This document summarizes guidelines for evaluating and treating preoperative anemia. It finds that preoperative hemoglobin level is the strongest predictor of blood transfusion need after surgery. Guidelines recommend determining hemoglobin levels for elective surgery patients around 28 days before the procedure. Treatment for preoperative anemia depends on the underlying cause, and may include oral or intravenous iron, erythropoietin stimulating agents, or addressing nutritional deficiencies. The goal is to optimize hemoglobin levels before elective surgery to reduce the risk of blood transfusions.
This document discusses relative blood volume (RBV) monitoring and its potential applications in dialysis. It provides an overview of RBV monitoring principles, compartmental fluid shifts, and RBV profiles in relation to intradialytic hypotension. While RBV monitoring shows promise for fluid management and blood pressure control, evidence from studies is mixed. The largest study to date found RBV monitoring increased mortality and hospitalizations. Further research is still needed to fully understand the clinical utility and appropriate applications of RBV monitoring.
The document discusses the paradoxical relationship between obesity and mortality in patients with kidney disease undergoing dialysis. Several studies are reviewed that found higher BMI in dialysis patients was associated with lower risks of death and hospitalization, unlike the general population where obesity increases health risks. The studies accounted for various factors and found even extreme obesity was protective. Weight gain over time was also associated with reduced mortality risk. The reasons for this reverse epidemiology are unclear but proposed mechanisms include increased stores of nutrients and anti-inflammatory proteins in adipose tissue.
ICN VIctoria: John Botha on Critical Care Renal FailureGerard Fennessy
Professor John Botha from Frankston Hospital in Melbourne talks at the April 2014 Victorian Intensive Care Network meeting on Renal Failure in Critical Care
A limited presentation about a) age related renal functional changes b) management of CKD, including advance care planning and transplantation referral c) management of potentially risky drugs in the elderly with CKD (NOACs)
The study to measure the level of serum annexin V in patients with renal hype...inventionjournals
ABSTRACT : Renovascular hypertension reflects the causal relation between anatomically evident arterial occlusive disease and elevated blood pressure. The coexistence of renal arterial vascular disease and hypertension roughly defines this type of nonessential hypertension. The aim of this study was to measure the level of serum Anti-Annexin V antibodies in patients with renal hypertension. Methods. This study was conducted on 115 patients, diagnosed with renal hypertension and hypertension. Informed consents were obtained from the patients and the study was approved by the Kharkiv National Medical University ethics committee. Ten healthy age and sex matched volunteers were included as a control group. All patients and controls were subjected to the following full history taking and thorough clinical examination. Routine laboratory testing included a complete blood count, and erythrocyte sedimentation rate (ESR) and kidney function tests (blood urea nitrogen and serum creatinine). Immunological tests for antinuclear antibody (ANA) and anticentromere antibodies (ACA) was performed by the indirect immunofluorescence technique. AntiScl-70 (anti-topoisomerase antibodies) and anticardiolipin antibodies (ACA: IgG and IgM) were tested using the ELISA technique. The anti-annexin V antibodies titre used the ZYMUTEST anti-Annexin IgG ELISA kit. [Hyphen-BioMed, France.]: to measure the IgG isotype of auto-antibodies to annexin V in human serum. Results. Anti-annexin V antibodies were present in 75% of patients (mean 83.46 ± 22.44 AU/mL) vs. 0% in the controls (mean 3.94 ± 4.5 AU/mL). Comparison between patients and controls as regards levels of anti-annexin V showed a highly significant difference (P < 0.001). Furthermore, correlation of anti-annexin V titres with the disease activity score in the patient group showed a statistically significant positive correlation (r = 0.51, P < 0.05).In addition, the anti-annexin V antibody titres in this study showed a highly significant positive correlation with ACL antibodies (r = 0.74, P < 0.001). Patients with antiphospholipid syndrome (APS) have been known to have a higher frequency of anti-annexin V antibodies, and thrombotic events have been reported more frequently in patients with positive anti-annexin V antibodies. Furthermore, inhibition of annexin V binding to negatively charged phospholipids may be an additional pathogenic mechanism of APS.
1) Several novel urinary biomarkers such as KIM-1, NGAL, and LFABP have been shown to be early predictors of acute kidney injury (AKI), rising in the urine within hours of injury compared to the rise in serum creatinine which occurs later.
2) Biomarkers like NGAL and KIM-1 have been shown to predict progression of AKI severity and long-term outcomes like need for renal replacement therapy and mortality.
3) Studies have demonstrated the utility of biomarkers like plasma NGAL measured at the time of clinical diagnosis of AKI after cardiac surgery to predict AKI severity and risk stratify patients for worse outcomes.
The document discusses biomarkers for detecting acute kidney injury (AKI). It notes that serum creatinine is currently used but is not an early indicator. Newer biomarkers like NGAL can detect AKI earlier, within 2 hours after an event instead of 1-2 days with creatinine. Having early biomarkers could allow for improved understanding, earlier treatment and better outcomes for AKI patients. The document reviews studies on NGAL for detecting AKI in settings like cardiac surgery, contrast-induced nephropathy, sepsis, and kidney transplantation.
Room a a01. mcgee-aki update on biomarkers and dx (en)SoM
This document discusses biomarkers and acute kidney injury. It begins by introducing biomarkers as a better way to assess and monitor kidney stress in real time compared to serum creatinine and urine output. The document then discusses how acute kidney injury (AKI) is common, deadly, costly and prevalent, especially in conditions like pneumonia, sepsis and major surgery. It notes that AKI identification in the ICU can be inconsistent. The document introduces novel urinary biomarkers TIMP-2 and IGFBP7 that were discovered to predict AKI within 12 hours and have been validated. It discusses how measuring these biomarkers could help identify kidney stress before damage occurs and allow for preventative measures. The document proposes building an algorithm around using the Nephro
This document discusses relative blood volume (RBV) monitoring and its potential applications in dialysis. It provides an overview of RBV monitoring principles, compartmental fluid shifts, and RBV profiles in relation to intradialytic hypotension. While RBV monitoring shows promise for fluid management and blood pressure control, evidence from studies is mixed. The largest study to date found RBV monitoring increased mortality and hospitalizations. Further research is still needed to fully understand the clinical utility and appropriate applications of RBV monitoring.
