The increasing interest in Lung Ultrasound (LUS) over the last years led to a great diffusion and better experience in using this technique, which became an essential tool for clinicians. During the current Coronavirus Disease 2019 (COVID-19) pandemic, LUS is being extensively applied to the evaluation and monitoring....
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...JohnJulie1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
Pulmonary Tuberculosis in Coronavirus Disease-19 Patients: Report of Casesasclepiuspdfs
The coronavirus disease 2019 (COVID-19) is known to cause severe respiratory illness manifesting in a spectrum of related disorders. Amidst the continuous evolution of this pandemic which has caused vast devastation globally, it is crucial to note that tuberculosis (TB), which also causes respiratory diseases, has and still affects over a quarter of the world’s population. Coinfection of both diseases have severe health implications. Therefore, it is vital to understand the effects of this novel virus on the immune system and coinfection with a bacterial infection, like TB. Based on peer-reviewed cases, there seems to be an associational relationship between COVID-19 and TB; research suggests both weaken the immune system and further complicate clinical outcomes, which was further explored in this paper.
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...JohnJulie1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
Pulmonary Tuberculosis in Coronavirus Disease-19 Patients: Report of Casesasclepiuspdfs
The coronavirus disease 2019 (COVID-19) is known to cause severe respiratory illness manifesting in a spectrum of related disorders. Amidst the continuous evolution of this pandemic which has caused vast devastation globally, it is crucial to note that tuberculosis (TB), which also causes respiratory diseases, has and still affects over a quarter of the world’s population. Coinfection of both diseases have severe health implications. Therefore, it is vital to understand the effects of this novel virus on the immune system and coinfection with a bacterial infection, like TB. Based on peer-reviewed cases, there seems to be an associational relationship between COVID-19 and TB; research suggests both weaken the immune system and further complicate clinical outcomes, which was further explored in this paper.
Repeated Hemoptysis With Progressive Bronchiectasis: A Case Report of Lady Wi...semualkaira
Bronchiectasis is a type of incurable structural lung disease with
clinical manifestations of chronic cough, expectoration or recurrent hemoptysis, which is often given anti-infection and symptomatic treatment. In this study, a patient suffering from bronchiectasis
with repeated hemoptysis caused by nontuberculous mycobacterium (NTM) was discussed. A 54-year-old female immunocompetent patient was admitted to our hospital due to repeated hemoptysis for 5 years. Computed tomography (CT) scan revealed progressive bronchiectasis in the upper and middle lobes of her right lung.
She subsequently underwent thoracoscopic lobectomy of the right
middle lobe plus segmentectomy of the anterior segment of the
right upper lobe. Postoperative pathological diagnosis was confirmed to be intracellular mycobacterium. In view of her results,
the patient was concluded to have “Lady Windermere syndrome”
and was clinically cured following 15 months of anti-NTM treatment.
Repeated Hemoptysis with Progressive Bronchiectasis: a case report of Lady Wi...komalicarol
Bronchiectasis is a type of incurable structural lung disease with
clinical manifestations of chronic cough, expectoration or recurrent hemoptysis, which is often given anti-infection and symptomatic treatment. In this study, a patient suffering from bronchiectasis
with repeated hemoptysis caused by nontuberculous mycobacterium (NTM) was discussed. A 54-year-old female immunocompetent patient was admitted to our hospital due to repeated hemoptysis for 5 years. Computed tomography (CT) scan revealed progressive bronchiectasis in the upper and middle lobes of her right lung.
