All of Us Research Program—Protocol v1.12
IRB Approval Date: 23 October 2019
Protocol Title All of Us Research Program 1
Principal Investigator(s) Joshua Denny, M.D., M.S.
Vanderbilt University Medical Center
+1 615 936-5033
Sponsor National Institutes of Health (NIH)
Primary Contact John Wilbanks
Sage Bionetworks
+1 617 838-6333
Protocol Version Core Protocol v.1.12 pre02
Date 16 October 2019
IRB reference AoU IRB Protocol # 2017-05
IRB Approval date v1.5: May 20, 2017
v1.6: Feb 13, 2018
v1.7: Mar 28, 2018
v1.8: Jul 11, 2018
v1.9 Oct 19, 2018
v1.10 Mar 05, 2019
v1.11 Aug 12, 2019
v1.12 Oct 23, 2019
1 Precision Medicine Initiative, PMI, All of Us, the All of Us logo, and “The Future of Health Begins
with You” are service marks of the U.S. Department of Health and Human Services.
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
2
Program Leadership and Governance
Leadership
The All of Us Research Program (AoURP) is a large collaborative initiative sponsored by the
National Institutes of Health (NIH). The research program functions as a consortium of awardees
from multiple institutions. Its governance involves representation from each awardee and
participant representatives. The consortium also includes the program director and project
scientists/specialists from NIH. Each awardee has responsibilities commensurate with expertise. See
Table 0–1: Program Unit Awardees for a list of NIH-funded awardees and contact Principal
Investigators (PIs).
Dr. Joshua Denny of Vanderbilt University Medical Center serves as the Principal Investigator on
behalf of the consortium.
Governance
The Steering Committee (SC) is the primary governing body of AoURP. The SC recommends
strategic directions for the program and oversees planning, coordination, and implementation of the
program’s overall operations. Its 50 voting members include PIs from each awardee as designated
in the notice of award; representation from NIH, comprising of the deputy director and chief
officers of AoURP; representation from community partners and participants (see section 3.1); and
additional representation as needed to ensure balanced representation of stakeholders. The
governance also includes an Executive Committee (EC) which is a small governing body composed
of 17 members, that ensures the program is effectively meeting its objectives and mission. The EC
proposes solutions to challenges and provides the Director with strategies, options, and information
to aid in programmatic decisions. The Director has discretion to delegate specific decisions to the
EC. Membership of the EC is determined by the Director and reflects the awardees within the
consortium with balanced interests to ensure effective deliberation.
The Steering Committee may appr.
The Philippine Council for Health Research and Development.docxJamaicaSalvador
The Philippine Council for Health Research and Development (PCHRD)
- is one of the three sectoral councils of the Department of Science and Technology (DOST).
- It is a forward-looking, partnership-based national body responsible for coordinating and monitoring research activities in the country.
- was created on March 17, 1982 through Executive order No. 784. In 1987, Executive Order No. 128 reaffirmed its existence and relevance. This directive reorganized the National Science and Technology Authority into what is now the Department of Science and Technology.
The Philippine Council for Health Research and Development.docxJamaicaSalvador
The Philippine Council for Health Research and Development (PCHRD)
- is one of the three sectoral councils of the Department of Science and Technology (DOST).
- It is a forward-looking, partnership-based national body responsible for coordinating and monitoring research activities in the country.
- was created on March 17, 1982 through Executive order No. 784. In 1987, Executive Order No. 128 reaffirmed its existence and relevance. This directive reorganized the National Science and Technology Authority into what is now the Department of Science and Technology.
The Patient Centered Primary Care Collaborative has been working for years to build evidence and knowledge about how to improve healthcare by providing a medical "home" for each of us - a place where all our records reside, where the staff know us, etc. This April 2010 by Executive Director Edwina Rogers shows the phenomenal range of results they've produced.
Public Financial Management, Health Governance, and Health SystemsHFG Project
While the importance of governance in a health system is well recognized, there is an overall lack of evidence and understanding of the dynamics of how improved governance can influence health system performance and health outcomes. There is still considerable debate on which governance interventions are appropriate for different contexts. This lack of evidence can result in avoidance of health governance efforts or an over-reliance on a limited set of governance interventions. As development partners and governments are increasing their emphasis on improving accountability and transparency of health systems and strengthening country policies and institutions to move towards universal health coverage (UHC), the need of this evidence is ever rising.
To address this evidence gap, the USAID’s Office of Health Systems (USAID/GH/OHS), the World Health Organization (WHO), and the Health Finance and Governance (HFG) Project launched an initiative in September 2016 to ‘Marshall the Evidence’ on how governance contributes to health system performance and improves health outcomes.
The overall objective of the initiative was to increase awareness and understanding of the evidence of what works and why in how governance contributes to health system performance, and how the field of health governance is evolving at the country level. This report provides a synthesis of the findings across the four themes. This report presents the findings of the Public Financial Management.
Better Health? Composite Evidence from Four Literature ReviewsHFG Project
The Marshaling the Evidence secretariat agreed that a cross-cutting synthesis paper was necessary to frame the work in the wider context of governance in health systems, drawing distinctions and consensus across all four TWG papers. Members of the secretariat, some of whom also were members of the TWGs, conducted the analysis across each TWG report and wrote the synthesis report. The report compiles results from the TWGs into a searchable database, contained in Annex 1. The report also lays the foundation for future action—from dissemination to further research agendas and policy plans.
Indian Council of Medical Research (ICMR).pptxSamikshaHamane
Introduction
Objective
Organisation structure
Roles & responsibilities of ICMR
Intramural research & Extramural research
General principles
Ethical Review Procedures
Composition
Training & regulation
Eysenbach AMIA Keynote: From Patient Needs to Personal Health ApplicationsGunther Eysenbach
AMIA Spring Conference, May 29th-31st, 2008, Phoenix/AZ. PHR Track Keynote covers: An international perspective on the importance of PHR/PHA development & research; patient needs (and other drivers of Personal Health Records); Emerging technological trends, with an emphasis on what Eysenbach calls PHR 2.0 – impact of Web 2.0 approaches e.g. to reduce attrition in ehealth applications
Eysenbach: Personal Health Applications and Personal Health RecordsGunther Eysenbach
Keynote talk at the AMIA Spring Conference in the PHR track (Personal Health Records), focussing on international develoments and a new paradigm which I call PHR 2.0
Allison Rogers
Professor Koenig
COMM 3313
October 12th, 2018
How My Race Has Impacted My Life
I. Introduction
a. How being white has affected my life in many ways
i. Positive factors from experience
ii. Negative factors from experience
iii. How this has impacted my communication
iv. Are my communication skills stronger or weaker from these experiences?
II. Positive factors from experience
a. Job market is more available to me
a. Opportunities come in simpler form to me
III. Negative factors from experience
a. Assumptions of me being white thinking my life is a breeze from others
b. The unfairness I see every day makes me feel guilty for being white
IV. How this has impacted my very own communication
a. I see things from a general point of view
b. I try my best to be personal when communicating.
c. I remember that we are all human beings who deserve equality.
V. Are my communication skills stronger or weaker?
a. Stronger – My experiences growing up have helped me communicate with everyone equally.
VI. Conclusion
a. The boundaries my race sets me in
b. The opportunities I have because of my race.
Works Cited
Orbe, M. P., & Harris, T. M. (2015). Interracial communication theory into practice. Los Angeles, CA: Sage.
https://www.psychologytoday.com/us/blog/listen/201803/being-white-in-age-color
https://www.tolerance.org/magazine/fall-2018/what-is-white-privilege-really
https://money.cnn.com/2016/04/13/media/whiteness-project/index.html
https://everydayfeminism.com/2015/11/lessons-white-privilege-poc/
https://www.bustle.com/articles/146867-how-white-privilege-affects-8-people-of-color-on-a-day-to-day-basis
Allison Rogers
Professor Koenig
COMM 3325
October 20th, 2018
Research Paper Conceptual Document:
“The Meaning of July Fourth for the Negro” by Frederick Douglas
1. What is the event or rhetorical moment I will be analyzing and why. Give a brief summary.
· I will be analyzing a speech by Fredrick Douglas that he gave on July 5th in 1852 called, “The Meaning of July Fourth for the Negro”. I chose this speech because I first read this speech this past spring semester in my gender studies class and it was so well written and worded that it literally just brought me to tears with so much emotion behind it. I want to analyze how Douglas put this together and his rhetorical process that he used in order to touch so many people with his words.
