Jürgen K. Rockstroh, MD, provides an update on the importance of HCV screening and the latest emerging treatment options for patients with HCV/HIV coinfection.
Why, when, and how to use pre exposure prophylaxis for hiv acquisition. 2014Hivlife Info
In this downloadable slide set, Marcy S. Gelman, RN, MSN, MPH, and Kevin M. O’Hara, PA, review essential considerations for midlevel providers administering PrEP
Format: Microsoft PowerPoint (.ppt)
File size: 825 KB
Date posted: 9/29/2014
Integrating Recent Data When Selecting First-line Antiretroviral Therapy.2015...Hivlife Info
Joseph J. Eron Jr., MD
W. David Hardy, MD
Paul E. Sax, MD
How do leading experts select first-line antiretroviral therapy for their HIV-infected patients?
Review these downloadable slides for key clinical trial data and the latest DHHS recommendations for first-line antiretroviral therapy.
Современное лечение ВИЧ: лечение ВИЧ у пациентов с вирусными гепатитами.Conte...hivlifeinfo
Современное лечение ВИЧ: лечение ВИЧ у пациентов с вирусными гепатитами.Contemporary Management of HIV. Managing HIV in Viral Hepatitis Coinfection.2016
In this downloadable slideset, David L. Wyles, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for ART management in patients with HIV and viral hepatitis coinfection.
Format: Microsoft PowerPoint (.ppt)
File size: 1.85 MB
Современное лечение ВИЧ : АРТ как профилактика.Contemporary Management of HIV...hivlifeinfo
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In this downloadable slideset, Kenneth Mayer, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for pre- and post-exposure prophylaxis in patients at risk for HIV infection.
Format: Microsoft PowerPoint (.ppt)
File size: 2.13 MB
Современное лечение ВИЧ: новые парадигмы в АРТ / Contemporary Management of H...hivlifeinfo
Набор слайдов c рассмотрением важных вопросов об АРТ первого ряда, арв-препаратами пролонгированного действия и схемами АРТ с двумя препаратами, акцент в публикации на роль новых стратегий.
Hepatitis C elimination in HIV-infected men who have sex with men: reality and challenges
Edward Cachay MD, MAS
February 23rd, 2018
UCSD HIV & Global Health Rounds
Why, when, and how to use pre exposure prophylaxis for hiv acquisition. 2014Hivlife Info
In this downloadable slide set, Marcy S. Gelman, RN, MSN, MPH, and Kevin M. O’Hara, PA, review essential considerations for midlevel providers administering PrEP
Format: Microsoft PowerPoint (.ppt)
File size: 825 KB
Date posted: 9/29/2014
Integrating Recent Data When Selecting First-line Antiretroviral Therapy.2015...Hivlife Info
Joseph J. Eron Jr., MD
W. David Hardy, MD
Paul E. Sax, MD
How do leading experts select first-line antiretroviral therapy for their HIV-infected patients?
Review these downloadable slides for key clinical trial data and the latest DHHS recommendations for first-line antiretroviral therapy.
Современное лечение ВИЧ: лечение ВИЧ у пациентов с вирусными гепатитами.Conte...hivlifeinfo
Современное лечение ВИЧ: лечение ВИЧ у пациентов с вирусными гепатитами.Contemporary Management of HIV. Managing HIV in Viral Hepatitis Coinfection.2016
In this downloadable slideset, David L. Wyles, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for ART management in patients with HIV and viral hepatitis coinfection.
Format: Microsoft PowerPoint (.ppt)
File size: 1.85 MB
Современное лечение ВИЧ : АРТ как профилактика.Contemporary Management of HIV...hivlifeinfo
Contemporary Management of HIV. Antiretroviral Therapy As Prevention.2016
In this downloadable slideset, Kenneth Mayer, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for pre- and post-exposure prophylaxis in patients at risk for HIV infection.
Format: Microsoft PowerPoint (.ppt)
File size: 2.13 MB
Современное лечение ВИЧ: новые парадигмы в АРТ / Contemporary Management of H...hivlifeinfo
Набор слайдов c рассмотрением важных вопросов об АРТ первого ряда, арв-препаратами пролонгированного действия и схемами АРТ с двумя препаратами, акцент в публикации на роль новых стратегий.