She subsequently underwent thoracoscopic lobectomy of the right
middle lobe plus segmentectomy of the anterior segment of the
right upper lobe. Postoperative pathological diagnosis was confirmed to be intracellular mycobacterium. In view of her results,
the patient was concluded to have “Lady Windermere syndrome”
and was clinically cured following 15 months of anti-NTM treatment.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature
CT scans still play a critical role in managing COVID-19. Patients with a severe coronavirus infection show different features on their computed tomography
Clinical analysis of 228 patients with pulmonary fungal diseases iWilheminaRossi174
Clinical analysis of 228 patients with pulmonary fungal diseases in China
Abstract
Background: Due to the lack of specific clinical manifestations and imaging features, the diagnosis of pulmonary fungal diseases is difficult. This study aims to investigate the clinical features of pulmonary fungal diseases.
Methods: We retrospectively analyzed the demographics, types of fungus,radiological characteristics,underlying diseases, the usage of steroid and immunosuppresants, laboratory tests of 228patients with pulmonary fungal disease diagnosed by pathological examination or laboratory culture from October 2011 to July 2018in Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology.
Results: A total of 228 patients, had a median age of 49years, which included 130 (57%) males and 98(43%) females. The most common fungal species identified were aspergillus (39.5 %), cryptococcus (18.4%), and mucormycosis (3.5 %).The main imaging findings were nodules or mass in 144 patients (63.2%), cavitation in 57 patients (25%),consolidation shadows or ground glass infiltrates in 15 patients (6.6%), and reverse halo sign in 12 patients (5.3%). The main infection sites were right upper lobe (26.8%), right lower lobe (21.5%) and the bronchus infection were 18 (7.9%) persons. For the underlying diseases, the prevalence of diseases was pulmonary tuberculosis (17.5%), bronchiectasis (16.2%), diabetes mellitus (9.2%) and the previous thoracic malignancy (6.6%) was common. The number of patients using steroid was 50% and the number of patients using immunosuppressant was 7%.
Conclusions: The imaging findings and the underlying diseases of patients should be taken into account when making diagnosis of pulmonary funga1disease for the purpo se to speculate the probable fungal pathogen and choose the most appropriate diagnostic tool.
Keywords:Pulmonary fungal disease; pathogen; imaging manifestation; Underlying disease; Clinical analysis; Chinese
(pneumomycosis; pulmonary mycosis?)invasive mould infection (IMI)Invasive fungal infections (IFIs),invasive aspergillosis
invasive mold disease, invasive aspergillosis, diabetes mellitus.
1. INTRODUCTION
In environment, the fungi produce small spores that are routinely inhaled and rapidly cleared from the normal host. However after long standing inhalation makes people more vulnerable to get effected .Moreover pulmonary fungal diseases are an opportunistic infection that predominantly attacks immunocompromised just as immunocompetent patients, however extensive utilization of gluccocorticoids and chemotherapeutics utilizes in patients make the pulmonary fungal disease no longer an uncommon occurrence. The complex underlying conditions such as pulmonary tuberculosis, bronchectasis, COPD and diabetes mellitus in the patients of pulmonary fungal disease and the non-specific nature of pathogen can confound identification and lead to under diagnosis. Due to its vague nature the dia ...
The severe acute respiratory syndrome-coronavirus-2-caused coronavirus disease-2019 (COVID-19) has arisen as a serious worldwide public health adversity. Early in the COVID-19 pandemic, an increased incidence of arterial and venous thrombosis was found, linked to systemic inflammation, immobilization, and a prothrombotic environment. Venous thromboembolism (VTE) can manifest itself in a variety of ways. A 55-year-old man presented to the emergency department with peripheral arterial disease (PAD) history.
Visit Here - https://pubrica.com/services/physician-writing-services/case-report/
Spontaneous Pneumomediastinum with Subcutaneous Emphysema in a COVID-19 Patientkomalicarol
A 39-year-old man presented to the emergency room with complaints of fever, shortness of breath and pronounced dry cough
for 1 week. On physical examination, his respiratory rate was 28
breaths/min and his oxygen saturation was 87 % on room air, improving to 96% on 8L/min oxygen via a non-rebreathing mask.
