On February 21, 2020, at Codogno Hospital (in the Lodi?s Province, Lombardy, Italy), Italy?s Coronavirus ?patient one? was discovered. In the following week the cases within the Province of Lodi increased exponentially and it was interpreted as a disease cluster originating from the hospital.
COVID 19- Basics beyond Basics by Dr. Brij Teli doc2rock
COVID-19: Basics Beyond Basics, is a concise presentation on Some Salient aspects and facts about Management of COVID-19 as per the Evidence based information on the day of Webinar.
Video of Webinar available at:
https://youtu.be/fjlgVzvwhM4
Can Join Telegram Group for Discussion: https://t.me/covindia
Target Audience being- Resident Doctors of Medicine, Pulmonary Medicine, Anesthesia, Pharmacology as well as Undergraduate Medical Students, Interns and HealthCare Workers from Various States of India as well as Outside India.
Covers aspects Like- Maskology, COVID-19 Antigen Detection Test, X-Ray & CT Findings of COVID-19, Cytokine Storm, Tocilizumab, Steroids & Recovery Trial, Covid Associated Coagulopathy(CAC), Hydroxychloroquine & the Controversies, Remdesivir, Convalescent Plasma, Awake Non-Intubated Prone Positioning, Thromboprophylaxis in COVID-19 including calculating SIC Score, Newer Trials and Publications, COVID-19 Vaccine Status, Favipiravir.
Covid-19 Brief Review | A holistic review at pandemic Akhtar Hussain
Presentation holistically and briefly covers the technical aspects of global pandemic. To put things in perspective a comparison woth recent pandemics is also included.
I have tried to make the presentation as rational and unbiased. Though with the ever coming developments daily some things might become redundant even in 10 days only. would love to get suggestions for improvement.
COVID 19- Basics beyond Basics by Dr. Brij Teli doc2rock
COVID-19: Basics Beyond Basics, is a concise presentation on Some Salient aspects and facts about Management of COVID-19 as per the Evidence based information on the day of Webinar.
Video of Webinar available at:
https://youtu.be/fjlgVzvwhM4
Can Join Telegram Group for Discussion: https://t.me/covindia
Target Audience being- Resident Doctors of Medicine, Pulmonary Medicine, Anesthesia, Pharmacology as well as Undergraduate Medical Students, Interns and HealthCare Workers from Various States of India as well as Outside India.
Covers aspects Like- Maskology, COVID-19 Antigen Detection Test, X-Ray & CT Findings of COVID-19, Cytokine Storm, Tocilizumab, Steroids & Recovery Trial, Covid Associated Coagulopathy(CAC), Hydroxychloroquine & the Controversies, Remdesivir, Convalescent Plasma, Awake Non-Intubated Prone Positioning, Thromboprophylaxis in COVID-19 including calculating SIC Score, Newer Trials and Publications, COVID-19 Vaccine Status, Favipiravir.
Covid-19 Brief Review | A holistic review at pandemic Akhtar Hussain
Presentation holistically and briefly covers the technical aspects of global pandemic. To put things in perspective a comparison woth recent pandemics is also included.
I have tried to make the presentation as rational and unbiased. Though with the ever coming developments daily some things might become redundant even in 10 days only. would love to get suggestions for improvement.
• Much is still unknown regarding the markers of disease and recovery process for SARS-CoV-2, including if and what immunity arises and which tests or markers can be useful in assessing immunity status
• A multi-phased plan is required to reopen the economy post-COVID-19, with significantly daily testing capacity (millions) required at all stages
o Challenges with scientific validation, regulatory, manufacturing, and ongoing logistics must be overcome to successfully ramp up testing capacities in the US
o Hundreds of molecular and serology tests are now available, but many have limited accuracy (high false positive/negative rates) due to the rapid development and lack of validation of these tests
• In this edition of Demystifying COVID-19 Testing, we highlight what is required now and in the future to move to a “new normal” and why it is challenging to get this testing up and running at volumes needed in the US
The Diagnostic & Testing virtual conference held on the 11th June 2020 was an inspiring event examining the role of both molecular and rapid diagnostics in tackling disease, infection and reducing the impact of COVID-19 within our communities and hospitals. The virtual conference explored how health professionals, academics and industry are driving diagnostic and testing usage within laboratories, pharmacies and community practice.
