All maze system with video tracking software is useful to study how drugs affects cellular function in the nervous
system and the way by which they influence the behaviour. This review focusses on Elevated plus maze, Y maze, T
maze, Zero maze, Water maze, Multiple unit open field enclosure, Radial arm maze, Tail suspension unit, Light and
dark unit, Novel object recognision test unit, Conditioned Place Preference unit and Barnes maze, which are used in
the evaluation of neuropharmacological and behavioural studies.
In this slide contains diabetics, classification, symptoms, complication, invivo and invitro screening models of anti diabetics.
Presented by: GEETHANJALI ADAPALA (Department of pharmacology).
RIPER, anantapur
In this slide contains diabetics, classification, symptoms, complication, invivo and invitro screening models of anti diabetics.
Presented by: GEETHANJALI ADAPALA (Department of pharmacology).
RIPER, anantapur
Behavioral phenotyping of mouse models of neurodegeneration Dewan Sumsuzzman
Behavioral phenotyping provides a quantitative marker for human disease symptoms, and a preclinical tool to assess new treatments. Several neurodegenerative animal models have been generated & characterized, during the characterization, behavioral science plays a crucial rule by identifying specific symptom in these animal models of human disorders.
Principles & Methods Of Radial Arm Maze, Y Maze & Plethysmometer.pptxVJInstruments
A Plethysmometer is a valuable piece of equipment used to measure the effectiveness of anti-inflammatory agents that are experimentally induced in rodents. It can also be used to test agents designed to reduce endemic conditions.
Behavioral phenotyping of mouse models of neurodegeneration Dewan Sumsuzzman
Behavioral phenotyping provides a quantitative marker for human disease symptoms, and a preclinical tool to assess new treatments. Several neurodegenerative animal models have been generated & characterized, during the characterization, behavioral science plays a crucial rule by identifying specific symptom in these animal models of human disorders.
Principles & Methods Of Radial Arm Maze, Y Maze & Plethysmometer.pptxVJInstruments
A Plethysmometer is a valuable piece of equipment used to measure the effectiveness of anti-inflammatory agents that are experimentally induced in rodents. It can also be used to test agents designed to reduce endemic conditions.
This file includes the general introduction to Alzheimer's, histopathology and Pharmacological treatment of Alzheimer's, preclinical screening models used in Alzheimer's. I hope this file may useful to life science students
A small display of additional laboratory machinery including a VJ Instruments...VJInstruments
A high rate of spontaneous alternation is indicative of good spatial working memory because it shows the rodent is aware of and able to switch between the two arms. VJ Instruments come up with instruments like fbd fluid bed dryer, double cone blender & ball mill in pharmaceutics.
In this paper, we present a microfluidic method to observe and analyze the physical elements of nematode navigation in real-time. We use microfluidic devices consisting of T-maze or cylindrical structures with varying geometry to study how nematodes make decisions. We found that the angle of the T-maze intersections affects the decision-making of these microscopic, soil-dwelling worms. Additionally, we were able to passively guide nematodes in a linear direction by adjusting the position and spacing of cylindrical obstacles in their path. To test our method, we conducted experiments on two nematode species (C. elegans and Oesophagostomum dentatum) without the use of chemical or electrical stimulants.
SWARM INTELLIGENCE FROM NATURAL TO ARTIFICIAL SYSTEMS: ANT COLONY OPTIMIZATIONFransiskeran
Successful applications coming from biologically inspired algorithm like Ant Colony Optimization (ACO)
based on artificial swarm intelligence which is inspired by the collective behavior of social insects. ACO
has been inspired from natural ants system, their behavior, team coordination, synchronization for the
searching of optimal solution and also maintains information of each ant. At present, ACO has emerged as
a leading metaheuristic technique for the solution of combinatorial optimization problems which can be
used to find shortest path through construction graph. This paper describe about various behavior of ants,
successfully used ACO algorithms, applications and current trends. In recent years, some researchers
have also focused on the application of ACO algorithms to design of wireless communication network,
bioinformatics problem, dynamic problem and multi-objective problem.
This paper explores how the adaptability of Caenorhabditis elegans locomotion behavior can be assessed through a movement-based assay. This assay is set up with a series of sinusoidal microchannels, featuring a fixed wavelength and modulating amplitude. These channels are comparable to the body diameter of the organism, and worms are allowed to travel from the input port to the output port. In regions that closely fit the worms' natural undulations, progress is quick and steady. As the channel amplitude changes along the device, the worm struggles to generate propulsive force, slows down, and eventually is unable to move forward. An array of locomotion parameters (average forward velocity, number and duration of pauses, range of contact angle, and cut-off region) are generated from the recorded videos to measure how the worm moves in the modulated sinusoidal channels. The device is tested on wild-type (N2) and two mutant (lev-8 and unc-38) C. elegans. We suggest that this passive, movement-based assay can be used to differentiate between nematodes with distinct locomotion phenotypes.
Navigating The Water and Y Maze A Comparative Analysis.pdfVJInstruments
The Y maze supplied by VJ Instruments is used in conjunction with other techniques, such as video tracking systems, to gain further insights into the neural mechanisms underlying spatial navigation and memory.
The water maze, also known as the Morris water maze, is a widely used experimental apparatus in neuroscience and behavioral research to study spatial learning and memory in animals. The water maze consists of a large circular pool or tank filled with water (typically opaque or colored) and a singular platform inside the water. The platform serves as the escape goal for the animal. The objective of the water maze is to assess an animal's ability to locate and remember the location of the escape platform.
The Ultimate Guide Over the past few years, the use of Y maze in this industr...VJInstruments
Over the years, the y- maze has been used to study a wide range of topics related to spatial memory and learning.
Researchers have also used the y- maze to investigate the effects of aging, brain damage, and genetic mutations on spatial cognition, as well as the neural and molecular mechanisms underlying spatial memory formation.
Meller et al (2012) Single Unit Firing Rates In Macaque SI (In Review)David
A manuscript describing my recent doctoral work characterizing the cortical representation of cutaneous sensory information. Currently in review for publication
Nematodes are microscopic, soil-dwelling worms that navigate through soil particles in search of food or a suitable host. Most nematode species employ a myriad of physical and chemical cues that define their navigation strategies. Here, we demonstrate a microfluidic method to observe and characterize the physical aspects of nematode navigation at real-time. The microfluidic devices comprise a series of interconnected T-maze or cylindrical structures of varying
geometry. At each physical intersection, nematodes are given the choice to migrate left or right. We found that this decision-making of nematodes is influenced by the angle of intersection of T-maze structures. We further showed that nematodes can be passively directed to move in a linear direction by carefully adjusting the position and spacing of cylindrical obstacles in its path. The experiments were conducted on
two nematodes (non-parasitic C. elegans and pigparasitic Oesophagostomum dentatum) and in the absence of any chemical or electrical stimulants.
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Welcome to Secret Tantric, London’s finest VIP Massage agency. Since we first opened our doors, we have provided the ultimate erotic massage experience to innumerable clients, each one searching for the very best sensual massage in London. We come by this reputation honestly with a dynamic team of the city’s most beautiful masseuses.
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
QA Paediatric dentistry department, Hospital Melaka 2020Azreen Aj
QA study - To improve the 6th monthly recall rate post-comprehensive dental treatment under general anaesthesia in paediatric dentistry department, Hospital Melaka
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)