Safety Man and Machine Presentation June-2019 Rev-1
Every Year a significant number of people get injured and killed by accidents involving vehicles in the workplace
Safety Man and Machine Presentation June-2019 Rev-1
Every Year a significant number of people get injured and killed by accidents involving vehicles in the workplace
FAIRSpectra - Towards a common data file format for SIMS imagesAlex Henderson
Presentation from the 101st IUVSTA Workshop on High performance SIMS instrumentation and machine learning / artificial intelligence methods for complex data.
This presentation describes the issues relating to storing and sharing data from Secondary Ion Mass Spectrometry experiments, and some potential solutions.
We present you a part of our Tampere University's team - FHAIVE!
Besides producing excellent science, they are in charge or coordinating this project as well Tampere University, Faculty of Medicine and Health Technology.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
FAIRSpectra - Towards a common data file format for SIMS imagesAlex Henderson
Presentation from the 101st IUVSTA Workshop on High performance SIMS instrumentation and machine learning / artificial intelligence methods for complex data.
This presentation describes the issues relating to storing and sharing data from Secondary Ion Mass Spectrometry experiments, and some potential solutions.
We present you a part of our Tampere University's team - FHAIVE!
Besides producing excellent science, they are in charge or coordinating this project as well Tampere University, Faculty of Medicine and Health Technology.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TES...Sérgio Sacani
We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a
bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the
lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors
42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations
with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory,
as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of
12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent
future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar
compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool
stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. Agricultural Machinery
You cannot beat horse power….
• Some of you love your tractors…..
• Farm lads used to love their horses!!!!
https://youtu.be/mwv8xY9qYfo?list=PLw7fy_uxP-
o_74N0EcEMHFCfULwqmRTZo
3. Agricultural Machinery
Much fitter than you…
• Horse lads used to plough how
many acres a day?
• And how far did they walk in a
day to do this?
• 1 acre a day
• Walked …..
4. Agricultural Machinery
1. Which horsepower is most
dangerous?
Today’s learning –
• Identify risks and dangers of agricultural machinery.
• List the main H&S rules that apply to your job.
5. Agricultural Machinery
Are horses more or less dangerous than tractors?
• What would the dangers be of ploughing with a horse?
• Kicked
• Bitten
• Foot trod on
• Foot run over by plough
• Slip fall
7. Agricultural Machinery
SPOT THE HAZZARDS! (BEFORE IT’S TO
LATE!)
• There are many possible hazards associated with machinery.
• Many of these are made more dangerous by the sheer power of
modern machinery.
• Can you point the hazards on the following
8. Agricultural Machinery
Tractor S______ E_____
R______ p____
M_____ p_____
H____ p______
E_______
P______
O______ h____
Sharp Edges
Rotating parts
Moving parts
High pressure
Electrical Parts
Other hazards
9. Agricultural Machinery
The main areas / focus of hazards
• Moving Parts
• High Pressure
• Sharp Edges
• Rotating Parts
• Electrical Parts
• Other Hazards
M
H
S
R
E
O
To remember these, make up
your own word or sentence
Richard of York Gain Battle In
Vain
Colours of the rainbow
Red, Orange, Yellow, Green,
Blue, Indigo, Violet
15. Agricultural Machinery
Learning to look for dangers…..
• If you think along lines of these areas for each machine / situation it
will help you identify the risks…
• And write risk assessments…..
16. Agricultural Machinery
1) Sharp edges –
• On machines that chop or cut
materials like mowers, chainsaws,
bale and straw choppers – can
cause major cuts and injuries.
17. Agricultural Machinery
2) Rotating parts –
• In particular power take-off shafts
on tractors which can trap clothes,
hair or arms at a wind-in rate of 1.5
metres per second, but also other
rotating parts on machines like
potato harvesters and augers.
19. Agricultural Machinery
3) Moving parts –
• Conveyors, drive belts and
pulleys can trap hands and
arms while hydraulic arms or
trailer bodies can fall and trap
people.
