This is a presentation on blockchain / distributed ledger technology given by Dr. Sean Manion at the Armed Forces Communication & Electronics Association C4i (Command, Control, Computers, Communication, and Intelligence) meeting at George Mason University on 22 May 2018. It gives an overview of blockchain/DLT as a critical enabler for government, a glimpse at the ecosystem for applications in health and science, and potential uses and challenges for application of the technology.