Antibacterial agents work by inhibiting bacterial cell growth or killing bacteria. They are classified based on their chemical origin and biological activity. They act on specific targets in the bacterial cell like the cell wall, ribosomes, or nucleic acids. Common mechanisms of action include inhibiting cell wall synthesis, bacterial protein synthesis, nucleic acid synthesis, or folic acid synthesis. Bacteria can develop resistance through mutations that prevent antibiotic binding or allow drug efflux. Side effects vary between classes but can include kidney toxicity, hearing loss, and gastrointestinal issues.
This presentation provides a comprehensive introduction to antibiotics, exploring their historical significance, classifications, and essential role in modern medicine. Attendees will gain a profound understanding of the diverse mechanisms through which antibiotics act to combat bacterial infections.
Outline:
Introduction to Antibiotics
Definition and historical context
Significance in treating bacterial infections
Classification of Antibiotics
Broad-spectrum vs. narrow-spectrum antibiotics
Classes: penicillins, cephalosporins, tetracyclines, etc.
Mechanisms of Antibiotic Action
Inhibition of cell wall synthesis (e.g., penicillins)
Disruption of protein synthesis (e.g., macrolides)
Inhibition of nucleic acid synthesis (e.g., quinolones)
Interference with metabolic pathways (e.g., sulfonamides)
Selective Toxicity
Understanding the concept and importance
How antibiotics target bacterial structures without harming human cells
Resistance to Antibiotics
Factors contributing to antibiotic resistance
Consequences and global impact
Case Studies
Examples of well-known antibiotics and their mode of action
Real-world applications and success stories
Future Trends and Challenges
Emerging technologies in antibiotic development
Strategies to address antibiotic resistance
Conclusion
Recap of key points
Emphasis on the critical role antibiotics play in public health
This presentation aims to provide a solid foundation for understanding antibiotics and their mode of action, catering to both beginners and those looking to deepen their knowledge in the field. Through engaging visuals and clear explanations, you will have a heightened awareness of the vital role antibiotics play in preserving human health while being mindful of the challenges posed by antibiotic resistance.
This presentation provides a comprehensive introduction to antibiotics, exploring their historical significance, classifications, and essential role in modern medicine. Attendees will gain a profound understanding of the diverse mechanisms through which antibiotics act to combat bacterial infections.
Outline:
Introduction to Antibiotics
Definition and historical context
Significance in treating bacterial infections
Classification of Antibiotics
Broad-spectrum vs. narrow-spectrum antibiotics
Classes: penicillins, cephalosporins, tetracyclines, etc.
Mechanisms of Antibiotic Action
Inhibition of cell wall synthesis (e.g., penicillins)
Disruption of protein synthesis (e.g., macrolides)
Inhibition of nucleic acid synthesis (e.g., quinolones)
Interference with metabolic pathways (e.g., sulfonamides)
Selective Toxicity
Understanding the concept and importance
How antibiotics target bacterial structures without harming human cells
Resistance to Antibiotics
Factors contributing to antibiotic resistance
Consequences and global impact
Case Studies
Examples of well-known antibiotics and their mode of action
Real-world applications and success stories
Future Trends and Challenges
Emerging technologies in antibiotic development
Strategies to address antibiotic resistance
Conclusion
Recap of key points
Emphasis on the critical role antibiotics play in public health
This presentation aims to provide a solid foundation for understanding antibiotics and their mode of action, catering to both beginners and those looking to deepen their knowledge in the field. Through engaging visuals and clear explanations, you will have a heightened awareness of the vital role antibiotics play in preserving human health while being mindful of the challenges posed by antibiotic resistance.
Student information management system project report ii.pdfKamal Acharya
Our project explains about the student management. This project mainly explains the various actions related to student details. This project shows some ease in adding, editing and deleting the student details. It also provides a less time consuming process for viewing, adding, editing and deleting the marks of the students.
Immunizing Image Classifiers Against Localized Adversary Attacksgerogepatton
This paper addresses the vulnerability of deep learning models, particularly convolutional neural networks
(CNN)s, to adversarial attacks and presents a proactive training technique designed to counter them. We
introduce a novel volumization algorithm, which transforms 2D images into 3D volumetric representations.
