Aquaporins regulate the transport of H2O through which of the following mechanisms?a. ATP hydrolysis causes a change in conformation to transport H2O.b.There is no real selectivity and any charged or nonpolar molecule can pass through the large pores which are always open.c. A change in membrane potential causes conformational changes to open the pore.d. The pore is always open and selectively binds water molecules through H-bonding to the backbone carbonyls of residues.e. Conformational changes open the pore in response to an increase in osmotic pressure..