2. What methods of evaluation will I be looking for?
· The methods of evaluation I will be looking for in this speech are the following:
(I) The speech objective
(II) The audience and context of the speech
(III) The speeches context and structure
(IV) The delivery skills and techniques he used
(V) Intangibles
3. 8 sources:
· https://www.artofmanliness.com/the-meaning-of-july-fourth-for-the-negro-by-frederick-douglas/
· http://masshumanities.org/files/programs/douglass/speech_abridged_med.pdf
· http://redandgreen.org/speech.htm
· https://www.pbs.org/wgbh/aia/part4/4h2927.html
· https://liber.
Allen 1Kiah AllenProfessor HirschENG1018 Feb. 2018Defo.docxsimonlbentley59018
Allen 1
Kiah Allen
Professor Hirsch
ENG101
8 Feb. 2018
Deforestation
The Amazon forest alone creates 20% of the worlds oxygen. It has decreased by 17% in the past 50 years because of deforestation (conserve-energy-future.com). Forest’s in general only cover 30% of the world (conserve-energy-future.com ). Deforestation is killing the trees that produce oxygen, without it humans can’t survive. Deforestation should be prohibited because large plants such as trees recycle air.
If deforestation is such a problem, why does it happen? Deforestation extracts the forest of its resources. It turns the forests into farms, ranches, or urban areas. The wood from trees are used for building or could be sold as fuel. Another big cause of deforestation is quarry’s. Quarry’s take up a lot of land, and once the quarry is abandoned is almost impossible to fix. Hydropower requires dams to be built. Dams create an enormous amount of flooding, which kills thousands of trees. The increase of population is also a cause of deforestation. The more people that are on earth the more land and resources we demand.
If deforestation continues it will have a huge negative impact on our air supply. Everyday a piece of the forests is being destroyed. The more trees that are being destroyed the less oxygen can be produced. Trees use photosynthesis to covert carbon dioxide into oxygen. Photosynthesis is the main producer of oxygen, and respiration and decay remove it. Urban areas have less oxygen then rural areas, because they don’t have many plants. Throughout history oxygen levels have been steadily decreasing. Once the oxygen levels hit 7% the air is too low to support human life (thenaturalhealthplace.com). Finding ways to apply reforestation would help increase oxygen.
There are many ways to apply reforestation to reverse the harm that’s been don’t to the world. One way is to plant trees. There are some cities who have made vertical forests. They plant trees and plants that surround the building. Going paperless would help as well. Since technology has advanced, paper isn’t really needed as often. Recycling and buying recycled products will help as well. The more that people recycle there will be less demand for natural resources and trees. Reforestation will help to reduce the concentration of carbon dioxide in the air.
Deforestation does have a huge negative impact on our world, but there are quite of bit of positive too. The positive effects of deforestation are that it does gives humans space to grow. With growth comes civilizations which means more jobs and revenue. Deforestations also gives us more food and resources to satisfy our needs. It means a more comfortable life for humans. The consequences of deforestation is not worth the temporary comfort that humans get from it.
Deforestation is a serious problem to maintain life on this planet. The decrease in oxygen could eventually mean the end to human kind. If we don’t do anything abo.
More Related Content
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The Patient Centered Primary Care Collaborative has been working for years to build evidence and knowledge about how to improve healthcare by providing a medical "home" for each of us - a place where all our records reside, where the staff know us, etc. This April 2010 by Executive Director Edwina Rogers shows the phenomenal range of results they've produced.
Public Financial Management, Health Governance, and Health SystemsHFG Project
While the importance of governance in a health system is well recognized, there is an overall lack of evidence and understanding of the dynamics of how improved governance can influence health system performance and health outcomes. There is still considerable debate on which governance interventions are appropriate for different contexts. This lack of evidence can result in avoidance of health governance efforts or an over-reliance on a limited set of governance interventions. As development partners and governments are increasing their emphasis on improving accountability and transparency of health systems and strengthening country policies and institutions to move towards universal health coverage (UHC), the need of this evidence is ever rising.
To address this evidence gap, the USAID’s Office of Health Systems (USAID/GH/OHS), the World Health Organization (WHO), and the Health Finance and Governance (HFG) Project launched an initiative in September 2016 to ‘Marshall the Evidence’ on how governance contributes to health system performance and improves health outcomes.
The overall objective of the initiative was to increase awareness and understanding of the evidence of what works and why in how governance contributes to health system performance, and how the field of health governance is evolving at the country level. This report provides a synthesis of the findings across the four themes. This report presents the findings of the Public Financial Management.
Better Health? Composite Evidence from Four Literature ReviewsHFG Project
The Marshaling the Evidence secretariat agreed that a cross-cutting synthesis paper was necessary to frame the work in the wider context of governance in health systems, drawing distinctions and consensus across all four TWG papers. Members of the secretariat, some of whom also were members of the TWGs, conducted the analysis across each TWG report and wrote the synthesis report. The report compiles results from the TWGs into a searchable database, contained in Annex 1. The report also lays the foundation for future action—from dissemination to further research agendas and policy plans.
Indian Council of Medical Research (ICMR).pptxSamikshaHamane
Introduction
Objective
Organisation structure
Roles & responsibilities of ICMR
Intramural research & Extramural research
General principles
Ethical Review Procedures
Composition
Training & regulation
Eysenbach AMIA Keynote: From Patient Needs to Personal Health ApplicationsGunther Eysenbach
AMIA Spring Conference, May 29th-31st, 2008, Phoenix/AZ. PHR Track Keynote covers: An international perspective on the importance of PHR/PHA development & research; patient needs (and other drivers of Personal Health Records); Emerging technological trends, with an emphasis on what Eysenbach calls PHR 2.0 – impact of Web 2.0 approaches e.g. to reduce attrition in ehealth applications
Eysenbach: Personal Health Applications and Personal Health RecordsGunther Eysenbach
Keynote talk at the AMIA Spring Conference in the PHR track (Personal Health Records), focussing on international develoments and a new paradigm which I call PHR 2.0
Allison Rogers
Professor Koenig
COMM 3313
October 12th, 2018
How My Race Has Impacted My Life
I. Introduction
a. How being white has affected my life in many ways
i. Positive factors from experience
ii. Negative factors from experience
iii. How this has impacted my communication
iv. Are my communication skills stronger or weaker from these experiences?
II. Positive factors from experience
a. Job market is more available to me
a. Opportunities come in simpler form to me
III. Negative factors from experience
a. Assumptions of me being white thinking my life is a breeze from others
b. The unfairness I see every day makes me feel guilty for being white
IV. How this has impacted my very own communication
a. I see things from a general point of view
b. I try my best to be personal when communicating.
c. I remember that we are all human beings who deserve equality.
V. Are my communication skills stronger or weaker?
a. Stronger – My experiences growing up have helped me communicate with everyone equally.
VI. Conclusion
a. The boundaries my race sets me in
b. The opportunities I have because of my race.
Works Cited
Orbe, M. P., & Harris, T. M. (2015). Interracial communication theory into practice. Los Angeles, CA: Sage.
https://www.psychologytoday.com/us/blog/listen/201803/being-white-in-age-color
https://www.tolerance.org/magazine/fall-2018/what-is-white-privilege-really
https://money.cnn.com/2016/04/13/media/whiteness-project/index.html
https://everydayfeminism.com/2015/11/lessons-white-privilege-poc/
https://www.bustle.com/articles/146867-how-white-privilege-affects-8-people-of-color-on-a-day-to-day-basis
Allison Rogers
Professor Koenig
COMM 3325
October 20th, 2018
Research Paper Conceptual Document:
“The Meaning of July Fourth for the Negro” by Frederick Douglas
1. What is the event or rhetorical moment I will be analyzing and why. Give a brief summary.
· I will be analyzing a speech by Fredrick Douglas that he gave on July 5th in 1852 called, “The Meaning of July Fourth for the Negro”. I chose this speech because I first read this speech this past spring semester in my gender studies class and it was so well written and worded that it literally just brought me to tears with so much emotion behind it. I want to analyze how Douglas put this together and his rhetorical process that he used in order to touch so many people with his words.
