The document discusses techniques for optimizing opcode caching in APC (Alternative PHP Cache) by tuning various APC configuration settings. These settings control aspects like the maximum file size to cache, number of files to cache, file update checking frequency, and enabling/disabling various caching defenses. It also recommends using more efficient locking mechanisms like futex locks over file locks for concurrency, using a more efficient serialization format like igbinary, and priming the cache before the site goes live.