Big data has the potential to transform nursing education and healthcare. It allows analysis of large, diverse datasets to reveal patterns and trends. Nursing has a long history of using data to improve patient care. Now, with big data and analytics, insights can be gained from vast amounts of structured and unstructured data from various sources. This can help personalize learning and predict outcomes. However, challenges include technical issues, privacy concerns, and developing a data-driven culture. With collaboration across sectors and letting the data speak, big data can advance nursing knowledge and the learning healthcare system.