The document discusses the paradoxical relationship between obesity and mortality in patients with kidney disease undergoing dialysis. Several studies are reviewed that found higher BMI in dialysis patients was associated with lower risks of death and hospitalization, unlike the general population where obesity increases health risks. The studies accounted for various factors and found even extreme obesity was protective. Weight gain over time was also associated with reduced mortality risk. The reasons for this reverse epidemiology are unclear but proposed mechanisms include increased stores of nutrients and anti-inflammatory proteins in adipose tissue.
ICN VIctoria: John Botha on Critical Care Renal FailureGerard Fennessy
Professor John Botha from Frankston Hospital in Melbourne talks at the April 2014 Victorian Intensive Care Network meeting on Renal Failure in Critical Care
A limited presentation about a) age related renal functional changes b) management of CKD, including advance care planning and transplantation referral c) management of potentially risky drugs in the elderly with CKD (NOACs)
The study to measure the level of serum annexin V in patients with renal hype...inventionjournals
ABSTRACT : Renovascular hypertension reflects the causal relation between anatomically evident arterial occlusive disease and elevated blood pressure. The coexistence of renal arterial vascular disease and hypertension roughly defines this type of nonessential hypertension. The aim of this study was to measure the level of serum Anti-Annexin V antibodies in patients with renal hypertension. Methods. This study was conducted on 115 patients, diagnosed with renal hypertension and hypertension. Informed consents were obtained from the patients and the study was approved by the Kharkiv National Medical University ethics committee. Ten healthy age and sex matched volunteers were included as a control group. All patients and controls were subjected to the following full history taking and thorough clinical examination. Routine laboratory testing included a complete blood count, and erythrocyte sedimentation rate (ESR) and kidney function tests (blood urea nitrogen and serum creatinine). Immunological tests for antinuclear antibody (ANA) and anticentromere antibodies (ACA) was performed by the indirect immunofluorescence technique. AntiScl-70 (anti-topoisomerase antibodies) and anticardiolipin antibodies (ACA: IgG and IgM) were tested using the ELISA technique. The anti-annexin V antibodies titre used the ZYMUTEST anti-Annexin IgG ELISA kit. [Hyphen-BioMed, France.]: to measure the IgG isotype of auto-antibodies to annexin V in human serum. Results. Anti-annexin V antibodies were present in 75% of patients (mean 83.46 ± 22.44 AU/mL) vs. 0% in the controls (mean 3.94 ± 4.5 AU/mL). Comparison between patients and controls as regards levels of anti-annexin V showed a highly significant difference (P < 0.001). Furthermore, correlation of anti-annexin V titres with the disease activity score in the patient group showed a statistically significant positive correlation (r = 0.51, P < 0.05).In addition, the anti-annexin V antibody titres in this study showed a highly significant positive correlation with ACL antibodies (r = 0.74, P < 0.001). Patients with antiphospholipid syndrome (APS) have been known to have a higher frequency of anti-annexin V antibodies, and thrombotic events have been reported more frequently in patients with positive anti-annexin V antibodies. Furthermore, inhibition of annexin V binding to negatively charged phospholipids may be an additional pathogenic mechanism of APS.
1) Several novel urinary biomarkers such as KIM-1, NGAL, and LFABP have been shown to be early predictors of acute kidney injury (AKI), rising in the urine within hours of injury compared to the rise in serum creatinine which occurs later.
2) Biomarkers like NGAL and KIM-1 have been shown to predict progression of AKI severity and long-term outcomes like need for renal replacement therapy and mortality.
3) Studies have demonstrated the utility of biomarkers like plasma NGAL measured at the time of clinical diagnosis of AKI after cardiac surgery to predict AKI severity and risk stratify patients for worse outcomes.
The document discusses biomarkers for detecting acute kidney injury (AKI). It notes that serum creatinine is currently used but is not an early indicator. Newer biomarkers like NGAL can detect AKI earlier, within 2 hours after an event instead of 1-2 days with creatinine. Having early biomarkers could allow for improved understanding, earlier treatment and better outcomes for AKI patients. The document reviews studies on NGAL for detecting AKI in settings like cardiac surgery, contrast-induced nephropathy, sepsis, and kidney transplantation.
Room a a01. mcgee-aki update on biomarkers and dx (en)SoM
This document discusses biomarkers and acute kidney injury. It begins by introducing biomarkers as a better way to assess and monitor kidney stress in real time compared to serum creatinine and urine output. The document then discusses how acute kidney injury (AKI) is common, deadly, costly and prevalent, especially in conditions like pneumonia, sepsis and major surgery. It notes that AKI identification in the ICU can be inconsistent. The document introduces novel urinary biomarkers TIMP-2 and IGFBP7 that were discovered to predict AKI within 12 hours and have been validated. It discusses how measuring these biomarkers could help identify kidney stress before damage occurs and allow for preventative measures. The document proposes building an algorithm around using the Nephro
PATIENT BLOOD MANAGEMENT Dr García Erce Mediterranean Anaemia Course4th cong...José Antonio García Erce
This document discusses strategies and protocols for optimizing hemoglobin levels in patients, known as "patient blood management". It begins by noting the high prevalence and risks of anemia. It then discusses how preoperative anemia increases risks like blood transfusions, complications, and mortality. The need for multimodal, multidisciplinary perioperative programs to improve anemia management via optimization of erythropoiesis, minimizing blood loss, and increasing anemia tolerance is discussed. Recommendations include testing hemoglobin and iron status at least 28 days before elective high-risk surgeries for patients over 60. The document emphasizes establishing evidence-based best practices and guidelines to improve patient outcomes through better anemia and blood management.
Curso de actualización en patient blood management. Taller CASTYM (Control Avanzado del Sangrado en Trauma y Cirugía Mayor). 2ª Edición
CURSOS EXTRAORDINARIOS UNIVERSIDAD DE ZARAGOZA. Jaca, Julio 2017
The document discusses a study of 729 patients who underwent coronary CT angiography (CTA) to assess for atherosclerotic disease. Of the 325 patients who had a normal calcium score on CT, 167 (51%) were found to have noncalcified plaque on coronary CTA. Additionally, 12 patients (3.7%) with a normal calcium score were found to have at least moderate stenosis, including 5 patients (1.5%) with severe stenosis, demonstrating that significant atherosclerotic disease can be present even without coronary calcification.
