Professor Jane Burridge leads a research group that aims to understand mechanisms of recovery following stroke and uses this knowledge to design rehabilitation technologies. Her research focuses on developing technologies like wearable sensors, brain stimulation, and functional electrical stimulation to measure movement and promote neuroplasticity. She conducts studies on topics like intensity of exercise in stroke recovery and links between trunk control and arm function. Her goal is to translate findings into cost-effective home-based therapies to improve outcomes for people with conditions like stroke and spinal cord injury.

1. Jane Burridge Professor of Restorative Neuroscience
Introduction
Professor Jane Burridge leads the Neurorehabilitation Research Group. Her
research aims to understand the mechanisms of sensory-motor recovery
following stroke. She and her group use this better understanding to design and
evaluate rehabilitation technologies that will improve recovery following central
nervous system lesions such as stroke and spinal cord injury
‘Stroke rehabilitation is changing. Already most rehabilitation takes place in
people own homes and over the next few years technologies to support them will
become commonplace’
Research Interests
My work is cross-disciplinary working with electronics, control, design and
signal processing engineers, psychologists and industrial partners. Together we
develop technologies for measurement and therapy to optimise recovery.
 Wearable sensors to monitor movement and muscle activity
 Non-Invasive Brain stimulation to modulate cortical activity and promote
neuroplasticity – key to recovery
 Using the Internet to support home-based rehabilitation in stroke and
traumatic brain injury
 Functional Electrical Stimulation to promote recovery in spinal cord
injury
 Longitudinal studies of stroke to understand the mechanisms on recovery
 Why is intensity of exercise important is stroke recovery, and how can we
promote it?
 Is there a link between regaining trunk control and upper limb function
following stroke?

2. Research projects
Mechanical Muscle Activity with Real-time Kinematics (M-MARK): A novel
combination of existing technologies to improve arm recovery following stroke
A systematic Exploration of Neuromuscular Electrical Stimulation in Spinal Cord
Injury: Stage 2, An International Questionnaire Study, INSPIRE
Study to find out the opinions of the spinal cord injury community about
Neuromuscular Electrical Stimulation (ES) so that the knowledge can be used to
direct research, technical development, and clinical and service provision.
Combining transcranial direct current stimulation (tDCS) with robotic hand
training for the severely impaired hand after stroke
The aim of this study is to examine the effect of combining transcranial direct
current stimulation with robotic hand and arm training for the impaired hand
and arm after stroke.
Development of an integrated service model incorporating innovative
technology for the rehabilitation of the upper limb following stroke, (Assistive
Technologies in Rehabilitation Following Stroke (ATRAS)
This programme of research seeks to significantly improve rehabilitation of the
hand and arm following a stroke by investigating the use of assistive
technologies to maximise recovery of function.
Shimmer Sensors for activity monitoring in post stroke upper limb rehabilitation
Development and pilot evaluation of a web-supported programme of Constraint
Induced Therapy following stroke (LifeCIT)
https://clinicaltrials.gov/ct2/show/NCT01350453?term=lifecit&rank=1
The aim of this study is to develop a web-based therapy programme (‘LifeCIT’) to
support patients carrying out Constraint Induced Therapy at home (with their
carer where possible) with online therapist support.
To view the website follow the link below and register with a username
comprising 2 letter and 2 numbers and a password of your own choice
https://pips.ecs.soton.ac.uk/player/play/LifeCIT_demo
More information is available at:
https://clinicaltrials.gov/ct2/show/NCT01350453

3. CV and Biography
Jane Helena Burridge, MCSP, LGSM, PhD, Professor of Restorative
Neuroscience. Faculty of Health Sciences, University of Southampton E-Mail
jhb1@soton.ac.uk
1973-1993 Basic grade and then Senior I Physiotherapist specialising in
stroke rehabilitation
1978 - 1990 Raise a family, study music and practice as music teacher and
freelance musician
1/93 - 1/99 Senior I / clinical specialist, research physiotherapist, Salisbury
District Hospital
12/99 –1/03 Senior Lecturer, Head of Postgraduate Education SOHPRS
University of Southampton
1/03 – 9/08 Senior Research Fellow / Senior Lecturer, SOHPRS, University of
Southampton
09/08 Professor of Restorative Neuroscience FOHS, University of
Southampton
I am Professor of Restorative Neuroscience at the University of Southampton,
where I lead the Neurorehabilitation Research Group and Chair the University of
Southampton Strategic Research group ‘Health Technology’. I graduated as a
physiotherapist from Bristol in the UK in 1973 and after working as a physical
therapist for four years, changed career and trained as a musician at the
Guildhall School of Music and Drama in London. I developed a career as a
performer and teacher of the flute and raised a family. In 1993 I began my PhD
study at the University of Southampton and graduated in 1999. My research
enabled response to Functional Electrical Stimulation for drop-foot to be better
predicted by accurate measurement of muscle dysfunction. In 1999 I took up a
senior lectureship at the University of Southampton as Head of Postgraduate
Education with the remit to design and validate a multi-disciplinary MSc in
Rehabilitation.
In 2008 I was appointed to my current position as Chair of Restorative
Neuroscience. Building on my experience as a clinical physiotherapist
specialising stroke, the aim of my work has been to understand the mechanisms
of recovery post-stroke and how this knowledge can be translated into evidence-
based and cost-effective therapy. My research has therefore been into the
development, evaluation and clinical application of novel rehabilitation
technologies, informed by a better understanding of motor control,
neuroplasticity and psychosocial factors. Most of my research is cross-
disciplinary involving collaboration with the disciplines of: electronics &
computer science, signal processing and health psychology.
Between 2009 and 2013, funded by a UK National Institute of Health Research
(NIHR) Programme grant, I explored the barriers to and opportunities for
rehabilitation technologies in upper limb rehabilitation following stroke. We

