S.Mohammadpour Sep 2018
 Unhappy cells in our brain are called: headaches, anxiety,
depression, memory loss, alzheimer's or stroke
 Unhappy cells in our chest are called: chest pain, palpitations,
arrhythmia, congestive heart failure, angina, heart attack
 We can do this with any cell in our body and come back with a
cause of poor circulation – even with cancer!
Happy Cells vs. Unhappy Cells
S.Mohammadpour Sep 2018
So the heroes??
S.Mohammadpour Sep 2018
S.Mohammadpour Sep 2018
The battle !!!!!
S.Mohammadpour Sep 2018
Carcinogens activate and chemopreventive agents suppress NF-κB activation, a major mediator of
inflammation
S.Mohammadpour Sep 2018
The other side of coin …
S.Mohammadpour Sep 2018
Various cancers that have been linked to environmental carcinogens. The carcinogens linked
to each cancer is shown inside bracket
S.Mohammadpour Sep 2018
Cancers that have been linked to alcohol and smoking. Percentages represent the cancer
mortality attributable to alcohol and smoking in men and women
S.Mohammadpour Sep 2018
Cancer deaths (%) linked to diet
S.Mohammadpour Sep 2018
Various cancers that have been linked to obesity. In the USA overweight and obesity could
account for 14% of all deaths from cancer in men and 20% of those in women
S.Mohammadpour Sep 2018
Now we know Health and Lifestyle Choices Can
Change our Genetic Make-Up
S.Mohammadpour Sep 2018
So let’s
BE KIND TO OUR GENES
S.Mohammadpour Sep 2018
S.Mohammadpour Sep 2018

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Cancer and life style

  • 1. Life style and cellular changes What is the story? Dr. S. Mohammadpour
  • 2. Lifestyle modification involves altering long-term habits, typically of eating or physical activity, and maintaining the new behavior for months or years. Lifestyle modification can be used to treat a range of diseases, The term lifestyle can denote the interests, opinions, behaviors, and behavioral orientations of an individual, group, or culture and may include views on politics, religion, health, intimacy, and more A lifestyle typically reflects an individual's attitudes, way of life, values, or world view. lifestyle definition S.Mohammadpour Sep 2018
  • 3. Most of the stories have three parts: Villain Hero battle S.Mohammadpour Sep 2018
  • 4. Diseases are bad guys: like cancers S.Mohammadpour Sep 2018
  • 5. The role of genes and environment in the development of cancer S.Mohammadpour Sep 2018
  • 6. Emotions The mind sends signals, the brain releases chemicals, and these messages are sent to our cells. someone that is in love, they are producing huge amounts of the feel-good hormones, dopamine and oxytocin. These hormones alter our brain chemistry to fulfill the growth potential of cells. Fear, releases a different set of chemicals (mainly stress hormones and inflammatory agents), which signals the cells to stop growing. nocebo effect= negative thought placebo effect= positive thoughts S.Mohammadpour Sep 2018
  • 7. Grandma’s behaviors Leave a Mark on Your Genes Your ancestors' lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain. •Positive beliefs •Yoga •Spirituality •Prayers •Positive Images and visualizations •Electromagnetic shifts •Optimism •Intention •Energy Medicine •Energy Psychology •Positive Thinking •Nurturing •Gratitude •Happy Social Networks •Acts of Kindness •Meditation •CompassionS.Mohammadpour Sep 2018
  • 8. how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span S.Mohammadpour Sep 2018
  • 9. Characteristics common to many cancers: S.Mohammadpour Sep 2018
  • 13. Epigenetic changes: how the genome learns from experience you can hack your environment to change your gene expression by epigenetic changes Epigenetics doesn’t change the genetic code, it changes how that’s read. S.Mohammadpour Sep 2018
  • 15. Telomeres ‐ non‐coding repeat sequences of DNA; cap and protect chromosomes – Telomeres shorten with cell division and DNA damage – Critically short telomeres can lead to • Cellular senescence • Genomic instability – Implications for disease risk Lifestyle and Environmental Factors Associated with Telomere Length S.Mohammadpour Sep 2018
  • 16. Your body is made up of 50 trillion cells. Every second your body produces 25 million new cells. This cell represents any cell of the body a brain cell, skin cell, liver cell etc. All cells need to be in close proximity to normal circulation or blood flow so they can continue to function properly. Happy Cells vs. Unhappy Cells “The Happy Cell” S.Mohammadpour Sep 2018
  • 17. “The Unhappy Cell” When food is digested the nutrients are first processed by the liver and are then released into the circulation or blood stream to feed the cells of our bodies. When circulation is blocked or partially blocked the required nutrients can not reach the cell. We call that cell “The Unhappy Cell” Happy Cells vs. Unhappy Cells S.Mohammadpour Sep 2018
  • 18.  Unhappy cells in our brain are called: headaches, anxiety, depression, memory loss, alzheimer's or stroke  Unhappy cells in our chest are called: chest pain, palpitations, arrhythmia, congestive heart failure, angina, heart attack  We can do this with any cell in our body and come back with a cause of poor circulation – even with cancer! Happy Cells vs. Unhappy Cells S.Mohammadpour Sep 2018
  • 22. Carcinogens activate and chemopreventive agents suppress NF-κB activation, a major mediator of inflammation S.Mohammadpour Sep 2018
  • 23. The other side of coin … S.Mohammadpour Sep 2018
  • 24. Various cancers that have been linked to environmental carcinogens. The carcinogens linked to each cancer is shown inside bracket S.Mohammadpour Sep 2018
  • 25. Cancers that have been linked to alcohol and smoking. Percentages represent the cancer mortality attributable to alcohol and smoking in men and women S.Mohammadpour Sep 2018
  • 26. Cancer deaths (%) linked to diet S.Mohammadpour Sep 2018
  • 27. Various cancers that have been linked to obesity. In the USA overweight and obesity could account for 14% of all deaths from cancer in men and 20% of those in women S.Mohammadpour Sep 2018
  • 28. Now we know Health and Lifestyle Choices Can Change our Genetic Make-Up S.Mohammadpour Sep 2018
  • 29. So let’s BE KIND TO OUR GENES S.Mohammadpour Sep 2018