Bone healing occurs through either primary or secondary healing processes. Primary healing involves direct bone formation without callus and occurs under conditions of absolute stability. Secondary healing involves indirect bone formation with callus and occurs when there is some interfragmentary motion providing relative stability. It proceeds in five stages over 3-4 months: hematoma formation, inflammation, soft callus formation, hard callus formation, and remodeling. Complications can include delayed union if healing is slowed, malunion if fragments heal in a misaligned position, or non-union if no healing occurs over an extended period.
Stages of Bone healing and madalities to enhance bone healing Surya Vijay Singh
Bone healing, direct bone healing, indirect bone healing, primary and secondary bone healing, stages of bone healing, substitute of bone healing, autografting and allograft, fracture healing
Bone fractures are a very common orthopedic injury resulting from trauma and sudden loads or stresses applied to bones or a result from bones being weakened by certain diseases. More than 250,000 femur fracture patients are seen per year in the U.S. on average. Bone fractures are either a complete or partial break in a bone and in some cases a simple cast to immobilize the injury site is not enough to completely heal the fracture.
Immobilization from casts may not be enough to completely heal the fracture if a malunion (when both ends of the fractured bone misalign) occurs and/or if a non-union (when the fracture gap is too large and the fractured ends cannot re-attach to one another) occurs. In the case of a malunion or non-union, a possible solution to the problem is by surgically inserting an intramedullary rod into the center canal (diaphysial) region of the injured bone and fixating it into place with screws.
Acute and Chronic Osteomyelitis - Infection of BoneRahul Singh
Acute and Chronic Osteomyelitis - Infection of Bone
http://essentialinspiration4u.blogspot.com
Osteomyelitis is defined as an acute or chronic inflammatory process of bone, bone marrow and its structure secondary to infection with micro organisms.
Duration , Mechanism & Host response.
Duration - Acute / Subacute / Chronic
Mechanism - Heamatogenous (tonsil , lungs , ear/ GIT) - Exogenous (injection , open fractures)
Host response - Pyogenic / Granulomatous
Introduction of bacteria from :
Outside through a wound or continuity from a neighboring soft tissue infection
Hematogenous spread from a pre existing focus (most common route of infection)
Stages of Bone healing and madalities to enhance bone healing Surya Vijay Singh
Bone healing, direct bone healing, indirect bone healing, primary and secondary bone healing, stages of bone healing, substitute of bone healing, autografting and allograft, fracture healing
Bone fractures are a very common orthopedic injury resulting from trauma and sudden loads or stresses applied to bones or a result from bones being weakened by certain diseases. More than 250,000 femur fracture patients are seen per year in the U.S. on average. Bone fractures are either a complete or partial break in a bone and in some cases a simple cast to immobilize the injury site is not enough to completely heal the fracture.
Immobilization from casts may not be enough to completely heal the fracture if a malunion (when both ends of the fractured bone misalign) occurs and/or if a non-union (when the fracture gap is too large and the fractured ends cannot re-attach to one another) occurs. In the case of a malunion or non-union, a possible solution to the problem is by surgically inserting an intramedullary rod into the center canal (diaphysial) region of the injured bone and fixating it into place with screws.
Acute and Chronic Osteomyelitis - Infection of BoneRahul Singh
Acute and Chronic Osteomyelitis - Infection of Bone
http://essentialinspiration4u.blogspot.com
Osteomyelitis is defined as an acute or chronic inflammatory process of bone, bone marrow and its structure secondary to infection with micro organisms.
Duration , Mechanism & Host response.
Duration - Acute / Subacute / Chronic
Mechanism - Heamatogenous (tonsil , lungs , ear/ GIT) - Exogenous (injection , open fractures)
Host response - Pyogenic / Granulomatous
Introduction of bacteria from :
Outside through a wound or continuity from a neighboring soft tissue infection
Hematogenous spread from a pre existing focus (most common route of infection)
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
2. Bone healing:
Bone healing is characterized by a process of
new bone formation with fusion of the bone
fragments.
3. Bone Healing
A. Healing of cortical bone:
1. Primary bone healing
(Direct healing /Healing without callus formation)
2. Secondary bone healing
(Indirect healing / Healing by callus formation)
B. Healing of the cancellous bone
4. Healing of Cortical Bone
Primary Bone Healing
• Absolute stability and
compression leads
to direct healing
• It occurs without any callus
formation
Secondary Bone Healing
• Relative stability leads to
indirect healing .
• It occurs with callus
formation.
5. Primary bone healing
• Direct fracture healing occurs:
Under conditions of absolute fracture stability as
provided by
lag screws,
compression plate and
TBW.
By direct osteonal remodeling.
Without callus formation.
• If the fracture site is absolutely stable – for example, an impacted
fracture in cancellous bone, or a fracture held by a metal plate with
absolute stability – there is no stimulus for callus.
• Osteoblastic new bone formation occurs directly between the
fragments.
6. Primary bone healing
Contact Healing
• Exposed fracture surfaces are in intimate contact
and held from the outset with absolute stability,
internal bridging may occasionally occur without
any intermediate stages.
Gap Healing
• It occurs even if there is a minimal gap.
• This is called gap healing.
• Gaps between the fracture surfaces are invaded by new
capillaries and osteoprogenitor cells growing in from the
edges, and new bone is laid down on the exposed surface
7. Primary bone healing
Cutting Cones
• By 3–4 weeks the fracture is solid enough to allow
penetration and bridging of the area by bone
remodelling units, i.e. osteoclastic ‘cutting cones’
followed by osteoblasts.