Circulating Tumor Cells and Cell-Free Nucleic Acids as Predictor Factors for ...AnonIshanvi
Pancreatic cancer remains as one of the most aggressive and deadliest of cancers largely due to formidable challenges in diagnosis and therapy. Consensus standard treatment for patients with nonmetastatic Pancreatic Cancer (PC) incorporates possible neoadjuvant chemotherapy with timely surgical resection and adjuvant chemotherapy. However, despite all the sophistication of modern radiological and endoscopic techniques, the decision regarding operability is often only made intra-operatively, therefore subjecting a patient to unnecessary surgical intervention, and postponing the possibility of starting early chemotherapy.
Research Progress in Chronic Lymphocytic LeukemiaAnonIshanvi
Cancer is an uncontrolled division of cell occurs due to genetic alterations and mutation. Chronic lymphocytic leukemia is the heterogeneous lymphocytic malignancy worldwide that leads to death.
Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and t...AnonIshanvi
Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics.
Increased of Protein O-Fucosyl Transferase 1 and 2 Genes Expression in Gastri...AnonIshanvi
Gastric cancer is one of the most common cancers in the world. Gastric cancer usually occurs at an advanced age (average ≥ 65 years) and has symptoms similar to gastric ulcers and other gastric infections, its early diagnosis is one of the major problems of this type of cancer. Molecular mechanisms initiate cancer and the molecular changes of normal cells compared to cancer cells are very important. dysfunction of Fucosyl transferase enzymes is associated with gastric cancer.
The impact of the SARS-CoV-2 infection in all areas at the national and international level is undeniable, the aftermath of this “tornado” will be visible for a long time, even when the infection manages to be controlled. Two aspects of great interest to those of us who work in the area of oncology must be considered: on the one hand, the need to contain and control the devastating effects of the disease forced a reorganization in the operation of services, giving priority to COVID, conversion of medical units to hospitals COVID created a high-risk scenario for patients with other types of pathologies; This reorganization includes the allocation of large amounts of budget to COVID areas to the detriment of patients with other types of equally serious diseases - such as cancer, among others - who cannot wait for care in better times.
Meta-Analysis of Lateral Lymph Node Dissection for Mid Lower Rectal Cancer: I...AnonIshanvi
Presence of lateral lymph node metastasis in rectal cancer was originally reported in the 1950s.Lateral lymph node metastasis occurs in 15 to 20% of patients with locally advanced low rectal cancer which escalates likelihood of local recurrence and reduced survival following neoadjuvant chemoradiotherapy (nCRT) and Total Mesolectal Excision (TME).
More Related Content
Similar to Can Lung Ultrasound in Patients with Fever of Unknown Origin Detect Early Signs of COVID-19 Pneumonia?
Repeated Hemoptysis With Progressive Bronchiectasis: A Case Report of Lady Wi...semualkaira
Bronchiectasis is a type of incurable structural lung disease with
clinical manifestations of chronic cough, expectoration or recurrent hemoptysis, which is often given anti-infection and symptomatic treatment. In this study, a patient suffering from bronchiectasis
with repeated hemoptysis caused by nontuberculous mycobacterium (NTM) was discussed. A 54-year-old female immunocompetent patient was admitted to our hospital due to repeated hemoptysis for 5 years. Computed tomography (CT) scan revealed progressive bronchiectasis in the upper and middle lobes of her right lung.
She subsequently underwent thoracoscopic lobectomy of the right
middle lobe plus segmentectomy of the anterior segment of the
right upper lobe. Postoperative pathological diagnosis was confirmed to be intracellular mycobacterium. In view of her results,
the patient was concluded to have “Lady Windermere syndrome”
and was clinically cured following 15 months of anti-NTM treatment.
