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BENIGN ODONTOGENIC
TUMORS
Dr DAVIS
NADAKKAVUKARAN
MALABAR DENTAL
COLLEGE
Benign tumors
 CLASSIFICATION :
1. Odontogenic tumors
2. Non -Odontogenic tumors
Benign Odontogenic tumors
CLASSIFICATION
1) odontogenic epithelium without odontogenic
ectomesenchyme
II) Odontogenic epithelium with odontogenic ectomesenchyme
with or without hard tissue formation
111)Odontogenic ectomesenchyme with or without included
odontogenic epithelium.
CLASSIFICATION
1. BENIGN ODONTOGENIC TUMORS
1). odontogenic epithelium without odontogenic ectomesenchyme
 1. Ameloblastoma
 2. Squamous odontogenic tumor
 3. Calcifying epithelial odontogenic tumor (pind borg tumor)
 4. Adenomatoid odontogenic tumor
II). Odontogenic epithelium with odontogenic ectomesenchyme with or
without hard tissue formation
 1. Ameloblastic fibroma
 2. Ameloblastic fibrodentinoma
 3. Ameloblastic fibro-odontoma
 4. Odontoameloblastoma
 5. odontoma
111).Odontogenic ectomesenchyme with or without included
odontogenic epithelium.
 1. Odontogenic fibroma
 2. Myxoma (myxofibroma)
 3. Cementoblastoma (benign cementoblastoma, true
cementoma)
General treatment of jaw
lesions
Gold,Upton and Marx in 1991 have presented a
standardised surgical terminology for the excision of
lesions in the bone.
All excisions of the lesions involving jaw bones can be
described by the following terminologies :-
 Enucleation
 Curettage [Involves removal of the pathologic tissue by
means of vigorous scraping.]
 Marsupialisation
 Recountouring
 Resection without continuity defect
 Resection with continuity defect
 Disarticulation
Principles of treatment of jaw
tumors
 Complete eradication of the lesion
 Preservation of normal tissue as permissible as
possible
 Excision with least morbidity
 Restoration of tissue loss form & function
 Long term follow up
ENUCLEATION
 PRINCIPLE: enucleation allows for the cystic cavity to be
covered by a mucoperiosteal flap and the space fills with blood
clot, which will eventually organize and form normal bone.
ADVANTAGES:
• Primary closure of wound
• Rapid healing
• Postoperative care is reduced
• Thorough examination of the entire cystic lining can be done.
DISADVANTAGES:
• Cannot observe the healing of cavity as with
marsupialization
• Weakening of jaws
• Damage to adjacent vital structures
• Pulpal necrosis
Marsupialization
Principle: Marsupialization/decompression, refers to
creating a surgical window in the wall of the cyst, and
evacuation of the cystic contents.
 This process decreases intra-cystic pressure and
promotes shrinkage of the cyst and bone fill. The only
portion that is removed is the piece removed to produce
the window.
Advantages:
 Simple procedure
 Spares vital structures
 Allows eruption of teeth
 Prevents oronasal, oroantral fistulae
 Prevents pathological fractures
 Reduces operating time
 Reduces blood loss
 Helps shrinkage of cystic lining
 Allows endosteal bone formation to take place
 Alveolar ridge is preserved
Disadvantages:
 Pathologic tissue is left in situ
 Histological examination of the entire cystic lining is not
done
 Prolonged healing time
 Inconvenience to the patient
 Prolonged follow up visits
 Periodic irrigation of the cavity
 Regular adjustments of plug
 Periodic changing of pack
 Secondary surgery may be needed
 Formation of slit like pockets that may harbor food stuffs
 Risk of invagination and new cyst formation
En-block resection/marginal
resection
 The tumor is removed along with a rim of uninvolved
bone, while maintaining the continuity of the jaw.
 This is the treatment of choice for small aggressive
lesions with high recurrence rate.
 Intraoral approach is used for lesions anterior to the
ramus of the mandible, whereas those lesions involving
the ramus of the mandible are approached extraorally
Segmental resection
Hemimandibulectomy or
partial mandibulectomy
 Continuity of the inferior border is not maintained
 Extraoral approach similar to that of en-block resection
INDICATION
 Lesions that have tendency to recur
 Lesions that extend close to inferior or posterior border
of mandible,the maxillary sinus or the nasal cavity.
 Lesion close to the borderbof the jaw with the possibility
of postoperative pathologic fracture
Maxillectomy
 In case of tumors involving the maxilla partial or total
maxillectomy are done
 Partial maxillectomy is done through an intraoral approach
 For hemimaxillectomy an extraoral approach known as Weber
Fergusson approach is indicated for adequate access into the
sinus and orbital areas.