The conference built upon the UK Diagnostics Summit held annually in London discussed how diagnostics and testing are tackling COVID-19, the technology in development, accuracy of COVID-19 tests as well as exploring current testing methods for cancer, diabetes, sepsis, urinary tract infections and HAI’S.
Find out why Rapid Testing for Antigens and Antibodies is the game changer in controlling the COVID-19 Pandemic and why it is the only solution for mass screening in care homes, universities, prisons, schools and businesses.
Final Project Case Study, Applied EpidemiologyEPI Case Study 4.docxvoversbyobersby
Final Project Case Study, Applied Epidemiology
EPI Case Study 4: Using Epidemiology in a TB Contact Investigation
Estimated Time to Complete Exercise: 1 hour 30 minutes
Suggested citation: New Jersey Medical School Global Tuberculosis Institute. /Incorporating Tuberculosis into Public Health Core Curriculum./ 2009: Epidemiology case Study 4: Using Molecular Epidemiology in a TB Contact Investigation STUDENT Version 1.0.
This exercise is drawn from an article published in Chest, “Mycobacterium tuberculosis Miniepidemic in a Church Gospel Choir” by Mangura and colleagues. 1 Specific aspects of the investigation have been altered, with permission from the authors, to assist in meeting the desired teaching objectives.
Students should be aware that this study describes one particular approach to a TB outbreak investigation. Despite nationally published guidelines and recommendations from the Centers for Disease Control and Prevention for conducting contact investigations, the actual practice implemented during these investigations can vary from program to program.
An epidemiologist investigating a TB outbreak works within the framework of an investigative team that includes persons with expertise in epidemiology, microbiology, TB surveillance, and environmental health. It is through the collaborative efforts of this team, with each member playing a critical role thatoutbreak investigations can result in a positive outcome.
Suggested Reading can be found on the CDC EXCITE website- How to Investigate an Outbreak: http://www.cdc.gov/excite/classroom/outbreak/index.htm
Note: The Works Cited page is in AMA (American Medical Association) style.
PART I. Identifying a Problem
This morning (June 21) the local health department (large town health department) received a telephone call from the infection control practitioner (ICP) from a nearby hospital reporting that 2 patients were seen in the emergency department (ED) late yesterday with complaints of fatigue, fever, night sweats, and cough. As part of their work-up, the ED physician ordered chest x-rays for both patients. The health department was informed that, in both cases, the radiology report indicated abnormal findings consistent with TB. As a result, both patients were admitted to the hospital with a diagnosis of suspected pulmonary TB. Once admitted, sputum samples collected from both patients were read as positive on microscopic smear with final culture identification pending.
You know that tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually affect the lungs (pulmonary TB) but also can affect any part of the body outside the lungs (extrapulmonary TB) with the most common sites being the lymph nodes, bone, kidney, and pleura. While TB disease was once the leading cause of death in the United States, it can now be treated successfully with appropriate antibiotics. However, if not diagnosed early or not treated appropriately, TB ...
This was a lecture I gave for the Upstate Nurse Practitioners Association. This is a comprehensive overview. I would to thank all health care professionals for doing their jobs as well as they can.
This is a lecture I gave for the Upstate Nurse Practitioner's Association September 29, 2020. Parts may no longer be valid, because the topic is changing so rapidly. I did the best I could.