Repeated Hemoptysis with Progressive Bronchiectasis: a case report of Lady Wi...komalicarol
Bronchiectasis is a type of incurable structural lung disease with
clinical manifestations of chronic cough, expectoration or recurrent hemoptysis, which is often given anti-infection and symptomatic treatment. In this study, a patient suffering from bronchiectasis
with repeated hemoptysis caused by nontuberculous mycobacterium (NTM) was discussed. A 54-year-old female immunocompetent patient was admitted to our hospital due to repeated hemoptysis for 5 years. Computed tomography (CT) scan revealed progressive bronchiectasis in the upper and middle lobes of her right lung.
She subsequently underwent thoracoscopic lobectomy of the right
middle lobe plus segmentectomy of the anterior segment of the
right upper lobe. Postoperative pathological diagnosis was confirmed to be intracellular mycobacterium. In view of her results,
the patient was concluded to have “Lady Windermere syndrome”
and was clinically cured following 15 months of anti-NTM treatment.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature.
Rare Case Of Primary Pulmonary Dedifferentiated Liposarcomasemualkaira
Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, expecially for
dedifferentiated subtype. We report the case of a 44-year-old African woman, healed from SARS-Covid, who presented with a 8
cm right lung ilary mass and underwent to a right intrapericardial pneumonectomy with diaphragmatic and pleural resections.
Histological test confirmed diagnosis of dedifferentiated primary
pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course and was discharged after 7 days.
On four months follow up the patient was still alive and without
evidence of disease. More studies have to be conducted because
very few cases are reported in literature
CT scans still play a critical role in managing COVID-19. Patients with a severe coronavirus infection show different features on their computed tomography
Clinical analysis of 228 patients with pulmonary fungal diseases iWilheminaRossi174
Clinical analysis of 228 patients with pulmonary fungal diseases in China
Abstract
Background: Due to the lack of specific clinical manifestations and imaging features, the diagnosis of pulmonary fungal diseases is difficult. This study aims to investigate the clinical features of pulmonary fungal diseases.
Methods: We retrospectively analyzed the demographics, types of fungus,radiological characteristics,underlying diseases, the usage of steroid and immunosuppresants, laboratory tests of 228patients with pulmonary fungal disease diagnosed by pathological examination or laboratory culture from October 2011 to July 2018in Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology.
Results: A total of 228 patients, had a median age of 49years, which included 130 (57%) males and 98(43%) females. The most common fungal species identified were aspergillus (39.5 %), cryptococcus (18.4%), and mucormycosis (3.5 %).The main imaging findings were nodules or mass in 144 patients (63.2%), cavitation in 57 patients (25%),consolidation shadows or ground glass infiltrates in 15 patients (6.6%), and reverse halo sign in 12 patients (5.3%). The main infection sites were right upper lobe (26.8%), right lower lobe (21.5%) and the bronchus infection were 18 (7.9%) persons. For the underlying diseases, the prevalence of diseases was pulmonary tuberculosis (17.5%), bronchiectasis (16.2%), diabetes mellitus (9.2%) and the previous thoracic malignancy (6.6%) was common. The number of patients using steroid was 50% and the number of patients using immunosuppressant was 7%.
Conclusions: The imaging findings and the underlying diseases of patients should be taken into account when making diagnosis of pulmonary funga1disease for the purpo se to speculate the probable fungal pathogen and choose the most appropriate diagnostic tool.
Keywords:Pulmonary fungal disease; pathogen; imaging manifestation; Underlying disease; Clinical analysis; Chinese
(pneumomycosis; pulmonary mycosis?)invasive mould infection (IMI)Invasive fungal infections (IFIs),invasive aspergillosis
invasive mold disease, invasive aspergillosis, diabetes mellitus.
1. INTRODUCTION
In environment, the fungi produce small spores that are routinely inhaled and rapidly cleared from the normal host. However after long standing inhalation makes people more vulnerable to get effected .Moreover pulmonary fungal diseases are an opportunistic infection that predominantly attacks immunocompromised just as immunocompetent patients, however extensive utilization of gluccocorticoids and chemotherapeutics utilizes in patients make the pulmonary fungal disease no longer an uncommon occurrence. The complex underlying conditions such as pulmonary tuberculosis, bronchectasis, COPD and diabetes mellitus in the patients of pulmonary fungal disease and the non-specific nature of pathogen can confound identification and lead to under diagnosis. Due to its vague nature the dia ...