20. Agricultural Machinery
4) High pressure –
• A jet of hydraulic oil or diesel fuel from a split pipe can cause major
damage to internal organs if injected into the body.
https://youtu.be/ClBXQ1dNYww
22. Agricultural Machinery
6) Other hazards –
• Such as exhaust fumes, noise
(which can cause hearing
damage) and whole body
vibration can damage limbs or
internal organs.
23. Agricultural Machinery
Some rules on tractors on roads…
• ‘Tractor’ (or a ‘category f tractor’) is defined in EU Regulation 167/2013.
• Covers vehicles that a layman would think of as a tractor, being a motor vehicle
designed to ‘pull, push, carry and actuate’ equipment to perform agricultural or
forestry work.
• Telescopic handlers (telehandlers) can also be type approved as tractors – the
operator can check his specific machine by referring to the manufacturer’s
information.
• Other telehandlers, along with combine harvesters, crop sprayers and
other agricultural machines fall into the wider definition of ‘agricultural
motor vehicles’.
• The weight limit for agricultural tractor and trailer combinations is 31
tonnes.
• The trailer itself is limited to 18.29 tonnes (including any load imposed on the tractor
through the hitch).
24. Agricultural Machinery
Telehandler etc weight limits
• A category B licence also allows the holder to drive other vehicles
which are registered as agricultural machines on the road.
• These include vehicles such as sprayers and telehandlers.
• However, there are age restrictions on the maximum vehicle weights
that can be driven by younger drivers:
• Agricultural vehicles up to 3.5 tonnes – minimum age 17
• Agricultural vehicles 3.5 tonnes to 7.5 tonnes – minimum age 18
• Agricultural vehicles over 7.5 tonne – minimum age 21
25. Agricultural Machinery
Rules of the road….
• List of ages and
what you can
do…
• 13 = drive on
farm
• 16 – take tractor
test
• 17?
• 18?
• 21?
Mark.Thompson@Askham-Bryan.ac.uk
Age What can you do /drive Limitations
13 It is illegal for children under the age of 13 years to either drive or ride on any all
agricultural machines including tractors, combines, sprayers, telehandlers and ATVs.
16 Take your tractor test (category F ) to
drive on the road
Restricted to driving an agricultural tractor
with a maximum width of 2.45m.
This width restriction applies to both the tractor and the trailer
with either a single axle or close coupled double axle.
17 Passed Car Test
Drive agricultural tractor on road subject
to same limitations as everyone else
Agricultural vehicles (combines, other
harvesters, sprayers, telehandlers) up to 3.5
tonnes – minimum age 17
18 Passed car test Agricultural vehicles 3.5 tonnes to 7.5 tonnes –
minimum age 18
21 Passed Car test Agricultural vehicles over 7.5 tonne –
minimum age 21
Category H – tracked vehicles
Tracked vehicles steered by their tracks are in a separate H
category. There is no automatic entitlement to drive vehicles in
category H linked to the B category
26. Agricultural Machinery
Provisional Licences
• Driving on provisional licences should only be for training purposes. Any
requirement to drive a vehicle for business purposes should be done on a
full licence only.
• Any person who is assisting an individual with the training of a vehicle
should be at least 21 years old or over, hold the relevant licence and be
experienced with the vehicle or machine which they supervising on.
• Vehicles under categories B1 (Light vehicles and Quadbikes), F (tractor), G
(road roller), H (track steered vehicle) and K (mowing machines and
pedestrian controlled vehicles) are not always designed to carry
passengers, meaning that learner drivers or operators are not required to
be supervised by an appropriately trained individual.
• Sufficient training on the vehicles or machines under these categories
should be carried out off-road before practicing on the public highway.