2. What methods of evaluation will I be looking for?
· The methods of evaluation I will be looking for in this speech are the following:
(I) The speech objective
(II) The audience and context of the speech
(III) The speeches context and structure
(IV) The delivery skills and techniques he used
(V) Intangibles
3. 8 sources:
· https://www.artofmanliness.com/the-meaning-of-july-fourth-for-the-negro-by-frederick-douglas/
· http://masshumanities.org/files/programs/douglass/speech_abridged_med.pdf
· http://redandgreen.org/speech.htm
· https://www.pbs.org/wgbh/aia/part4/4h2927.html
· https://liber.
Allen 1Kiah AllenProfessor HirschENG1018 Feb. 2018Defo.docxsimonlbentley59018
Allen 1
Kiah Allen
Professor Hirsch
ENG101
8 Feb. 2018
Deforestation
The Amazon forest alone creates 20% of the worlds oxygen. It has decreased by 17% in the past 50 years because of deforestation (conserve-energy-future.com). Forest’s in general only cover 30% of the world (conserve-energy-future.com ). Deforestation is killing the trees that produce oxygen, without it humans can’t survive. Deforestation should be prohibited because large plants such as trees recycle air.
If deforestation is such a problem, why does it happen? Deforestation extracts the forest of its resources. It turns the forests into farms, ranches, or urban areas. The wood from trees are used for building or could be sold as fuel. Another big cause of deforestation is quarry’s. Quarry’s take up a lot of land, and once the quarry is abandoned is almost impossible to fix. Hydropower requires dams to be built. Dams create an enormous amount of flooding, which kills thousands of trees. The increase of population is also a cause of deforestation. The more people that are on earth the more land and resources we demand.
If deforestation continues it will have a huge negative impact on our air supply. Everyday a piece of the forests is being destroyed. The more trees that are being destroyed the less oxygen can be produced. Trees use photosynthesis to covert carbon dioxide into oxygen. Photosynthesis is the main producer of oxygen, and respiration and decay remove it. Urban areas have less oxygen then rural areas, because they don’t have many plants. Throughout history oxygen levels have been steadily decreasing. Once the oxygen levels hit 7% the air is too low to support human life (thenaturalhealthplace.com). Finding ways to apply reforestation would help increase oxygen.
There are many ways to apply reforestation to reverse the harm that’s been don’t to the world. One way is to plant trees. There are some cities who have made vertical forests. They plant trees and plants that surround the building. Going paperless would help as well. Since technology has advanced, paper isn’t really needed as often. Recycling and buying recycled products will help as well. The more that people recycle there will be less demand for natural resources and trees. Reforestation will help to reduce the concentration of carbon dioxide in the air.
Deforestation does have a huge negative impact on our world, but there are quite of bit of positive too. The positive effects of deforestation are that it does gives humans space to grow. With growth comes civilizations which means more jobs and revenue. Deforestations also gives us more food and resources to satisfy our needs. It means a more comfortable life for humans. The consequences of deforestation is not worth the temporary comfort that humans get from it.
Deforestation is a serious problem to maintain life on this planet. The decrease in oxygen could eventually mean the end to human kind. If we don’t do anything abo.
All workings, when appropriate, must be shown to substantiate your.docxsimonlbentley59018
All workings, when appropriate, must be shown to substantiate your answers.
Question 1 [14 marks]
Financial statement disclosures
You are the financial accountant for Superstore Ltd, and are in the process of preparing its financial statements for the year ended 30 June 2018. Whilst preparing the financial statements, you become aware of the following situations:
1. On 1 July 2017, the directors made a decision, using information obtained over the last couple of years, to revise the useful life of an item of manufacturing equipment. The equipment was acquired on 1 July 2015 for $800,000, and has been depreciated on a straight-line basis, based on an estimated useful life of 10 years and residual value of nil. Superstore Ltd uses the cost model for manufacturing equipment. The directors estimate that as at 1 July 2017, the equipment has a remaining useful life of 6 years and a residual value of nil. No depreciation has been recorded as yet for the year ended 30 June 2018 as the directors were unsure how to account for the change in the 2018 financial statements, and unsure whether the 2016 and 2017 financial statements will need to be revised as a result of the change.
2. In June 2018, the accounts payable officer discovered that an invoice for repairs to equipment, with an amount due of $20,000, incurred in June 2017, had not been paid or provided for in the 2017 financial statements. The invoice was paid on 12 July 2018. The repairs are deductible for tax purposes. The accountant responsible for preparing the company’s income tax returns will amend the 2017 tax return, and the company will receive a tax refund of $6,000 as a result (30% x $20,000). No journal entries have been done as yet in the accounting records of Superstore Ltd, as the directors are unsure how to account for this situation, and what period adjustments need to be made in.
3. Superstore Ltd holds shares in a listed public company, ABC Ltd, which are valued in the draft financial statements on 30 June 2018 at their market value on that date - $600,000. A major fall in the stock market occurred on 10 July 2018, and the value of Superstore’s shares in ABC Ltd declined to $250,000.
4. On 21 July 2018, you discovered a cheque dated 20 April 2018 of $32,000 authorised by the company’s previous accountant, Max. The payment was for the purchase of a swimming pool at Max’s house. The payment had been recorded in the accounting system as an advertising expense. You advise the directors of this fraudulent activity, and they will investigate.
Assume that each event is material.
Required:
i) State the appropriate accounting treatment for each situation. Provide explanations and references to relevant paragraphs in the accounting standards to support your answers. Where adjustments to Superstore Ltd’s financial statements are required, explain which financial statements need to be adjusted (ie. 2016, 2017, 2018 or 2019).
ii) Prepare any note disclosures and adjusting j.
All yellow highlight is missing answer, please answer all of t.docxsimonlbentley59018
All yellow highlight is missing answer, please answer all of the questions in detail. *** Please redo question#4 and answer them relate to the questions.
Thank you
Anna in the Tropics
Literature has the power to affect even the humblest of lives. Anna in the Tropics
presents the story of a family of Cuban cigar rollers whose lives in the 1920s Florida are
brightened up and disturbed at the same time by a stranger, a lector, who reads aloud about
the passions of Tolstoy and his heroine Anna Karenina. It is common practice for employees
at the factory run by this Cuban family to be entertained by as they carry out the mundane
chores at hand – those of rolling of cigars and sorting tobacco leaves. But as those in the
factory begin to get caught up in Tolstoy’s classic, willingly or not, the book begins to work
subtle and profound changes in their emotional lives. This essay will analyze the themes
covered in Anna in the Tropics, even as it seeks to explore the various ways in which the
play’s characters are affected as the lector reads to them – along with their fellow workers, to
educate and stimulate their minds in the course of the doldrums of their repetitive tasks.
One of the very first things to note in this story is how certain tensions between old
traditions and new ways are reflected. The factory workers, for instance, are threatened by
new, mechanical cigar rolling machines because they themselves roll cigars by hand, which is
the traditional way (Cruz 19). It is not just the workers whose future is uncertain, however.
Even the very tradition of the lector, who reads out loud to the cigar rollers so that any tedium
in the factory may be broken, while at the same time facilitating the ease of passing time, is at
risk (Cruz 8). Since listening to the lector is often the closest thing to a formal education that
cigar-rollers might experience, the ending of this tradition, in particular, could signify the
demise of an informal method of learning (Aiello).
The significance of the lector is not only about giving factory workers some
semblance of an informal education, however, but it is also reflective of the theme of Cuban
heritage that is present throughout the play. The Cuban culture and traditions comprise a key
theme because first, the play is set within the Cuban American community which is living in
Ybor City in Tampa, Florida (Cruz 2). Second, it is apparent that Cuban Americans prefer to
stay within their own cultural community whenever they can help it, which explains how they
have been able to keep their old traditions. Their cigar-rolling factory, for instance, is not run
in the same fashion that American companies are, what with a lector being availed to
entertain the workers – as demanded by Cuban traditions (Cruz 9). The characters in this
story are defined and destroyed against the standard of Cuban heritage.
As the play begins, the previous lector has jus.
All models are wrong. Some models are useful.—George E. P. B.docxsimonlbentley59018
All models are wrong. Some models are useful.
—George E. P. Box (1919–2013)
Statistician
Describing and explaining social phenomena is a complex task. Box’s quote speaks to the point that it is a near impossible undertaking to fully explain such systems—physical or social—using a set of models. Yet even though these models contain some error, the models nevertheless assist with illuminating how the world works and advancing social change.