The severe acute respiratory syndrome-coronavirus-2-caused coronavirus disease-2019 (COVID-19) has arisen as a serious worldwide public health adversity. Early in the COVID-19 pandemic, an increased incidence of arterial and venous thrombosis was found, linked to systemic inflammation, immobilization, and a prothrombotic environment. Venous thromboembolism (VTE) can manifest itself in a variety of ways. A 55-year-old man presented to the emergency department with peripheral arterial disease (PAD) history.
Visit Here - https://pubrica.com/services/physician-writing-services/case-report/
Spontaneous Pneumomediastinum with Subcutaneous Emphysema in a COVID-19 Patientkomalicarol
A 39-year-old man presented to the emergency room with complaints of fever, shortness of breath and pronounced dry cough
for 1 week. On physical examination, his respiratory rate was 28
breaths/min and his oxygen saturation was 87 % on room air, improving to 96% on 8L/min oxygen via a non-rebreathing mask.
Similar to Can Lung Ultrasound in Patients with Fever of Unknown Origin Detect Early Signs of COVID-19 Pneumonia? (16)
Circulating Tumor Cells and Cell-Free Nucleic Acids as Predictor Factors for ...AnonIshanvi
Pancreatic cancer remains as one of the most aggressive and deadliest of cancers largely due to formidable challenges in diagnosis and therapy. Consensus standard treatment for patients with nonmetastatic Pancreatic Cancer (PC) incorporates possible neoadjuvant chemotherapy with timely surgical resection and adjuvant chemotherapy. However, despite all the sophistication of modern radiological and endoscopic techniques, the decision regarding operability is often only made intra-operatively, therefore subjecting a patient to unnecessary surgical intervention, and postponing the possibility of starting early chemotherapy.
Research Progress in Chronic Lymphocytic LeukemiaAnonIshanvi
Cancer is an uncontrolled division of cell occurs due to genetic alterations and mutation. Chronic lymphocytic leukemia is the heterogeneous lymphocytic malignancy worldwide that leads to death.
Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and t...AnonIshanvi
Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics.
Increased of Protein O-Fucosyl Transferase 1 and 2 Genes Expression in Gastri...AnonIshanvi
Gastric cancer is one of the most common cancers in the world. Gastric cancer usually occurs at an advanced age (average ≥ 65 years) and has symptoms similar to gastric ulcers and other gastric infections, its early diagnosis is one of the major problems of this type of cancer. Molecular mechanisms initiate cancer and the molecular changes of normal cells compared to cancer cells are very important. dysfunction of Fucosyl transferase enzymes is associated with gastric cancer.
The impact of the SARS-CoV-2 infection in all areas at the national and international level is undeniable, the aftermath of this “tornado” will be visible for a long time, even when the infection manages to be controlled. Two aspects of great interest to those of us who work in the area of oncology must be considered: on the one hand, the need to contain and control the devastating effects of the disease forced a reorganization in the operation of services, giving priority to COVID, conversion of medical units to hospitals COVID created a high-risk scenario for patients with other types of pathologies; This reorganization includes the allocation of large amounts of budget to COVID areas to the detriment of patients with other types of equally serious diseases - such as cancer, among others - who cannot wait for care in better times.
Meta-Analysis of Lateral Lymph Node Dissection for Mid Lower Rectal Cancer: I...AnonIshanvi
Presence of lateral lymph node metastasis in rectal cancer was originally reported in the 1950s.Lateral lymph node metastasis occurs in 15 to 20% of patients with locally advanced low rectal cancer which escalates likelihood of local recurrence and reduced survival following neoadjuvant chemoradiotherapy (nCRT) and Total Mesolectal Excision (TME).
