Backbone.js is a JavaScript MVC framework that allows developers to build single page applications. It includes models, views, and controllers (routers). Models represent data, views display models, and routers handle navigation between views. Collections are groups of models that can be filtered, sorted, and manipulated. Views can display both individual models and entire collections. Events can be bound to views to handle user interactions. The framework uses a client-side routing system to change views based on the URL hash fragment.