The document discusses blood disorders, focusing on sickle cell anemia, a genetic disorder caused by abnormal hemoglobin that leads to sickle-shaped red blood cells, which struggle to carry oxygen. It outlines the hereditary aspects of the disease, detailing different probabilities of inheritance based on parental traits, and lists symptoms and potential complications, such as organ damage and stroke. The document emphasizes the importance of blood testing for hemoglobin S to diagnose the condition.

1. Presented By:-Laxmi kumari

2. BLOOD DISORDERS

3. Sickle cell anemia
Haemophilia
Anemia
Thalessemia
Leukemia

4. It is a genetic disorder that affects red
blood cells causing them to become
sickle shaped.
RBCs aren’t enough healthy to carry
adequate oxygen throughout body.
It is due to abnormal hemoglobin.

5. Discribed in 1910 by Dr. James Herrick
In 1917 – Genetic basis for SCD by Dr. V. Emmel
In 1922 - Dr. V.R Mason names the disease Sickle Cell
Anemia.
Autosomal recessive disorder.
Arise from a mutation in Hb-gene
Normally, human RBCs are flexible & round moving easily
through blood vessels. But in this case it become sickle
shaped, irregular, sticky & rigid that’s why it also sticks
with blood vessel

8.  If one parent has sickle
cell anemia trait
(HbAS) and the other
has sickle cell anemia
(HbSS) then there is
50% chances of any
given child will get
sickle cell anemia
 In this case, no child
will be compelety
unaffected

9.  If both parents have
sickle cell trait (HbAS)
then there will only
25% chances to be
child with sickle cell
anemia
 25% child will be
totally normal
 And other 50% with
sickle cell anemia trait

11. There are some symptoms of SCA
•Anemia
•Periodic pain
• Painful swelling of hands and feet
•Frequent infection
•Delayed growth
•Vision problem

12. SCA can lead to host of complications, such as:
• Organ Damage
• Leg ulcer
• Blindness
• Gallstones
• Acute chest syndrome
• Pulmonary hypertension
• stroke

13.  Blood test for hemoglobin s