Analyzing Speech Outcomes in Hemiglossectomy Patients Using Telecare PlatformAnonIshanvi
Dysarthria is a common postoperative sequela of glossectomy and can greatly impact daily function and Quality of Life (QOL). It is important to study the anatomic and physiological factors that influence speech function, even with the challenges of conducting clinical research during the COVID pandemic. Therefore, our study aims to 1) display the feasibility of using a telecare platform to conduct clinical research; 2) analyze speech outcomes of patients who underwent hemiglossectomy with radial forearm free flap (RFFF) tongue reconstruction.
Uterine Myoma, Risk Factor and Pathophysiology: A Review ArticleAnonIshanvi
Uterine myoma is a benign neoplasm composed of uterine smooth muscle and connective tissue that supports it and is often referred to as fibromyoma, leiomyoma, fibroids. Can be single or multiple and reach large sizes (100 pounds). It has a tough consistency, with a clear cap boundary so that it can be removed from the surroundings. Uterine myoma, also known as leiomyoma or fibroid is a benign tumor that is often found in women of reproductive age (20-25%). At age> 35 years the incidence is higher, that is, closer to 40%. The high incidence of uterine myomas between the ages of 35 and the ages of 50 indicates a relationship between the incidence of uterine myomas and estrogen.
Functional Disparity of Carcinoma Associated Fibroblasts in Different Stages ...AnonIshanvi
Carcinoma associated fibroblasts (CAFs) are known responsible for immune evasion and growth of cancer and the crosstalk between CAFs and the immune system is still unidentified.
Linitis plastica is a diffuse form of gastric cancer and accounts for about 10% of all cases of gastric malignancy and its exact general population distribution is unknown. There are no characteristic or specific symptoms, the symptoms are similar to those of other forms of stomach cancer and can manifest as a feeling of fullness after eating, nausea and vomiting, epigastric pain, weight loss, and progressive dysphagia [1]. Plastic linitisis characterized by malignant glandular proliferation of cricoid cells in the fibrous stroma, which ultimately leads to thickening and rigidity of the stomach wall.
On February 21, 2020, at Codogno Hospital (in the Lodi?s Province, Lombardy, Italy), Italy?s Coronavirus ?patient one? was discovered. In the following week the cases within the Province of Lodi increased exponentially and it was interpreted as a disease cluster originating from the hospital.
COVID-19 is a new strain of Coronaviruses virus declared by the World Health Organization (WHO) as a pandemic on March 11th, 2020. While the majority of patients with COVID-19 typically have characteristic respiratory presentations subsequently
Deadenylase Expression in Small Cell Lung Cancer Related To Clinical Characte...AnonIshanvi
Lung cancer is the second common malignancy and the most aggressive cancer worldwide with late diagnosis and poor prognosis. The search for biomarkers that promote early diagnosis and improve therapeutic strategies focuses to the understanding of the mechanisms underlying cancer development and progression
Marital Status and Survival in Patients with Multiple Myeloma: The Role of Ma...AnonIshanvi
Despite better understanding of Multiple Myeloma (MM) and the development of novel therapeutic strategies which improved overall survival, MM still remain largely incurable. This warrants a better understanding of socio-demographic factors that may influence disease course and outcomes across MM patient
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...AnonIshanvi
Myeloid/lymphoid neoplasms associated with eosinophilia and PCM1-JAK2 is a provisional entity in WHO 2016. Prior case reports have shown quite a few clinical presentations in different patients with this chromosome translocation,characterized by eosinophilia in combination with myelodysplastic/ myeloproliferative neoplasms, acute myeloid leukemia(AML) and rarely, T-lymphoblastic lymphoma(T-LBL) or B-acute
Stereotactic Radiation Therapy of Lung Cancers and Subsequent Parenchymal Alt...AnonIshanvi
Stereotactic body radiation therapy (SBRT) is one of the standard radical treatments in stage I nonsmall cell lung cancer (NSCLC) and an option for lung metastases. The pulmonary parenchymal CT alterations at 3, 6 and 12 months are the object of a prospective analysis in patients submitted to SBRT, to define factors affecting the different radiological alteration
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Hypoparathyroidism (HypoPT) is an endocrine disease with low calcium and inappropriately low (insufficient) circulating PTH levels. HypoPT may have an autoimmune pathogenesis, however, the most common causes of chronic HypoPT are iatrogenic: mostly thyroid or parathyroid surgery. Much less frequently HypoPT...