4. identified key factors such as lack of education and awareness (of both
healthcare professionals and patients and carers) into rehabilitation
technologies, paucity of evidence-based research and NHS funding systems that
inhibit the introduction of new technological approaches to stroke rehabilitation.
My work is funded mainly by the UK NIHR and Engineering and Physical Science
Research Council (EPSRC), the EU FP7 and medical charities. It has focused on
developing home-based rehabilitation technologies, combining robot therapy
with Functional Electrical Stimulation (FES) using Iterative Learning Control,
and with non-invasive brain stimulation using transcranial direct current
stimulation in the treatment of post-stroke hemiplegia. My work also includes
measurement of changes in EEG activity (synchronisation and de-
synchronisation) in healthy people and in stroke rehabilitation using robot
therapy. Working with signal processing engineers, we are developing novel
ways to measure and analyse motor control and spasticity and how impairments
relate to function in older people and patients with stroke. In collaboration with
Health Psychologists we are interested in motivation and adherence in
neurological rehabilitation and barriers to adoption of new technologies.
In collaboration with Health Psychologists I have conducted research, funded
mainly by the NIHR Research for Patient Benefit (RfPB) (2011-2014) into ways
in which patients can be motivated to adhere to their stroke rehabilitation
programme. Based on one of the few technologies that has strong research
evidence, Constraint Induced Movement Therapy (CIMT), but which has not
translated in clinical practice we developed a web-based support programme to
enable patients to use CIMT at home without additional therapist input.
Most recently (Nov 2015) I was awarded an NIHR Invention for Innovation (i4i)
grant to develop a new technology combining mechanomyography and inertial
sensors into a garment to provide feedback to patients and therapists on amount
and quality of upper extremity movement following stroke. This work involves
collaboration with Imperial College London, two NHS Trusts and two UK
companies.
I regularly review proposals and projects for EU FP7 and (H2020), Future and
Emerging Technologies, including Neurobotics and currently the NEBIAS project,
Wellcome Trust, NIHR and EPSRC. I was President of the International
Functional Electrical Stimulation Society from 2011- 2014 and am currently a
member of the Editorial board of the Journal of Neurorehabilitation and Neural
Repair, and the International Journal of Research in Rehabilitation. I am
frequently invited to speak at major International conferences and summer
schools e.g. UK Stroke Forum, World Conference of Neurorehabilitation and US
STEP VI, (https://u.osu.edu/ivstep/).
I am a Consultant for International rehabilitation technology companies
including: Bioness http://www.bioness.com/Home.php and MindMaze
http://www.mindmaze.ch and member of the Scientific Board of Directors,
Hocoma A/C Zurich http://www.hocoma.com/en/

5. PhD supervision: I have Supervised 10 PhD students to completion and am
currently supervising 8 students, three of whom are International. I have
examined more than 14 PhD students including students from Europe and New
Zealand.
Education: I teach at Undergraduate and Masters level and co-led an EU Life-
Long Learning project (€450k) to develop an MSc in Advanced Rehabilitation
Technologies (MSc ART), which involved four European awarding partners and
five Associate partners.
http://www.southampton.ac.uk/healthsciences/postgraduate/taught_courses/
msc_advanced_rehabilitation_technologies.page
Current / Recent Research Grants:
1. 2015-2017: PI: NIHR i4i: Mechanical Muscle Activity with Real-time
Kinematics (M-MARK): A novel combination of existing technologies to
improve arm recovery following stroke (£861k)
2. 2013- 2016: PI: Donaldson, Gall, Roberts. INSPIRE Hospital and home-
based feasibility study of an iCycle for functional recovery after
incomplete spinal cord injury (£38.057) Plus externally funded PhD
studentship
3. 2011–2015: PI: NIHR RfPB: Development and pilot evaluation of a web-
supported programme of Constraint Induced Therapy following stroke
(LifeCIT) (£249,634)
4. 2012-2015: CI EU FP7 ICT Telemedicine System Empowering Stroke
Patients to Fight Back StrokeBack (€3.03M)
5. 2011–2014: CI: Rogers, Freeman. EPSRC Restoration of Reach and Grasp
in Stroke Patients using Electrical Stimulation and Haptic Feedback
EP/I01909X/1 (£464,231) [0.2FTE]
6. 2011-2014: CI: MRC/NIHR Efficacy and Mechanism Evaluation
programme grant. “Clinical efficacy of functional strength training for
upper limb motor recovery early after stroke: neural correlates and
prognostic indicators”. (PI: Pomeroy, Co-applicants: Ward, Johansen-Berg,
van Vilet, Burridge, Hunter, Lemon, Rothwell, Weir, Norrie, Wing, Barton),
£1.2 million
7. 2011-2014: PI: Wessex Medical Trust: Combining transcranial Direct
current stimulation (tDCS) with robot hand training for the severely
impaired hand after stroke (£19,223) Plus externally funded PhD
studentship
8. 2009-2013: Co-applicant NIHR Programme Grant: Development of an
integrated service model incorporating innovative technology for the
rehabilitation of the upper limb following stroke (NIHR RP-PG-0707-
10012) (£1.9M)