The document is a flowchart describing the biosynthesis of heme. It shows that heme is synthesized from succinyl CoA and glycine in the mitochondria of cells, with the exception of red blood cells which lack mitochondria. Key steps include the rate-limiting reaction of ALA synthase, followed by reactions involving ALA dehydrogenase, uroporphyrinogen synthase, and ferrochelatase which inserts iron to form heme.

1. Biosynthesis of Heme [Flowchart]

2. Biosynthesis of Heme
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Succinyl CoA + Glycine
δ Aminolevulinic acid (ALA)
Prophobilinogen (PBG)
Hydroxymethylbilane (HMB)
ALA synthase [Rate Limiting Step ]
ALA dehydrogenase [Zn 2+]
Uroporphyrinogen- III (UPG III)
Coproporpyrinogen- III
UPG decarboxylase
Uroporphyrinogen- synthase
Uroporphyrinogen- III synthase
CYTOPLASM
MITOCHONDRIA Heme
Corporphyrinogen
Oxidase
(in Mitochondria)
Protoporphyrinogen- IX
Ferrochelatase
(heme synthase)
Fe+2
All Cells Except RBC [Lacks Mitochondria]
Mostly in Liver and Bone Marrow
(-) Lead Poisoning
↑ 4 CO2

3. Brain Teaser
The Decarboxylation of Uroporhyrinogen takes place in Cytoplasm ? True / False