The competent quantitative researcher understands the balance between making statements related to theoretical understanding of relationships and recognizing that our social systems are of such complexity that we will always have some error. The key, for the rigorous researcher, is recognizing and mitigating the error as much as possible.
As a graduate student and consumer of research, you must recognize the error that might be present within your research and the research of others.
To prepare for this Discussion:
Use the Walden Library Course Guide and Assignment Help found in this week’s Learning Resources to search for and select a quantitative article that interests you and that has social change implications.
As you read the article, reflect on George Box’s quote in the introduction for this Discussion.
For additional support, review the
Skill Builder: Independent and Dependent Variables
, which you can find by navigating back to your Blackboard Course Home Page. From there, locate the Skill Builder link in the left navigation pane.
By Day 3
Post a very brief description (1–3 sentences) of the article you found and address the following:
1. Describe how you think the research in the article is useful (e.g., what population is it helping? What problem is it solving?).
2. Using Y=
f
(X) +E notation, identify the independent and dependent variables.
3. How might the research models presented be wrong? What types of error might be present in the reported research?
Frankfort-Nachmias, C., & Leon-Guerrero, A. (2018).
Social statistics for a diverse society
(8th ed.). Thousand Oaks, CA: Sage Publications.
· Chapter 1, “The What and the Why of Statistics” (pp. 1–21)
Wagner, W. E. (2016).
Using IBM® SPSS® statistics for research methods and social science statistics
(6th ed.). Thousand Oaks, CA: Sage Publications.
· Chapter 1, “Overview”
Dietz, T., & Kalof, L. (2009).
Introduction to social statistics: The logic of statistical reasoning
. West Sussex, United Kingdom: Wiley-Blackwell.
Introduction to Social Statistics: The Logic of Statistical Reasoning, 1st Edition by Dietz, T.; Kalof, L. Copyright 2009 by John Wiley & Sons - Books. Reprinted by permission of John Wiley & Sons - Books via the Copyright Clearance Center.
·
Chapter 1, “An Introduction to Quantitative Analysis” (pp. 1–31)
Dietz, T., & Kalof, L. (2009).
Introduction to social statistics: The logic of statistical reasoning
. West Sussex, United Kingdom: Wiley-Blackwell.
Introdu.
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Class Tetris5044ObjectApplicationTetris5044public class Tetris5044
extends Application
The main application class; for internal use only.
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For internal use only.
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getHostServices, getParameters, getUserAgentStylesheet, init, launch, launch, notifyPreloader, setUserAgentStylesheet, stopMethods inherited from class Object
clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, waitConstructor DetailTetris5044public Tetris5044()Method Detailstartpublic void start(Stage primaryStage)
throws Exception
For internal use only.
Specified by:start in class ApplicationParameters:primaryStage - for internal use only.Throws:Exception - for internal use only.mainpublic static void main(String[] args)
For internal use only.
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ALL WORK MUST BE ORIGINAL, CITED, IN APA FORMAT & WILL BE SUBMITTED .docxsimonlbentley59018
ALL WORK MUST BE ORIGINAL, CITED, IN APA FORMAT & WILL BE SUBMITTED TO TURN-IT-IN. THIS IS A DISCUSSION POST. DUE DATE IS SUNDAY, 06/21/22 @ 2PM EASTERN STANDARD TIME.
Discussion Question #2:
If you had the authority, what steps would you take to secure America's digital infrastructure?
.
ALL WORK MUST BE ORIGINAL, CITED IN APA FORMAT AND WILL BE SUBMITTED.docxsimonlbentley59018
ALL WORK MUST BE ORIGINAL, CITED IN APA FORMAT AND WILL BE SUBMITTED TO TURN IT IN. MINIMUM WORD COUNT IS 1500 NOT INCLUDING THE TITLE PAGE. DUE DATE IS MONDAY 06/22/20 @ 12 NOON EASTERN STANDARD TIME.
Assignment:
1. The first sentence of Chapter 2 reads, “The saying that ‘people receive the kind of policing they deserve” ignores the role power plays in the kind, quality, and distribution of police service.” Discuss what this sentence means in the context of contemporary policing in the United States.
2. Beginning in 1929, August Vollmer, as head of the National Commission on Law Observance and Enforcement, established 10 principles vital in reforming the police. Discuss the importance of the principles in providing the underpinnings for modern policing.
3. Explain how technology has affected communities of interest in the United States.
4. Explain the contributions of the Chicago School in studies of the community.
.
All Wet! Legacy of Juniper Utility has residents stewingBy Eri.docxsimonlbentley59018
All Wet!
Legacy of Juniper Utility has residents stewing
By Erin Foote Marlowe
·
·
Last Friday, a collection of men and women sat in Marion Palmateer's plush Southeast Bend living room and told a story of frustration, talking over one another and becoming increasingly angry about their understanding of the legacy of Juniper Utility and what it means to them.
These folks who gathered on Palmateer's soft white couch and chairs consider themselves the modern-day victims in the more- than-a-decade-old saga of Juniper Utility Co., a water service provider formerly owned by housing developer Jan Ward in Southeast Bend. In 2002, it was condemned by Bend for what the city said was risk of catastrophic failure.
Money and "authority" are at the core of the story now for this group, as opposed to the low water pressures of a decade ago—a problem that became so egregious that, by 2001, it became a challenge to take a shower or fill a washing machine. Water lines routinely broke down.
The people in Palmateer's living room, "a loose collection of individuals," as they call themselves, are residents of neighborhoods formerly served by Juniper Utility, including Timber Ridge, Mountain High, Tillicum Village and Nottingham Square. They are frustrated with a history they felt they had no control over but is now costing them in water bills they believe will cost them thousands more per year than they ever expected.
In 2004, homeowners association representatives from their neighborhoods signed an agreement with the city that said the owners of the roughly 700 homes of the neighborhoods would pay 100 percent of the costs associated with providing water to the neighborhoods, including making improvements to the system.
But this group of residents feels the agreement wasn't in their best interest and they had no say in the decision. An HOA board member at the time said a ballot was not sent out to homeowners for approval and, because there was no vote of homeowners, these frustrated residents believe this 2004 agreement could be illegal. Further underscoring the issue, it appears the agreement was never recorded with the county clerk's office. So, when these new people bought houses in these neighborhoods, the tab for paying to upgrade the water system didn't show up in their title searches.
"Think of the banks that lent against it," said Dan Kehoe, a resident of Mountain High who has taken a lead role in challenging the agreements between the HOAs and the city. "That's called bank fraud and people go to jail for it."
But although frustrations over this agreement are evidently fresh for these residents, it would appear that the issue should be moot because in 2011 the HOAs and the city reached a new agreement—one that should reduce costs for residents.
"We moved them from a bad agreement to a good agreement," said city of Bend Finance Director Sonia Andrews. "From something that would cost them a lot to something that would be more reasonable."
Each homeowne.
All three of the Aristotle, Hobbes, and Douglass readings discussed .docxsimonlbentley59018
All three of the Aristotle, Hobbes, and Douglass readings discussed power in different ways. How is power related to justice? How should it be shifted in order to better serve all citizens? Please reflect on this idea of power and refer to at least two of the three philosophers listed.
Note: You should write enough to make your point, but can aim form 6-8 sentences or so (but there is no minimum or limit).
.
All rights reserved. No part of this report, including t.docxsimonlbentley59018
All rights reserved. No part of this report, including
the trends presented in this report, may be
reproduced or transmitted in any form or by any
means whatsoever (including presentations, short
summaries, blog posts, printed magazines, use
of images in social media posts) without express
written permission from the author, except in the
case of brief quotations (50 words maximum and
for a maximum of 2 quotations) embodied in critical
articles and reviews, and with clear reference to
the original source, including a link to the original
source at http://eventmb.com/Event-Trends-2018.
Please refer all pertinent questions to the publisher.
COPYRIGHT
TABLE OF
CONTENTS
:: 2 COPYRIGHT
5 INTRODUCTION
7 MACRO TRENDS AFFECTING THE EVENT INDUSTRY. A FORECAST.
8 10 Trends in EVENTTECH
Julius Solaris
23 10 Trends in VENUES
Pádraic Gilligan
35 10 Trends in EVENT MARKETING AND SOCIAL MEDIA
Becki Cross
54 10 Trends in DESTINATIONS
Julius Solaris and Pádraic Gilligan
65 10 Trends in EVENT EXPERIENCE
Roger Haskett
80 10 Trends in EVENT DECOR AND STYLING
Kate Patay, CPCE
91 10 Trends in DESTINATION MANAGEMENT COMPANIES (DMCS)
Cindy Y. Lo, DMCP
102 ABOUT THE AUTHORS
105 CMP CREDITS
105 CREDITS AND THANKS
105 DISCLAIMER
AD
http://eventmb.com/2A6WKga
The event industry is navigating through the strongest wave of change of
the past 10 years. Never before has this industry experienced this level
of transformation in so many aspects of the event planning process.