Hepatitis C elimination in HIV-infected men who have sex with men: reality and challenges
Edward Cachay MD, MAS
February 23rd, 2018
UCSD HIV & Global Health Rounds
Современное лечение ВИЧ : лечение возрастных пациентов.2017/Contemporary Management of HIV. Management of Aging Patients.2017
In this downloadable slideset, Edgar Turner Overton, MD, and Program Director Joseph J. Eron, Jr., MD, review key data on managing aging patients with HIV.
Source: Contemporary Management of HIV
Date Posted: 4/24/2017
HIV Alert:ART Considerations for Aging Patients.2018hivlifeinfo
In this downloadable slideset, Eric S. Daar, MD, and David A. Wohl, MD, provide expert recommendations for older patients with HIV, both in terms of ART selection and general management.
Format: Microsoft PowerPoint (.ppt)
File size: 545 KB
Date posted: 2/12/2018
Cardiovascular Disease in HIV-Infected Patients.Predict It and Prevent It.2015Hivlife Info
In this downloadable slideset, Priscilla Y. Hsue, MD, and David A. Wohl, MD, discuss data on using traditional and newer markers and modalities to predict and prevent cardiovascular disease in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 3.21 MB
Date posted: 7/16/2015
Contemporary Management of HIV.How Aging Affects ART Management.2018hivlifeinfo
In this downloadable slideset, Expert Faculty review key data on managing aging patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 720 KB
Date posted: 3/7/2018
Современное лечение ВИЧ: АРТ у пациентов с сопутствующими заболеваниями.Conte...hivlifeinfo
Современное лечение ВИЧ:АРТ у пациентов с сопутствующими заболеваниями.//Contemporary Management of HIV. Managing ART in HIV-Infected Patients With Common Comorbidities. 2016
In this downloadable slideset, David A. Wohl, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for managing ART in the context of common comorbidities.
Format: Microsoft PowerPoint (.ppt)
File size: 3.51 MB
In this downloadable slideset, Joel E. Gallant, MD, MPH, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at upcoming agents currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 3.00 MB
Date posted: 6/15/2015
Современное лечение ВИЧ: новые подходы к оптимизации АРТ/Contemporary Managem...hivlifeinfo
Вопросы, связанные с АРТ первого ряда, смена арв-стратегии для пациентов с вирусной супрессией, акцентом на возрастающую роль новыхантиретровирусных стратегий.
Richard Garfein, PhD, MPH
Professor
Herbert Wertheim School of Public Health and Human Longevity Science
Adjunct Professor
Division of Infectious Disease and Global Public Health
Department of Medicine
University of California, San Diego
Amutha Rajagopal, MD
Associate Physician Diplomate
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
HIV and Cardiovascular Disease.How Worried Should We Be ? 2015Hivlife Info
In this downloadable slideset, David A. Wohl, MD, reviews the association between HIV and cardiovascular disease, including potential contributing factors and best practices in prevention.
Format: Microsoft PowerPoint (.ppt)
File size: 5.01 MB
Date posted: 6/26/2015
Department of Global Health Lecture Series
Judd Walson
December 2, 2008
'Delaying HIV-1 Disease Progression in Pre-HAART Positives; The Role of Treating Endemic
Maile Young Karris, MD
Associate Professor
Co-Director San Diego Center for AIDS Research Clinical Investigations Core
Divisions of Infectious Diseases & Global Public Health and Geriatrics & Gerontology
Department of Medicine
University of California San Diego
Evolving Switch Strategies for Virologically Suppressed HIV-Infected Patients...Hivlife Info
Доктор David A. Wohl при участии группы экспертов, рассматривает основные исследования о том, когда и как, при каких условиях переводить пациентов со стабильной супрессией ВИЧ на новые методы лечения .
Современное лечение ВИЧ : лечение возрастных пациентов.2017/Contemporary Management of HIV. Management of Aging Patients.2017
In this downloadable slideset, Edgar Turner Overton, MD, and Program Director Joseph J. Eron, Jr., MD, review key data on managing aging patients with HIV.
