The document summarizes key aspects of haemostasis including the vascular, platelet and clotting phases. It describes tests used to diagnose bleeding disorders affecting primary (platelets) and secondary (clotting factors) hemostasis. Clinical features of platelet and coagulation disorders are compared. The implications of bleeding disorders for periodontal treatment are discussed, highlighting the need to modify procedures and use hemostatic measures depending on the nature and severity of the underlying condition.
The document summarizes key aspects of haemostasis including the vascular, platelet and coagulation phases. It describes tests used to diagnose bleeding disorders affecting platelets or coagulation factors. Managing dental procedures in patients with bleeding disorders requires modifying treatment based on the nature and severity of the disorder to minimize risks of bleeding. Pre-operative assessment of bleeding history and factors is important to guide management and prevent post-operative bleeding complications.
This document discusses the approach to managing bleeding in children. It covers various causes of bleeding including platelet disorders like thrombocytopenia from conditions like ITP, coagulation disorders, and dysfunctional fibrinolysis. It provides details on evaluating the clinical history and performing examinations and lab tests to identify the underlying cause. Specific conditions discussed in more depth include ITP, hemophilia, vitamin K deficiency, and DIC. Treatment approaches are described for replacing coagulation factors, corticosteroids, IVIG, platelet transfusions, and managing thrombotic disorders.
This document summarizes a seminar presentation on approaches to bleeding disorders in pediatric patients. It provides an overview of homeostasis and the blood clotting process, as well as some common bleeding disorders seen in pediatrics. The diagnosis of bleeding disorders involves taking a medical history, performing a physical exam, and conducting laboratory investigations such as platelet count, bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time to evaluate the platelet count and function, as well as factors in the intrinsic and extrinsic coagulation pathways.
This document provides information on approaches to bleeding disorders and thrombocytopenia. It discusses idiopathic thrombocytopenic purpura (ITP), including that it is characterized by thrombocytopenia under 100,000/cm and shortened platelet survival due to the presence of antiplatelet antibodies. ITP most commonly affects children ages 2-10 years and presents with bruising of the skin and mucous membranes. Evaluation involves platelet counts and smears, while treatment options include corticosteroids, intravenous immunoglobulin, and anti-Rho(D) immune globulin.
Approach to a child with bleeding for UGsCSN Vittal
This document discusses hemostasis and bleeding disorders. It covers platelet disorders, coagulation factor deficiencies, and vascular disorders that can cause bleeding. Evaluation of bleeding disorders includes obtaining a medical history, physical examination, and laboratory tests like platelet count, bleeding time, prothrombin time, and factor assays. Specific disorders discussed include hemophilia A, hemophilia B, and von Willebrand disease. Treatment involves replacing the deficient clotting factor through blood component transfusion or recombinant factor replacement.
This document discusses coagulopathy, which refers to medical disorders involving abnormal blood clotting due to deficiencies or issues with platelets, clotting factors, or the fibrinolytic system. It defines various bleeding disorders and coagulation tests. Specific conditions covered include immune thrombocytopenic purpura (ITP), von Willebrand disease, hemophilia A/B, and disseminated intravascular coagulation (DIC). Treatment involves replacing the deficient clotting factor, managing underlying causes, or administering medications depending on the condition causing the coagulopathy. Complications can include excessive bleeding, joint damage, and transmission of infections.
This document provides an overview of approach to bleeding and evaluation of bleeding disorders. It discusses the basics of hemostasis including platelets and clotting factors. Common bleeding disorders like thrombocytopenia, hemophilia, and von Willebrand disease are described. The evaluation of bleeding disorders includes history, physical exam, and screening laboratory tests. Specific coagulation factor deficiencies, liver disease, disseminated intravascular coagulation, and acquired coagulation factor inhibitors are also reviewed. Treatment focuses on supporting hemostasis and addressing underlying causes.
The document summarizes key aspects of haemostasis including the vascular, platelet and coagulation phases. It describes tests used to diagnose bleeding disorders affecting platelets or coagulation factors. Managing dental procedures in patients with bleeding disorders requires modifying treatment based on the nature and severity of the disorder to minimize risks of bleeding. Pre-operative assessment of bleeding history and factors is important to guide management and prevent post-operative bleeding complications.
This document discusses the approach to managing bleeding in children. It covers various causes of bleeding including platelet disorders like thrombocytopenia from conditions like ITP, coagulation disorders, and dysfunctional fibrinolysis. It provides details on evaluating the clinical history and performing examinations and lab tests to identify the underlying cause. Specific conditions discussed in more depth include ITP, hemophilia, vitamin K deficiency, and DIC. Treatment approaches are described for replacing coagulation factors, corticosteroids, IVIG, platelet transfusions, and managing thrombotic disorders.