The Gibraltar COVID-19 Cohort: Determining the True Incidence and Severity Ra...asclepiuspdfs
COVID-19 is a new infectious disease with an unclear incidence and an unknown rate of progression to severe disease. The Gibraltar COVID-19 Cohort utilises two distinct cohorts - a clinical cohort and a random population based cohort -, to provide an accurate assessment of case severity rate. Design: Retrospective analysis of a SARS-CoV2 RT-PCR point prevalence study and a RT-PCR confirmed positive clinical case cohort to calculate case severity rates. Settings and Participants: Over a three day period nasopharyngeal swabs were sampled from a randomly selected 1.2% of the population of Gibraltar and then analysed via RT-PCR to determine the background incidence of COVID-19 infection. The results were then analysed and compared to the clinical case cohort. The rate of progression to severe COVID-19 disease in those with COVID-19 infection was then calculated.
Circulating Tumor Cells and Cell-Free Nucleic Acids as Predictor Factors for ...AnonIshanvi
Pancreatic cancer remains as one of the most aggressive and deadliest of cancers largely due to formidable challenges in diagnosis and therapy. Consensus standard treatment for patients with nonmetastatic Pancreatic Cancer (PC) incorporates possible neoadjuvant chemotherapy with timely surgical resection and adjuvant chemotherapy. However, despite all the sophistication of modern radiological and endoscopic techniques, the decision regarding operability is often only made intra-operatively, therefore subjecting a patient to unnecessary surgical intervention, and postponing the possibility of starting early chemotherapy.
Research Progress in Chronic Lymphocytic LeukemiaAnonIshanvi
Cancer is an uncontrolled division of cell occurs due to genetic alterations and mutation. Chronic lymphocytic leukemia is the heterogeneous lymphocytic malignancy worldwide that leads to death.
Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and t...AnonIshanvi
Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics.
• Much is still unknown regarding the markers of disease and recovery process for SARS-CoV-2, including if and what immunity arises and which tests or markers can be useful in assessing immunity status
• A multi-phased plan is required to reopen the economy post-COVID-19, with significantly daily testing capacity (millions) required at all stages
o Challenges with scientific validation, regulatory, manufacturing, and ongoing logistics must be overcome to successfully ramp up testing capacities in the US
o Hundreds of molecular and serology tests are now available, but many have limited accuracy (high false positive/negative rates) due to the rapid development and lack of validation of these tests
• In this edition of Demystifying COVID-19 Testing, we highlight what is required now and in the future to move to a “new normal” and why it is challenging to get this testing up and running at volumes needed in the US
The Diagnostic & Testing virtual conference held on the 11th June 2020 was an inspiring event examining the role of both molecular and rapid diagnostics in tackling disease, infection and reducing the impact of COVID-19 within our communities and hospitals. The virtual conference explored how health professionals, academics and industry are driving diagnostic and testing usage within laboratories, pharmacies and community practice.
The conference built upon the UK Diagnostics Summit held annually in London discussed how diagnostics and testing are tackling COVID-19, the technology in development, accuracy of COVID-19 tests as well as exploring current testing methods for cancer, diabetes, sepsis, urinary tract infections and HAI’S.
Find out why Rapid Testing for Antigens and Antibodies is the game changer in controlling the COVID-19 Pandemic and why it is the only solution for mass screening in care homes, universities, prisons, schools and businesses.
Final Project Case Study, Applied EpidemiologyEPI Case Study 4.docxvoversbyobersby
Final Project Case Study, Applied Epidemiology
EPI Case Study 4: Using Epidemiology in a TB Contact Investigation
Estimated Time to Complete Exercise: 1 hour 30 minutes
Suggested citation: New Jersey Medical School Global Tuberculosis Institute. /Incorporating Tuberculosis into Public Health Core Curriculum./ 2009: Epidemiology case Study 4: Using Molecular Epidemiology in a TB Contact Investigation STUDENT Version 1.0.
This exercise is drawn from an article published in Chest, “Mycobacterium tuberculosis Miniepidemic in a Church Gospel Choir” by Mangura and colleagues. 1 Specific aspects of the investigation have been altered, with permission from the authors, to assist in meeting the desired teaching objectives.