Lezione Magistrale del Prof. Cerasola al congresso di Nefrocardiologia su ipertensione e rischio cardio renale
Trani Nov 2013
Prof. Giovanni Cerasola
Professore di Medicina Interna
Head of the European Society of Hypertension Excellence Centre e Presidente della Società Italiana di NefroCardiologia
Delegato del Rettore per l'attività edilizia ed il potenziamento infrastrutturale del Policlinico Universitario.
Dipartimento di Medicina Interna e Specialistica - Università degli Studi di Palermo
This study compared outcomes of steroid withdrawal versus continued steroid therapy in kidney and heart transplant recipients. Over 1500 patients were enrolled from 1994-2002 and followed for 5-6 years on average. Results showed that steroid withdrawal led to superior patient and graft survival rates compared to controls continuing steroids. Steroid withdrawal also reduced risks of complications like osteoporosis and cataracts. However, it was associated with a small increased risk of acute rejection episodes. Overall, the study suggests that steroid withdrawal after 6 months is safe and effective for transplant recipients.
The document discusses the history and development of dialysis for treating acute renal failure. It describes how Dr. Haas invented the first dialysis machine for humans in 1928 but all 6 of his initial patients died. Dr. Kolff then created the second human dialysis machine in 1943 and was able to successfully treat his first patient. The document also examines biomarkers like KIM-1 and NGAL that can help diagnose acute kidney injury earlier than creatinine. It analyzes the RIFLE criteria for classifying the severity of acute renal failure.
This document discusses renal complications associated with hematologic malignancies and their treatment. It provides 3 key points:
1) Lymphomatous infiltration of the kidneys is a common but under-recognized complication of malignant lymphomas, seen in up to one-third of patients on autopsy. Bilateral symmetrical kidney enlargement is the most common imaging finding.
2) Chemotherapies used to treat hematologic malignancies can cause acute kidney injury through tumor lysis syndrome or direct nephrotoxicity. Ifosfamide, in particular, is associated with proximal tubule dysfunction and Fanconi syndrome.
3) Long-term renal complications of chemotherapy include chronic kidney disease, which may progress even after
This summarizes a journal club discussion on a clinical trial examining the effects of allopurinol treatment in patients with chronic kidney disease (CKD). The trial found that allopurinol attenuated the decline in glomerular filtration rate compared to controls and reduced cardiovascular events and inflammatory markers. However, the study had some limitations as an open-label, single-center trial with a small sample size. While allopurinol showed potential benefits, larger and more robust studies are still needed before strongly recommending its use to attenuate CKD progression.
This document discusses strategies and protocols for optimizing hemoglobin levels in patients through patient blood management. It begins by outlining the high rates of preoperative anemia seen in various surgical specialties, from 25% to over 50% depending on the procedure. Preoperative anemia is associated with increased risks of mortality, morbidity, length of hospital stay, blood transfusions, and healthcare costs. The document emphasizes the importance of treating preoperative anemia to improve surgical outcomes and lower transfusion rates. It promotes the use of patient blood management strategies that include early anemia screening and treatment, as well as alternatives to allogeneic blood transfusions when possible.
This document discusses the remodeling of the brachial artery (AB) in arterial hypertension (HTA). It covers the following key points:
1. AB remodeling in HTA can be adaptive/compensatory (increasing diameter and wall thickness to maintain luminal area) or maladaptive. Imaging techniques like ultrasound can evaluate AB morphology and function.
2. Spectral Doppler analysis of AB blood flow shows broadening of the spectral envelope in HTA, reflecting increased arterial stiffness. Flow-mediated dilation (%FMD) evaluates endothelial function. Lower %FMD correlates with cardiovascular risk factors and subclinical atherosclerosis.
3. AB remodeling correlates with target organ damage in HTA. Different HTA phenotypes (e
This study compared balanced crystalloids (lactated Ringer's and Plasma-Lyte A) to normal saline in over 15,000 critically ill patients admitted to ICUs at Vanderbilt University Medical Center. The primary outcome was a composite of major adverse kidney events within 30 days. Results showed the absolute risk of the primary outcome was 1.1% lower in patients who received balanced crystalloids compared to saline. Subgroup analyses found greater differences in patients with sepsis and those receiving larger fluid volumes. The authors conclude balanced crystalloids may reduce the risk of new renal replacement therapy, persistent renal dysfunction, or death compared to saline in critically ill adults.
This document summarizes strategies for preventing chronic kidney disease (CKD). It discusses several key risk factors for CKD, including diabetes, hypertension, obesity, and smoking. It then outlines primary and secondary prevention approaches. For primary prevention, lifestyle modifications and controlling risk factors like blood pressure and blood sugar are emphasized. For secondary prevention in patients with existing kidney disease, tight control of blood pressure and glucose is important, along with use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers to slow disease progression. Clinical trials demonstrate that controlling these modifiable risk factors can significantly reduce the risk of end-stage renal disease.
This document discusses the relationship between iron deficiency, anemia, and quality of life in patients with chronic heart failure. It presents results from a study of 552 chronic heart failure patients which found that those with iron deficiency had significantly worse health-related quality of life scores compared to those without iron deficiency, regardless of their anemia status. Iron deficiency was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. This suggests that iron deficiency is a key determinant of poorer quality of life in chronic heart failure patients over and above any effects of anemia.
Contraindications, futility & fraility in liver transplantDr. Rohit Saini
This document discusses contraindications and factors used to assess futility for liver transplantation (LTx). It covers absolute and relative contraindications to LTx. Scores like MELD, SOFT, and UCLA are used to predict post-LTx outcomes and futility. Factors like frailty, age, comorbidities, acute liver failure criteria, and ACLF grade impact survival. The concept of a "transplantation window" in ACLF is discussed. Precipitating events, physical frailty, sarcopenia, cardiovascular disease, and pulmonary hypertension also influence futility decisions for LTx.