This document summarizes a seminar presentation on approaches to bleeding disorders in pediatric patients. It provides an overview of homeostasis and the blood clotting process, as well as some common bleeding disorders seen in pediatrics. The diagnosis of bleeding disorders involves taking a medical history, performing a physical exam, and conducting laboratory investigations such as platelet count, bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time to evaluate the platelet count and function, as well as factors in the intrinsic and extrinsic coagulation pathways.
This document provides information on approaches to bleeding disorders and thrombocytopenia. It discusses idiopathic thrombocytopenic purpura (ITP), including that it is characterized by thrombocytopenia under 100,000/cm and shortened platelet survival due to the presence of antiplatelet antibodies. ITP most commonly affects children ages 2-10 years and presents with bruising of the skin and mucous membranes. Evaluation involves platelet counts and smears, while treatment options include corticosteroids, intravenous immunoglobulin, and anti-Rho(D) immune globulin.
Approach to a child with bleeding for UGsCSN Vittal
This document discusses hemostasis and bleeding disorders. It covers platelet disorders, coagulation factor deficiencies, and vascular disorders that can cause bleeding. Evaluation of bleeding disorders includes obtaining a medical history, physical examination, and laboratory tests like platelet count, bleeding time, prothrombin time, and factor assays. Specific disorders discussed include hemophilia A, hemophilia B, and von Willebrand disease. Treatment involves replacing the deficient clotting factor through blood component transfusion or recombinant factor replacement.
This document discusses coagulopathy, which refers to medical disorders involving abnormal blood clotting due to deficiencies or issues with platelets, clotting factors, or the fibrinolytic system. It defines various bleeding disorders and coagulation tests. Specific conditions covered include immune thrombocytopenic purpura (ITP), von Willebrand disease, hemophilia A/B, and disseminated intravascular coagulation (DIC). Treatment involves replacing the deficient clotting factor, managing underlying causes, or administering medications depending on the condition causing the coagulopathy. Complications can include excessive bleeding, joint damage, and transmission of infections.
This document provides an overview of approach to bleeding and evaluation of bleeding disorders. It discusses the basics of hemostasis including platelets and clotting factors. Common bleeding disorders like thrombocytopenia, hemophilia, and von Willebrand disease are described. The evaluation of bleeding disorders includes history, physical exam, and screening laboratory tests. Specific coagulation factor deficiencies, liver disease, disseminated intravascular coagulation, and acquired coagulation factor inhibitors are also reviewed. Treatment focuses on supporting hemostasis and addressing underlying causes.
In this Slide we will talk about coagulation Disorders in periodontics in detail
Also discuss about anticoagulant,antiplatelet
And Thrombocytopenic purpura treatment and laboratory tests etc.
This document discusses disseminated intravascular coagulopathy (DIC), an acquired syndrome characterized by widespread blood clotting. It can be acute or chronic. Acute DIC develops rapidly from sudden exposure to clotting factors, while chronic DIC reflects slower, continuous exposure. Signs include bleeding and organ dysfunction. Diagnosis is based on clinical evaluation and lab tests of clotting factors and platelets. Treatment focuses on the underlying cause, with replacement of platelets or clotting factors for severe bleeding.
Oral consideration and laboratory investigations of bleeding and clotting dis...kashmira483
This document provides information on bleeding and clotting disorders. It discusses the pathophysiology of hemostasis including the vascular, platelet, coagulation, and fibrinolytic phases. It describes different types of bleeding disorders like vessel wall disorders, platelet disorders, and coagulation disorders. Laboratory tests for identifying bleeding disorders are outlined. Oral manifestations and dental considerations for management are summarized. Local hemostatic agents and systemic agents for different bleeding disorders are also mentioned.
Bleeding disorders result from defects in hemostasis due to abnormalities in blood vessels, platelets, or coagulation factors. Hemostasis involves primary hemostasis where platelets form a platelet plug and secondary hemostasis where a fibrin clot is formed. Common bleeding disorders include hemophilia A which is a coagulation factor VIII deficiency mostly affecting males, immune thrombocytopenia where autoantibodies destroy platelets, and von Willebrand disease where von Willebrand factor is defective. Screening tests for bleeding disorders include bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time which assess platelet function and levels of coagulation factors.
This document discusses the approach to disorders of bleeding and thrombosis. It covers the main components of hemostasis including the vascular endothelium, platelets, coagulation system, and fibrinolysis. It then discusses specific factors, disorders, investigations, and treatments related to bleeding and thrombotic disorders. The key points are that a thorough history, examination, and screening coagulation tests are needed to evaluate a patient. Additional targeted tests may be needed to identify the underlying cause, which could include a deficiency or inhibitor. Treatment depends on the specific disorder diagnosed.
