The Artificial Intelligence Institute at the University of South Carolina aims to be recognized as a top institution for AI applications and impact in the Southeast US and among the top in selected AI subareas. It focuses on exceptional student outcomes through many AI courses, high impact translational research, and applying AI across the university. The Institute has grown from 7 members in 2019 to over 25 in 2020, including faculty, students, postdocs, and interns. It collaborates widely across various colleges and departments at USC as well as with other universities and industry. The Institute conducts interdisciplinary, real-world applied research across many domains like healthcare, education, disasters, cybersecurity, and more to solve real problems and have measurable impact.