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By
CH. Vamsi Krishna (m.pharm)
1
2
• 3D printing is also called as additive manufacturing.
• Early Additive Manufacturing (AM) equipment and
materials were developed in the 1981.
• In1981, Hideo Kodama of Nagoya Municipal Industrial
Research Institute invented two AM fabricating methods of
a three-dimensional plastic model with photo-hardening
polymer, where the UV exposure area is controlled by a
mask pattern or the scanning fiber transmitter. 3
4
ADVANTAGES
DISADVANTAGES
5
6
7
8
SPRITAM
SPRITAM is the first prescription drug product
approved by the U.S. Food and Drug Administration
(FDA) that is manufactured using 3D printing
technology.
MANUFACTURER: Apreciapharmaceuticals
9
ABOUT SPRITAM
• Drug : levetiracetam
• Route of administration: oral
• Usage : partial onset seizures in people 4 years of age
myoclonic seizures in people 12 years of age
primary generalized tonic-clonic seizures in
people 6 years of age
• Indication : SPRITAM is recommended for use in
people weighing 20 kg (44 lbs) or more.
10
11
ZIP DOSE TECHNOLOGY
• Zip Dose Technology combines formulation science
with the unique manufacturing capabilities of three-
dimensional (3D) printing.
• Developed by Aprecia pharmaceuticals
• It produces and develops formulations of medicines
that rapidly disintegrate with a sip of liquid, even at
high dose loads.
12
Various methodologies used in 3d printing
FDM: Fused Deposition Modeling
SLA : Stereolithography
SLS : Selective Laser Sintering
13
Fused Deposition Modeling (FDM):
Additive (principle)
by laying down
materials in layers
plastic filament or
metal wire
Stepper motors to
move extrusion
head
CAM software
Nozzle
small beads of
thermoplastic
material 14
Materials used in FDM
 ABS: Acronitrile Butadiene Styrene
 ABSi: Acronitrile Butadiene Styrene Biocompatible
 ABS-M30: Acronitrile Butadiene Styrene (smooth
and opaque)
 PC: Poly Carbonate(more tensile strength)
15
Advantages
• Even low cost 3D printers have enough resolution for
many applications.
• Cost effective and water proof
• Multiple material colours are available.
• High accuracy
• Fast lead times
16
Disadvantages
 More area in slices required
 Temperature fluctuations during productions
17
STERIOLITHOGRAPHY(SLA)
principle: converts
liquid
materials(plastics)
into solid
photopolymer "resin"
(vat of liquid which is
ultraviolet curable)
a resin- filled blade
laser beam(for tracing)
ultraviolet laser(to
build layers )
SLA's elevator
platform
Subsequent layers 18
19
Advantages
• High precision
• Good Quality of product
• Smooth finish
• Expensive machines
• Unit production
Disadvantages
20
Selective Laser Sintering (SLS)
Principle: High power laser (for example, a carbon dioxide
laser) to fuse small particles.
Selectively fuses powdered material by scanning cross-
sections generated from a 3-D digital description.
After each cross-section is scanned, the powder bed is
lowered by one-layer thickness, a new layer of material is
applied on top, and the process is repeated until the part is
completed. Sintering takes place..
21
22
Advantages
• Powder itself provides necessary support
• Easy to remove not sintered powder.
• Thermal distortion of polymers
• Rough surface finish
Disadvantages
23
3d printing of human organs
24
3d printing of food
25
Applications
Manufacturing applications
• Cloud-based additive manufacturing
• Mass customization
• Rapid manufacturing
• Research
26
Medical application
• Bio printing
• Medical devices
• Pills
27
Industrial applications
• Industrial Art and Jewellery
• Automotive industry
• Construction
• Firearms
• Computers and robots
• Soft Sensors and Actuators
28
Sociocultural applications
• Art and Jewellery
• Communication
• Domestic use
• Education and research
29
30
Reference
• 3D Printer Technology – Animation of layering" .
Create It Real. Retrieved 2012- 01-31.