 An incision is made to split the lip along the philtrum upto and
around the alar base, continuing along the lateral surface of
nose upto medial canthus of the eye
 Intraorally the incision is continued down through the
gingival margin.
 It is connected with a horizontal incision at the depth of the
labiobuccal vestibule,extending back to the maxillary
tuberosity.
 From here the incision is turned medially across the
posterior edge of the hard palate.
 It then turns 90 degree anteriorly several millimeters to
proximal side of midline.
 Lip incision is made from the skin to the mucous
membrane,continuing intraorally to the buccal sulcus incision
extending posteriorly to the tuberosity.
 A subperiosteal flap is elevated extending superiorly till the
infraorbital rim, thus exploring the lateral surface of the
maxilla and zygoma
 Infraorbital nerve and vein are ligated and sectioned
 A cut is made in the zygoma along the zygomaticomaxillary
suture extending to the orbital floor
 a cut is made at the frontal process of maxilla extending to
the nasal fossa
 Two cuts are connected along the orbital floor
 Cut is then extended into the hard palate
 Pterygoid plates are seperated using a curved
osteotome to separate maxilla
 Sectioned maxilla removed
 Skin graft can be used
 Defect is packed with a tincture benzoin guaze and
maintained with a maxillary splint or obturator
 Skin incisions are closed in layers
1 .AMELOBLASTOMA
 Ameloblastoma is defined as“usually unicentric, non-
functional, intermittent in growth , anatomically benign and
clinically persistent.”
 Is a true neoplasm of odontogenic epithelial origin.
ORIGIN
Origin may be from:
 Cell rests of enamel organ
 Remanants of hertwigs sheath
 Epithelial rests of malassez
 Epithelium of odontogenic cysts
 Basal cells of the surface epithelium of jaws
CLASSIFICATION
 CENTRAL OR INTRAOSSEUS
 PERIPHERAL OR EXTRAOSSEUS
CLINICAL FEATURES
 No significant sex predilection.
 Age : 20-60 years
 Swelling and facial assymetry chief complaint
 Swelling is typically asymptomatic
 Average size is 4.3cms
 Discovered due to local effects such as tooth mobility,occlusal
alterations and failure of eruption of teeth.
 More than 80% of the cases occur in the mandible
 ramus area involvement 3 times more common than the other
areas
R/F
 Radiographically this lesion may appear as soap bubble
,honey comb ,tennis racket pattern .
 In some places , cortices are expanded and spared ,and
in other regions ,they are destroyed
 Root resorption is a common finding
HISTOPATHOLOGY
6 histopathologic subtypes are seen
1. Follicular
2. Acanthomatous
3. Granular cell
4. Basal cell
5. Desmoplastic
6. plexiform
Management
AIM OF Rx:
 Complete eradication of the lesion
 Reconstruction of the resultant defect
1. Radical and conservative surgery
2. Curettage[usually not considered as Rx modality since intraosseus
multicystic lesions recurrence rate is 55-100% after curettage & for
intraosseus unicystic lesions -18-25%]
3. Chemical and electrocautery
4. Radiation
5. Combination of surgery and radiation
Rx for intraosseus
solid/multicystic ameloblastoma:
 Enbloc resection or marginal resection without
continuity defect.
 Segmental resection with continuity defect .
 Partial maxillectomy [tumour confined to maxilla
without orbital floor involvement ]
 Total maxillectomy [Orbital floor involved but not
the peri orbital area]
 Total maxillectomy with orbital exentration[tumor
involving orbital contents ]
 Skull base resection along with neuro surgical
procedure [tumor involving the skull bone ]
2. ADENOMATOIDODONTOGENICTUMOR[AOT]
 1ST recognised by Stafne
 Uncommon tumor
 Occurs mostly in association with unerupted permanent
teeth {maxillary cuspid[74%]}
 It is now considered as hamartomatous malformation
 [Hamartoma : An abnormal proliferation of tissues,
native to that part. It is a focal malformation which
resembles a neoplasm, grossly & Microscopically]
CLINICAL FEATURES
 Age :10-20 yrs [rare after 30yrs ]
 F.M65%> MALE
 Site ;maxilla :anterior region
 Vast majority of the lesions measured between 1.5cms-
3.ocms
 it is seen to occur in the gingiva or within jaw bones
RADIOGRAPHIC FEATURES
 Unilocular radiolucency surrounding crown of impacted
teeth extend apically beyond CEJ.
