biosynthesis of aspartate

1. PRESENTATION ON BIOSYNTHESIS
ASPARTATE AMINO ACID
GOVERNMENT PHARMACY COLLEGE
SAJONG RUMTEK

2. SUBMITTED BY 5TH SEMESTER STUDENTS
1. SACHIN KUMAR PRASAD
2. SARASWATI SHARMA
3. ABISHEK BHATTRAI
4. PREM DORJEE TAMANG
5. BABITA PRADHAN
6. DEEKU CHETTRI
7. PRIYA KUMARI
8. PINKI KUMARI
9. DINESH REGMI
10. AVAY PRADHAN

3. CONTENTS 1
Introduction
02
Types of aspartic acid
3
Biosynthesis
4
Functions of aspartic acid
05
Uses and Health benefits

4. What is amino acid?
● Amino acid, any of a group of organic molecules that consist of a basic amino group
(―NH2), an acidic carboxyl group (―COOH), and an organic R group (or side chain)
that is unique to each amino acid. The term amino acid is short for α-amino [alpha-
amino] carboxylic acid. Each molecule contains a central carbon (C) atom, called the
α-carbon, to which both an amino and a carboxyl group are attached. The remaining
two bonds of the α-carbon atom are generally satisfied by a hydrogen (H) atom and
the R group.
● The formula of a general amino acid is:
The amino acids differ from
each other in the particular
chemical structure of the R
group.

5. Nonessential means that our
bodies produce an amino acid,
even if we do not get it from the
food we eat. Nonessential amino
acids include: alanine, arginine,
asparagine, aspartic acid,
cysteine, glutamic acid,
glutamine, glycine, proline,
serine, and tyrosine
NON-ESSENTIAL
Essential amino acids cannot be
made by the body. As a result,
they must come from food.The 9
essential amino acids are:
histidine, isoleucine, leucine,
lysine, methionine, phenylalanine,
threonine, tryptophan, and valine
TYPES OF AMINO ACID
ESSENTIAL

6. • This is non essential and glucogenic amino acid.
• Aspartate is also known as aspartic acid.
• In 1868, aspartic acid was isolated from legume in plant
seeds and is apparently known as an amino acid
obtained as a product of the hydrolysis of protein.
INTRODUCTION
Chemical formula C4H7NO4
Molar mass 133.103 g·mol
−1
Appearance colourless crystals
Density 1.7 g/cm
3
Melting point 270 °C (518 °F;
543 K)
Boiling point 324 °C (615 °F;
597 K) (decomposes)
Solubility in water 4.5 g/L

7.  It contains an amino group and a
carboxylic acid. Its α-amino group is in
the protonated –NH+
3 form and its α-
carboxylic acid group is deprotonated
−COO− .
 Chemical formula of aspartic acid is C4H7NO4
STRUCTURE

8. L-ASPARTIC ACID
TYPES OF ASPARTIC ACID
D-ASPARTIC ACID

9. —D-ASPARTIC ACID
 D- aspartic acid is used in body functions but not
necessarily in the making of the body proteins.
 It is commonly used to reduce the feelings of tiredness, to
boost the athletic capabilities or to increase the size and
strength of the body muscles.
 It can affect the level of testosterone in a male body
playing a larger role in the development of male
reproductive tissues.

10. L-ASPARTIC ACID • L-aspartic acid is the L- enantiomer of aspartic acid.
• It has a role as an E.coli metabolite, a mouse metabolite and a
neurotransmitter.
• L- aspartic acid has been found throughout all human tissues, and
has also detected in most biofluid, including blood, breastmilk,
saliva, and sweat.
• Within the cell, L-aspartic acid is primarily located in the
cytoplasm and mitochondria.
• It exists in all eukaryotes, ranging from yeast to human.
• L- aspartic acid participates in a number of enzymatic reaction

11. VEGETABLE SOURCESDIETARY SOURCES OF
ASPARTIC ACID
OAT FLAKES
AVOCADO

12. MOLASSES
SUGAR BEETS

13. ANIMAL
SOURCES
SAUSAGE MEATOYSTERS

14. BIOSYNTHESIS OF ASPARTATE
● In the human body aspartate is most frequently synthesis
though the transamination of oxaloacetate.
● The biosynthesis of aspartate is facilitated by an
aminotransferase enzyme.
● The transfer of an amine group from another molecule such
as alanine or glutamine yield aspartate and an alpha-keto
acid.

16. FUNCTION OF
ASPARTIC ACID
● In the urea cycle , aspartate reacts with citruillin to form
arginosuccinate, which is cleaved , forming an essential
amino acid arginine and fumarate.
● Aspartate reacts with inosine monophosphate(IMP) to form
adenosine monophosphate (AMP).
● This amino acid is necessary for stamina brain and neural
health.

18. USES
1. It is used to reduce feelings of tir.edness
2. Improve athletic performance.
3. Increase the size and strength of muscles
4. It is also used to treat depression and fatigue
5. Aspartates are taken orally to reduce fatigue, and enhance athletic
performance
6. Mineral aspartates have also resulted in blood pressure lowering
effects and enhanced wound healing.

19. 3
1 2
4
Female fertility
Increase testosterone levels Promote sperm quality
HEALTH
BENEFITS
Enhance memory

20. REFRENCE
 https://www.planetayurveda.com/library/aspartic-acid
 https://en.m.wikipedia.org/wiki/Aspartic_acid#:~:text
=Sources-
,Dietary%20sources,meats%2C%20sausage%20meat
%2C%20wild%20game
 https://www.vedantu.com/chemistry/aspartic-acid
 https://www.slideshare.net/mobile/mprasadnaidu/bio
synthesis-of-amino-acids

21. THANK YOU!