Source: Contemporary Management of HIV
Date Posted: 4/24/2017
HIV Alert:ART Considerations for Aging Patients.2018hivlifeinfo
In this downloadable slideset, Eric S. Daar, MD, and David A. Wohl, MD, provide expert recommendations for older patients with HIV, both in terms of ART selection and general management.
Format: Microsoft PowerPoint (.ppt)
File size: 545 KB
Date posted: 2/12/2018
Cardiovascular Disease in HIV-Infected Patients.Predict It and Prevent It.2015Hivlife Info
In this downloadable slideset, Priscilla Y. Hsue, MD, and David A. Wohl, MD, discuss data on using traditional and newer markers and modalities to predict and prevent cardiovascular disease in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 3.21 MB
Date posted: 7/16/2015
Contemporary Management of HIV.How Aging Affects ART Management.2018hivlifeinfo
In this downloadable slideset, Expert Faculty review key data on managing aging patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 720 KB
Date posted: 3/7/2018
Современное лечение ВИЧ: АРТ у пациентов с сопутствующими заболеваниями.Conte...hivlifeinfo
Современное лечение ВИЧ:АРТ у пациентов с сопутствующими заболеваниями.//Contemporary Management of HIV. Managing ART in HIV-Infected Patients With Common Comorbidities. 2016
In this downloadable slideset, David A. Wohl, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for managing ART in the context of common comorbidities.
Format: Microsoft PowerPoint (.ppt)
File size: 3.51 MB
In this downloadable slideset, Joel E. Gallant, MD, MPH, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at upcoming agents currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 3.00 MB
Date posted: 6/15/2015
Современное лечение ВИЧ: новые подходы к оптимизации АРТ/Contemporary Managem...hivlifeinfo
Вопросы, связанные с АРТ первого ряда, смена арв-стратегии для пациентов с вирусной супрессией, акцентом на возрастающую роль новыхантиретровирусных стратегий.
Richard Garfein, PhD, MPH
Professor
Herbert Wertheim School of Public Health and Human Longevity Science
Adjunct Professor
Division of Infectious Disease and Global Public Health
Department of Medicine
University of California, San Diego
Amutha Rajagopal, MD
Associate Physician Diplomate
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
HIV and Cardiovascular Disease.How Worried Should We Be ? 2015Hivlife Info
In this downloadable slideset, David A. Wohl, MD, reviews the association between HIV and cardiovascular disease, including potential contributing factors and best practices in prevention.
Format: Microsoft PowerPoint (.ppt)
File size: 5.01 MB
Date posted: 6/26/2015
Department of Global Health Lecture Series
Judd Walson
December 2, 2008
'Delaying HIV-1 Disease Progression in Pre-HAART Positives; The Role of Treating Endemic
Maile Young Karris, MD
Associate Professor
Co-Director San Diego Center for AIDS Research Clinical Investigations Core
Divisions of Infectious Diseases & Global Public Health and Geriatrics & Gerontology
Department of Medicine
University of California San Diego
Evolving Switch Strategies for Virologically Suppressed HIV-Infected Patients...Hivlife Info
Доктор David A. Wohl при участии группы экспертов, рассматривает основные исследования о том, когда и как, при каких условиях переводить пациентов со стабильной супрессией ВИЧ на новые методы лечения .
What the new hepatitis C protease inhibitors Incivek and Victrelis mean for people coinfected with HIV & HCV and for health departments. Presented at the NASTAD annual meeting 5/23/11.
Случаи и разногласия по ВИЧ в 2019 году: европейские перспективы / Cases and...hivlifeinfo
Learn unique perspectives across Europe on PrEP, rapid ART initiation, ART in women, and options for switching ART.
Format: Microsoft PowerPoint (.ppt)
File Size: 1.33 MB
Released: July 10, 2019
Новые данные с конференции по ВИЧ-инфекции CROI 2017/Clinical Impact of New D...hivlifeinfo
Clinical Impact of New Data From CROI 2017
Expert faculty members Joel E. Gallant, MD, MPH, and Charles B. Hicks, MD, summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File size: 1.25 MB
Date posted: 3/3/2017
What I Use and Why: Expert Strategies for Selecting the Best ART Regimen for ...hivlifeinfo
In this case-based downloadable slideset, Joseph J. Eron, Jr., MD, summaries optimal evidence-based ART management strategies for a variety of patients with HIV infection based on 2 recent expert faculty panel discussions.