TREATMENT
 Conservative excision or enucleation
3. Calcifying epithelial
odontogenic tumour
 First described by pindborg in 1956
 Some suggest that ceot arises from stratum intermedium
 Others say it arises from dental lamina
Clinical features
 Occurs in middle age
 It occurs more in the mandible
than in maxilla in the ratio of
2:1
 An extraosseous CEOT also
occurs which is similar to
intraosseous tumor
RADIOGRAPHIC FEATURES
 It shows considerable radiographic variation
 Combined pattern of mixed radiolucent and radiopaque pattern seen.
 Honey comb pattern also seen.
 Scattered flecks of calcification seen throughout the radiolucency
giving rise to descriptive term of a driven snow appearance.
4.AMELOBLASTIC FIBROMA
 Relative uncommon tumor
 Simultaneous proliferation of both epithelial and
mesenchymal components without formation of enamel
and dentin
 Classic example of mixed tumor
CLINICAL FEATURES
 Occurs commonly in the molar region of mandible
 Slight predilection for males
 Does not infiltrate between trabeculae of bone instead it
enlarges by gradual expansion
 Discovered on routine examination
5. ODONTOMA
 It represents a hamartomatous malformation rather than
neoplasm
 The enamel and dentin formed are laid down in a
disorganized manner because the odontogenic cells
formed fails to reach normal stage of
morphodifferentiation
 Compound composite odontoma-the enamel and dentin
are laid down in such a fashion that the structures bear
considerable anatomic resemblance to normal teeth
 Complex composite odontoma-when dental calcified
tissues are simply an irregular mass bearing no
resemblance to normal teeth
CLINICAL FEATURES
 Occurs most frequently in the 2nd to 3rd decades
 No gender predilection
 Occurs more in the mandible
 Some cases reported to occur in the condyles
 It is not rapidly growing
7.CEMENTOBLASTOMA
 It appears to be a true neoplasm of functional
cementoblasts which form a large mass of cementum or
cementum like tissue on the tooth root
CLINICAL FEATURES
 Occurs under 25 years of age.
 No gender predilection.
 Mandible affected 3 times more than maxilla.
 Mandibular6 is most affected.
 Tooth involved is vital.
 Lesion is slow growing.
RADIOLOGIC FEATURES
 Tumor mass attached to tooth root and appears as well
circumscribed dense radioopaque mass often surrounded
by a thin,uniform radiolucent line
MANAGEMENT
 Enucleation can be done.
 Tooth attached can be extracted with the lesion
THANK YOU

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BENIGN ODONTOGENIC TUMORS.pptx

  • 2. Benign tumors  CLASSIFICATION : 1. Odontogenic tumors 2. Non -Odontogenic tumors
  • 3. Benign Odontogenic tumors CLASSIFICATION 1) odontogenic epithelium without odontogenic ectomesenchyme II) Odontogenic epithelium with odontogenic ectomesenchyme with or without hard tissue formation 111)Odontogenic ectomesenchyme with or without included odontogenic epithelium.
  • 4. CLASSIFICATION 1. BENIGN ODONTOGENIC TUMORS 1). odontogenic epithelium without odontogenic ectomesenchyme  1. Ameloblastoma  2. Squamous odontogenic tumor  3. Calcifying epithelial odontogenic tumor (pind borg tumor)  4. Adenomatoid odontogenic tumor
  • 5. II). Odontogenic epithelium with odontogenic ectomesenchyme with or without hard tissue formation  1. Ameloblastic fibroma  2. Ameloblastic fibrodentinoma  3. Ameloblastic fibro-odontoma  4. Odontoameloblastoma  5. odontoma
  • 6. 111).Odontogenic ectomesenchyme with or without included odontogenic epithelium.  1. Odontogenic fibroma  2. Myxoma (myxofibroma)  3. Cementoblastoma (benign cementoblastoma, true cementoma)
  • 7. General treatment of jaw lesions Gold,Upton and Marx in 1991 have presented a standardised surgical terminology for the excision of lesions in the bone. All excisions of the lesions involving jaw bones can be described by the following terminologies :-  Enucleation  Curettage [Involves removal of the pathologic tissue by means of vigorous scraping.]  Marsupialisation  Recountouring  Resection without continuity defect  Resection with continuity defect  Disarticulation
  • 8. Principles of treatment of jaw tumors  Complete eradication of the lesion  Preservation of normal tissue as permissible as possible  Excision with least morbidity  Restoration of tissue loss form & function  Long term follow up
  • 9. ENUCLEATION  PRINCIPLE: enucleation allows for the cystic cavity to be covered by a mucoperiosteal flap and the space fills with blood clot, which will eventually organize and form normal bone. ADVANTAGES: • Primary closure of wound • Rapid healing • Postoperative care is reduced • Thorough examination of the entire cystic lining can be done.
