The Black Death was a devastating global pandemic of bubonic plague that originated in Asia and spread to Europe in the mid-1300s, killing approximately 50 million people in Europe. It spread through contact with infected rats and their fleas, which would bite humans and transmit the disease. Sailing ships provided an ideal environment for the spread of infected rats and fleas between ports. Physicians at the time did not understand the disease and relied on ineffective and sometimes dangerous treatments. The pandemic eventually declined due to the practice of quarantining the infected and improved hygiene and medical practices.