Applications of Non Traditional Machining (NTM) in Pharmaceutical Industry
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Applications of Non Traditional Machining (NTM) in Pharmaceutical Industry
- 1. Applications of NTM in Pharmaceutical Industry B.Sc. Graduation Project
- 2. Main Objective Main Objective Apps of NTM in Pharma. Industry Pharma- Facility Suitable equipment Study How to Recondition Applying NTM to handle the equipment Dims Measure. Die Specs. Tool Inserts CNTs Fabrication by NTM Effect of CNTs on Pharma. industry Graphene field Apps Generation of Graphene oxide by NTM Graphene oxide fighting bacteria Tool Perspective END Product Perspective Blocked Blocked Blocked Blocked
- 4. Tool Perspective (Soft Gelatin Die) Die specs 16 OBL 5*23 chamfered Average theoretical working hours 3000 hr. Average Actual working hours 1500*2000 The die can be sharpened 3 times But they just sharpening it 2 times Each recut (sharpening) is 15 Microns Starting die pressure 4 bar Die material Aluminum 7075 Alloy Outer Diameter of the die including edges * length 4 inch * 6 inch Edge width 1.3-1.5 millimeter Minimum sealing 12 Thou Actual sealing 15-20 Thou Dies Price/set $ 4000 Recut (sharpening) cost/set $ 1500
- 5. Tool Perspective (Die Measurements) • 3D Scanning • Replica • Direct Measurements
- 6. Non-Traditional Machining processes Nontraditional machining processes Mechanical Thermal Chemical & electrochemical USM WJM AWJM EDM EBM LBM IBM PBM CHM PCM ECM
- 7. Non-Traditional Machining (Wire EDM) Reciprocating Wire EDM wire Drumcontinuous feed Wire EDM Machine • Wire EDM is a special form of EDM which uses a continuously moving conductive wire electrode.
- 9. Center Allocating • 18 mm diameter of wire • From steel
- 10. Wire Pass
- 11. Tool Perspective (Die Reconditioning)
- 12. Tool Perspective (Die testing) Soft gel Die Sector Surface Roughness in Ra (µm) Machined Sector 5.5 Anodized Sector 1.5
- 13. Tool Perspective (Die testing) Soft gel Die Sector Vickers Value (HV) Load Time Machined Sector 206 – 214 300 g 30 Sec. Anodized Sector 196 – 198 300 g 30 Sec. Vickers HardnessTest
- 14. Product Perspective (NanoTechno. Intro.) • Nanotechnology is the world that every thing on it is measured by nanometer • In general, the size of a nanoparticle spans the range between 1 and 100 nm.
- 15. Product Perspective (CNTs) • Fabrication of CNTs using Non-Traditional Machining Arc Discharge Laser Ablation
- 16. Product Perspective (CNTs & Drug Delivery) Selective OrganTreatment Low DrugToxicity
- 17. Product Perspective (Graphene) Ultrasonic MachiningTechnique CO2 Laser Reduction
- 18. Product Perspective (Graphene and bacteria fighting) • Antibiotics resistant Bacteria • Graphene antibacterial activity
- 19. Conclusion • Soft Gel Die Cost $4500 • Soft Gel Die worn after 100 million capsule ~ 1000 hr. • Soft Gel Die Reconditioning by CNC Cylindrical grinding in America with $1500 • Wire EDM Reconditioning cost $300 • GrapheneVs Bacteria, dose must be standardized before any implementation. • CNTs as a byproduct by EDMing Y.H. Guu Apps of CNTs in NTM and Microscopy • CNTs addition to EDM, CNTs and Drug delivery
- 20. Recommendations • More engineering wise care • Invest in the research of new Nano Materials • Soft Gel Die inserts
- 21. Recommendations (Soft Gel Die inserts) • Why inserts (3 recuts then scrap) • Body Pharma. Grade polymer
- 22. Recommendations (Soft Gel Die inserts) • Extruded Aluminum section
- 23. Recommendations (Soft Gel Die inserts) • Inserts
- 24. Recommendations (Soft Gel Die inserts) • Assembly
- 25. Recommendations (Soft Gel Die inserts)
- 26. Questions?
- 27. Why Wire EDM • The CNC Wire EDM Machine Feed Resolution up to 1µm • High Skilled Operator needed for Cylindrical Grinding • The Availability of CNC Cylindrical Grinding Machine
- 28. WhyVickers • 120 degree diamond tip • Cutting edge 1.3 mm while brinell have 10 mm diameter steel sphere • Rockwell hardness not available (10 mm diameter or 120 degree diamond) • leeb hardness test not applicable (flat large surface area is needed)