Anti-rheumatoid drugs form a crucial arsenal in the battle against rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by inflammation of the joints. These medications, including Disease-Modifying Anti-Rheumatic Drugs (DMARDs), biologics, and immunomodulators, work by targeting the underlying inflammatory processes that drive RA progression. By suppressing the overactive immune response responsible for joint damage, these drugs not only alleviate symptoms but also aim to halt disease progression and preserve joint function. From traditional agents like methotrexate to cutting-edge biologic therapies such as TNF-alpha inhibitors and JAK inhibitors, anti-rheumatoid drugs offer a spectrum of treatment options tailored to individual patient needs. Understanding their mechanisms of action, potential side effects, and therapeutic benefits is paramount in optimizing the management of RA and improving patients' quality of life." Cure from the clutches of rheumatoid arthritis with our illuminating presentation on anti-rheumatoid drugs. Dive into the world of disease-modifying agents, biologics, and immunomodulators meticulously crafted to tame inflammation and preserve joint health. Uncover the science behind these therapeutic marvels, their mechanisms of action, and their pivotal role in managing autoimmune disorders. Whether you're a medical professional, researcher, or patient seeking relief, this presentation equips you with essential knowledge to navigate the landscape of rheumatoid arthritis treatment." Unlock the mysteries of anti-rheumatoid drugs with this insightful presentation. From traditional DMARDs to groundbreaking biologics, delve into the mechanisms and therapeutic effects of these medications in combating rheumatoid arthritis. Explore the latest research, clinical applications, and patient outcomes, empowering your understanding of rheumatologic care. Whether you're a healthcare practitioner, researcher, or patient seeking knowledge, embark on a journey toward clearer comprehension and improved treatment outcomes in rheumatoid arthritis management.

1. Nagpur college of pharmacy
Present By :- Ku.
Sakshi Ghasle
Topic Name :-
Antirheumatoid
drugs

2. Rheumatoid Arthritis:-
Rheumatoid arthritis is a chronic inflammatory disorder
that can affect more than just your joints. In some
people, the condition can damage a wide variety of
body systems, including the skin, eyes, lungs, heart and
blood vessels.
• An autoimmune disorder, rheumatoid arthritis occurs
when your immune system mistakenly attacks your
own body’s tissues

4. Symptoms :-
* Signs and symptoms of rheumatoid
arthritis may include:
•Tender, warm, swollen joints
•Joint stiffness that is usually worse
in the mornings and after inactivity
•Fatigue, fever and loss of appetite

5. Early rheumatoid arthritis tends to affect your smaller joints first —
particularly the joints that attach your fingers to your hands and your toes
to your feet.
As the disease progresses, symptoms often spread to the wrists, knees, ankles,
elbows, hips and shoulders. In most cases, symptoms occur in the same joints
on both sides of your body.
About 40% of people who have rheumatoid arthritis also experience signs and
symptoms that don't involve the joints. Areas that may be affected include:
•Skin
•Eyes
•Lungs
•Heart
•Kidneys
•Vessel
•Salivary glands
•Nerve tissue
•Bone marrow
•Blood vessels

8. Risk factors
Factors that may increase your risk of rheumatoid arthritis include:
•Your sex. Women are more likely than men to develop rheumatoid arthritis.
•Age. Rheumatoid arthritis can occur at any age, but it most commonly begins
in middle age.
•Family history. If a member of your family has rheumatoid arthritis, you may
have an increased risk of the disease.
•Smoking. Cigarette smoking increases your risk of developing rheumatoid
arthritis, particularly if you have a genetic predisposition for developing the
disease. Smoking also appears to be associated with greater disease severity.
•Excess weight. People who are overweight appear to be at a somewhat
higher risk of developing rheumatoid arthritis.

9. Complications :-
Rheumatoid arthritis increases your
risk of developing:
Osteoporosis
Rheumatoid nodules.
Dry eyes and mouth.
Infections
Abnormal body composition.
Carpal tunnel syndrome.
Heart problems.
Lung disease.
Lymphoma

12. Antirheumatoiddrugs :-
Disease modifying anti –
rheumatoid grugs ( DMART’S )
Adjuvant
drugs
Non – Biological
Drugs
Immuno
Suppressants :-
• Methotrexate
• Azathioprine
• Cycloporine
Other immuno
modulators:-
• Sulfasalazine
• Hydroxychlor
o-quanin
• Leflubamide
• Tofacitinif
Biological
agents
TNF – Alfa
Inhibitors
• Etanercept
• Infliximab
• Adalimumab
Other
Biological
• Anakinra
• Abatacept
• Rituximab
Prednizolone and
other
glucocorticoid

13. DMART’S
Disease Modifying Anti-rheumatic drugs
• Methotrexate:-
• Dihydrofolate reductase inhibitor
has immunosuppressive and
anti-inflammatory property .
• To inhibit cytokinin production .
• Oral low dose (7.4-15 mg )
weekly .
• First Choice drug .
• Elimination mainly renal.

14. MTXAdverse effects:-
• Hepatotoxicity
• Bone 🦴 marrow suppression.
• Dispepsia, oral ulcers
• Teratogenicity

18. TNF :- Tumour necrosis factor:-
• TNF is a potent inflammatory
cytokinin
• TNF is a produced mainly by
macrophages and monocytes.
• TNF is major contributor to
the inflammatory and
destructive changes that
occur in RA