When to dialyse a patient and with what modality of dialysis will be topic of discussion.The recent advances and debates surrounding the topic will be discussed in detail
This document discusses acute-on-chronic liver failure (ACLF), comparing existing definitions from APASL, EASL/CLIF, and NASCELD. It notes that while not consistent, the definitions lay groundwork for future research. The APASL definition focuses on an acute hepatic insult leading to liver failure within 4 weeks in patients with chronic liver disease/cirrhosis. EASL/CLIF and NASCELD have broader definitions not requiring liver failure, instead focusing on extrahepatic organ failures. The document also discusses the "golden window" period for treatment, reversibility of ACLF, grading systems for prognosis, and the APASL ACLF research consortium database.
- Recorded videos of the lecture:
English Language version of this lecture is available at: https://youtu.be/-Ynxvhbcl7U
Arabic Language version of this lecture is available at: https://youtu.be/QpK_toctVlw
- Visit our website for more lectures: www.NephroTube.com
- Subscribe to our YouTube channel: www.youtube.com/NephroTube
- Join our facebook group: www.facebook.com/groups/NephroTube
- Like our facebook page: www.facebook.com/NephroTube
- Follow us on twitter: www.twitter.com/NephroTube
PHARMACOLOGICAL MANAGEMENT OF PERIOPERATIVE ANAEMIA: OUR EXPERIENCE WITH INTRAVENOUS IRON IN ORTHOPAEDIC SURGERY
ISBT CONGRESS 2007
SETS CONGRESO 2007
PATIENT BLOOD MANAGEMENT
Ponencia ISBT-SETS Madrid 2007. IRON INTRAVENOUS AND SURGERY. Muñoz and Garcí...José Antonio García Erce
This document summarizes an experience using intravenous iron in orthopaedic surgery patients. It discusses using IV iron to treat preoperative anemia in both elective and non-elective orthopaedic procedures, such as hip fracture repair. The results showed IV iron reduced transfusion rates and helped optimize hemoglobin levels in the perioperative period. It concludes that IV iron administration may be suggested for patients undergoing orthopedic surgery expected to develop severe postoperative anemia.
PATIENT BLOOD MANAGEMENT Dr García Erce Mediterranean Anaemia Course4th cong...José Antonio García Erce
This document discusses strategies and protocols for optimizing hemoglobin levels in patients, known as "patient blood management". It begins by noting the high prevalence and risks of anemia. It then discusses how preoperative anemia increases risks like blood transfusions, complications, and mortality. The need for multimodal, multidisciplinary perioperative programs to improve anemia management via optimization of erythropoiesis, minimizing blood loss, and increasing anemia tolerance is discussed. Recommendations include testing hemoglobin and iron status at least 28 days before elective high-risk surgeries for patients over 60. The document emphasizes establishing evidence-based best practices and guidelines to improve patient outcomes through better anemia and blood management.
Curso de actualización en patient blood management. Taller CASTYM (Control Avanzado del Sangrado en Trauma y Cirugía Mayor). 2ª Edición
CURSOS EXTRAORDINARIOS UNIVERSIDAD DE ZARAGOZA. Jaca, Julio 2017
The document discusses a study of 729 patients who underwent coronary CT angiography (CTA) to assess for atherosclerotic disease. Of the 325 patients who had a normal calcium score on CT, 167 (51%) were found to have noncalcified plaque on coronary CTA. Additionally, 12 patients (3.7%) with a normal calcium score were found to have at least moderate stenosis, including 5 patients (1.5%) with severe stenosis, demonstrating that significant atherosclerotic disease can be present even without coronary calcification.
Lezione Magistrale del Prof. Cerasola al congresso di Nefrocardiologia su ipertensione e rischio cardio renale
Trani Nov 2013
Prof. Giovanni Cerasola
Professore di Medicina Interna
Head of the European Society of Hypertension Excellence Centre e Presidente della Società Italiana di NefroCardiologia
Delegato del Rettore per l'attività edilizia ed il potenziamento infrastrutturale del Policlinico Universitario.
Dipartimento di Medicina Interna e Specialistica - Università degli Studi di Palermo
This study compared outcomes of steroid withdrawal versus continued steroid therapy in kidney and heart transplant recipients. Over 1500 patients were enrolled from 1994-2002 and followed for 5-6 years on average. Results showed that steroid withdrawal led to superior patient and graft survival rates compared to controls continuing steroids. Steroid withdrawal also reduced risks of complications like osteoporosis and cataracts. However, it was associated with a small increased risk of acute rejection episodes. Overall, the study suggests that steroid withdrawal after 6 months is safe and effective for transplant recipients.
The document discusses the history and development of dialysis for treating acute renal failure. It describes how Dr. Haas invented the first dialysis machine for humans in 1928 but all 6 of his initial patients died. Dr. Kolff then created the second human dialysis machine in 1943 and was able to successfully treat his first patient. The document also examines biomarkers like KIM-1 and NGAL that can help diagnose acute kidney injury earlier than creatinine. It analyzes the RIFLE criteria for classifying the severity of acute renal failure.
This document discusses renal complications associated with hematologic malignancies and their treatment. It provides 3 key points:
1) Lymphomatous infiltration of the kidneys is a common but under-recognized complication of malignant lymphomas, seen in up to one-third of patients on autopsy. Bilateral symmetrical kidney enlargement is the most common imaging finding.
2) Chemotherapies used to treat hematologic malignancies can cause acute kidney injury through tumor lysis syndrome or direct nephrotoxicity. Ifosfamide, in particular, is associated with proximal tubule dysfunction and Fanconi syndrome.
3) Long-term renal complications of chemotherapy include chronic kidney disease, which may progress even after
This summarizes a journal club discussion on a clinical trial examining the effects of allopurinol treatment in patients with chronic kidney disease (CKD). The trial found that allopurinol attenuated the decline in glomerular filtration rate compared to controls and reduced cardiovascular events and inflammatory markers. However, the study had some limitations as an open-label, single-center trial with a small sample size. While allopurinol showed potential benefits, larger and more robust studies are still needed before strongly recommending its use to attenuate CKD progression.