  • 10. DISADVANTAGES: • Cannot observe the healing of cavity as with marsupialization • Weakening of jaws • Damage to adjacent vital structures • Pulpal necrosis
  • 11. Marsupialization Principle: Marsupialization/decompression, refers to creating a surgical window in the wall of the cyst, and evacuation of the cystic contents.  This process decreases intra-cystic pressure and promotes shrinkage of the cyst and bone fill. The only portion that is removed is the piece removed to produce the window.
  • 12. Advantages:  Simple procedure  Spares vital structures  Allows eruption of teeth  Prevents oronasal, oroantral fistulae  Prevents pathological fractures  Reduces operating time  Reduces blood loss  Helps shrinkage of cystic lining  Allows endosteal bone formation to take place  Alveolar ridge is preserved
  • 13. Disadvantages:  Pathologic tissue is left in situ  Histological examination of the entire cystic lining is not done  Prolonged healing time  Inconvenience to the patient  Prolonged follow up visits  Periodic irrigation of the cavity  Regular adjustments of plug  Periodic changing of pack  Secondary surgery may be needed  Formation of slit like pockets that may harbor food stuffs  Risk of invagination and new cyst formation
  • 14. En-block resection/marginal resection  The tumor is removed along with a rim of uninvolved bone, while maintaining the continuity of the jaw.
  • 15.  This is the treatment of choice for small aggressive lesions with high recurrence rate.  Intraoral approach is used for lesions anterior to the ramus of the mandible, whereas those lesions involving the ramus of the mandible are approached extraorally
  • 16. Segmental resection Hemimandibulectomy or partial mandibulectomy  Continuity of the inferior border is not maintained  Extraoral approach similar to that of en-block resection
  • 17. INDICATION  Lesions that have tendency to recur  Lesions that extend close to inferior or posterior border of mandible,the maxillary sinus or the nasal cavity.  Lesion close to the borderbof the jaw with the possibility of postoperative pathologic fracture
  • 18. Maxillectomy  In case of tumors involving the maxilla partial or total maxillectomy are done
  • 19.  Partial maxillectomy is done through an intraoral approach  For hemimaxillectomy an extraoral approach known as Weber Fergusson approach is indicated for adequate access into the sinus and orbital areas.  An incision is made to split the lip along the philtrum upto and around the alar base, continuing along the lateral surface of nose upto medial canthus of the eye
  • 20.
  • 21.  Intraorally the incision is continued down through the gingival margin.  It is connected with a horizontal incision at the depth of the labiobuccal vestibule,extending back to the maxillary tuberosity.  From here the incision is turned medially across the posterior edge of the hard palate.  It then turns 90 degree anteriorly several millimeters to proximal side of midline.
  • 22.  Lip incision is made from the skin to the mucous membrane,continuing intraorally to the buccal sulcus incision extending posteriorly to the tuberosity.  A subperiosteal flap is elevated extending superiorly till the infraorbital rim, thus exploring the lateral surface of the maxilla and zygoma  Infraorbital nerve and vein are ligated and sectioned  A cut is made in the zygoma along the zygomaticomaxillary suture extending to the orbital floor  a cut is made at the frontal process of maxilla extending to the nasal fossa
  • 23.  Two cuts are connected along the orbital floor  Cut is then extended into the hard palate  Pterygoid plates are seperated using a curved osteotome to separate maxilla  Sectioned maxilla removed  Skin graft can be used  Defect is packed with a tincture benzoin guaze and maintained with a maxillary splint or obturator  Skin incisions are closed in layers
  • 24. 1 .AMELOBLASTOMA  Ameloblastoma is defined as“usually unicentric, non- functional, intermittent in growth , anatomically benign and clinically persistent.”  Is a true neoplasm of odontogenic epithelial origin.