Format: Microsoft PowerPoint (.ppt)
File size: 1.64 MB
Date posted: 11/25/2015
Clinical Impact of New HIV Data From CROI 2019hivlifeinfo
March 4-7, 2019; Seattle, Washington
In this downloadable slideset, expert faculty members summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File Size: 576 KB
Released: March 22, 2019
“Тяжелые” категории пациентов с хроническим гепатитом C- возможности терапии....Hivlife Info
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HCV Alerts- Rapid Response to Practice-Changing Advances From EASL 2015Hivlife Info
In this downloadable slideset, Mark S. Sulkowski, MD, discusses key practice-changing data from the 2015 liver disease meeting in Vienna.
Format: Microsoft PowerPoint (.ppt)
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This downloadable slideset summarizes key studies selected by Andrew J. Muir, MD, David R. Nelson, MD, and Norah Terrault, MD, MPH, regarding the use of investigational agents for treating hepatitis C presented at the 2015 Annual Meeting of the European Association for the Study of the Liver.
Format: Microsoft PowerPoint (.ppt)
File size: 1.99 MB
Grinspoon S.Сердечно-сосудистые заболевания у пациентов с ВИЧ- парадигма и пр...Hivlife Info
Grinspoon S Cardiovascular disease in HIV patients: an emerging paradigm and call to action. 2015 Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, abstract 134, 2015.
Сердечно-сосудистые заболевания у пациентов с ВИЧ- парадигма и призыв к действию.Статины. [CROI 2015]
Fall 2014 HIV Update.Clinical Impact of New Data From ICAAC 2014, IDWeek 2014...Hivlife Info
In this downloadable slideset, Joseph J. Eron, Jr., MD and Jürgen K. Rockstroh, MD, review key HIV studies presented at the 2014 Interscience Conference on Antimicrobial Agents and Chemotherapy, 2014 IDWeek, and 2014 HIV Drug Therapy Glasgow.
Format: Microsoft PowerPoint (.ppt)
File size: 1.70 MB
Should Integrase Inhibitors Be Your First Choice When Starting HIV Therapy- E...Hivlife Info
In this downloadable slideset, Joseph J. Eron, Jr., MD, and Daniel Kuritzkes, MD, review key data on the evolving use of INSTIs in patients beginning HIV therapy.
Format: Microsoft PowerPoint (.ppt)
File size: 2.29 MB
Современный взгляд на АГ и ХСН. Спорные и нерешенные вопросы. Новые возможнос...Hivlife Info
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Best Practices in the Management of HCV/HIV Coinfection: Optimizing Treatment Success.2014
1. Jürgen K. Rockstroh, MD
Professor of Medicine
University of Bonn
Bonn, Germany
Best Practices in the Management
of HCV/HIV Coinfection:
Optimizing Treatment Success
This program is supported by an educational grant from
2. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
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should be consulted before using any therapeutic product discussed. Readers should verify all information
and data before treating patients or using any therapies described in these materials.
4. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Disclosures
Jürgen K. Rockstroh, MD, has disclosed that he has received
consulting fees from AbbVie, Bionor, Bristol-Myers Squibb,
Boehringer Ingelheim, Gilead Sciences, GlaxoSmithKline, Merck
Sharp & Dohme, Novartis, Pfizer, Roche, Tibotec/Janssen, Tobira,
and ViiV. He has also received research support from AbbVie and
Merck.
The following planners and managers, Edward King, MA;
Jenny Schulz, PhD; and Michael Westhafer, MD, hereby state
that they or their spouse/life partner do not have any financial
relationships or relationships to products or devices with any
commercial interest related to the content of this activity of any
amount during the past 12 months.
5. Please review the slide notes
for a discussion by Jürgen K.