This document discusses the management of coagulopathy and bleeding risk in a patient with chronic liver disease undergoing surgery. It notes that the patient has mildly abnormal coagulation tests including an INR of 2.2, but that such tests do not reliably predict bleeding risk. It emphasizes that prophylactic transfusions are not recommended and that bleeding is best managed by addressing its underlying cause rather than by correcting coagulation parameters. Active bleeding should be treated with vasoconstrictors, endoscopic therapies, and restrictive transfusions as needed while avoiding volume overload.
The document discusses hemostasis and its main components: the vascular endothelium, platelets, coagulation system, and fibrinolysis. It describes how the endothelium normally prevents clotting but can promote it, and the roles of von Willebrand factor, platelets, and coagulation factors. Key factors preventing coagulation are also outlined. The extension of clots is controlled by fibrinolysis and its regulating factors. Thrombotic disorders and their causes are examined, along with risks factors, effects, and approaches to arterial and venous thrombosis patients.
The document discusses surgical haemostasis, which is the process of preventing or stopping blood loss from injured blood vessels during or after surgery. It defines haemostasis and outlines its importance in surgery. The physiology of haemostasis is described, involving vasoconstriction, platelet plug formation, and coagulation/fibrin formation. Causes of bleeding during or after surgery are discussed, including defects in haemostasis or platelet function. Methods of achieving haemostasis are covered, such as mechanical techniques like pressure, sutures, and cauterization, as well as chemical agents, blood products, and thermal techniques. Management of haemostasis in the pre-operative, intra-operative, and post-operative periods
APPROACH TO BLEEDING DISORDERS/PLATELET DISORDERS.pptxgreeshmagopinath14
This case suggests a diagnosis of thrombocytopenia. The key features are:
- Recent history of infection suggesting a secondary cause
- Purpura and petechiae on examination
- No family history suggesting an acquired rather than inherited cause
- Thrombocytopenia is a likely diagnosis which would explain the bleeding manifestations.
Further workup should include a CBC with platelet count to confirm thrombocytopenia and evaluate for possible secondary causes like ITP.
Dental Management of Patients with Bleeding DisordersDr Afsal S M
The document discusses the dental management of patients with bleeding disorders. It defines bleeding disorders and classifies them into vascular, platelet, and coagulation factor deficiencies. It describes specific disorders like hemophilia A/B, von Willebrand disease, and thrombocytopenic purpura. For dental procedures involving patients with bleeding disorders, the document recommends consulting hematologists, using local hemostatic agents, and in some cases replacing coagulation factors. It provides guidance for managing anticoagulated patients on medications like heparin, warfarin, and aspirin. The goal is to minimize bleeding risks during and after dental treatments through careful techniques and medical coordination.
Nephritis is a inflammation of kidney .
It is classified into various types like lupus nephritis ,interstitial nephritis , glomerulonephritis ,pyelonephritis.
Lupus nephritis is an inflammation of kidney due to autoimmune disorder named as lupus .
It is inflammation of lower urinary tract .
This document discusses disorders of hemostasis, including primary and secondary hemostasis, the coagulation cascade, and fibrinolysis. It describes platelet function and von Willebrand factor in primary hemostasis and how platelet aggregation initiates secondary hemostasis through the coagulation cascade. Testing of the hemostatic system includes complete blood count, platelet count, bleeding time, prothrombin time, partial thromboplastin time, and assessment of specific coagulation factor deficiencies. Causes of thrombocytopenia like decreased production, splenic sequestration, and increased destruction are outlined.
This document discusses hemostasis and blood transfusion. It begins with definitions of hemostasis and describes the five stages of hemostasis: vascular phase, platelet phase, coagulation phase, clot retraction, and fibrinolysis. It then discusses investigations for disorders of hemostasis, including clinical evaluation and laboratory tests. Major disorders of hemostasis are outlined, including inherited and acquired issues with blood vessels, platelets, and coagulation. The document also covers blood components, indications for component therapy, and potential complications of blood transfusion.
This document provides an overview of coagulopathy in children. It begins with objectives and definitions. It then discusses various types of bleeding disorders including quantitative and qualitative platelet disorders, coagulation factor disorders like hemophilia, and acquired disorders like disseminated intravascular coagulation. For each condition, it covers causes, clinical features, laboratory findings, and treatment strategies. It concludes with perioperative considerations and strategies for managing coagulopathy in children undergoing surgery.
This document discusses bleeding disorders in children, including the pathophysiology, etiology, clinical features, and management of conditions like hemophilia, von Willebrand disease, idiopathic thrombocytopenic purpura (ITP), and vitamin K deficiency. It covers the mechanisms of hemostasis and coagulation factors. Common causes of abnormal bleeding include vascular defects, platelet defects, and coagulation abnormalities. Clinical features may include bruising, purpura, epistaxis, and bleeding after procedures or trauma. Investigations include complete blood count, prothrombin time, activated partial thromboplastin time, and coagulation factor levels. Management focuses on preventing active bleeding and treating acute bleeds.
