Appium setup on mac for iOS and Android involves installing Homebrew, Xcode, Xcode command line tools, Appium, and WebDriverAgent. The document outlines steps to install these prerequisites, create a sample iOS app, and configure the WebDriverAgent project to enable app testing on real iOS devices using Appium. It also provides instructions for setting up Android development on mac, including installing Java JDK, Android Studio, and creating an emulator for testing Android apps on virtual devices.