Rockstroh, MD
7. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Background and Epidemiology
HIV accelerates the natural course of hepatitis C[1]
Successful antiretroviral therapy can slow fibrosis progression but not
back to the rate in HCV monoinfection[2]
Liver disease associated with HCV infection has become a leading
cause of morbidity and mortality among HCV/HIV-coinfected patients[3]
HIV/HCV epidemiology[4]
– Approximately 25% of HIV+ patients are coinfected with HCV
– Approximately 80% of HIV+ patients who inject drugs are coinfected with
HCV
– All patients with HIV infection should be tested for HCV
HIV+ patients are at 4.1 times the risk of HCV as HIV- patients[5]
1. Rockstroh JK, et al. Am J Gastroenterol. 1996;91:2563-2568. 2. Graham CS, et al. Clin Infect Dis.
2001;33:562-569. 3. Weber R, et al. Arch Intern Med. 2006;166:1632-1641. 4. CDC. HIV and viral
hepatitis. May 2013. 5. Yaphe S, et al. Sex Transm Infect. 2012;88:558-564.
8. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Sexual Transmission of HCV Among
HIV+ MSM: An Emerging Population
Reports of epidemic of sexually transmitted HCV among HIV+ MSM
– United States: 6-fold higher incidence rate in HIV+ vs HIV- MSM[6]
– Swiss HIV Cohort Study: HCV incidence increased 18-fold from
1998 to 2011[7]
– Sydney, Australia: 9% of HIV+ MSM coinfected with HCV vs 1.9%
HIV- MSM[8]
– Amsterdam, Netherlands: HIV/HCV coinfection prevalence
increased from 14.6% to 20.9% from 2000-2007[9]
Phylogenic analysis indicates HCV transmission clusters in some
areas[9,10]
6. Witt MD, et al. Clin Infect Dis. 2013;57:77-84. 7. Wandeler G, et al. Clin Infect Dis. 2012;55:1408-1416.
8. Lea T, et al. Sexual Health. 2013;10:448-451. 9. Urbanus AT, et al. AIDS. 2009;23:F1-F7.
10. MMWR. 2011;60:945-950.
9. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Risk Factors for Sexual HCV Transmission
Among HIV+ MSM
Multiple factors associated with HCV transmission[11,12]
– Unprotected receptive anal intercourse
– Online casual sexual partners
– Sex at sex venues
– Older age
– Syphilis
– Recreational drug use
– Drinking > 13 alcoholic drinks per week
11. Witt MD, et al. Clin Infect Dis. 2013;57:77-84. 12. Larsen C, et al. PLoS ONE. 2011;6:e29322.
11. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Screening, Surveillance, Treatment
Initiation for HCV in HIV+ Patients
US and international treatment guidelines recommend[13-
16]:
– HCV screening at HIV diagnosis, then annually and as
indicated
– More frequent surveillance if ongoing risk (eg, MSM, IDU)
– HCV RNA if HCV Ab+ or suspected acute infection
13. EACS Guidelines, Version 7.0. October 2013. 14. DHHS Antiretroviral Guidelines for Adults and
Adolescents. February 2013. 15. Brook G, et al. HIV Med. 2010;11:1-30. 16. Ghany MG, et al. Hepatology.
2009;49:1335-1374.
13. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Why Is HCV Therapy Deferred in Many
HIV/HCV-Coinfected Patients?
Challenges with interferon- and/or ribavirin-based regimen
Anticipated approval of new agents
– Greater efficacy
– All-oral regimens
– Shorter duration
– Improved tolerability
– Fewer drug-drug interactions
14. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Challenges With Telaprevir- or Boceprevir-
Based HCV Therapy in Coinfected Patients
Regimen complexity[17,18]
– High pill burden
– Long duration, complex RGT rules
– Multiple drug-drug interactions
– Overlapping toxicities
– With/without food dosing requirements
Tolerability
– Additional AEs beyond peginterferon/ribavirin
17. Taylor LE, et al. Clin Infect Dis. 2012;55(suppl 1):S33-S42. 18. DHHS Antiretroviral Guidelines for
Adults and Adolescents. February 2013.
15. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Specific Risks of Deferring Therapy in
HIV/HCV-Coinfected Patients
Accelerated rate of HCV-related hepatic fibrosis
progression in coinfected patients with increasing immune
deficiency[19-22]
– Progression to cirrhosis risk 3-fold higher in coinfected vs
HCV-monoinfected patients[20]
– Relative risk of decompensated liver disease 6-fold higher in
coinfected vs HCV-monoinfected patients[21]
Coinfected patients have reduced access to liver
transplantation and reduced survival
19. Taylor LE, et al. Clin Infect Dis. 2012;55(suppl 1:S33-42). 20. DHHS Antiretroviral Guidelines for
Adults and Adolescents. February 2013. 21. Naggie S, et al. Gastroenterology. 2012;142:1324-1334.
22. Macías J, et al. Clin Infect Dis. 2013;57:1401-1408.
16. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
HCV Coinfection vs Monoinfection:
Cumulative Incidence of Decompensation
10-year hepatic decompensation risk 83% higher in coinfected
patients
– Adjusted HR 1.83 (95% CI: 1.54-2.18)
P < .001
HIV/HCV coinfected
HCV monoinfected
0.074
0.048
23. Lo Re V, et al. IAC 2012. Abstract WEAB0102.
0
0.1
0.2
0 1 2 3 4 5 6 7 8 9 10
Yrs to Hepatic Decompensation
17. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Importance of Informed Deferral:
Know What You Are Waiting for
Need for individualized decision-making and informed
consent
Stepwise progress in HCV therapy anticipated
– New interferon-based regimens
– All-oral regimens retaining ribavirin
– All-oral regimens of just DAAs
Uncertain timeline
Initial DAA studies excluded coinfected patients
18. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Assessing HIV+ Patients for Immediate or
Deferred HCV Therapy
Antiretroviral therapy for HIV treatment-naive HIV/HCV-
coinfected patients
– CD4+ cell count < 500 cells/mm3: initiate antiretroviral
therapy for HCV treatment optimization[24,25]
– CD4+ cell count > 500 cells/mm3: may defer antiretroviral
therapy until HCV therapy completed[25]
24. EACS Guidelines, Version 7.0. October 2013. 25. DHHS Antiretroviral Guidelines for Adults and
Adolescents. February 2013. 26. Macías J, et al. Clin Infect Dis. 2013;2013;57:1401-1408.
HCV Therapy in HIV/HCV-Coinfected, HCV Treatment-Naive Patients
Liver Fibrosis
Consider
HCV Therapy
Eligible to
Defer HCV Therapy
No/minimal fibrosis (F0-F2)[24,25] ●
Advanced fibrosis (F3-F4); cirrhosis[26] ●
20. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
SVR With PegIFN/RBV by Genotype:
Coinfection vs Monoinfection
27. Carrat F, et al. JAMA. 2004;292:2839-2848. 28. Laguno M, et al. Hepatology. 2009;49:22-31. 29.
Chung RT, et al. N Engl J Med. 2004;351:451-459. 30. Torriani FJ, et al. N Engl J Med. 2004;351:438-450.
31. Núñez M, et al. AIDS Res Hum Retroviruses. 2007;23:972-982. 32. Peginterferon alfa 2a [package
insert].
SVR Range, %
HIV/HCV Coinfection HCV Monoinfection
GT1 or
GT4[27-31]
GT2 or
GT3[27-31]
GT1 or
GT4[32]
GT2 or
GT3[32]
PegIFN/RBV
(600-1200 mg)
14-35 44-73 0-82* 76-82
*SVR rates for GT1 or GT4 unaffected by baseline viral titer. PegIFN/RBV for 48 weeks
using 1000 mg or 1200 mg dose of pegIFN resulted in higher rates of SVR compared
with 24 weeks of therapy and/or 800 mg dose of pegIFN.
21. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Proposed Optimal Duration of PegIFN/RBV
Therapy in Coinfected Patients
33. EACS Guidelines, Version 7.0. October 2013.
*In patients with baseline low viral load and
minimal liver fibrosis.
**Where no access to DAA available or high
chances of cure even with dual therapy
(favorable IL28B genotype, low HCV viral
load, and no advanced fibrosis).
