This document presents several case studies demonstrating the myriad presentations of Anti-Phospholipid Antibody Syndrome (APLA Syndrome). The cases include a woman who developed gangrene of her fingers and was treated with low molecular weight heparin; a woman who had recurrent abortions and delivered with anticoagulation treatment; and a woman who developed deep vein thrombosis and was found to have various positive autoantibodies. The document demonstrates that APLA Syndrome can present with issues like thrombocytopenia, Budd-Chiari syndrome, pancreatitis, and cerebral sinus thrombosis.

1. APLA SYNDROME - Anti
Phospholipid Antibody Syndrome
Myriad Presentation
Dr.Anita
Dr.K.S.V.Chalam,Dr.A.Lalitha,Dr.A.P.Naveen
Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy

3. • Polyarthritis and rash
• Gangrene of tips of fingers
• Treated with LMWH and then acitrom
• Recovered completely
• ANA , DsDNA , Anti Cardiolipin positive
• On follow up

4. • 28 yr. female
• Recurrent abortions
• Anti cardiolipin antibodies positive
• Started on anticoagulants
• Delivered a female baby with LMWH

5. ACA SYNDROME

6. • 34 yr. female
• Polyarthritis and skin rash
• Developed swelling of leg
• Doppler showed DVT
• ANA,DsDNA,Smith and Anti cardiolipin Ab.
positive

8. • Presented with septicemia and MODS
• Recovered completely except for thrombocytopenia
• ANA positive – treated with steroids
• After 1 yr. developed swelling of abdomen
• U/S s/o Budd Chiari
• Investigations confirmed APLA

10. • 12 yr. girl
• Recurrent abdominal pain
• Confirmed as pancreatitis
• Later symptoms of rash and arthritis
• Investigations for SLE and APLA positive
• On immunomodulants and acitrom
• Developed CNS lupus and recovered

12. • Presented with convulsions
• MRI brain – large bleed
• Thrombocytopenia
• MR Venogram – Sup. Saggital sinus thrombosis
• APLA workup positive