This document discusses strategies and protocols for optimizing hemoglobin levels in patients through patient blood management. It begins by outlining the high rates of preoperative anemia seen in various surgical specialties, from 25% to over 50% depending on the procedure. Preoperative anemia is associated with increased risks of mortality, morbidity, length of hospital stay, blood transfusions, and healthcare costs. The document emphasizes the importance of treating preoperative anemia to improve surgical outcomes and lower transfusion rates. It promotes the use of patient blood management strategies that include early anemia screening and treatment, as well as alternatives to allogeneic blood transfusions when possible.
This document discusses the remodeling of the brachial artery (AB) in arterial hypertension (HTA). It covers the following key points:
1. AB remodeling in HTA can be adaptive/compensatory (increasing diameter and wall thickness to maintain luminal area) or maladaptive. Imaging techniques like ultrasound can evaluate AB morphology and function.
2. Spectral Doppler analysis of AB blood flow shows broadening of the spectral envelope in HTA, reflecting increased arterial stiffness. Flow-mediated dilation (%FMD) evaluates endothelial function. Lower %FMD correlates with cardiovascular risk factors and subclinical atherosclerosis.
3. AB remodeling correlates with target organ damage in HTA. Different HTA phenotypes (e
This study compared balanced crystalloids (lactated Ringer's and Plasma-Lyte A) to normal saline in over 15,000 critically ill patients admitted to ICUs at Vanderbilt University Medical Center. The primary outcome was a composite of major adverse kidney events within 30 days. Results showed the absolute risk of the primary outcome was 1.1% lower in patients who received balanced crystalloids compared to saline. Subgroup analyses found greater differences in patients with sepsis and those receiving larger fluid volumes. The authors conclude balanced crystalloids may reduce the risk of new renal replacement therapy, persistent renal dysfunction, or death compared to saline in critically ill adults.
This document summarizes strategies for preventing chronic kidney disease (CKD). It discusses several key risk factors for CKD, including diabetes, hypertension, obesity, and smoking. It then outlines primary and secondary prevention approaches. For primary prevention, lifestyle modifications and controlling risk factors like blood pressure and blood sugar are emphasized. For secondary prevention in patients with existing kidney disease, tight control of blood pressure and glucose is important, along with use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers to slow disease progression. Clinical trials demonstrate that controlling these modifiable risk factors can significantly reduce the risk of end-stage renal disease.
This document discusses the relationship between iron deficiency, anemia, and quality of life in patients with chronic heart failure. It presents results from a study of 552 chronic heart failure patients which found that those with iron deficiency had significantly worse health-related quality of life scores compared to those without iron deficiency, regardless of their anemia status. Iron deficiency was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. This suggests that iron deficiency is a key determinant of poorer quality of life in chronic heart failure patients over and above any effects of anemia.
Contraindications, futility & fraility in liver transplantDr. Rohit Saini
This document discusses contraindications and factors used to assess futility for liver transplantation (LTx). It covers absolute and relative contraindications to LTx. Scores like MELD, SOFT, and UCLA are used to predict post-LTx outcomes and futility. Factors like frailty, age, comorbidities, acute liver failure criteria, and ACLF grade impact survival. The concept of a "transplantation window" in ACLF is discussed. Precipitating events, physical frailty, sarcopenia, cardiovascular disease, and pulmonary hypertension also influence futility decisions for LTx.
When to dialyse a patient and with what modality of dialysis will be topic of discussion.The recent advances and debates surrounding the topic will be discussed in detail
This document discusses acute-on-chronic liver failure (ACLF), comparing existing definitions from APASL, EASL/CLIF, and NASCELD. It notes that while not consistent, the definitions lay groundwork for future research. The APASL definition focuses on an acute hepatic insult leading to liver failure within 4 weeks in patients with chronic liver disease/cirrhosis. EASL/CLIF and NASCELD have broader definitions not requiring liver failure, instead focusing on extrahepatic organ failures. The document also discusses the "golden window" period for treatment, reversibility of ACLF, grading systems for prognosis, and the APASL ACLF research consortium database.
- Recorded videos of the lecture:
English Language version of this lecture is available at: https://youtu.be/-Ynxvhbcl7U
Arabic Language version of this lecture is available at: https://youtu.be/QpK_toctVlw
- Visit our website for more lectures: www.NephroTube.com
- Subscribe to our YouTube channel: www.youtube.com/NephroTube
- Join our facebook group: www.facebook.com/groups/NephroTube
- Like our facebook page: www.facebook.com/NephroTube
- Follow us on twitter: www.twitter.com/NephroTube
PHARMACOLOGICAL MANAGEMENT OF PERIOPERATIVE ANAEMIA: OUR EXPERIENCE WITH INTRAVENOUS IRON IN ORTHOPAEDIC SURGERY
ISBT CONGRESS 2007
SETS CONGRESO 2007
PATIENT BLOOD MANAGEMENT
Ponencia ISBT-SETS Madrid 2007. IRON INTRAVENOUS AND SURGERY. Muñoz and Garcí...José Antonio García Erce
This document summarizes an experience using intravenous iron in orthopaedic surgery patients. It discusses using IV iron to treat preoperative anemia in both elective and non-elective orthopaedic procedures, such as hip fracture repair. The results showed IV iron reduced transfusion rates and helped optimize hemoglobin levels in the perioperative period. It concludes that IV iron administration may be suggested for patients undergoing orthopedic surgery expected to develop severe postoperative anemia.
This document discusses the management of variceal bleeding, specifically focusing on esophageal and gastric varices. It provides an overview of endoscopic and medical therapies for controlling acute esophageal variceal bleeding such as endoscopic band ligation, sclerotherapy, and pharmacologic therapies like octreotide. For gastric varices, it describes different classification systems and challenges in managing bleeding, noting endoscopic therapies like sclerotherapy, ligation, and glue injection can control acute bleeding but have high rebleeding risks. It emphasizes a multidisciplinary approach is often needed for gastric variceal management.
1) Fluid overload is associated with worse outcomes in patients with acute kidney injury (AKI), including increased mortality and decreased renal recovery. Several studies have shown relationships between greater fluid accumulation and higher risk of death.
2) Fluid balance may also impact renal recovery - more positive fluid balances are linked to less renal recovery in some studies. Restricting fluids appears beneficial for outcomes in some patients.