HCV RNA
negative
Wk 4 Wk 12 Wk 24 Wk 48 Wk 72
GT2/3
GT1/4**
Stop
Stop
GT2/3
GT1/4
24-wk
therapy*
48-wk
therapy
72-wk
therapy
HCV RNA
positive
HCV RNA
negative
HCV RNA
positive
> 2 log drop
in HCV RNA
< 2 log drop
in HCV RNA
22. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Study 110: Telaprevir + PegIFN/RBV in
GT1 HCV/HIV Coinfection
Phase II randomized controlled
trial[34]
– Telaprevir TID + pegIFN/RBV vs
pegIFN/RBV alone for 48 weeks
HCV treatment-naive HIV+ patients
(N = 60)
No HIV breakthrough
Safety and tolerability
– Increased pruritus, headache,
nausea, rash, and dizziness with
telaprevir-based therapy
– Anemia: 18% in both groups
SVR comparable to GT1 HCV-
monoinfected patients (75%)[35]
No ART
EFV/TDF/FTC
ATV/ritonavir
+ TDF/FTC
Total
SVR(%)
n/N = 5/
7
11/
16
12/
15
28/
38
Telaprevir +
PegIFN/RBV
PegIFN/RBV
2/
6
4/
8
4/
8
10/
22
34. Sulkowski MS, et al. Ann Intern Med. 2013;159:86-96.
35. Jacobson IM, et al. N Engl J Med. 2011;364:2405-2416.
100
80
60
40
20
0
71 69
80
74
33
50 50
45
23. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Study P05411: Boceprevir + PegIFN/RBV
in GT1 HCV/HIV Coinfection
Phase II randomized controlled
trial[36]
– PegIFN/RBV lead-in 4 weeks then
boceprevir + pegIFN/RBV for 44
weeks vs pegIFN/RBV alone for 48
weeks
HCV treatment-naive HIV+ patients
(N = 98)
– All with HIV-1 RNA < 50 cells/mL
on antiretroviral therapy
No difference in HIV breakthrough
Safety and tolerability
– Increased anemia, pyrexia, and
decreased appetite with boceprevir-
based therapy
SVR comparable to GT1 HCV-
monoinfected patients (68%)[37]
0
20
40
60
80
100
SVR(%)
PegIFN/RBV
n/N = 10/34
29
40/64
63
Boceprevir +
PegIFN/RBV36. Sulkowski M, et al. Lancet Infect Dis. 2013;13:597-605.
37. Poordad F, et al. N Engl J Med. 2011;364:1195-1206.
24. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Recommendations for Coadministration of
TVR and BOC With Select Antiretroviral Agents
Antiretroviral Agent
Telaprevir Boceprevir
Europe[38-40] US[41] Europe[38-40] US[41]
Atazanavir/ritonavir
Monitor for
hyperbilirubinemia
Standard dose
Case-by-case
consideration
Do not use
Darunavir/ritonavir;
fosamprenavir/ritonavir
; lopinavir/ritonavir
Not
recommended
Not
recommended
Not
recommended
Not
recommended
Raltegravir
No dose
adjustment
No dose
adjustment
No dose
adjustment
No dose
adjustment
Efavirenz
Increase dose
(1125 mg q8h)
Increase dose
(1125 mg q8h)
Not
recommended
Do not use
Rilpivirine
No dose
adjustment
No guidance
No dose
adjustment
No dose
adjustment[44]
38. Telaprevir [EU package insert]. 39. Boceprevir [EU package insert]. 40. Kakuda TN, et al. IWCPHT 2012. Abstract O-18. 41.
DHHS Antiretroviral Guidelines for Adults and Adolescents. February 2013. 42. Simeprevir [package insert]. 43. Sofosbuvir
[package insert]. 44. Boceprevir [package insert].