Students should be aware that this study describes one particular approach to a TB outbreak investigation. Despite nationally published guidelines and recommendations from the Centers for Disease Control and Prevention for conducting contact investigations, the actual practice implemented during these investigations can vary from program to program.
An epidemiologist investigating a TB outbreak works within the framework of an investigative team that includes persons with expertise in epidemiology, microbiology, TB surveillance, and environmental health. It is through the collaborative efforts of this team, with each member playing a critical role thatoutbreak investigations can result in a positive outcome.
Suggested Reading can be found on the CDC EXCITE website- How to Investigate an Outbreak: http://www.cdc.gov/excite/classroom/outbreak/index.htm
Note: The Works Cited page is in AMA (American Medical Association) style.
PART I. Identifying a Problem
This morning (June 21) the local health department (large town health department) received a telephone call from the infection control practitioner (ICP) from a nearby hospital reporting that 2 patients were seen in the emergency department (ED) late yesterday with complaints of fatigue, fever, night sweats, and cough. As part of their work-up, the ED physician ordered chest x-rays for both patients. The health department was informed that, in both cases, the radiology report indicated abnormal findings consistent with TB. As a result, both patients were admitted to the hospital with a diagnosis of suspected pulmonary TB. Once admitted, sputum samples collected from both patients were read as positive on microscopic smear with final culture identification pending.
You know that tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually affect the lungs (pulmonary TB) but also can affect any part of the body outside the lungs (extrapulmonary TB) with the most common sites being the lymph nodes, bone, kidney, and pleura. While TB disease was once the leading cause of death in the United States, it can now be treated successfully with appropriate antibiotics. However, if not diagnosed early or not treated appropriately, TB ...
This was a lecture I gave for the Upstate Nurse Practitioners Association. This is a comprehensive overview. I would to thank all health care professionals for doing their jobs as well as they can.
This is a lecture I gave for the Upstate Nurse Practitioner's Association September 29, 2020. Parts may no longer be valid, because the topic is changing so rapidly. I did the best I could.
The Gibraltar COVID-19 Cohort: Determining the True Incidence and Severity Ra...asclepiuspdfs
COVID-19 is a new infectious disease with an unclear incidence and an unknown rate of progression to severe disease. The Gibraltar COVID-19 Cohort utilises two distinct cohorts - a clinical cohort and a random population based cohort -, to provide an accurate assessment of case severity rate. Design: Retrospective analysis of a SARS-CoV2 RT-PCR point prevalence study and a RT-PCR confirmed positive clinical case cohort to calculate case severity rates. Settings and Participants: Over a three day period nasopharyngeal swabs were sampled from a randomly selected 1.2% of the population of Gibraltar and then analysed via RT-PCR to determine the background incidence of COVID-19 infection. The results were then analysed and compared to the clinical case cohort. The rate of progression to severe COVID-19 disease in those with COVID-19 infection was then calculated.
Circulating Tumor Cells and Cell-Free Nucleic Acids as Predictor Factors for ...AnonIshanvi
Pancreatic cancer remains as one of the most aggressive and deadliest of cancers largely due to formidable challenges in diagnosis and therapy. Consensus standard treatment for patients with nonmetastatic Pancreatic Cancer (PC) incorporates possible neoadjuvant chemotherapy with timely surgical resection and adjuvant chemotherapy. However, despite all the sophistication of modern radiological and endoscopic techniques, the decision regarding operability is often only made intra-operatively, therefore subjecting a patient to unnecessary surgical intervention, and postponing the possibility of starting early chemotherapy.
Research Progress in Chronic Lymphocytic LeukemiaAnonIshanvi
Cancer is an uncontrolled division of cell occurs due to genetic alterations and mutation. Chronic lymphocytic leukemia is the heterogeneous lymphocytic malignancy worldwide that leads to death.
Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and t...AnonIshanvi
Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics.
Increased of Protein O-Fucosyl Transferase 1 and 2 Genes Expression in Gastri...AnonIshanvi
Gastric cancer is one of the most common cancers in the world. Gastric cancer usually occurs at an advanced age (average ≥ 65 years) and has symptoms similar to gastric ulcers and other gastric infections, its early diagnosis is one of the major problems of this type of cancer. Molecular mechanisms initiate cancer and the molecular changes of normal cells compared to cancer cells are very important. dysfunction of Fucosyl transferase enzymes is associated with gastric cancer.
The impact of the SARS-CoV-2 infection in all areas at the national and international level is undeniable, the aftermath of this “tornado” will be visible for a long time, even when the infection manages to be controlled. Two aspects of great interest to those of us who work in the area of oncology must be considered: on the one hand, the need to contain and control the devastating effects of the disease forced a reorganization in the operation of services, giving priority to COVID, conversion of medical units to hospitals COVID created a high-risk scenario for patients with other types of pathologies; This reorganization includes the allocation of large amounts of budget to COVID areas to the detriment of patients with other types of equally serious diseases - such as cancer, among others - who cannot wait for care in better times.
Meta-Analysis of Lateral Lymph Node Dissection for Mid Lower Rectal Cancer: I...AnonIshanvi
Presence of lateral lymph node metastasis in rectal cancer was originally reported in the 1950s.Lateral lymph node metastasis occurs in 15 to 20% of patients with locally advanced low rectal cancer which escalates likelihood of local recurrence and reduced survival following neoadjuvant chemoradiotherapy (nCRT) and Total Mesolectal Excision (TME).
Analyzing Speech Outcomes in Hemiglossectomy Patients Using Telecare PlatformAnonIshanvi
Dysarthria is a common postoperative sequela of glossectomy and can greatly impact daily function and Quality of Life (QOL). It is important to study the anatomic and physiological factors that influence speech function, even with the challenges of conducting clinical research during the COVID pandemic. Therefore, our study aims to 1) display the feasibility of using a telecare platform to conduct clinical research; 2) analyze speech outcomes of patients who underwent hemiglossectomy with radial forearm free flap (RFFF) tongue reconstruction.
Uterine Myoma, Risk Factor and Pathophysiology: A Review ArticleAnonIshanvi
Uterine myoma is a benign neoplasm composed of uterine smooth muscle and connective tissue that supports it and is often referred to as fibromyoma, leiomyoma, fibroids. Can be single or multiple and reach large sizes (100 pounds). It has a tough consistency, with a clear cap boundary so that it can be removed from the surroundings. Uterine myoma, also known as leiomyoma or fibroid is a benign tumor that is often found in women of reproductive age (20-25%). At age> 35 years the incidence is higher, that is, closer to 40%. The high incidence of uterine myomas between the ages of 35 and the ages of 50 indicates a relationship between the incidence of uterine myomas and estrogen.
Functional Disparity of Carcinoma Associated Fibroblasts in Different Stages ...AnonIshanvi
Carcinoma associated fibroblasts (CAFs) are known responsible for immune evasion and growth of cancer and the crosstalk between CAFs and the immune system is still unidentified.
Linitis plastica is a diffuse form of gastric cancer and accounts for about 10% of all cases of gastric malignancy and its exact general population distribution is unknown. There are no characteristic or specific symptoms, the symptoms are similar to those of other forms of stomach cancer and can manifest as a feeling of fullness after eating, nausea and vomiting, epigastric pain, weight loss, and progressive dysphagia [1]. Plastic linitisis characterized by malignant glandular proliferation of cricoid cells in the fibrous stroma, which ultimately leads to thickening and rigidity of the stomach wall.