• The bone is continually remodeled by cutter cones.
• Osteoclasts leads tunnel across fractures site.
• Path for vessles and osteobasts to follow, creating
new osteons.
8. Primary bone healing
• An osteon is a basic construction unit also called
haversian system.
• Each osteon has a central canal, containing blood
vessels and a small amount of connective tissue with
interconnecting channels surrounded by concentric
layers of bone, the laminae.
• There are no osteons in cancellous bone.
• Due to the activity of cutter cones, tunnels are cut
through the compact bone, resulting in the creation of
new haversian osteons in their wake which bridges the
fractures.
10. Primary bone healing
• With rigid metal fixation,however, the absence of
callus means that there is a long period during
which the bone depends entirely upon the metal
implant for its integrity, increasing the risk of
implant failure.
• Moreover, the implant diverts stress away from
the bone, which may become osteoporotic
and may not recover fully until the metal is
removed.
11. Secondary bone healing
Healing by callus, though less direct (indirect
healing) has distinct advantages:
it ensures mechanical strength while
the bone ends heal, and
with increasing stress the callus grows
stronger and stronger
(according to Wolff’s law)
12. Secondary bone healing
• Indirect healing occurs when there is still
some small interfragmentary motion—a
condition called “relative stability”.
• It is thought that the interfragmentary motion
stimulates callus formation.
• Secondary bone healing is the most common
form of healing in tubular bones;
in the absence of rigid fixation,
it proceeds in five stages
14. Stages Approximate
Time
Essential Features
1.Haematoma
formation
At the time of
injury
At the time of injury,
bleeding occurs from the bone and soft tissues.
2.Inflammation 1–7 days
postfracture
The inflammatory process starts rapidly when the
fracture haematoma forms and
cytokines are released, and lasts until fibrous
tissue, cartilage, or bone formation begins.
Osteoclasts are formed to remove
the necrotic ends of bony fragments.
3. Soft callus
formation
After 2–3
weeks
The first soft callus is formed.
This is about the time when the fragments can no
longer move freely.
The strain applied to the cells in the fracture
gap modifies their growth factor expression and
progenitor cells are stimulated to become
osteoblasts.
The cells form a cuff of woven bone periosteally.
The fracture can now still angulate but
is stable in length.
15. Stages Approximate Time Essential Features
4.Hard callus
formation
3–4 months When the fracture ends are linked
together, the hard callus starts and lasts
until the fragments are firmly united (3–4
months).
Bone callus forms at the periphery of the
fracture and progressively moves centrally.
5.Remodelling Few months to several
years.
The woven bone is slowly replaced
by lamellar bone.
18. Healing of cancellous bone:
• Has a different pattern.
• Bone is of uniform spongy texture and has no
medullary cavity so that there is large area of contact
between the trabeculae, has rich blood supply.
• Heals by creeping substitution i.e. new blood vessels
invade the trabecula and bone opposition takes place
directly on the surface of trabeculum.
• Union occur directly between the bony trabeculae
• Haematoma formation
• Inflammation and cellular proliferation
• Mature osteoblasts lay down woven bone in the
intercellular matrix
• Fracture unites
21. Delayed union
• Union is considered delayed when healing has not
advanced at the average rate for the location and the
type of fracture but healing is still possible (usually 3-
6 months).
• Often can be treated successfully by cast that allows
as much function as possible and can be continued 4
to 12 additional weeks.
• Electrical stimulation and external ultrasound are
other non operative options.
• Treatment of the cause.
22. • Open reduction to remove the interposed tissue
and to appose the widely separated fractures if
it was due to poor reduction.
• If planned for ORIF with plate and screws, then
use the bone grafts.
• In closed intramedullary nailing, graft usually
are not needed but if open nailing is done to
achieve reduction, a graft usually is added.
23. Malunion
• Is the one when healing
of the fracture
fragments occur in non
anatomical position.
• Generally are caused by
the inaccurate
reduction or ineffective
immobilization during
healing.
24. Malunion can impair function in several ways:
• Abnormal joint surface can cause irregular load
transfer and arthritis of the joint in lower
extremities.
• Rotation and angulation can interfere with the
proper balance or gait in lower extremities and
positioning in upper extremities.
• Overriding of the fragment and the bone loss can
result in perceptible shortening.
• Movements of the neighboring joints can be
blocked.
25. • Objective of surgery of malunion is to restore the
function.
• Surgery rarely justified for the cosmetic reason
alone.
• Operative treatment of malunion of most of the
fractures should not be considered until 6 to 12
months after the fracture has occurred.
• In intra-articular fractures surgery is required
earlier to restore the satisfactory function.
• Degree of osteoporosis and soft tissue atrophy
should be evaluated before surgery.
• Various corrective surgery can be done.
26. Non- union
• No clear criteria.
• US FDA defined nonunion as “established when
a minimum of 9 months has lapsed since injury
and the fracture shows no visible signs of
healing for last three months.”
• Causes:
• Aseptic non-union:
Mechanical instability, Impired vascularity
• Septic non-union: Infected osteosynthesis
27. • Nonunion of long bones has been found common
when fractures are:
1. Open
2. Infected
3. Segmental, usually the middle fragment
4. Insufficient immobilization
5. Treated by ill advised open reduction
6. Distracted either by traction or plate and screws
7. Irradiated bone
In case of tibia, delay in weight bearing, an intact
fibula and fracture of the distal third of tibia are more
important factors in the development of nonunion.