3) Choice of IV fluid may also influence AKI risk. Hydroxyethyl starches (HES) and liberal albumin administration are associated with higher rates of AKI compared to crystalloids in some studies. Chloride-restrictive IV solutions may reduce AKI compared to chloride-liberal fluids.
This document summarizes research on acute kidney injury (AKI) in critical care. It discusses changing incidence and mortality rates of AKI over time. It defines AKI and classifies its stages of severity. It also analyzes risk factors for AKI, evaluates the use of crystalloids versus colloids for fluid resuscitation, and discusses prevention and management of AKI.
1) Dr. Claire Higham presented on various endocrinology topics related to oncology, including electrolyte disorders, diabetes complications, immunotherapy toxicities, and bone health issues.
2) The document discussed a case of severe hyponatremia in a patient with small cell lung cancer, likely caused by SIADH. SIADH is the most common cause of hyponatremia in cancer patients.
3) Management of hyponatremia in cancer patients can be challenging given the non-transient nature of SIADH. Tolvaptan may be preferable to other options as it is more effective for cancer-related SIADH.
Bleeding and coagulation in cirrhosis.pptxShivPathak11
This document summarizes key points about coagulation in patients with cirrhosis. Some of the main points covered include:
- Cirrhosis represents a state of delicately balanced hemostasis rather than an auto-anticoagulated state as previously thought.
- Conventional coagulation tests like PT/INR do not accurately predict bleeding risk in cirrhosis as they do not account for the complex balance between pro- and anti-coagulant factors.
- Viscoelastic tests (VETs) like thromboelastography (TEG) and thromboelastometry (ROTEM) provide more useful information about hemostasis in cirrhosis compared to conventional tests
This document provides an overview of gastrointestinal bleeding, including:
- Clinical presentation and definitions of upper and lower GI bleeding
- Core principles of assessment, stabilization, determining bleeding source, stopping active bleeding, and treatment/prevention
- Risk stratification based on vital signs and estimated blood loss
- Differential diagnosis and management of acute upper GI bleeding including endoscopic findings, therapies, and outcomes
- Risk factors, scoring systems, and definitions used in gastrointestinal bleeding management
This document provides information on Budd-Chiari syndrome (BCS), including its definition, epidemiology, etiology, clinical features, diagnosis, pathophysiology, management, and role of medical and minimally invasive treatments. BCS is defined as obstruction of the hepatic veins or inferior vena cava, causing hepatic venous outflow obstruction. Common causes include infections, malignancies, and prothrombotic disorders. Clinical features include abdominal pain, ascites, hepatomegaly, and jaundice. Diagnosis involves imaging like ultrasound, CT, MRI and angiography. Management depends on the cause and includes anticoagulation, thrombolysis, angioplasty, stenting, TIPS, and
This document provides an overview of gastrointestinal bleeding, including:
- Clinical presentation and definitions of upper and lower GI bleeding
- Core principles of assessment, stabilization, determining bleeding source, stopping active bleeding, and treatment/prevention
- Risk stratification scoring systems like Blatchford and Rockall scores
- Differential diagnosis and management of acute upper GI bleeding from sources like peptic ulcers, varices, and Mallory-Weiss tears
- Endoscopic findings, therapies, and outcomes for peptic ulcer bleeding
- Management of variceal bleeding with band ligation or TIPS procedures
- Guidelines for antibiotic prophylaxis and management of ulcer bleeding from professional organizations
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This presentation discusses the latest evidence for blood transfusion triggers in the intensive care unit of various clinical condition including severe sepsis, GI bleed, post surgical cases, and post cardiac surgery among other cnditions
This document provides definitions and diagnostic criteria for acute kidney injury (AKI) according to the Acute Kidney Injury Network and RIFLE criteria. It discusses causes of AKI including prerenal azotemia, intrinsic renal disease, and postrenal obstruction. It also reviews biomarkers for early AKI detection and outcomes associated with AKI. Treatment is largely supportive though some promising pharmacologic approaches are discussed.
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Rrt in icu dr said khamis zagazig april 2018 latestFarragBahbah
The document provides an overview of renal replacement therapy (RRT) modalities for critically ill patients with acute kidney injury (AKI). It discusses the history and evolution of RRT, including intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT). The pros and cons of IHD and CRRT are presented. Key considerations for RRT include which modality to use, anticoagulation options, dialysate buffers, and membranes. Guidelines for determining therapy dose and duration and criteria for discontinuing RRT are summarized. Outcomes with IHD versus CRRT remain unclear due to limitations of existing studies. Overall, the document reviews best practices for delivering RRT to critically ill AK
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2. 2
Role of preoperative anemia evaluation and
correction in surgery?
• Much of the variability in transfusion need
for a given surgery lies with patient
variables and not with surgical variables.
• When performed by an experienced
surgeon, a given type of surgery will result
in similar blood loss for most patients,
despite significant differences in patient
blood volume or starting hematocrit.
Palmer T, Anesth Analg 2003;96:369 –75
3. • Aim of the study:
to analyse the clinical factors that would be useful in
predicting patients who would require blood transfusion.
• Evaluated parameters were:
age, gender, body weight, operation, pre-op Hb, actual
blood loss, postop Hb level, whether a patient developed
symptoms of anaemia (e.g. shortness of breath, dizziness or
weakness), whether transfusion was administered and, if so,
the number of units transfused.
• There were no autologous donations.
4
4. 5
• The univariate analysis revealed a significant
relationship between postoperative blood Tx and
pre-op Hb levels (P=0.001), weight (P= 0.019)
and age (P=0.018) and not gender (P=0.47).
• However, multivariate analysis identified a
significant relationship only between the need for
transfusion and the pre-op Hb (P=0.0001) with
weight (P=0.169) and age (P=0.058) being
discounted as significant factors
5. Univariate analysis
relationship between Tx and
•Preop Hb (p = 0.0001)
•Duration of surgery (p= 0.0001)
•Weight (p= 0.002),
•Height (p = 0.019),
•Gender (p=0.0056).