COVID-19 is a new strain of Coronaviruses virus declared by the World Health Organization (WHO) as a pandemic on March 11th, 2020. While the majority of patients with COVID-19 typically have characteristic respiratory presentations subsequently
Deadenylase Expression in Small Cell Lung Cancer Related To Clinical Characte...AnonIshanvi
Lung cancer is the second common malignancy and the most aggressive cancer worldwide with late diagnosis and poor prognosis. The search for biomarkers that promote early diagnosis and improve therapeutic strategies focuses to the understanding of the mechanisms underlying cancer development and progression
Marital Status and Survival in Patients with Multiple Myeloma: The Role of Ma...AnonIshanvi
Despite better understanding of Multiple Myeloma (MM) and the development of novel therapeutic strategies which improved overall survival, MM still remain largely incurable. This warrants a better understanding of socio-demographic factors that may influence disease course and outcomes across MM patient
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...AnonIshanvi
Myeloid/lymphoid neoplasms associated with eosinophilia and PCM1-JAK2 is a provisional entity in WHO 2016. Prior case reports have shown quite a few clinical presentations in different patients with this chromosome translocation,characterized by eosinophilia in combination with myelodysplastic/ myeloproliferative neoplasms, acute myeloid leukemia(AML) and rarely, T-lymphoblastic lymphoma(T-LBL) or B-acute
Stereotactic Radiation Therapy of Lung Cancers and Subsequent Parenchymal Alt...AnonIshanvi
Stereotactic body radiation therapy (SBRT) is one of the standard radical treatments in stage I nonsmall cell lung cancer (NSCLC) and an option for lung metastases. The pulmonary parenchymal CT alterations at 3, 6 and 12 months are the object of a prospective analysis in patients submitted to SBRT, to define factors affecting the different radiological alteration
Hypoparathyroidism - Not Only after StrumectomyUnusual Presentations of the R...AnonIshanvi
Hypoparathyroidism (HypoPT) is an endocrine disease with low calcium and inappropriately low (insufficient) circulating PTH levels. HypoPT may have an autoimmune pathogenesis, however, the most common causes of chronic HypoPT are iatrogenic: mostly thyroid or parathyroid surgery. Much less frequently HypoPT...
Higher Rates of Helicobacter Pylori Infection and Gastric Intestinal Metaplas...AnonIshanvi
The rate of Helicobacter pylori (H. pylori) infection is higher in minority patients in the United States [1]. Gastric intestinal metaplasia (IM) is associated with H. pylori infection and carries an increased risk for gastric cancer over time, in particular for patients from regions of high gastric cancer incidence [2]
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...AnonIshanvi
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies
Myelomastocytic leukemia is a very rare variant of myeloid leukemia, behaves clinically very aggressive and belongs to the group of so-called metachromatic leukemias. Metachromatic leu- kemias comprise leukemias with at least 10 to 20% tumor cells exhibiting metachromatic gran- ules: mast cell leukemia
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. We are looking for another easier way to manage. We propose an
alternative to nasopharyngeal swab strategy, supported by the ini-
tial data of a study we are conducting.
Among the diagnostic alternatives to swab, the qualitative serolog-
ical test exposes the incidence of infection in subjects by detection
of IgM/IgG antibodies produced against the virus. For this rea-
son, we chose qualitative NADAL® COVID-19 IgG/IgM Rapid
Table 1: Clinical Characteristics of subjects
Covid19 +
Confirmed group
IgM IgM/IgG IgG Doubt
n=21 2 9 9 1*
Covid 19 unknown Negative Diagnosis Quantitative detected+ in 25 positive patients Swab +
n=254 229 25 14 7#
Covid19 negative Confirmed - quantitative
Quantitative not
done
Discordant quantitative Swab control
n=229/254 45 184 5** 5 neg***
Test (test cassette) REF 243001N-10, by Nal Von Minden GmbH
(Germany); execution of test requires a finger-prick blood sample
and provides a qualitative result (yes/no) within 15 minutes with a
declared diagnostic sensitivity of 94.1% and specificity of 99.2%.