Attendees, suppliers and event planners have to deal with ‘new’ and
‘different’ on many levels.
As a segue from last year’s report, we are again looking at the five major
areas impacted by this change:
G TECHNOLOGY
G EVENT MARKETING
G VENUES
G DESTINATIONS
G EVENT DESIGN
We are also looking at two new categories of trends:
G EVENT STYLING
G DESTINATION MANAGEMENT COMPANIES
(DMCS)
The spend for these items represent a massive input for the industry and we
feel times are mature enough to analyze developments on a yearly basis.
:: INTRODUCTION
10 EVENT
TRENDS FOR
2018
Julius Solaris
10 Event Trends for 2018
:: 5
AD
http://eventmb.com/2iVmZfW
MACRO TRENDS AFFECTING THE
EVENT INDUSTRY. A FORECAST.
There are common themes you will find in the following categories of
trends. We refer to these as macro trends. They are inherent to the
economic, political, social and technological developments happening
around us. Here are the most significant affecting the event industry:
G Sexual Harassment. With the explosion worldwide of the #metoo
movement and the very public charges against many celebrities,
politicians and people of influence, it seems it is finally time for the event
industry to reflect on sexual harassment. Many reports have popped up
of events being at the ideal stage for harassment or violence to happen.
As a result there is increased pressure to step up the measures to protect
attendees against perpetrators. A mo.
All PrinciplesEvidence on Persuasion Principles This provides som.docxsimonlbentley59018
All PrinciplesEvidence on Persuasion Principles: This provides some guidance how much confidence you can place on the principles Analyzed by J. Scott Armstrong on December 8, 2010; re-analyzed by Elliot Tusk on May 26, 2011Common senseReceived wisdomNo evidenceExpert opinionNon-experimental evidenceSingle experimentSome experimental evidenceMuch experimental evidenceCommentsSUMNumberPrinciple1INFORMATION1.1Benefits1.1.1Describe specific, meaningful benefits111.1.2Communicate a Unique Selling Principle (USP)1111.2News1.2.1Provide news, but only if it is real111.2.2If real news is complex, use still media11.3Product or service1.3.1Provide product information that customers need11.3.2Provide choices11.3.3When there are many substantive, multi-dimensional options, organize them and provide guidance11.3.4Make the recommended choice the default choice11.3.5Inform committed customers that they can delete features, rather than add them11.3.6To reduce customer risk, use a product-satisfaction guarantee11.4Price1.4.1State prices in terms that are meaningful and easy to understand111.4.2Use round prices111.4.3Show the price to be a good value against a reference price11.4.4If quality is not a key selling point, consider advertising price reductions11.4.5Consider partitioned prices when the add-on prices seem fair and small relative to the base price11.4.6To retain customers, consider linking payments to consumption11.4.7Consider separating payments from benefits- if the payments are completed before the benefits end11.4.8State that the price can be prepaid if it might reduce uncertainty for consumers111.4.9Use high costs to justify high prices11.4.10When quality is high, do not emphasize price11.4.11Use high prices to connote high quality111.4.12For inexpensive products, state price discounts as percentage saved; for expensive products, state price discounts as dollars saved- or present both11.4.13Minimize price information for new products11.4.14Consider bundling prices of features or complementary products or services if they are desirable for nearly all customers11.4.15Advertise multi-unit purchases for frequently purchased low-involvement products if it is also in the consumers' interest11.5Distribution1.5.1Include information on when, where and how to buy the product111.5.2Feature a sales channel when it is impressive11.5.3Use the package to enhance the product11.5.4If a product is desirable, specify delivery dates rather than waiting times11.5.5Tell customers they can achieve benefits over a long time period if you want to reduce the use of an offer- and vice versa12INFLUENCE2.1Reasons2.1.1Provide a reason12.1.2For high-involvement products, the reasons should be strong12.2Social Proof2.2.1Show that the product is widely used12.2.2Focus on individuals similar to the target market112.3Scarcity2.3.1State that an attractive product is scarce when it is true12.3.2Restrict sales of the product112.4Attribution2.4.1Attribute favorable behavior and traits.
All papers may be subject to submission for textual similarity revie.docxsimonlbentley59018
All papers may be subject to submission for textual similarity review to Turnitin.com for the detection of plagiarism
those are the two quistions
What are the disadvantages of Henrietta in particular and her colleagues, pursuing careers in astronomy during this time period? Choose one scene and describe how character relationships and the outcome of the play would change if the central characters were male instead of female.
--
I don't have the book , i need someone who can have it and answer the two questions
silent sky by lauren gunderson
answer 2 questions in 4 pages double space
.
All of us live near some major industry. Describe the history of an .docxsimonlbentley59018
All of us live near some major industry. Describe the history of an industry in the city you live in or a nearby city.
How has the industry changed over the last fifty years?
What cultural changes have occurred to drive those changes?
What do you see as the future of industry in the city?
.
All participants must read the following article ATTACHED Agwu.docxsimonlbentley59018
All participants must read the following article: ATTACHED
* Agwu, E. & Ohaegbu, V.A. (2015). Strategic management of the benefits and challenges of HR outsourcing in effective organizational management. Journal of Business Studies Quarterly, 7, 2, 85-108. Retrieved from http://jbsq.org/wp-content/uploads/2015/12/December_2015_6.pdf
Participants will be assigned to groups.
Within each group, members will assume the role of a VP of Human Resources. In this role, list both the organizational opportunities and challenges of utilizing some level of outsourcing of at least 2 HR processes.
* Your list should include a minimum of three (3) opportunities and challenges for each process, especially as they pertain to driving enterprise goals, and organizational culture.
* Provide supporting statements from the article, our texts and other readings/resources, for your positions.
Reporting and Valuation for
Undergraduates
1
Below is a 2-part question. Please create a word document and/or spreadsheet to answer the following
prompts. Upload your response according to the directions.
Part I: Reporting and Financial Statement Analysis
1. Given the following income statements, calculate the estimated cash flow for years 20x1 and 20x2.
2. Given the following income statements, calculate the interest coverage (time interest earned) ratio
for years 20x1 and 20x2.
3. Given the following income statements, calculate the net profit margin ratio for years 20x1 and
20x2.
Income Statement for years 20x1 and 20x2
20x1 20x2
Sales $5,450 $5,000
Operating Costs excluding Depreciation and Amortization 4,775 4,250
EBITDA 675 750
Depreciation and Amortization 40 180
EBIT $635 $570
Interest Expense 62 200
EBT $573 $370
Taxes (40%) 229 148
NI $344 $222
4. Based solely on the following balance sheets, calculate the current ratio for years 20x1 and 20x2?
5. Based solely on the following balance sheets, calculate the debt ratio for years 20x1 and 20x2.
Balance Sheet ending December 31 for years 20x1 and 20x2
20x1 20x2
Assets:
Cash $275 $250
Short Term Investments 55 50
Accounts Receivable 375 250
Inventories 825 750
Total Current Assets $1,530 $1,300
Net Plant and Equipment 2,925 2,750
Total Assets $4,455 $4,050
Liabilities:
Notes Payable $192 $100
Accounts Payable 580 100
Miscellaneous Payables 245 250
Total Current Liabilities $1,017 $450
Long-Term Debt 550 500
Total Liabilities $1,567 $950
Reporting and Valuation for
Undergraduates
2
Common Stock 2154 2,600
Retained Earnings 734 500
Less Treasury Stock 46 0
Total Shareholder Equity $2,888 $3,100
Liabilities and Shareholder Equity $4,455 $4,050
6. Based on both the income statements and balance sheets, calculate the return on assets (return on
investment) ratios for years 20x1 and 20x2.
7. Based on both the income statements and balance sheets, calculate the total asset turnover ratio
for years 20x1 and 20x2. .