This document summarizes phases of bleeding disorders and provides information on laboratory tests, clinical presentations, vascular defects, platelet disorders, coagulation disorders, drugs used to treat bleeding disorders, and management of specific disorders like hemophilia, von Willebrand disease, and thrombocytopenia. It discusses the primary and secondary phases of hemostasis, intrinsic and extrinsic coagulation pathways, and laboratory tests used to monitor these pathways. Clinical signs of liver disease, genetic coagulation disorders, and leukemia are outlined. Causes, inheritance patterns, and treatments for various bleeding disorders are detailed.
Hemostasis
Seminar Prepared by :-
Mohammed Saadi
Mohammed Musa
Hussein Jassam
Mahmoud Ahmed
Internal Medicine
College of Medicine - University of Kirkuk
This document discusses bleeding disorders and provides details on specific disorders such as von Willebrand disease, hemophilia, and immune thrombocytopenia. It describes the pathophysiology of hemostasis and the coagulation cascade. Signs and symptoms of bleeding disorders are outlined depending on whether they affect the primary or secondary phase of hemostasis. The diagnostic approach and differential diagnosis for evaluating bleeding disorders is also summarized.
The document discusses various aspects of hemostasis including:
1. Hemostasis involves biological processes that stop bleeding through vascular wall integrity, maintaining blood fluidity, and forming clots at sites of injury.
2. Abnormalities of hemostasis include hemorrhagic diathesis, thrombosis, and disseminated intravascular coagulation (DIC).
3. Hemorrhagic diathesis has causes related to vascular disorders, thrombocytopenia, thrombocytopathy, and coagulopathy.
Water-Borne-Diseases commonly prevalent in IndiaFaisal Mohd
Poor water quality can lead to waterborne diseases, which account for around 3% of deaths worldwide. Contaminated water may carry viruses like hepatitis A and E, bacteria such as E. coli that cause diseases like cholera and typhoid fever, and parasites that lead to diseases like diarrhea, dysentery, and giardiasis. Proper precautions include drinking clean water, washing hands regularly, thoroughly cooking food, and using water purifiers. Common waterborne diseases discussed include typhoid fever, cholera, giardiasis, dysentery, hepatitis A, and salmonella.
ORAL AND MAXILLOFACIAL principles of surgery.pptxFaisal Mohd
This document outlines key principles of surgery, including pre-surgical evaluation and preparation of the patient, basic necessities for surgery such as adequate visibility and assistance, proper techniques for incisions and flap design, tissue handling, haemostasis, dead space management, wound closure, and post-operative care such as edema control and nutrition. The goal is to provide a framework for evaluating patients, performing surgery, and promoting proper healing.
In this Slide we will talk about coagulation Disorders in periodontics in detail
Also discuss about anticoagulant,antiplatelet
And Thrombocytopenic purpura treatment and laboratory tests etc.
This document discusses disseminated intravascular coagulopathy (DIC), an acquired syndrome characterized by widespread blood clotting. It can be acute or chronic. Acute DIC develops rapidly from sudden exposure to clotting factors, while chronic DIC reflects slower, continuous exposure. Signs include bleeding and organ dysfunction. Diagnosis is based on clinical evaluation and lab tests of clotting factors and platelets. Treatment focuses on the underlying cause, with replacement of platelets or clotting factors for severe bleeding.
Oral consideration and laboratory investigations of bleeding and clotting dis...kashmira483
This document provides information on bleeding and clotting disorders. It discusses the pathophysiology of hemostasis including the vascular, platelet, coagulation, and fibrinolytic phases. It describes different types of bleeding disorders like vessel wall disorders, platelet disorders, and coagulation disorders. Laboratory tests for identifying bleeding disorders are outlined. Oral manifestations and dental considerations for management are summarized. Local hemostatic agents and systemic agents for different bleeding disorders are also mentioned.
Bleeding disorders result from defects in hemostasis due to abnormalities in blood vessels, platelets, or coagulation factors. Hemostasis involves primary hemostasis where platelets form a platelet plug and secondary hemostasis where a fibrin clot is formed. Common bleeding disorders include hemophilia A which is a coagulation factor VIII deficiency mostly affecting males, immune thrombocytopenia where autoantibodies destroy platelets, and von Willebrand disease where von Willebrand factor is defective. Screening tests for bleeding disorders include bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time which assess platelet function and levels of coagulation factors.