Multivariate analysis
relationship only between TX and
•Preop Hb (p = 0.0001)
•Weight (p = 0.011);
7
% Pts transfused
• Hb < 13 g = 69%
• Hb 13-15g = 36%
• Hb > 15 g = 13%
J Bone Joint Surg Am 2002; 84-A: 216–20
6. 8
Anemie preoperatorie: Valutazione e
trattamento
Definition
According to WHO:
• Hb < 13 g/dL in men
• Hg < 12 g/dL in women
7. 9
Anemie preoperatorie: Valutazione e
trattamento
Prevalence
In general population (NHANES study in US):
– Overall: 4.4 – 5.9% of general population
– Age > 65: 11% of men and 10.2% of women
In surgical patients
– 5% -75% of elective surgical Pts (Goodnough
et al 2005)
– 24% of elective orthopedic pts in Belgium
(Van Linden et al, TATM 2010)
– 35% of elective orthopedic pts in US audit
(Wilson A, 2004)
8. 10
PPrreeooppeerraattiivvee AAnneemmiiaa
Distribution of baseline Hct orthopedic surgical patients operated at
Gaetano Pini Orthopedic Institute in 1997
Baseline Hct
N° pts 20.5% -
29.9 %
30% -
33.9%
34% -
39.9%
40% -
55.9%
Total 2183 6.% 12% 46% 36%
Female 1522 6.5% 13.3% 54.6% 25.6%
Male 661 4.5% 7.5% 27% 61%
Arthrosis 1298 1.5% 5.5% 48% 45%
Reumat . Art hrit . 82 7% 18% 52% 23%
Cancer 103 14% 6% 38% 32%
Sepsis 57 14% 28% 30% 8%
Other 643 9.5% 17.5% 42% 31%
Mercuriali F, Inghilleri G, Biffi E. Int J Artif Organs 2000; 23: 221-31
9. 11
EEvvaalluuaattiioonn ooff AAnneemmiiaa
The evaluation of the anemic preoperative patient should
always begin with a thorough history and physical exam.
History
– Symptoms of bleeding (menstrual blood loss,
hematochezia or melena, hematemesis, hemoptosys,
hematuria)
– Symptoms of underlying illness (malignancy,
renal failure, endocrinopathies [thyroid disorders],
infections, liver disease)
– Past history (prev Hb values and therapies,
splenectomy, trasnsfusions, blood donation)
– Social history (occupational hazards, dietary
habits, alchol and illicid drug use)
10. 12
EEvvaalluuaattiioonn ooff AAnneemmiiaa
The evaluation of the anemic preoperative patient should
always begin with a thorough history and physical exam.
Physical examination
Focus on manifestations and potential etiology of
anemia:
– Pallor of the skin
– Jaundice
– Signs of bleeding,
– Purpura,
– Petechiae
– Hepatosplenomegaly,
– Lymphadenopathy
– Pelvic and rectal examination may need to be
performed to evaluate sources of blood loss
11. 13
EEvvaalluuaattiioonn ooff AAnneemmiiaa
Diagnostic evaluation
Initial laboratory testing
– Complete blood count
– Reticulocyte count
– Peripheral blood smear
Additional exams (selected on the basis of initial testing
results, history and physical examination)
– Iron metabolism parameters (serum ferritin, serum iron,
transferrin saturation)
– Vit B12, Folate
– CPR
– Fecal occult blood test
– Endoscopic testing
– Renal, Liver, thyroid function parameters
– Bone marrow biopsy
– DAT, Aptoglobulin, Abnormal Hb.
12. 14
Patel MS, Carson JL. Anemia in the preoperative
patient.
Anestesiology Clin 2009; 27: 751-60
13. 16
Iron deficiency anemia (IDA)
• IDA is the most common nutritional deficiency
around the globe
• > 30% of anemia due to iron deficiency
Diagnosis
Serum Ferritin < 30 ng / dL *
Serum iron < 40 - 60 μg / dL
Transferrin saturation < 15 - 20%
* Concomitant evaluation of CPR has been suggested to
identify falsely elevated ferritin value secondary to
concurrent inflammation (Yang et al Am J Clin Nutr. 2008; 87:1892)
14. 17
Iron deficiency anemia (IDA)
Further parameters
• Soluble transferrin receptors (sTfR)
– Reflects erythropoiesis. Not affected by inflammation. Advantage
over Ferritin not fully demonstrated
• Ratio between sTfR and Ferritin (sTfR-F ratio)
– Helpful in evaluating IDA in patients with anemia of chronic
inflammation
• Zinc protoporphyrin/heme ratio (ZPP/H)
– Reliable in reflecting the bone marrow iron status. Lacks ability
to distinguish between ACD and IDA
• Reticulocyte hemoglobin content
– Early indicator of the response to iron therapy
16. Iron deficiency without anemia
Potential role of MCV as a screening marker to detect ID conditions in
20
blood donors and surgical patients (evaluated donors n° = 2301)
MCV value
< 80 < 84 <86
N° of cases 63
(2,7%)
227
(9.8%)
467
(20%)
Mean Ferritin value 32+47 48+60 62+77
Median ferritin val. 13 24 37
N° of cases with
Ferritin <30 ng/mL
50
(79%)
132
(58%)
211
(45%)
Data from Niguarda Hospital and AVIS Comunale Milano - 2006
17. 21
Iron deficiency anemia (IDA)
Treatment
• Oral iron support
– Iron is most easily given in the oral form.
– The least expensive form is ferrous sulfate.
– Provide 65mg of iron per 325 mg tablet.
– Dose: in adult 150-200 mg of elemental iron per day.
– Better absorption in acidic gastric env (+ Ascorbic Ac
avoid antacid.
– Reticulocytosis in 7-10 days.
– Increase of Hb by 1 g/dL every 2-3 weeks.
– Helicobacter Pylori infection and chronic gastritis limit
the efficacy
18. 22
Best Practice & Reserch Clinical Haematology 2005;18: 319-332
19. 23
Chertow GM, et al.
Update on adverse drug events
associated with parenteral iron.
Nephrol Dial Transplant (2006) 21: 378–382
Life threatening events x million doses
Ferro
Saccarato
Ferro
Glucon.