27. Agricultural Machinery
ATVs
• Training It is a legal requirement for
employers to provide adequate
training for employees who use
work equipment such as ATVs, and
to make sure that only employees
who have received appropriate
training in their safe use, including
the use of any towed equipment or
attachments, are permitted to ride
them.
• The same requirements apply to the
self-employed.
28. Agricultural Machinery
Why Does Health &Safety Matter?
• In the last 5 years an average 32 of people have died each year due
to Agricultural activities.
• The worker fatality rate is higher than any other industry sector.
30. Agricultural Machinery
Health and Safety – Legislation
• It is vitally important that you as an operator understand the codes of
practice in relation to H&S legislation.
• Below is listed a number of legislative codes relating to machinery
operation.
1. Health and Safety at Work act (HSWA 1974) –
2. Personal Protective Equipment Regulations (PPE 1992) –
3. Provision and Use of Work Equipment Regulations (PUWER 1998) –
4. Lifting Operations and Lifting Equipment Regulations (LOLER 1998)
5. Manual Handling Operations Regulations (MHOR 1992) –
31. Agricultural Machinery
Health and Safety at Work act (HSWA 1974)
• A safe system/way of performing work
• A safe place to perform the work in
• Safe equipment and machinery to perform the work
• They must ensure work colleagues are competent in their roles
• They must carry out the relevant risk assessments
• Employers should be transparent and inform workers of any work-related
risks
• They should appoint a ‘competent person’ to oversee the health and safety
• Employers must consult with workplace safety representatives and set up a
workplace safety committee if a union is recognised
• Employers should provide adequate facilities for staff welfare
32. Agricultural Machinery
Personal Protective Equipment Regulations
(PPE 1992)
• Personal Protective
Equipment Regulations (PPE
1992) places a duty on every
employer in Great Britain to
ensure that suitable PPE is
provided to 'employees' who
may be exposed to a risk to
their health or safety while
at work.
33. Agricultural Machinery
Using any machine
• Health and Safety Regulations
• Should always refer to
• PUWER – 1998 Provision + Use of
Work Equipment Regulations
34. Agricultural Machinery
PUWER – What it says…..
• Regulation 4 Suitability of work equipment
• (1) Every employer shall ensure that work equipment is so constructed
or adapted as to be suitable for the purpose for which it is used or
provided.
• (2) In selecting work equipment, every employer shall have regard to
the working conditions and to the risks to the health and safety of
persons which exist in the premises or undertaking in which that work
equipment is to be used and any additional risk posed by the use of
that work equipment.
• (3) Every employer shall ensure that work equipment is used only for
operations for which, and under conditions for which, it is suitable.
35. Agricultural Machinery
PUWER – What it says…..
• Regulation 5 Maintenance
• (1) Every employer shall ensure that work equipment is maintained in
an efficient state, in efficient working order and in good repair.
• (2) Every employer shall ensure that where any machinery has a
maintenance log, the log is kept up to date.
36. Agricultural Machinery
Using any machine (tractor) for a job
• PUWER Applies….
• Equipment must be suitable for job only used for intended job
• Maintained in efficient order and good repair
37. Agricultural Machinery
Lifting Operations
• LOLER – Lifting Operations + Lifting
Equipment Regulations.
• LOLER requires that all equipment used
for lifting is fit for purpose, appropriate
for the task, suitably marked and, in
many cases, subject to statutory
periodic 'thorough examination'.
38. Agricultural Machinery
Manual Handling Operations
Regulations
(MHOR 1992)
• The employer shall so far as is reasonably
practicable, avoid the need for his
employees to undertake any manual
handling operations at work which involve a
risk of injury
• Where not possible, the employer shall
make a suitable and sufficient assessment
of all such operations which cannot be
avoided,
• The employer shall take appropriate steps
to reduce the risk of injury during those
operations to the lowest level reasonably
practicable
39. Agricultural Machinery 39
• Take reasonable care of their own health and safety and that of others
• Co-operate with the employer in discharging their duties under the act
Main Duties of Employees
Under the Health & Safety at Work Act 1974 - Section 7
And Under the Management of Health & Safety at Work
Regulations 1999
Shout if you think there is a safety problem
40. Agricultural Machinery 40
• Take reasonable care of your own H&S
• Take care of others who may be affected by what you do
• Take care of others who may be affected by things that you fail to
do eg. reporting problems
• Co-operate with employer in meeting legal obligations
• Use all equipment and machinery provided safely
• Follow instructions and be ‘fit’ for work
• No alcohol
• Don’t fool around
• Wear P.P.E.