When combined with 3D convolution and deep curriculum learning optimization (CLO), itsignificantly improves
the immunity of models against localized universal attacks by up to 40%. We evaluate our proposed approach
using contemporary CNN architectures and the modified Canadian Institute for Advanced Research (CIFAR-10
and CIFAR-100) and ImageNet Large Scale Visual Recognition Challenge (ILSVRC12) datasets, showcasing
accuracy improvements over previous techniques. The results indicate that the combination of the volumetric
input and curriculum learning holds significant promise for mitigating adversarial attacks without necessitating
adversary training.
Courier management system project report.pdfKamal Acharya
It is now-a-days very important for the people to send or receive articles like imported furniture, electronic items, gifts, business goods and the like. People depend vastly on different transport systems which mostly use the manual way of receiving and delivering the articles. There is no way to track the articles till they are received and there is no way to let the customer know what happened in transit, once he booked some articles. In such a situation, we need a system which completely computerizes the cargo activities including time to time tracking of the articles sent. This need is fulfilled by Courier Management System software which is online software for the cargo management people that enables them to receive the goods from a source and send them to a required destination and track their status from time to time.
Final project report on grocery store management system..pdfKamal Acharya
In today’s fast-changing business environment, it’s extremely important to be able to respond to client needs in the most effective and timely manner. If your customers wish to see your business online and have instant access to your products or services.
Online Grocery Store is an e-commerce website, which retails various grocery products. This project allows viewing various products available enables registered users to purchase desired products instantly using Paytm, UPI payment processor (Instant Pay) and also can place order by using Cash on Delivery (Pay Later) option. This project provides an easy access to Administrators and Managers to view orders placed using Pay Later and Instant Pay options.
In order to develop an e-commerce website, a number of Technologies must be studied and understood. These include multi-tiered architecture, server and client-side scripting techniques, implementation technologies, programming language (such as PHP, HTML, CSS, JavaScript) and MySQL relational databases. This is a project with the objective to develop a basic website where a consumer is provided with a shopping cart website and also to know about the technologies used to develop such a website.
This document will discuss each of the underlying technologies to create and implement an e- commerce website.
Overview of the fundamental roles in Hydropower generation and the components involved in wider Electrical Engineering.
This paper presents the design and construction of hydroelectric dams from the hydrologist’s survey of the valley before construction, all aspects and involved disciplines, fluid dynamics, structural engineering, generation and mains frequency regulation to the very transmission of power through the network in the United Kingdom.
Author: Robbie Edward Sayers
Collaborators and co editors: Charlie Sims and Connor Healey.
(C) 2024 Robbie E. Sayers
Cosmetic shop management system project report.pdfKamal Acharya
Buying new cosmetic products is difficult. It can even be scary for those who have sensitive skin and are prone to skin trouble. The information needed to alleviate this problem is on the back of each product, but it's thought to interpret those ingredient lists unless you have a background in chemistry.
Instead of buying and hoping for the best, we can use data science to help us predict which products may be good fits for us. It includes various function programs to do the above mentioned tasks.
Data file handling has been effectively used in the program.
The automated cosmetic shop management system should deal with the automation of general workflow and administration process of the shop. The main processes of the system focus on customer's request where the system is able to search the most appropriate products and deliver it to the customers. It should help the employees to quickly identify the list of cosmetic product that have reached the minimum quantity and also keep a track of expired date for each cosmetic product. It should help the employees to find the rack number in which the product is placed.It is also Faster and more efficient way.
Sachpazis:Terzaghi Bearing Capacity Estimation in simple terms with Calculati...Dr.Costas Sachpazis
Terzaghi's soil bearing capacity theory, developed by Karl Terzaghi, is a fundamental principle in geotechnical engineering used to determine the bearing capacity of shallow foundations. This theory provides a method to calculate the ultimate bearing capacity of soil, which is the maximum load per unit area that the soil can support without undergoing shear failure. The Calculation HTML Code included.
Forklift Classes Overview by Intella PartsIntella Parts
Discover the different forklift classes and their specific applications. Learn how to choose the right forklift for your needs to ensure safety, efficiency, and compliance in your operations.
For more technical information, visit our website https://intellaparts.com
2. What are antibacterial agents?
An antibacterial is an agent that inhibits bacterial growth or kills bacteria.
often used synonymously with the term antibiotic(s).
The term antibiotic was first used in 1942 by Selman Waksman.