This document discusses the approach to disorders of bleeding and thrombosis. It covers the main components of hemostasis including the vascular endothelium, platelets, coagulation system, and fibrinolysis. It then discusses specific factors, disorders, investigations, and treatments related to bleeding and thrombotic disorders. The key points are that a thorough history, examination, and screening coagulation tests are needed to evaluate a patient. Additional targeted tests may be needed to identify the underlying cause, which could include a deficiency or inhibitor. Treatment depends on the specific disorder diagnosed.
This document discusses the management of coagulopathy and bleeding risk in a patient with chronic liver disease undergoing surgery. It notes that the patient has mildly abnormal coagulation tests including an INR of 2.2, but that such tests do not reliably predict bleeding risk. It emphasizes that prophylactic transfusions are not recommended and that bleeding is best managed by addressing its underlying cause rather than by correcting coagulation parameters. Active bleeding should be treated with vasoconstrictors, endoscopic therapies, and restrictive transfusions as needed while avoiding volume overload.
The document discusses hemostasis and its main components: the vascular endothelium, platelets, coagulation system, and fibrinolysis. It describes how the endothelium normally prevents clotting but can promote it, and the roles of von Willebrand factor, platelets, and coagulation factors. Key factors preventing coagulation are also outlined. The extension of clots is controlled by fibrinolysis and its regulating factors. Thrombotic disorders and their causes are examined, along with risks factors, effects, and approaches to arterial and venous thrombosis patients.
The document discusses surgical haemostasis, which is the process of preventing or stopping blood loss from injured blood vessels during or after surgery. It defines haemostasis and outlines its importance in surgery. The physiology of haemostasis is described, involving vasoconstriction, platelet plug formation, and coagulation/fibrin formation. Causes of bleeding during or after surgery are discussed, including defects in haemostasis or platelet function. Methods of achieving haemostasis are covered, such as mechanical techniques like pressure, sutures, and cauterization, as well as chemical agents, blood products, and thermal techniques. Management of haemostasis in the pre-operative, intra-operative, and post-operative periods
APPROACH TO BLEEDING DISORDERS/PLATELET DISORDERS.pptxgreeshmagopinath14
This case suggests a diagnosis of thrombocytopenia. The key features are:
- Recent history of infection suggesting a secondary cause
- Purpura and petechiae on examination
- No family history suggesting an acquired rather than inherited cause
- Thrombocytopenia is a likely diagnosis which would explain the bleeding manifestations.
Further workup should include a CBC with platelet count to confirm thrombocytopenia and evaluate for possible secondary causes like ITP.
Dental Management of Patients with Bleeding DisordersDr Afsal S M
The document discusses the dental management of patients with bleeding disorders. It defines bleeding disorders and classifies them into vascular, platelet, and coagulation factor deficiencies. It describes specific disorders like hemophilia A/B, von Willebrand disease, and thrombocytopenic purpura. For dental procedures involving patients with bleeding disorders, the document recommends consulting hematologists, using local hemostatic agents, and in some cases replacing coagulation factors. It provides guidance for managing anticoagulated patients on medications like heparin, warfarin, and aspirin. The goal is to minimize bleeding risks during and after dental treatments through careful techniques and medical coordination.
Nephritis is a inflammation of kidney .
It is classified into various types like lupus nephritis ,interstitial nephritis , glomerulonephritis ,pyelonephritis.
Lupus nephritis is an inflammation of kidney due to autoimmune disorder named as lupus .
It is inflammation of lower urinary tract .
This document discusses disorders of hemostasis, including primary and secondary hemostasis, the coagulation cascade, and fibrinolysis. It describes platelet function and von Willebrand factor in primary hemostasis and how platelet aggregation initiates secondary hemostasis through the coagulation cascade. Testing of the hemostatic system includes complete blood count, platelet count, bleeding time, prothrombin time, partial thromboplastin time, and assessment of specific coagulation factor deficiencies. Causes of thrombocytopenia like decreased production, splenic sequestration, and increased destruction are outlined.
This document discusses hemostasis and blood transfusion. It begins with definitions of hemostasis and describes the five stages of hemostasis: vascular phase, platelet phase, coagulation phase, clot retraction, and fibrinolysis. It then discusses investigations for disorders of hemostasis, including clinical evaluation and laboratory tests. Major disorders of hemostasis are outlined, including inherited and acquired issues with blood vessels, platelets, and coagulation. The document also covers blood components, indications for component therapy, and potential complications of blood transfusion.
This document provides an overview of coagulopathy in children. It begins with objectives and definitions. It then discusses various types of bleeding disorders including quantitative and qualitative platelet disorders, coagulation factor disorders like hemophilia, and acquired disorders like disseminated intravascular coagulation. For each condition, it covers causes, clinical features, laboratory findings, and treatment strategies. It concludes with perioperative considerations and strategies for managing coagulopathy in children undergoing surgery.