Ferro
destrano
20. Trattamento della carenza marziale
Esperienza Gaetano Pini
Risultati ottenuti in Pz sideropenici con basso Hct trattati con Fe IV
24
Pz valutati 1186
Pz trattati con Fe IV 52 (4.4%)
Età (anni) 44±15
Ferritina Basale 24.2±17
Sideremia 62.4±24
MCV 82±8.5
Hct basale 36.2±2
Fe somministrato (mg) 898±428
Hct dopo terapia 38.9±2.7
Produzione di RBC (mL) 157±87
21. 25
Iron
deficiency
anemia
(IDA)
Treatment
• Underlying cause
must be treated;
• Recommendations
for unexplained IDA
include endoscopy
22. 26
G. Inghilleri
Anemia of chronic disease
immune driven
a)Impaired proliferation
of erythroid progenitors
cells;
b)Blunted erythropoietin
response
c)Disregulation of iron
homeostasis;
23. 27
Clinical conditions
associated with ACD
• Heart failure
J Am Coll Cardiol 2008;52:501–11
• Critically ill patients
Transf Med Rev 2006; 20:27-33
• Ageing
Blood Rev 2001; 15(1): 9-18
• Major joint arthrosis
Br J Anesth 2007; 99:801-8
26. 30
EErryytthhrrooppooiieettiicc SSttiimmuullaattiinngg AAggeennttss
Eritropoietin (EPO)
• Acts synergistically with IL-3 and GM-CSF
to expand the BFU-E compartment
• Stimulates proliferation, maturation, and
hemoglobin formation by committed
erythroid progenitors (CFU-E)
• Stimulates the early release of
reticulocytes from marrow into the
circulation
• Inhibit apoptosis
27. 31
rHuEPO in surgery
The response to treatment is not
dependent on patient age or gender, but
on the administered rHuEPO dose and the
availability of essential nutrients, such as
iron (the use of IV iron may allow for a
reduction of total rHuEPO dose), folate or
vitamin B12.
Approximately Hb increases by 1-2 g/dL
per week of treatment with 200U-600U/Kg
of rHuEPO
28. 32
rHuEPO in surgery
Perioperative rHuEPO administration is
indicated for patients scheduled for elective
orthopaedic surgery where moderateto-high
blood loss is expected when their Hb is
> 100 g/l and < 130 g/l.
Two prospective RCTs (896 patients) and
one case–control study (770 patients) found
that preoperative rHuEPO administration
significantly reduced ABT rate (AOR 0·63;
95% CI 0·21–0·49)
29. 33
Study 1
• Indication for PABD was based
on comparison of each patient’s
RBC reserve with mean
estimated perioperative RBC
loss:
• PABD indicated if RBC reserve
was < 800 mL (THA) or <1000
mL (TKA), Hct > 33%, life
expectancy of 10 yr, no medical
contraindication, and consent of
the patient.
• 2 AB units were collected
preop.
Study 2
• EPO instead of PABD when
Hct <37%, life expectancy > 10
yrs
• 3 weekly SC doses of 600
UI/kg .
• Oral ferrous sulfate 320 mg
daily in association with EPO.
• No PABD in case of baseline
Hct > 39%. PABD only in Pts
with baseline hct between
37%-39%. Triggers for any
transfusion (autologous or
allogeneic) were identical
31. rHuEPO in surgery
rHuEPO 300 UI/Kg For 10 days For 4 days
rHuEPO 40.000UI
or 600 UI/Kg
35
Preoperative use of rHuEPO: EEaacchh aarrrrooww iinnddiiccaatteess SSCC
rrHHuuEEPPOO pplluuss IIVV iirroonn iinnffuussiioonn
week -3 -2 -1 0 (surgery) +1
week -3 -2 -1 0 (surgery) +1
32. Methods
• Application of a restrictive TT (Hb < 8 g/dl)
• Perioperative administration of IV iron sucrose (3 x 200 mg/48
h) (group 1, n=115).
• Some Pts received preop rHuEPO (40 000 IU sc) on
admission (group 2, n=81).
Results
• Significant differences in periop ABT (60% vs. 42%, for
groups 1 and 2, respectively; P=0.013).
• Postoperative Hb on postop days 7 and 30 was higher in
group 2 than in group 1.
• Administration of rHuEPO did not increase postop
complications or 30-day mortality rate.
36
Vox Sanguinis (2009) 97, 260–267
33. 37
rHuEPO in surgery
Safety
The FDA has recently stated that the use of
ESAs may increase the risk for thrombotic
events in the peri-surgical setting
Jerkins JK. 2007 Erythropoiesis stimulating agents
http://www.fda.gov/ola/2007/esa062607.htlm
However, this occurred mostly in pts with
preoperative Hb > 13 g/dl
34. 38
6
5
4
3
2
1
0
rHuEPO in surgery
IIrroonn SSuupppplleemmeennttaattiioonn
Oral vs IV iron in rHuEPO treatment
Placebo rHuEPO 300IU/kg rHuEPO 600IU/kg
N° of predeposited units
Oral Iron
IV iron
700
600
500
400
300
200
100
0
Placebo rHuEPO 300IU/kg rHuEPO 600IU/kg
mL of RBCcollected
Oral Iron
IV iron
Mercuriali F, Zanella A, Barosi G, et al Use of erythropoietin to increase the volume
of autologous blood donated by orthopedic patients. Transfusion 1993; 33: 55-60
35. Detection, evaluation and management of
preoperative anemia. NATA Guidelines (2010)
• We recommend that elective surgical
patients have an Hb level determination as
close to 28 day before the scheduled
surgical procedure as possible;
• We suggest that patient’s target Hb before
elective surgery be within the normal
range (female 12 g/dL; male 13 g/dL)
according to WHO criteria
Goodnough LT, Earnshaw P, Maniatis A. NATA Guidelines Working Group
TATM 2010; 11 (suppl 2): 10-11
39
36. Detection, evaluation and management of
preoperative anemia. NATA Guidelines (2010)
• We recommend that laboratory testing be
performed to further evaluate anemia for
nutritional deficiencies, chronic renal
insufficiency, and/or chronic inflammatory
disease;
• We recommend that nutritional deficiencies be
treated;
• We suggest that ESA be used for anemic patient
in whom nutritional deficiencies have been ruled
out and/or corrected
Goodnough LT, Earnshaw P, Maniatis A. NATA Guidelines Working Group
TATM 2010; 11 (suppl 2): 10-11
40