ALL of the requirements are contained in the attached document. T.docxsimonlbentley59018
ALL
of the requirements are contained in the attached document. The Veronica case study is attached also.
To prepare:
Review "Working With Survivors of Human Trafficking: The Case of Veronica." Think about how one might become an ally to victims of human trafficking . Then go to a website that addresses human trafficking either internationally or domestically.
Post
a brief description of the website you visited (Websites contained below). Explain how you might support Veronica and other human trafficking victims incorporating the information you have found. Explain how you can begin to increase your awareness of this issue and teach others about human trafficking victims. Describe opportunities to get involved and become an ally to those who have been trafficked. Identify steps you can take to begin to support this group.
.
All five honorees cared greatly about the success of Capella lea.docxsimonlbentley59018
All five honorees cared greatly about the success of Capella learners and most were heavily involved in bettering their communities and others. Dr. Ford in particular fulfilled this desire by helping others to help themselves. Describe how you plan to use your education to better your community or help others to help themselves, and how receiving this scholarship will help you in doing so? 250-750 word essay
All of our honorees brought great personal and professional successes to their work environment. What would you consider one of your greatest professional successes? How did your success benefit your organization and its people? 250- 750 word essay
Respond to Tawnya and Noeme post
Creating the ideal marketing plan requires many steps and gathering data. “Knowing the needs of the customer and having a clearly articulated mission will help to target the message to an audience who will be most interested in the service that is being provided” (Sciarra, Lynch, Adams, & Dorsey (2016) p. 340). To find these needs, a needs assessment can be done. After gathering the results, a plan can start to form. Creating a Strength, Weakness, Opportunities, and Threats chart (SWOT) will give you a broader view on how to target your population.
“The first step in conducting SWOT analysis is to identify your stakeholders and data that has already been collected” (Sciarra, (2016) p. 340). Your stakeholders will guide you into the right direction for a plan of action. Looking at the type of population including the children, families, and staff members will give you the data to create your SWOT. Moving forward with the data, now to breakdown your SWOT data analysis and create a marketing plan. Strengths; reviewing this section will give you an objective overview of any changes needing to be made. Strengths can consist of staff, location, cliental, and possibly opportunities. If there are areas of weakness this gives us the ability to make changes. Moving forward with those changes leads us to Weakness, do we see a pattern of areas? What can we do to upgrade or change these areas we have identified? Moving on next to Opportunities, what options do we have beyond what we have now? Is there room for growth both financially and structurally? Finally, Threats to evaluate. Are we looking at opening a facility next door to two other highly rated centers that may cause us competition and difficulty building a successful business? Is there a possibility that the area is losing population and economic strength? Gathering the data and taking a step back and reviewing all the pro’s and con’s will give us a bigger picture when deciding which way to market our audience.
Taking a look at the strengths from all the gathered data will give you a good direction to follow for reaching protentional public relations opportunities. For an example, location, your childcare facility has a prime location in your town and your coming up on your grand opening soon. Planning an.
All of the instructions will be given to you in a document. One docu.docxsimonlbentley59018
All of the instructions will be given to you in a document. One document is the guidelines and the other is a sample to help guide you (and to make it a little more easier). For the background information summary, the section titled Significant assessment findings during days of care can be placed in a table. Also the medications can be placed in a table as well. I will also attach a NANDA Nursing Diagnosis to help for the "Risk for".
.
All financial statement audits will include an audit of the inve.docxsimonlbentley59018
All financial statement audits will include an audit of the inventory cycle. You should plan for the audit by setting the audit objectives. For this assignment, write and submit 300–400 words that set specific internal controls that should be included to meet the following management assertions:
Existence
Completeness
Accuracy or valuation
Rights and obligations
Presentation and disclosure
.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
All of Us Research Program—Protocol v1.12 IRB Approval Dat.docx
1. All of Us Research Program—Protocol v1.12
IRB Approval Date: 23 October 2019
Protocol Title All of Us Research Program 1
Principal Investigator(s) Joshua Denny, M.D., M.S.
Vanderbilt University Medical Center
+1 615 936-5033
Sponsor National Institutes of Health (NIH)
Primary Contact John Wilbanks
Sage Bionetworks
+1 617 838-6333
Protocol Version Core Protocol v.1.12 pre02
Date 16 October 2019
IRB reference AoU IRB Protocol # 2017-05
IRB Approval date v1.5: May 20, 2017
v1.6: Feb 13, 2018
v1.7: Mar 28, 2018
v1.8: Jul 11, 2018
v1.9 Oct 19, 2018
v1.10 Mar 05, 2019
2. v1.11 Aug 12, 2019
v1.12 Oct 23, 2019
1 Precision Medicine Initiative, PMI, All of Us, the All of Us
logo, and “The Future of Health Begins
with You” are service marks of the U.S. Department of Health
and Human Services.
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
2
Program Leadership and Governance
Leadership
The All of Us Research Program (AoURP) is a large
collaborative initiative sponsored by the
National Institutes of Health (NIH). The research program
functions as a consortium of awardees
from multiple institutions. Its governance involves
representation from each awardee and
participant representatives. The consortium also includes the
program director and project
scientists/specialists from NIH. Each awardee has
responsibilities commensurate with expertise. See
Table 0–1: Program Unit Awardees for a list of NIH-funded
3. awardees and contact Principal
Investigators (PIs).
Dr. Joshua Denny of Vanderbilt University Medical Center
serves as the Principal Investigator on
behalf of the consortium.
Governance
The Steering Committee (SC) is the primary governing body of
AoURP. The SC recommends
strategic directions for the program and oversees planning,
coordination, and implementation of the
program’s overall operations. Its 50 voting members include PIs
from each awardee as designated
in the notice of award; representation from NIH, comprising of
the deputy director and chief
officers of AoURP; representation from community partners and
participants (see section 3.1); and
additional representation as needed to ensure balanced
representation of stakeholders. The
governance also includes an Executive Committee (EC) which is
a small governing body composed
of 17 members, that ensures the program is effectively meeting
its objectives and mission. The EC
proposes solutions to challenges and provides the Director with
strategies, options, and information
to aid in programmatic decisions. The Director has discretion to
delegate specific decisions to the
EC. Membership of the EC is determined by the Director and
reflects the awardees within the
consortium with balanced interests to ensure effective
deliberation.
The Steering Committee may approve the formation of
additional governance bodies– committees,
4. task forces, boards, etc. – as necessary to fulfill the mission of
AoURP. The purpose of these
additional governance bodies is to alleviate the bandwidth
constraints of the SC and EC by
gathering subject-matter experts from within the consortium to
oversee discussion and develop
policies, recommendations, or guidelines related to their
assigned topic.
Figure 0–1: Governance Structure
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
3
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
4
Table 0–1: Program Unit Awardees
Biobank
Stephen Thibodeau Mayo Clinic
5. Communications Awardees
Ronnie Tepp HCM
Patrick McGovern Wondros
DRC—Data and Research Center
Sekar Kathiresan Broad Institute
Joshua Denny Vanderbilt University Medical Center
David Glazer Verily
HPOs—Health Care Provider Organizations Primary Sites
RMCs—Regional Medical Centers (Contact PIs listed)
David Goldstein New York City Precision Medicine Consortium
Lucila Ohno-Machado California Precision Medicine
Consortium
Christine Johnson Henry Ford Health System
Jordan Smoller New England Precision Medicine Consortium
Philip Greenland Illinois Precision Medicine Consortium
Akinlolu Ojo University of Arizona
Steve Reis University of Pittsburgh
Bruce Korf University of Alabama at Birmingham
Murray Brilliant Marshfield Clinic Research Institute
Stephan Zuchner University of Miami Health System
FQHCs—Federally Qualified Health Centers
Parinda Khatri Cherokee Health Systems
Yashoda Sharma Community Health Center, Inc.
Eric Schlueter Eau Claire Cooperative Health Center
Carmen Chinea HRHCare
Donna Antoine-LaVigne Jackson-Hinds Comprehensive
Health Center
6. Fatima Muñoz San Ysidro Health Center
VAMCs—Veterans Affairs Medical Centers
Christopher J. O’Donnell United States Department of
Veterans Affairs
PTSC—Participant Technology Systems Center
Praduman Jain Vibrent Health
TPC—The Participant Center
Eric Topol Scripps Translational Science Institute
Community Partner Awards
Patricia Watkins Lattimore Delta Research and Educational
Foundation
Edgar Gil Rico National Alliance for Hispanic Health
Mitchell Lunn San Francisco General Hospital Foundation
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
5
Gretchen Funk Fifty Forward
Fornessa T. Randal The Asian Health Coalition
For more information, see
https://allofus.nih.gov/funding/awardees
https://allofus.nih.gov/funding/awardees
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
7. 6
Table of Contents
PROGRAM LEADERSHIP AND GOVERNANCE
...............................................................................................
