This document discusses antiparkinsonian drugs used to treat Parkinson's disease. It begins by introducing antiparkinsonian drugs and Parkinson's disease. It then classifies antiparkinsonian drugs into anticholinergic agents, dopaminergic agents, and monoamine oxidase type B inhibitors. One specific anticholinergic agent, trihexyphenidyl, is discussed in more detail, covering its trade name, classification, dosage, mechanism of action, indications, contraindications, side effects, and nursing responsibilities when administering the drug.

1. ANTIPARKINSONIAN DRUGS
PRESENTED BY …..
MR.SUBIN RAJ R
ASST.PROFESSOR,RAMA NURSING COLLEGE
KANPUR

3. INTRODUCTION
ANTIPARKINSONIAN IS A GROUP OF DRUG WHICH IS INTENDED
TO TREAT AND RELIEVE THE SYMPTOMS OF PARKINSON’S
DISEASE. PARKINSON’S DISEASE IS A CHRONIC PROGRESSIVE
MOTOR DISORDER CHARACTERIZED BY RIGIDITY, TREMOR AND
BRADYKINESIA.
MOST OF THESE AGENTS ACT BY EITHER
INCREASING DOPAMINE ACTIVITY AND REDUCING
ACETYLCHOLINE ACTIVITY IN THE CNS.

4. CLASSIFICATION
1. ANTICHOLINERGIC AGENT –
*TRIHEXYPHENIDYL
*BENZTROPINE
*BIPERIDEN
2. DOPAMINERGIC AGENT-
* BROMOCRIPTIN
*CARBIDOPA/LEVODOPA
3. MONOAMINE OXIDASE TYPE B INHIBITORS
*SELEGILINE

5. TRIHEXYPHENIDYL
TRIHEXYPHENIDYL ( BENZHEXOL ) IS A DRUG THAT
COMES UNDER ANTICHOLINERGIC AGENTS OF
ANTIPARKINSONIAN DRUG GROUP.
IT IS MAINLY USED TO TREAT THE UNUSUAL NERVE
IMPULSES AND STIFFNESS OF MUSCLES.

6. CONT….
• TRADE – ARTANE
• CLASS – ANTICHOLINERGIC AGENTS
• DOSE – 1-2MG/DAY
• ROUTE- ORALLY

7. MECHANISM OF ACTION
IT ACTS BY INCREASING THE RELEASE OF DOPAMINE
FROM PRESYNAPTIC VESICLES, BLOCKING THE
REUPTAKE OF DOPAMINE INTO PRESYNAPTIC NERVE
TERMINALS OR BY EXERTING AGONIST EFFECT ON
POSTSYNAPTIC DOPAMINE RECEPTORS.

8. INDICATION
DRUG INDUCED PARKINSONISM
ADJUNCT IN MANAGEMENT OF PARKINSONISM

9. CONTRAINDICATIONS
• THYROTOXICOSIS
• HYPERSENSTIVITY TO ARTANE
• NARROW ANGLE GLAUCOMA
• URINARY TRACT INFECTIONS
• ANGINA
• PREGNANCY

10. SIDE EFFECTS
1. DIZZINESS
2. BLURRED VISION
3. HEADACHE
4. CONFUSION
5. TACHYCARDIA
6. DRY MOUTH
7. NAUSEA AND VOMITING

11. NURSING RESPONSIBILITY
• CHECK WHETHER THE PATIENT IS ALLERGIC TO DRUG
• ASSESS THE PARKINSONIAN AND EXTRAPYRAMIDAL
SYMPTOMS.
• INSTRUCT THE PATIENT ABOUT FREQUENT ORAL HYGIENE.
• CAUTION THE PATIENT THAT THIS MEDICINE MAY
PRODUCE OVER HEATING BY DECREASING PERSPIRATION

12. CONT….
• ASSESS THERAPEUTIC RESPONSE
• MONITOR BLOOD PRESSURE FREQUENTLY
• CHECK FOR THE SIDE EFFECTS OF DRUG
• CAUTION THE PATIENT TO CHANGE THE POSITION
SLOWLY TO MINIMIZE ORTHOSTATIC HYPOTENSION

13. THANK
YOU