Note: Telaprevir and boceprevir interact with CYP3A4/5 and p-glycoprotein. Simeprevir should not be
coadministered with any boosted or unboosted PI or any NNRTI except rilpivirine.[42] Sofosbuvir has no
reported DDIs with HIV drugs except tipranavir/ritonavir.[43]
26. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Advantages of Future HCV Therapies
Once-daily dosing
Shorter duration
Simpler regimens—no response-guided therapy
Fewer adverse events
Interferon-free
High efficacy
27. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Caveats to Future HCV Therapies
Clinical trial data in HIV/HCV coinfection still emerging
– DDI data incomplete
– Performance outside select trial populations yet to be seen
Timeline
– Late 2013: FDA approval of simeprevir (GT1) and sofosbuvir
(GT1-4)
– 2014: anticipated FDA approval of faldaprevir (GT1);
first all-oral regimens for GT1 expected to be approved
Costs uncertain, but likely an issue in many regions
28. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
C212 Study: Simeprevir + PegIFN/RBV in
GT1 HCV/HIV Coinfection
Phase III randomized controlled
trial[45]
– 24- or 48-week regimens: SPV +
pegIFN/RBV for 12 weeks, then
pegIFN/RBV alone
HCV treatment-naive or -
experienced HIV+ patients
(N = 106)
– 88% on ART (VL < 50 cells/mL)
– Excluded: boosted PIs,
NNRTIs other than RPV
Safety profile similar to
monoinfected pts
– Pruritus and photosensitivity in
20% and 2%, respectively
SVR comparable to GT1 HCV-
monoinfected pts (80%)[46]
7/
10
16/
28
100
80
60
40
20
0
SVR12(%)
78/
106
74
Overall
70
42/
53
79
Naive
57
13/
15
87
Relapsers
n/N =
Partial Null
45. Dieterich D, et al. EACS 2013. Abstract LBPS9/5. 46. Jacobson I, et al. EASL 2013. Abstract 1425.
29. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
PHOTON-1: Sofosbuvir + RBV in GT1/2/3
HIV/HCV Coinfection
Phase III open-label study
– 12- (GT2/3 treatment-naive) or 24-
week regimens (GT1 treatment-
naive, GT2/3 treatment
experienced): sofosbuvir + RBV
HCV treatment-naive or -
experienced HIV+ patients
(N = 223)
– Approx 76% on ART (VL < 50
cells/mL), various standard
regimens
Safety profile similar to
monoinfected patients; consistent
with RBV
– Most frequent AEs: fatigue,
insomnia, headache, nausea,
diarrhea
2 patients had transient HIV
rebound due to nonadherence
47. Sulkowski MS, et al. AASLD 2013. Abstract 212.
n/N
87/
114
Virologic Outcomes for
Treatment-Naive Patients
by GT
76
88
67
0
20
40
60
80
100
GT1 GT2 GT3
SVR12(%)
23/
26
28/
42
30. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
STARTVerso4: Faldaprevir + PegIFN/RBV
in GT1 HCV/HIV Coinfection
Phase III open-label study
– 24- or 48-week regimens:
faldaprevir + pegIFN/RBV for 12 or
24 weeks, then pegIFN/RBV alone
HCV treatment-naive or previous
relapser HIV+ patients (N = 308)
– 96% on ART (VL < 50 cells/mL)
Safety profile similar to
monoinfected pts
– Most frequent AEs: nausea, fatigue,
diarrhea, headache
– Decrease in hemoglobin consistent with
pegIFN/RBV historical data
1 patient had HIV rebound requiring
new ART regimen
*24 wks of therapy; †12 wks of therapy
49. Rockstroh JK, et al. AASLD 2013. Abstract 1099.
72
79
84
0
20
40
60
80
100
Faldaprevir
120 mg*
Faldaprevir
240 mg†
Faldaprevir
240 mg*
n/N =
89/
123
66
84
72/
86
SVR4(%)
32. clinicaloptions.com/hepatitis
Best Practices in the Management of HCV/HIV Coinfection
Summary
Liver disease leading cause of morbidity and mortality in
HIV/HCV coinfection
– Antiretroviral therapy may slow progression
HCV screening at HIV diagnosis and at least annually
HCV treatment considerations
– Treat now or wait for future options?
– First-generation DAAs complex, long duration, AEs, DDIs
– New agents may improve outcomes with shorter therapy,
fewer AEs
– Consider HCV disease stage and risk of progression