3. HOW ARE THEY CLASSIFIED?
on the basis of chemical/biosynthetic origin into
Natural (ex- penicillin)
semisynthetic
synthetic(ex-Sulfanilamide)
On biological activity; according to their biological effect on
microorganisms:
bactericidal agents kill bacteria,
and bacteriostatic agents slow down or stall bacterial growth.
4. The bacterial cell
The success of antibacterial agents owes much to the fact that they can act
selectively
against bacterial cells rather than animal cells.
This is largely due to the fact that
bacterial cells and animal cells differ both in their structure and in the biosynthetic
pathways which proceed inside them.
5. WHERE THEY WORK?
Rifamycins
Cell wall
Penicillins
Cephalosporins
cycloserine
polymyxins
sulfonamides
Chloramphenicol
Streptomycin
tetracyclines
Ribosomes
capsule
cytoplasm
6. MECHANISM OF ACTIONS
Inhibition of cell
wall synthesis
Inhibition of
bacterial protein
synthesis
Inhibition of
Nucleic Acid
Synthesis
Inhibition of
Folic Acid
Synthesis
Penicillins
Cephalosphorins
Imipenem
Meropenem
Aztreonam
vancomycin
Aminoglycosides
Chloramphenicol
Macrolides
Tetracycline
Streptogrmins
linezolid
Fluoroquinolones
Rifampin
Sulfonamides
Trimethoprim
Pyrimethamine
7. Inhibition of cell wall synthesis:
Penicillins, cephalosphorins, imipenem, meropenem, aztreonam,
vancomycin
bacteriocidal
Must have beta-lactum ring in them which binds and blocks
transpeptidases known as penicillin-binding proteins(PBP) which causes the
final cross links between the pentapeptides of peptidoglycan layer.
Mechanism of resistance:
Penicillin
cephalosporin
Penicillinases: break the
beta lactam ring structure (
staphylococci)
Structural changes in PBP’s
(MRSA), S. pneumococci
Change in porin structure:
concerns the gram negative
organism
8.
9. Inhibition of bacterial protein synthesis
Aminoglycosides,Chloramphenicol,Macrolides,Tetracycline,Streptogrmins, Linezolid.
Bactericidal and bacteriostatic.
The primary steps in the process that are attacked are
the formation of the 30S initiation complex (made up of mRNA, the 30S ribosomal
subunit and formyl-methionyl-transfer RNA),ex Streptomycin (A-glycosides)
the formation of the 70S ribosome by the 30S initiation complex and the 50S ribosome,ex
Kanamycin and tobramycin and
the elongation process of assembling amino acids into a polypeptide.ex Lincomycin,
chloramphenicol.
RIBOSOME
12. Inhibition of Nucleic Acid Synthesis
Fluoroquinolones(levofloxacin, norfloxacin),Rifampin
Bacteriocidal
Can inhibit DNA gyrase or RNA polymerase
Mechanism of resistance:
an alteration of alpha subunit of DNA gyrase
(chromosomal)
beta subunit of RNA polymerase (chromosomal) is
altered
13. Quinolones are a key group of antibiotics that interfere with DNA synthesis by
inhibiting topoisomerase, most frequently topoisomerase Iv and topoisomer ii (DNA
gyrase) , an enzyme involved in DNA replication. DNA gyrase relaxes supercoiled
DNA molecules and initiates transient breakages and rejoins phosphodiester bonds
in superhelical turns of closed-circular DNA. This allows the DNA strand to be
replicated by DNA or RNA polymerases.
14. Rifampicin blocks initiation of RNA synthesis by specifically inhibiting bacterial
RNA polymerase. It does not interact with mammalian RNA polymerases,
making it specific for Gram-positive bacteria and some Gram-negative
bacteria.
Mechanism of resistance:
an alteration of alpha subunit of DNA gyrase
(chromosomal)
beta subunit of RNA polymerase (chromosomal) is altered
15. Inhibition of Folic Acid Synthesis
Sulfonamides, Trimethoprim, Pyrimethamine
Bacteriostatic
Binds and blocks enzymes mainly pteridine synthesase, dihydrofolate
reductase responsible for folic acid synthesis.
What are Folic Acid?
Folic acid enzymes are nessary for the synthesis of amino acids, hence necessary for bacterial protein
synthesis.
Folic acid