• Follow rules
• Competent
• Where do mobile phones fit into all this?
Main Duties of Employees = YOU
Under the Health & Safety at Work Act 1974 - Section 7
41. Agricultural Machinery
Employees
• Use equipment safely
• Is training required?
• Follow Manufacturers' guidance
• What if don’t?
• ‘Clocking’ tractors!
• Stall tractor or smash implement!
• Reduce furrow width on vary
plough before turn over!
• Too much torque – wreck headstock
42. Agricultural Machinery
1. Which horsepower is most
dangerous?
Today’s learning –
• Identify risks and dangers of agricultural machinery.
• List the main H&S rules that apply to your job.
Editor's Notes
Brainstorm onto IWB
Todays Learning:
Duty 1 Undertake "safe and effective" activities as instructed and actively record daily activity. For example, cleaning machinery
Duty 5 Operate agricultural vehicles relevant to the business safely, legally and in line with current legislation
Duty 8 Monitor and maintain farm machinery as instructed. For example, checking oil in farm machinery,
Knowledge
K1: How to prepare risk assessments including identifying risks and hazards on the farm, and where to get advice and guidance
KS: How to prepare and operate agricultural vehicles and attachments in accordance with relevant legislation. For example, tractor, quad bike, All Terrain Vehicle (ATV), Forklift
K6: Concepts of good environmental, social and economic practice, including regulations, subsidies and basic understanding of how to contribute to government-led sustainability and zero carbon targets
K8: The most commonly used technology or automation options. For example, GPS tracking and why maintenance is needed.
K15: Correct labelling of resources for transport, assessment of the most appropriate method of transport, safe and correct loading, securing, protection of the load during transportation within the parameters of the farm business
Skills
S1: Identify hazards and risks in the workplace, prepare risk assessments and demonstrate high level of health and safety awareness at all times.
S5: Legally operate a farm vehicle and each attachment according to health and safety requirements. For example, tractors and ATVs along with other vehicles integral to the business.
S8: Carry out maintenance of farm machinery and equipment, as instructed
39
40
Todays Learning:
Duty 1 Undertake "safe and effective" activities as instructed and actively record daily activity. For example, cleaning machinery
Duty 5 Operate agricultural vehicles relevant to the business safely, legally and in line with current legislation
Duty 8 Monitor and maintain farm machinery as instructed. For example, checking oil in farm machinery,
Knowledge
K1: How to prepare risk assessments including identifying risks and hazards on the farm, and where to get advice and guidance
KS: How to prepare and operate agricultural vehicles and attachments in accordance with relevant legislation. For example, tractor, quad bike, All Terrain Vehicle (ATV), Forklift
K6: Concepts of good environmental, social and economic practice, including regulations, subsidies and basic understanding of how to contribute to government-led sustainability and zero carbon targets
K8: The most commonly used technology or automation options. For example, GPS tracking and why maintenance is needed.
K15: Correct labelling of resources for transport, assessment of the most appropriate method of transport, safe and correct loading, securing, protection of the load during transportation within the parameters of the farm business
Skills
S1: Identify hazards and risks in the workplace, prepare risk assessments and demonstrate high level of health and safety awareness at all times.
S5: Legally operate a farm vehicle and each attachment according to health and safety requirements. For example, tractors and ATVs along with other vehicles integral to the business.
S8: Carry out maintenance of farm machinery and equipment, as instructed