This document summarizes guidelines for antibiotic prophylaxis for infective endocarditis and prosthetic joints. It recommends prophylaxis for certain high-risk cardiac conditions when undergoing dental procedures, including prosthetic cardiac valves or congenital heart disease. It also recommends prophylaxis for joint replacement patients undergoing dental work, including those who are immunocompromised or have certain medical conditions. The document reviews recommended antibiotic regimens for these patients and exceptions where prophylaxis is not needed.