.. 2
1 BACKGROUND AND SCIENTIFIC RATIONALE
.................................................................................... 11
1.1 PILOT ACTIVITIES
...............................................................................................
.............................................................. 11
2 OBJECTIVES
...............................................................................................
................................................. 14
2.1 WHAT IS THE ALL OF US RESEARCH
PROGRAM?............................................................................
.......................... 14
3 STUDY OVERVIEW
...............................................................................................
..................................... 15
3.1 PARTICIPANTS REPRESENTATIVES
...............................................................................................
............................... 16
3.2 CREATING A RESOURCE FOR RESEARCH
...............................................................................................
...................... 17
3.3 MAKING THE RESOURCE ACCESSIBLE FOR
RESEARCH
............................................................................................
19
3.4 STUDY TIMELINE/STUDY DURATION
8. ...............................................................................................
........................... 20
4 SELECTION OF PARTICIPANTS
...............................................................................................
............... 20
4.1
ELIGIBILITY..........................................................................
...............................................................................................
20
4.2 INCLUSION AND EXCLUSION CRITERIA
...............................................................................................
......................... 21
4.3 VULNERABLE POPULATIONS
...............................................................................................
........................................... 21
5 RECRUITMENT OUTREACH
...............................................................................................
..................... 22
5.1 OUTREACH TO HPO MEMBERS
...............................................................................................
...................................... 23
5.2 OUTREACH TO DIRECT VOLUNTEERS
...............................................................................................
........................... 24
5.3 THE SUPPORT CENTER
...............................................................................................
..................................................... 24
5.4 OUTREACH TO COMMUNITIES
............................................................................... ................
........................................ 25
5.5 MOBILE ENGAGEMENT ASSET
...............................................................................................
........................................ 27
5.6 SUMMARY OF OUTREACH AND ENGAGEMENT
9. APPROACHES
................................................................................ 27
5.7 READABILITY OF OUTREACH AND ENROLLMENT
MATERIALS
............................................................................. 28
6 ENROLLMENT
...............................................................................................
............................................. 29
6.1 ENROLLMENT STRATEGIES
.................................................................................... ...........
.............................................. 29
6.2 LEVELS OF
ENROLLMENT.......................................................................
......................................................................... 29
6.3 ACCOUNT CREATION
...............................................................................................
......................................................... 31
6.4 INFORMATION COLLECTED PRIOR TO INFORMED
CONSENT
................................................................................. 31
6.5 INFORMED CONSENT OVERVIEW
...............................................................................................
................................... 31
6.6 ELECTRONIC CONSENT
...............................................................................................
..................................................... 33
6.7 DATA OVERSIGHT AND CHOICE OF LAW
...............................................................................................
...................... 37
6.8 MONITORING ENROLLMENT
...............................................................................................
........................................... 38
7 WHAT IS INVOLVED? PROGRAM
PROCEDURES........................................................................
10. ........ 41
7.1 PARTICIPANT-PROVIDED INFORMATION (PPI)
...............................................................................................
........ 42
7.2 USE OF PERSONAL HEALTH TECHNOLOGIES
...............................................................................................
.............. 43
7.3 PHYSICAL MEASUREMENTS
...............................................................................................
............................................. 45
7.4 BIOSPECIMEN COLLECTION
...............................................................................................
............................................. 46
7.5 BIOSPECIMEN PROCESSING AND STORAGE
...............................................................................................
................. 48
7.6 ELECTRONIC HEALTH RECORDS (EHRS)
...............................................................................................
.................... 51
7.7 DATA LINKAGE
...............................................................................................
................................................................... 51
7.8 EARLY AND LONG-TERM PARTICIPANT
INVOLVEMENT
......................................................................................... 53
8 RISKS/BENEFITS ASSESSMENT
...............................................................................................
.............. 56
8.1 RISKS
...............................................................................................
..................................................................................... 56
8.2 BENEFITS
.......................................................................................... .....
............................................................................. 58
8.3 RISK/BENEFIT ANALYSIS
11. ...............................................................................................
................................................ 60
9 ISSUES TO CONSIDER
...............................................................................................
................................ 60
9.1 PAYMENT FOR PARTICIPANTS
...............................................................................................
........................................ 60
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
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9.2 HANDLING ON-SITE REPORTABLE EVENTS
...............................................................................................
................ 61
9.3 PARTICIPATION OPTIONS: DEACTIVATE AND
WITHDRAWAL PROCEDURES
..................................................... 62
9.4 DESTRUCTION OF
SPECIMENS...........................................................................
............................................................. 64
10 ACCESS TO INDIVIDUAL-LEVEL INFORMATION FOR
PARTICIPANTS ......................................... 65
10.1 PRINCIPLES OF INDIVIDUAL-LEVEL INFORMATION
AVAILABILITY .....................................................................
65
10.2 INDIVIDUAL-LEVEL PROGRAM INFORMATION
...............................................................................................
........... 65
12. 10.3 INFORMATION ACCESS TECHNOLOGIES
...............................................................................................
....................... 67
10.4 INDIVIDUAL-LEVEL INFORMATION ACCESS
PROCESSES...........................................................................
.............. 68
10.5 PHYSICAL MEASUREMENTS—RETURN OF
MEDICALLY ACTIONABLE
RESULTS.............................................. 70
10.6 PARTICIPANT-PROVIDED INFORMATION AND EHR
...............................................................................................
. 74
10.7 ACCESS TO BIOSPECIMEN-DERIVED INFORMATION
(NON-GENETIC) ................................................................
74
10.8 ACCESS TO GENOMIC RESULTS
...............................................................................................
....................................... 74
11 CREATION OF THE ALL OF US RESEARCH PROGRAM
RESOURCE................................................. 75
11.1 THE RAW DATA REPOSITORY
...............................................................................................
........................................ 75
11.2 THE CURATED DATA REPOSITORY
...............................................................................................
................................ 75
11.3 THE PTSC DATA REPOSITORY
...............................................................................................
....................................... 76
12 ACCESS TO THE RESOURCE FOR RESEARCH
...................................................................................... 77
12.1 ALL OF US DATA ACCESS GOVERNANCE
...............................................................................................
....................... 78
13. 12.2 ACCESS AND USE OF DATA
...............................................................................................
.............................................. 79
12.3 ACCESS AND USE OF BIOSPECIMENS
...............................................................................................
............................. 82
12.4 CONTACTING PARTICIPANTS
...............................................................................................
.......................................... 82
13 CONFIDENTIALITY, PRIVACY, AND SECURITY
.................................................................................. 83
13.1 SECURITY POSTURE
...............................................................................................
........................................................... 84
13.2 FISMA AND ITS SIGNIFICANCE TO THE ALL OF US
RESEARCH PROGRAM .........................................................
84
13.1 OVERVIEW OF PRIVACY AND DATA
CONFIDENTIALITY PROTECTIONS
.............................................................. 87
14 POST-ENROLLMENT ENGAGEMENT STRATEGY
............................................................................... 91
14.1 CONCEPTUAL FRAMEWORK
...............................................................................................
............................................ 92
14.2 APPROACH TO ENGAGEMENT
...............................................................................................
......................................... 93
14.3 RETENTION
...............................................................................................
.......................................................................... 95
15 SITE MONITORING, RECORD KEEPING, AND QUALITY
ASSURANCE ........................................... 98
14. 15.1 HPO AND DV ENROLLMENT SITE MONITORING
...............................................................................................
...... 98
15.2 TRAINING EXPECTATIONS
........................................................................................... ....
................................................ 99
16 REFERENCES
...............................................................................................
............................................. 101
17 LIST OF TERMS AND ACRONYMS
...............................................................................................
......... 103
18 LIST OF APPENDICES
...............................................................................................
.............................. 107
19 PROTOCOL VERSIONS
...............................................................................................
............................. 108
All of Us Research Program—Protocol v1.11 pre02
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Table of Tables
TABLE 0–1: PROGRAM UNIT AWARDEES
...............................................................................................