This document discusses bleeding disorders in children, including the pathophysiology, etiology, clinical features, and management of conditions like hemophilia, von Willebrand disease, idiopathic thrombocytopenic purpura (ITP), and vitamin K deficiency. It covers the mechanisms of hemostasis and coagulation factors. Common causes of abnormal bleeding include vascular defects, platelet defects, and coagulation abnormalities. Clinical features may include bruising, purpura, epistaxis, and bleeding after procedures or trauma. Investigations include complete blood count, prothrombin time, activated partial thromboplastin time, and coagulation factor levels. Management focuses on preventing active bleeding and treating acute bleeds.
This document summarizes phases of bleeding disorders and provides information on laboratory tests, clinical presentations, vascular defects, platelet disorders, coagulation disorders, drugs used to treat bleeding disorders, and management of specific disorders like hemophilia, von Willebrand disease, and thrombocytopenia. It discusses the primary and secondary phases of hemostasis, intrinsic and extrinsic coagulation pathways, and laboratory tests used to monitor these pathways. Clinical signs of liver disease, genetic coagulation disorders, and leukemia are outlined. Causes, inheritance patterns, and treatments for various bleeding disorders are detailed.
Hemostasis
Seminar Prepared by :-
Mohammed Saadi
Mohammed Musa
Hussein Jassam
Mahmoud Ahmed
Internal Medicine
College of Medicine - University of Kirkuk
This document discusses bleeding disorders and provides details on specific disorders such as von Willebrand disease, hemophilia, and immune thrombocytopenia. It describes the pathophysiology of hemostasis and the coagulation cascade. Signs and symptoms of bleeding disorders are outlined depending on whether they affect the primary or secondary phase of hemostasis. The diagnostic approach and differential diagnosis for evaluating bleeding disorders is also summarized.
The document discusses various aspects of hemostasis including:
1. Hemostasis involves biological processes that stop bleeding through vascular wall integrity, maintaining blood fluidity, and forming clots at sites of injury.
2. Abnormalities of hemostasis include hemorrhagic diathesis, thrombosis, and disseminated intravascular coagulation (DIC).
3. Hemorrhagic diathesis has causes related to vascular disorders, thrombocytopenia, thrombocytopathy, and coagulopathy.
Water-Borne-Diseases commonly prevalent in IndiaFaisal Mohd
Poor water quality can lead to waterborne diseases, which account for around 3% of deaths worldwide. Contaminated water may carry viruses like hepatitis A and E, bacteria such as E. coli that cause diseases like cholera and typhoid fever, and parasites that lead to diseases like diarrhea, dysentery, and giardiasis. Proper precautions include drinking clean water, washing hands regularly, thoroughly cooking food, and using water purifiers. Common waterborne diseases discussed include typhoid fever, cholera, giardiasis, dysentery, hepatitis A, and salmonella.
ORAL AND MAXILLOFACIAL principles of surgery.pptxFaisal Mohd
This document outlines key principles of surgery, including pre-surgical evaluation and preparation of the patient, basic necessities for surgery such as adequate visibility and assistance, proper techniques for incisions and flap design, tissue handling, haemostasis, dead space management, wound closure, and post-operative care such as edema control and nutrition. The goal is to provide a framework for evaluating patients, performing surgery, and promoting proper healing.
complicationsoflocalanesthesia new.pptxFaisal Mohd
This document outlines local and systemic complications that can occur from dental injections. It discusses local complications such as paresthesia, hematoma, pain on injection, facial nerve paralysis, infection, trismus, needle breakage, soft tissue injury, edema, and ocular complications. Systemic complications covered include overdose, allergy, predisposing factors, clinical manifestations, and management. Prevention and treatment approaches are provided for each complication.
This document provides guidelines for managing various medical emergencies that may occur in a dental office setting. It outlines protocols for responding to issues like loss of consciousness, asthma attacks, allergic reactions, chest pain, and cardiac events. The protocols emphasize recognizing the problem, discontinuing treatment, activating the office emergency plan, performing basic life support measures, and determining whether definitive on-site care or emergency medical system activation is required.
The document discusses the differences between healthy and junk food, noting that healthy foods contain more vitamins, proteins and nutrients while being less fatty and caloric, helping to keep people active and immune systems strong, whereas junk foods are high in fat and calories but low in proteins and nutrients, making people lazy and potentially obese. It also covers the essential components of a balanced diet including carbohydrates, proteins, fats, vitamins, minerals, and water, as well as their functions and food sources.
The document discusses seals from the Harappan civilization. It states that the seals are believed to have been used for commercial purposes, with some also carried as amulets or identity cards. All of the seals had pictures of animals and writing in an unknown script.
The document describes procedures to test foods for the presence of starch, proteins, and fats. Students will perform tests on various food items using iodine, copper sulfate solution, and sodium hydroxide to identify which nutrient is abundant in each food. The results will be tabulated and used to answer quiz questions about identifying nutrients in different foods like potatoes, eggs, and milk based on the chemical tests.
