Calcium channel blockers (CCBs) disrupt the movement of calcium through calcium channels. CCBs are used as antihypertensive drugs to decrease blood pressure in patients with hypertension. They are particularly effective against large vessel stiffness in elderly patients. CCBs are also frequently used to alter heart rate, prevent cerebral vasospasm, and reduce chest pain caused by angina pectoris. While CCBs have been shown to be more effective than beta blockers at lowering cardiovascular mortality, they are associated with more side effects such as constipation, dizziness, headache, and fluid build up in the legs.

1. Calcium channel blockers
Mr.B.CHAKRAPANI M.pharm
Associate PROFESSOR
PHARMACOLOGY&clinicalpharmacolgy
Balaji college of pharmacy
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21. Calcium channel blockers (CCB), calcium
channel antagonists or calcium antagonists
are several medications that disrupt the
movement of calcium (Ca2+) through calcium
channels.
Calcium channel blockers are used
as antihypertensive drugs, i.e., as medications
to decrease blood pressure in patients
with hypertension.

22.  CCBs are particularly effective against large
vessel stiffness, one of the common causes of
elevated systolic blood pressure in elderly
patients.
Calcium channel blockers are also frequently
used to alter heart rate, to prevent cerebral
vasospasm, and to reduce chest pain caused
by angina pectoris.

23. CCBs have been shown to be slightly more
effective than beta blockers at
lowering cardiovascular mortality, but they are
associated with more side effects.

25. Side effects
Side effects of these drugs may include but are
not limited to:
Constipation
Dizziness, headache, redness in the face
Fluid build up in the legs and ankle edema
Gingival overgrowth
Rapid heart rate
Slow heart rate