  • 25. ORIGIN Origin may be from:  Cell rests of enamel organ  Remanants of hertwigs sheath  Epithelial rests of malassez  Epithelium of odontogenic cysts  Basal cells of the surface epithelium of jaws
  • 26. CLASSIFICATION  CENTRAL OR INTRAOSSEUS  PERIPHERAL OR EXTRAOSSEUS
  • 27. CLINICAL FEATURES  No significant sex predilection.  Age : 20-60 years  Swelling and facial assymetry chief complaint  Swelling is typically asymptomatic  Average size is 4.3cms  Discovered due to local effects such as tooth mobility,occlusal alterations and failure of eruption of teeth.  More than 80% of the cases occur in the mandible  ramus area involvement 3 times more common than the other areas
  • 28. R/F  Radiographically this lesion may appear as soap bubble ,honey comb ,tennis racket pattern .  In some places , cortices are expanded and spared ,and in other regions ,they are destroyed  Root resorption is a common finding
  • 29. HISTOPATHOLOGY 6 histopathologic subtypes are seen 1. Follicular 2. Acanthomatous 3. Granular cell 4. Basal cell 5. Desmoplastic 6. plexiform
  • 30. Management AIM OF Rx:  Complete eradication of the lesion  Reconstruction of the resultant defect 1. Radical and conservative surgery 2. Curettage[usually not considered as Rx modality since intraosseus multicystic lesions recurrence rate is 55-100% after curettage & for intraosseus unicystic lesions -18-25%] 3. Chemical and electrocautery 4. Radiation 5. Combination of surgery and radiation
  • 31. Rx for intraosseus solid/multicystic ameloblastoma:  Enbloc resection or marginal resection without continuity defect.  Segmental resection with continuity defect .  Partial maxillectomy [tumour confined to maxilla without orbital floor involvement ]  Total maxillectomy [Orbital floor involved but not the peri orbital area]  Total maxillectomy with orbital exentration[tumor involving orbital contents ]  Skull base resection along with neuro surgical procedure [tumor involving the skull bone ]
  • 32. 2. ADENOMATOIDODONTOGENICTUMOR[AOT]  1ST recognised by Stafne  Uncommon tumor  Occurs mostly in association with unerupted permanent teeth {maxillary cuspid[74%]}  It is now considered as hamartomatous malformation  [Hamartoma : An abnormal proliferation of tissues, native to that part. It is a focal malformation which resembles a neoplasm, grossly & Microscopically]
  • 33. CLINICAL FEATURES  Age :10-20 yrs [rare after 30yrs ]  F.M65%> MALE  Site ;maxilla :anterior region  Vast majority of the lesions measured between 1.5cms- 3.ocms  it is seen to occur in the gingiva or within jaw bones
  • 34. RADIOGRAPHIC FEATURES  Unilocular radiolucency surrounding crown of impacted teeth extend apically beyond CEJ. TREATMENT  Conservative excision or enucleation
  • 35. 3. Calcifying epithelial odontogenic tumour  First described by pindborg in 1956  Some suggest that ceot arises from stratum intermedium  Others say it arises from dental lamina
  • 36. Clinical features  Occurs in middle age  It occurs more in the mandible than in maxilla in the ratio of 2:1  An extraosseous CEOT also occurs which is similar to intraosseous tumor
  • 37. RADIOGRAPHIC FEATURES  It shows considerable radiographic variation  Combined pattern of mixed radiolucent and radiopaque pattern seen.  Honey comb pattern also seen.  Scattered flecks of calcification seen throughout the radiolucency giving rise to descriptive term of a driven snow appearance.
  • 38.
  • 39. 4.AMELOBLASTIC FIBROMA  Relative uncommon tumor  Simultaneous proliferation of both epithelial and mesenchymal components without formation of enamel and dentin  Classic example of mixed tumor
  • 40. CLINICAL FEATURES  Occurs commonly in the molar region of mandible  Slight predilection for males  Does not infiltrate between trabeculae of bone instead it enlarges by gradual expansion  Discovered on routine examination
  • 41. 5. ODONTOMA  It represents a hamartomatous malformation rather than neoplasm  The enamel and dentin formed are laid down in a disorganized manner because the odontogenic cells formed fails to reach normal stage of morphodifferentiation
  • 42.  Compound composite odontoma-the enamel and dentin are laid down in such a fashion that the structures bear considerable anatomic resemblance to normal teeth  Complex composite odontoma-when dental calcified tissues are simply an irregular mass bearing no resemblance to normal teeth
  • 43. CLINICAL FEATURES  Occurs most frequently in the 2nd to 3rd decades  No gender predilection  Occurs more in the mandible  Some cases reported to occur in the condyles  It is not rapidly growing
  • 44. 7.CEMENTOBLASTOMA  It appears to be a true neoplasm of functional cementoblasts which form a large mass of cementum or cementum like tissue on the tooth root
  • 45. CLINICAL FEATURES  Occurs under 25 years of age.  No gender predilection.  Mandible affected 3 times more than maxilla.  Mandibular6 is most affected.  Tooth involved is vital.  Lesion is slow growing.
  • 46. RADIOLOGIC FEATURES  Tumor mass attached to tooth root and appears as well circumscribed dense radioopaque mass often surrounded by a thin,uniform radiolucent line MANAGEMENT  Enucleation can be done.  Tooth attached can be extracted with the lesion