The document provides instructions for using the OnDemand3D CD Viewer. To use the viewer, insert the CD and open the files. Select a project file by double clicking the file icon. You can then switch between modules by clicking the "Activated" button. The document notes that on Windows 7, you may need to manually run the "CDViewer.exe" file if the auto-run function is disabled.
Rigid internal fixation involves directly visualizing and fixing fractured bone segments using hardware like plates, screws, and wires. It provides sufficient rigidity to withstand forces from chewing. Rigid internal fixation aims to keep fractured bone ends together, immobilize the fracture site, and promote primary bone healing. Dynamic compression plates use an inclined plane and compression screws to draw bone fragments together across a fracture for rigid fixation. Miniplates provide semi-rigid fixation that allows some movement between bone fragments. They are commonly used for mandibular fractures.
The document defines and classifies tumors of the oral cavity, discussing their etiology, clinical features, diagnosis and treatment. It covers both benign and malignant tumors of epithelial and connective tissue origin, including common tumors like fibroma, papilloma, squamous cell carcinoma and melanoma. Management involves surgical excision for benign lesions and surgery with or without radiation/chemotherapy for malignant tumors based on staging.
Conscious sedation involves using drugs to induce a state of depressed consciousness while maintaining the patient's ability to respond appropriately to stimulation. It provides advantages for both patients and surgeons by reducing anxiety, pain and recovery time while allowing optimal operating conditions. Common drugs used include opioids, benzodiazepines, propofol and ketamine which provide analgesia, anxiolysis and amnesia. Careful monitoring of vital signs and appropriate precautions are needed, especially in high risk patients. The goal is rapid onset and recovery with minimal side effects.
PRESERVATION OF GOLDEN TEMPLE AMRITSAR.pptxFaisal Mohd
The Golden Temple in Amritsar is a sacred site for Sikhs that symbolizes their faith and universal brotherhood. In 2014, the paintings on the inner walls of the Golden Temple were preserved through a treatment process that involved pre-consolidation to secure flaking paint, cleaning with triethanol amine, fixing flakes, consolidation and filling in lost areas, and in-painting. Religious sites are important to preserve the history embodied in their rituals and structures.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central19various
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
37. Approach to the diagnosis of bleeding
disorder
Clinical Evaluation
History
Physical Examination
Family history
Laboratory Evaluation
Screening test
Specific test
38.
39. Clinical Features of Bleeding Disorders
Platelet disorders Coagulation
disorders
Site of bleeding Skin Deep in soft
tissues
(epistaxis, gum, Mucous
vaginal, GI tract) membranes,
joints, muscles)
Petechiae Yes No
Ecchymoses (“bruises”) Small, superficial Large, deep
Hemarthrosis / muscle bleeding Extremely rare Common
Bleeding after cuts & scratches Yes No
Bleeding after surgery or trauma Immediate, Delayed (1-2
days),
usually mild often severe
42. Tests for Primary Hemostasis
• Bleeding time platelet & vascular phases
• PFA – 100 system Platelet function
• Platelet count Quantification of platelets
• Blood smear Quantitative & morphological
abnormalities of platelets ,
Detection of underlying
haemotological disorder
43. Tests for Secondary hemostasis
• Clotting factor Crude test of coagulation phase
• Prothrombin factor Extrensic & common pathway
• Activated partial
thromboplastin time Intrensic & common pathway
49. INR
INR: International normalized ratio
-was established by the WHO and the International Committee on Thrombosis
and Hemostasis for reporting the results of prothrombin tests
-All PT results are standardized by this calculation:
INR= ( Patient PT / Control PT)ISI
ISI= International sensitivity index
- Given by the manufacturer for each particular thromboplastin reagent and
instrument combination
55. SPECIFIC TESTS
Tests for specific Platelet Functions
1. Platelet aggregration test
2. Flow cytometry
3. Test for platelet secretion
4. Clot retraction test
5. Platelet procoagulant activity
Test for Coagulation Phase
1. Quantitative estimation of Fibrinogen
2. Coagulation factor assays
3. F XIII Qualitative assay
Latex agglutination test for Fibrinolysis
57. HEMORRHAGIC DISORDERS
Hemorrhagic syndromes are characterized by a disorder
of one or more factors that participate in hemostasis.
The majority of hemorrhagic syndromes are blood vessel
disorders, platelet number and function disorders, or
coagulation factor disorders:
• vasculopathies
• thrombocytopenias
• thrombocytopathies
• coagulopathies.
58. Vasculopathies
• Vasculopathies may be inherited or acquired. Inherited
forms result from blood vessel structure disorders
(inherited telangiectasia,Rendu-Osler-Weber’s disease)
while acquired disorders can be a consequence of
inflammatory or immune processes that damage blood
vessel walls.