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The rate of Helicobacter pylori (H. pylori) infection is higher in minority patients in the United States [1]. Gastric intestinal metaplasia (IM) is associated with H. pylori infection and carries an increased risk for gastric cancer over time, in particular for patients from regions of high gastric cancer incidence [2]
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Can Lung Ultrasound in Patients with Fever of Unknown Origin Detect Early Signs of COVID-19 Pneumonia?
1. Annals of Clinical and Medical
Case Reports
ISSN 2639-8109
Case Report
Can Lung Ultrasound in Patients with Fever of Unknown Origin
Detect Early Signs of COVID-19 Pneumonia?
Di Marzio G1*
, Giugno V1
, Domanico A1
, Schiavone C2
and Accogli E1
1
Ultrasound Centre, Maggiore Hospital, Largo B. Nigrisoli, Bologna, Italy
2
Department of Medicine and Aging Sciences, University of Chieti G d'Annunzio, Chieti, Italy
1. Abstract
The increasing interest in Lung Ultrasound (LUS) over the last years led to a great diffusion and
better experience in using this technique, which became an essential tool for clinicians. During
the current Coronavirus Disease 2019 (COVID-19) pandemic, LUS is being extensively applied
to the evaluation and monitoring of lung damage in infected patients, improving their manage-
2. Key words
LungUltrasound(LUS);SevereAcute
Respiratory Syndrome Coronavirus
2 (SARS-CoV-2); Coronavirus Dis-
ease 2019 (COVID-19); Pneumonia;
Acute Respiratory Distress Syndrome
(ARDS)
3. Introduction
ment in various clinical settings.
In this case report we describe the detection of very early ultrasonographic signs of lung in-
volvement in a patient who presented no clinical signs of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) pneumonia, but who developed respiratory symptoms and tested
positive for SARS-CoV-2 infection 22 days later.
This raises questions about the use of LUS to detect and monitor very early signs of lung disease
in paucisymptomatic patients with low clinical suspicion of COVID-19.
Moreover, interesting questions are raised regarding the use of LUS as a means to consistently
observe the timing of lung disease evolution, which to this day remains unknown.
technique can provide important information about COVID-19
Over the last few years, Lung Ultrasound (LUS) has developed
considerably as an important tool for clinical evaluation and mon-
itoring in various clinical settings: from daily clinical practice in
Emergency Departments and Internal Medicine Wards, with pa-
tients presenting pulmonary symptoms and clinical signs, to pa-
tients with Acute Respiratory Distress Syndrome (ARDS) in Inten-
sive Care Units (ICU) [1,2].
Several studies have described the ultrasonographic patterns that
reflect the alterations in lung parenchyma when it is affected by
pathological conditions that change its constitutional air- predom-
inant structure [3-6].
The recent outbreak of Severe acute respiratory syndrome coro-
navirus 2(SARS-CoV-2) epidemic – emerged in December 2019
in Wuhan, China [7], and rapidly spread throughout the world to
become pandemic, with pneumonia and respiratory failure as its
main clinical features, provoked a debate in the scientific commu-
nity about the potential role of LUS in the management of patients
with Coronavirus disease 2019 (COVID-19) [8,9].