• https://www.researchgate.net/publication/2895226
63
• Study Shows High Accuracy of Medicinal 3D
Printing by Joseph Young | Feb 14, 2017 | 3D
Printing, 3D Printing Materials, Medical 3D Print
31
32

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121725101003-3D printing.pptx

  • 1. By CH. Vamsi Krishna (m.pharm) 1
  • 2. 2
  • 3. • 3D printing is also called as additive manufacturing. • Early Additive Manufacturing (AM) equipment and materials were developed in the 1981. • In1981, Hideo Kodama of Nagoya Municipal Industrial Research Institute invented two AM fabricating methods of a three-dimensional plastic model with photo-hardening polymer, where the UV exposure area is controlled by a mask pattern or the scanning fiber transmitter. 3
  • 4. 4
  • 6. 6
  • 7. 7
  • 8. 8
  • 9. SPRITAM SPRITAM is the first prescription drug product approved by the U.S. Food and Drug Administration (FDA) that is manufactured using 3D printing technology. MANUFACTURER: Apreciapharmaceuticals 9
  • 10. ABOUT SPRITAM • Drug : levetiracetam • Route of administration: oral • Usage : partial onset seizures in people 4 years of age myoclonic seizures in people 12 years of age primary generalized tonic-clonic seizures in people 6 years of age • Indication : SPRITAM is recommended for use in people weighing 20 kg (44 lbs) or more. 10
  • 11. 11
  • 12. ZIP DOSE TECHNOLOGY • Zip Dose Technology combines formulation science with the unique manufacturing capabilities of three- dimensional (3D) printing. • Developed by Aprecia pharmaceuticals • It produces and develops formulations of medicines that rapidly disintegrate with a sip of liquid, even at high dose loads. 12
  • 13. Various methodologies used in 3d printing FDM: Fused Deposition Modeling SLA : Stereolithography SLS : Selective Laser Sintering 13
  • 14. Fused Deposition Modeling (FDM): Additive (principle) by laying down materials in layers plastic filament or metal wire Stepper motors to move extrusion head CAM software Nozzle small beads of thermoplastic material 14
  • 15. Materials used in FDM  ABS: Acronitrile Butadiene Styrene  ABSi: Acronitrile Butadiene Styrene Biocompatible  ABS-M30: Acronitrile Butadiene Styrene (smooth and opaque)  PC: Poly Carbonate(more tensile strength) 15
  • 16. Advantages • Even low cost 3D printers have enough resolution for many applications. • Cost effective and water proof • Multiple material colours are available. • High accuracy • Fast lead times 16
  • 17. Disadvantages  More area in slices required  Temperature fluctuations during productions 17
  • 18. STERIOLITHOGRAPHY(SLA) principle: converts liquid materials(plastics) into solid photopolymer "resin" (vat of liquid which is ultraviolet curable) a resin- filled blade laser beam(for tracing) ultraviolet laser(to build layers ) SLA's elevator platform Subsequent layers 18
  • 19. 19
  • 20. Advantages • High precision • Good Quality of product • Smooth finish • Expensive machines • Unit production Disadvantages 20
  • 21. Selective Laser Sintering (SLS) Principle: High power laser (for example, a carbon dioxide laser) to fuse small particles. Selectively fuses powdered material by scanning cross- sections generated from a 3-D digital description. After each cross-section is scanned, the powder bed is lowered by one-layer thickness, a new layer of material is applied on top, and the process is repeated until the part is completed. Sintering takes place.. 21
  • 22. 22
  • 23. Advantages • Powder itself provides necessary support • Easy to remove not sintered powder. • Thermal distortion of polymers • Rough surface finish Disadvantages 23
  • 24. 3d printing of human organs 24
  • 25. 3d printing of food 25
  • 26. Applications Manufacturing applications • Cloud-based additive manufacturing • Mass customization • Rapid manufacturing • Research 26
  • 27. Medical application • Bio printing • Medical devices • Pills 27
  • 28. Industrial applications • Industrial Art and Jewellery • Automotive industry • Construction • Firearms • Computers and robots • Soft Sensors and Actuators 28
  • 29. Sociocultural applications • Art and Jewellery • Communication • Domestic use • Education and research 29
  • 30. 30
  • 31. Reference • 3D Printer Technology – Animation of layering" . Create It Real. Retrieved 2012- 01-31. • https://www.researchgate.net/publication/2895226 63 • Study Shows High Accuracy of Medicinal 3D Printing by Joseph Young | Feb 14, 2017 | 3D Printing, 3D Printing Materials, Medical 3D Print 31
  • 32. 32