........................................... 4
TABLE 0–2: PROTOCOL SYNOPSIS
15. ...............................................................................................
......................................................... 9
TABLE 4–1: VULNERABLE POPULATIONS EXCLUDED AT
LAUNCH................................................................................
....... 22
TABLE 7–1: ESTIMATED DURATION OF PARTICIPANT
JOURNEY
.......................................................................................... 41
TABLE 7–2: SURVEY COMPLETION TIMES
...................................................................................... .........
....................................... 43
TABLE 7–3: QUESTIONS TO PARTICIPANTS PRIOR TO
SCHEDULING THE BLOOD SAMPLE COLLECTION ............
47
TABLE 9–1: PARTICIPATION OPTIONS
...............................................................................................
.............................................. 62
TABLE 10–1: MEDICALLY ACTIONABLE FINDINGS AT
THE TIME OF BASELINE PHYSICAL MEASUREMENTS ....
70
TABLE 12–1: DATA ACCESS BY TYPE
...............................................................................................
................................................. 81
TABLE 13–1: THREAT ASSESSMENT
...............................................................................................
.................................................. 88
Table of Figures
FIGURE 0–1: GOVERNANCE STRUCTURE
...............................................................................................
............................................ 2
FIGURE 1–1: PPI DEVELOPMENT PROCEDURE
...............................................................................................
.............................. 12
16. FIGURE 3–1: PARTICIPANT INTERACTION FLOW
............................................................................... ................
......................... 19
FIGURE 6–1: PARTICIPANT JOURNEY
...............................................................................................
................................................ 30
FIGURE 7–1: BIOSPECIMEN FLOWCHART
...............................................................................................
........................................ 49
FIGURE 7–2: DATA WORKFLOW SAMPLE FOR
PARTICIPANTS......................................................................
......................... 54
FIGURE 10–1: ALL OF US RESEARCH PROGRAM
INDIVIDUAL-LEVEL INFORMATION: DATA AND
RESULTS......... 66
FIGURE 10–2: DATA FLOW FOR PARTICIPANTS AND HPO
STAFF
......................................................................................... 68
FIGURE 10–3 EXAMPLE OF PHYSICAL MEASUREMENT
CARD—CO-BRANDED
................................................................ 72
FIGURE 10–4 EXAMPLE OF PHYSICAL MEASUREMENT
CARD—5 X7 FORMAT
................................................................ 73
FIGURE 11–1: CURATED DATASET
...............................................................................................
..................................................... 77
FIGURE 13–1: ALL OF US RESEARCH PROGRAM
CONNECTIONS AND DATA FLOW
........................................................ 84
17. All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
9
Protocol Synopsis
Table 0–2: Protocol Synopsis
TITLE All of Us Research Program (All of Us)
SPONSOR National Institutes of Health (NIH)
FUNDING
ORGANIZATION
National Institutes of Health (NIH)
NUMBER OF SITES Multiple sites through selected Health
Care Provider organizations
(HPOs) and Direct Volunteer (DV) partners, and sites
representing
core functions, such as the Biobank, Data and Research Center
(DRC), Participant Technology Systems Center (PTSC), other
technology partners , and Community Partners.
RATIONALE Precision medicine is an approach to disease
treatment and prevention
that seeks to maximize effectiveness by considering individual
variability in genes, environment, and lifestyle. Precision
medicine
18. seeks to redefine our understanding of disease onset and
progression,
treatment response, and health outcomes through the more
precise
measurement of molecular, environmental, physiologic, and
behavioral factors that contribute to health and disease. This
understanding will lead to more accurate diagnoses, more
rational
disease prevention strategies, better treatment selection, and the
development of novel therapies.
By enrolling a diverse group of one million or more participants
who
provide questionnaire responses—participant-provided
information
(PPI), electronic health record (EHR) data, biospecimens,
physical
measurements, and permission for re-contact—for many years,
the All
of Us Research Program will have the scale and scope to enable
research for a wide range of diseases, both common and rare, as
well
as increasing our understanding of healthy states.
STUDY DESIGN At its core, this is a large longitudinal cohort
program with repeated
engagement of participants to create a research resource that
enables a
variety of future observational and interventional studies, some
of
which will require subsequent IRB approvals.
PRIMARY OBJECTIVE To build a robust research resource
composed of PPI, environmental,
19. physiologic, genetic, and health data plus biospecimens from
one
million or more research participants reflecting the diversity of
the
United States.
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
10
This resource will facilitate the exploration of biological,
social, and
environmental determinants of health and disease.
NUMBER OF
PARTICIPANTS AND
ENROLLMENT
MODES
One million or more individuals willing and able to answer
questionnaires (PPI), provide biospecimens and physical
measurements, share their EHR data, and authorize re-contact
will be
enrolled via two modes, whichever is most convenient for the
participant: through HPOs or DV sites, using digital interfaces.
We
expect that many more than one million individuals may enroll
into
the cohort and complete some of these components (see Section
20. 4,
Selection of Participants).
PARTICIPANT
SELECTION
CRITERIA
Inclusion Criteria:
• Adults 18 and older with decisional capacity to consent
• Currently reside in the United States or a territory of the
United States
Exclusion Criteria:
• Prisoners at the time of enrollment
DURATION OF
PARTICIPATION AND
DURATION OF STUDY
Duration of Study: The All of Us Research Program is expected
to
last at least 10 years, with active enrollment occurring in the
first five
years.
Duration of Participation: Participation is expected to last for
the
entire duration of the research program, with regular data
contribution
and follow-up.
PRIMARY ENDPOINT Collection and curation of rich
21. participant health and biospecimen
data accessible to the research community, to enable a broad
spectrum
of research studies.
SECONDARY
ENDPOINTS
Build the infrastructure to enroll participants, collect
biospecimens,
and securely share health-related data for ongoing research.
SAFETY
EVALUATIONS
Safeguards are in place to maintain the privacy of the
participants, the
confidentiality of the biospecimens, and the security of the data
collected through the research program (see Section 13,
Confidentiality, Privacy, and Security).
All of Us Research Program—Protocol v1.11 pre02
IRB Approval Date
11
1 Background and Scientific Rationale
22. Our current approach to health care is informed by clinical
trials that have sample sizes in the
thousands, or tens of thousands, meaning that we typically lack
the statistical power to make fine-
grained predictions about how a given treatment will affect a
given individual. As a result, therapies
often fail in practice and most interventions fail to integrate
with most patients’ own knowledge and
lifestyles. Historically, this approach is characterized by a lack
of inclusion and diversity in clinical
study; that is, the benefits of precise and personalized
interventions may not be accruing equitably
across society.
Precision medicine is an approach to disease prevention,
diagnosis, and treatment that seeks to
maximize effectiveness by considering individual variability in
genes, environment, and lifestyle.
Precision medicine seeks to redefine our understanding of
disease onset and progression, treatment
response, and health outcomes through the combined analysis of
biological, environmental, and
behavioral factors that contribute to health and disease. This
understanding may lead to more
rational disease prevention strategies, more accurate diagnoses,
better treatment selection, and the
development of novel therapies. The promise of precision
medicine can only be achieved with input
from a broad population that reflects the true diversity and life
experiences of those in the United
States.
By combining health-related information from one million or
more diverse participants, the All of
Us Research Program will have the right scale and inclusive
scope to enable research for a wide
23. range of diseases, both common and rare. A cohort of this size
will have the statistical power to
detect associations between genetic and environmental
exposures and a wide variety of health
outcomes. A deliberately inclusive strategy that prioritizes
groups historically underrepresented in
biomedical research (UBR) should provide enough power for
meaningful subgroup analyses and
lead to the most precise medicine for these groups. Outcomes of
this research could include novel
prevention and screening strategies, earlier and more precise
diagnoses, new and more rational use
of therapies, and improved understanding of why some people
remain healthy despite exposures
and risk factors for disease.
Coincident with advancing the science of medicine is a
changing culture of health care practice and
biomedical research that engages individuals as active partners.
The All of Us Research Program
aims to actively engage participants and their advocates in all
aspects of the research program,
including governance, oversight, design, conduct,
dissemination, and evaluation. Participants will
not only provide their biological, health, behavioral, and
environmental data, they will also be able
to access their information, learn about the research being
conducted, and be partners in the
discovery process. This ongoing partnership between the
research program and participants is
described in Section 14, …