Various authors have described how LUS can be even more infor-
mative than traditional Chest Radiography (CXR), and how this
pneumonia [10, 11]. These patients present a wide range of ultra-
sonographic patterns, such as the thickening of the pleural line
with pleural irregularity; the variation of B-lines patterns includ-
ing focal, multifocal and confluent (white lung); and parenchymal
consolidations. More complex and progressively worsening ul-
trasonographic findings are described in patients with severe and
deteriorating lung involvement – suggesting a potential keyrole of
LUS as a tool for close monitoring in these patients- with strong
correlation with Chest CT findings[11].
4. Case Report
On March 15, 2020, while hospitalized, a 41-year-old woman was
referred to theUltrasound Centre in the Medical Department of
Maggiore Hospital, Bologna, for abdomen ultrasound.
She presented to our hospital’s emergency department on March
10, 2020 having run a low-grade fever [37.8°C] for five days, ac-
companied by headache and two episodes of involuntary move-
ment of her right extremities, followed by loss of contact with the
environment.
She was an obese patient with a clinical history of childhood febrile
convulsions, for which she had been treated pharmacologically.
*Corresponding Author (s): Giulia Di Marzio, Ultrasound Centre, Maggiore Hospital, Largo
B. Nigrisoli, 2 - 40133 Bologna, Italy Tel: +39 051 6478663, E-mail: giulia.dimarzio2@gmail.
com
Citation: Di Marzio G, Can Lung Ultrasound in Patients with Fever of Unknown Origin Detect Early
Signs of COVID-19 Pneumonia?. Annals of Clinical and Medical Case Reports. 2020; 4(2): 1-3.
http://www.acmcasereport.com/
Volume 4 Issue 2- 2020
Received Date: 19 May 2020
Accepted Date: 29 May 2020
Published Date: 01 June 2020
3. Volume 4 Issue 2-2020 Case Report
More data are needed on all levels - biological, anatomic-patho-
logical and epidemiological. In the case in point, the Chest CT
performed during the second hospitalization showed ground-glass
opacities in the right lung and a parenchymal consolidation in the
inferior area of the left lung.
Ground-glass opacities can be considered earlier findings of
COVID-19 than parenchymal consolidations, that are likely to be a
subsequent expression of lung damage[18].
A comparison between LUS and CT imaging showed a strict cor-
respondence between the site of parenchymal consolidation shown
by CT imaging and the site where the ultrasonographic examina-
tion had shown pleural thickening and significant interstitial in-
volvement with B-lines.
What happened between the moment when LUS was performed
and the second CT imaging that showed COVID-19 interstitial
pneumonia? According to the literature, the SARS-CoV-2 infection
could have evolved with different pathogenetic mechanisms and
timing in lung parenchyma damage, leading to the clinical man-
ifestations that we observed 22 days later. Finally, we suggest that
LUS findings may have been an expression of early lung damage
and we therefore assume that, in the case of patients with non-spe-
cific symptoms and with in the current epidemiological context,
LUS could be used to detect very early features of lung damage .
6. Conclusion
The widespread use and knowledge of LUS in recent years has
turned it into an essential tool for clinicians. Initially developed
in emergency and critical care settings, its importance has increas-
ingly grown within internal medicine wards. During the current
COVID-19 pandemic, LUS is being extensively applied to the eval-
uation and monitoring of lung damage in infected patients, leading
to a significant improvement in the management of patients when
integrated into the clinicalcontext.
Considering that clinical manifestations in SARS-CoV-2 infections
can vary and that parenchymal damage in lung involvement can
be incremental and progressive, we suggest that LUS could detect
very early signs of lung disease in paucisymptomatic patients, and
serve as an alert to increase the attention threshold and the clinical
mon- itoring in such patients.
Furthermore, interesting questions are raised regarding the use of
LUS as a means to consistently study the timing of lung disease
evolution, which to this day remains unknown.
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http://www.acmcasereport.com/ 3