• In clinical practice, acquired disorders are found more
frequently (secondary purpuras, infections,
effects of some drugs, allergic purpura, effect of aspirin,
vitamin C deficiency, etc.).
59. Thrombocytopenias
• Thrombocytopenia, or reduced circulating platelet count,
can be inherited or acquired; the acquired form being
more frequent.
• Thrombocytopenia occurs as a result of:
– decreased platelet formation with normal platelet
survival time (effects of irradiation, drugs, malignant
tissue pressure on bone marrow, leukemias, aplastic
anemias) or
− increased platelet degradation or platelet deposit in
spleen with decreased platelet survival (DIC, effects
of drugs, bacterial or viral infections, inherited idiopathic
thrombocytopenic purpura, chronic leukemias, lupus
erythematosus,Hodgkin’s disease, massive transfusions
and liver cirrhosis).
60. Thrombocytopathies
• Inherited Qualitative Platelet Disorders may be due
to abnormalities of
1. platelet membrane glycoproteins,
- Glanzmann Thrombastenia, abnormal GPIIb/IIIa
– Bernard-Soulier Syndrome, abnormal GPIb, GPIX and
GPV
– platelet-type of vWD, abnormal GPIb
2. platelet granules,
• These may occur due to absence of granules in
platelets, storage pool disorder (characterized by
disturbed platelet aggregation to collagen, adrenaline
and thrombin), or disturbed release (absence of T A2).
61. 3. platelet coagulant activity, or
4. signal transduction and secretion.
• defects in arachidonic acid metabolism,
• cyclooxigenase deficiency, platelets unable to produce
thromboxane; endothelium may not produce
prostacyclin,
• thromboxane synthesis deficiency, and
• defects in platelet secretion and the second wave of
platelet aggregation, found in response to epinephrine or
ATP.
63. ACQUIRED BLOOD CLOTTING
DISORDERS
They occur in:
– vitamin K deficiency,
– liver diseases,
– liver transplantation,
– disseminated intravascular coagulation,
– renal diseases,
– primary pathological fibrinolysis
– during the course of anticoagulant therapy.
64. • The extent and severity of periodontal disease
determines the necessity for a surgical or nonsurgical
treatment approach in its management.
• The nature and severity of an acquired bleeding
disorder, and the degree of invasive dental procedures,
determines the need to modify the treatment to be
provided.
• Various Illnesses, along with pharmacotherapy,may
contribute to the tendency for excessive bleeding.
65. Pre-operative management of patients starts with a medical
history focusing on the previous bleeding history of the
patient and medical conditions associated with bleeding.
Presence of following illness may need a modification in
treatment protocol to minimize the risk of intra-operative
and postoperative bleeding.
• Chronic renal failure
• Lack of vitamin K
• Liver failure
• Aspirin
• Antiplatelet medication
• Anticoagulant therpay
66. • Platelet count should be assessed
Surgeries
• Iv infusion 1 hr before
• Level should be 50% higher in plasma for
Regional anesthesia
Missing factors
• Antifibrinolytic mouthwash (Lee , Boyle)
Scaling and root
planing
• regional anesthesia should be avoided
LA
• Conservative design
• Mandibular molar
Flap
• Curettage of extraction socket
• Granulation tissue
Prevention of
infection
Intra-operative measures include a number of systemic and local
measures administered prior to, or during, the procedure to prevent
unlikely bleeding diathesis.
67. Hemostatic agent
• Absorbable
gelatin
• Absorbable
collagen
• Microfibrillar
collagen
• Oxidised
cellulose
• Thrombin
• Tranexamic acid
• Fibrin glue
• PRP
Other means
• Sponge
• Surgical splint
• Electrocautery
• Laser
• Moistened or
hemostatic
soaked gauze
Hard tissue
• Bone burnishing
• Bone wax
68. General recommendations is crucial for preventing
bleeding, postoperatively.
Prohibition of
Rinsing
Liquid , high
protein diet
Antifibrinolytic
mouthwash
Antibiotics
Pain
medication
69. References :-
• Textbook of Medical Physiology ,10th edition,Hall &
Guyton
• Essentials of hematology , Shirish M Kawthalkar
• Periodontal Medicine, Rose
• Bleeding disorders and periodontology, Philip
Vassilopoulos & Kent Palcanis , Periodontology 2000,
Vol. 44, 2007, 211–223.
• Coagulation Pathway and Physiology, Jerry B. Lefkowitz
• Hemostasis And Hemorrhagic Disorders, R. Baklaja, M.
C. Pešic´, J. Czarnecki
• Platelet function analysis,Paul Harisson, Blood Reviews
(2005) 19, 111–123