The test can be done by a single individual without medical or
laboratory skills. It costs 12$ each.
At to date, we observed 275 people (Table1), some of them are
outpatients. Our trial is actually ongoing.
*Covid19+ with swab negative since March 20, 2020; ** Diasorin IgG pos, Abbott IgG neg; ***
swabs negative in 5 Diasorin +, Abbott IgG neg; # only 7/25 serological test+ had a swabs detection.
21/275 people had known positive to Covid19 during the last
weeks with swabs negative after disease. They were tested after
discharge with negative swab. We used these subjects as control.
20 of them were IgG or IgM or IgG/IgM positive according to
Sethuraman [4] as reported in Table1. The last of these subjects
have had swab positive March 7 and negative March, 21. He had a
qualitative test two months later with a doubtful outcome. Anyway
the rapid test is useful to confirm an immune response in people
with known disease.
We also diagnosed 25/254 healthy subjects; 5/25 were people
close to Covid19 + patients. This last subgroup [5] was not before
tested by swab because asymptomatic. They just respected a quar-
antine period.
We also had 229/254 negative people without signs of disease de-
tecting by rapid test.
In 59 of them (59/254) rapid test negative (45) or positive (14)
was confirmed by qualitative method too [5]. In the other cases we
couldn’t do the double test. On the contrary in 5/250 cases we had
qualitative negative response but quantitative IgG positive (Diaso-
rin). Anyway all these 5 subjects have had swabs negative and a
IgG negative with other quantitative test (Abbott).
In summary we can affirm that rapid test:
1) is able to always show an immune response in subjects with
previous disease diagnosed with nasopharyngeal swab;
2) is able to define how many people have been infected by having
been cohabitants of positive subjects;
3) identifies the paucisymptomatic or asymptomatic subjects who
have had recent or previous unknown contact with Covid19;
4) identifies subjects who have never had a documented infection
and can be considered healthy;
5) there is equivalence between rapid qualitative and quantitative
serological tests in 59 of 64 cases observed.
As in the case of ascertaining a state of pregnancy, the woman
uses a rapid test and then goes to the hospital for a quantitative test
followed by a specialist visit, even in the case of Covid19 we will
have to get used to personally monitoring the state of our health
and that of our family members at least monthly or more frequent-
ly.
Furthermore, this diagnostic method could be used in patients
attending our day hospitals to perform anticancer treatments. It
would not be just a cancer population screening because if the pa-
tients were found to be positive for IgM they could be quickly
started to a nasopharyngeal swab.
Using before treatment in outpatients could give us further useful
information to keep our work clean.
Thinking to the Poet, how many roads must a man walk down,
before you call him healthy?
The answer is our scientific knowledge, using an autonomous, in-
expensive and rapid quality test that with mask, fever monitoring
and social distancing could do the difference.
References
1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel
coronavirus from patients with pneumonia in China, 2019. N Engl J
Med. 2020; 382: 727-33
2. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch
C, et al. Transmission of 2019-nCoV infection from an asymptomat-
ic contact in Germany. N Engl J Med. 2020; 382: 970-1.
3. Patel R, Babady E, Theel ES, Storch GA, Pinsky BA, St George K, et
al. Report from the American Society for Microbiology COVID-19
International Summit, 23 March 2020: Value of Diagnostic Testing
for SARS–CoV-2/COVID19. mBio Mar. 2020; 11(2): e00722-20.
4. Sethuraman N, Sundararaj SJ, Ryo A. Interpreting Diagnostic Tests
for SARS-CoV-2, JAMA. 2020; 323(22): 2249-51.
5. Xiang F, Wang X, He X, Peng Z, Yang B, Zhang J, et al. Antibody
detection and dynamic characteristics in patients with COVID-19.
Clin Infect Dis. 2020; 71(8): 1930-4.
clinicsofoncology.com 2
Volume 3 Issue 4 -2020 Short Communication