Backbone.js is a popular JavaScript MVC framework that provides structure for single-page web applications. It includes models for managing application data, views for rendering UI components, and a router for handling navigation between views. Backbone promotes separation of concerns, giving each component clearly defined responsibilities. Models can communicate with servers via RESTful APIs or websockets to retrieve and sync data. Collections manage ordered sets of models and can also fetch data from servers. Views are used to render templates and interface with models. The router maps URLs to functions that control navigation between views. Overall, Backbone provides a useful framework for building structured, scalable client-side JavaScript applications.