Aging and Epidermal Growth Factor (EGF)

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The document discusses aging and the role of epidermal growth factor (EGF) in skin regeneration. As we age, skin undergoes changes like wrinkling and thinning due to a loss of collagen, fat, and muscle. Aging also impacts skin at the cellular level by reducing cell signaling, division, and repair. EGF is a growth factor that plays an important role in promoting cell division and differentiation. It works by binding to EGF receptors on cells and triggering downstream signaling pathways. EGF can help stimulate skin regeneration by promoting keratinocyte proliferation and hyaluronic acid production. The document promotes EGF and peptide products from Maha Chemicals that can be used in anti-aging personal care applications.

Science

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Aging & Epidermal
Growth Factor (EGF)
1

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What is Aging
 Gradual decline in organ functionality with reduction in ability to maintain
homeostasis under stress
 Facial aging begins with surface and subsurface structural changes in multiple
facial tissue layers, inducing skin, fat, muscle and bone.
 As aging, Skin undergoes several changes
- Wrinkle or sag
- Reduction in collagen
- Thinner(loss of fat and muscle)
- Drier(loss of water)
- Less elastic(loss of collagen)

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Loss of Fat

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Loss of bone

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Skin Elasticity vs Muscle Tension
 Muscle Tension on skin less elastic is
one of factors causing wrinkles
 Ease the muscle, less wrinkle!! (AHP)

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Various Wrinkles on Face

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Signs of Facial Aging

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What causes Aging?
(Chronological or normal aging)

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Extrinsic VS Intrinsic
Accelerating Intrinsic aging

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Physiological process of Aging
Loss of
Fat, Muscle,
bone
We need
Humectant,
emollient
We need
collagen
booster
We need anti-
oxidant and skin
regeneration
agents
We need
whitening agents

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Aging in Cellular Level
Cause loss of
cell signalling
process
Cause
DNA/Cell
damage
Cause loss of
cell signalling
process
Cause
inflammation
and chronic
disease
Cause lower
cell
proliferation
Cause lower
cell division,
key protein
synthesis

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Aged tissues lacks the
regeneration function
 As aging, cell
repair system
will defect

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Skin Regeneration
Need cell division to replace
damaged cells

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Cell Division in Young and Old

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What Triggers Cell Division?
 Growth factor, any of a group
of proteins that stimulate the
growth of specific cell.
 Growth factors play an
important role in promoting
cellular differentiation and cell
division.

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The Effect of Growth Factor(GF) in Cell Division

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Epidermal Growth Factor (EGF)

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Epidermal
Growth Factor (EGF)
** the extracellular matrix (ECM) is
a collection of extracellular
molecules secreted by cells that
provides structural and
biochemical support to the
surrounding cells
**The brown color indicates the
localization of hyaluronan, whereas the
blue counterstain (hematoxylin) shows cell
nuclei.

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Epidermal Growth Factor (EGF)
**Hyaluronan is also called hyaluronic acid secreted by
keratinocyte

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Our Products
1.GROWTH FACTOR(1ppm, 10ppm, 100ppm)
2.PEPTIDE(100ppm, 1000ppm)

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THANK YOU
(65) 68631808 Jinki.hong@mahachem.com www.mahachem.comMAHA CHEMICALS (ASIA) PTE LTD
51 TUAS WEST DRIVE
SINGAPORE 638415
23
For more details on our anti-aging ingredients
for personal care application, you may find
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You may choose to subscribe our newsletter
here as well.

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ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!

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This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome. It's based on the first part of this research paper: The cost of information acquisition by natural selection Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577

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快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样

hozt8xgk

学校原件一模一样【微信：741003700 】《(UAM毕业证书)马德里自治大学毕业证学位证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。本公司拥有海外各大学样板无数，能完美还原。 1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700 【主营项目】一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！二.真实使馆公证(即留学回国人员证明,不成功不收费) 三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度) 如果您处于以下几种情况： ◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】 ◇面对父母的压力，希望尽快拿到； ◇不清楚认证流程以及材料该如何准备； ◇回国时间很长，忘记办理； ◇回国马上就要找工作，办给用人单位看； ◇企事业单位必须要求办理的 ◇需要报考公务员、购买免税车、落转户口 ◇申请留学生创业基金留信网认证的作用: 1:该专业认证可证明留学生真实身份 2:同时对留学生所学专业登记给予评定 3:国家专业人才认证中心颁发入库证书 4:这个认证书并且可以归档倒地方 5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息 6:个人职称评审加20分 7:个人信誉贷款加10分 8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才

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Applied Science: Thermodynamics, Laws & Methodology.pdf

University of Hertfordshire

When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best. Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level. Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.

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在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样

vluwdy49

学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。本公司拥有海外各大学样板无数，能完美还原。 1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700 【主营项目】一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！二.真实使馆公证(即留学回国人员证明,不成功不收费) 三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度) 如果您处于以下几种情况： ◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】 ◇面对父母的压力，希望尽快拿到； ◇不清楚认证流程以及材料该如何准备； ◇回国时间很长，忘记办理； ◇回国马上就要找工作，办给用人单位看； ◇企事业单位必须要求办理的 ◇需要报考公务员、购买免税车、落转户口 ◇申请留学生创业基金留信网认证的作用: 1:该专业认证可证明留学生真实身份 2:同时对留学生所学专业登记给予评定 3:国家专业人才认证中心颁发入库证书 4:这个认证书并且可以归档倒地方 5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息 6:个人职称评审加20分 7:个人信誉贷款加10分 8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才

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Pixeldarts

How Race, Age and Gender Shape Attitudes Towards Mental Health

ThinkNow

Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits. To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups. Technology For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did. While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis. Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad. Age and Gender When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same. Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers. Race Affects Attitudes As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).

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Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.

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Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.

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contently

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Search Engine Journal

The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands. It’s important that you’re ready to implement new strategies in 2024. Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024. You’ll learn: - The latest trends in AI and automation, and what this means for an evolving paid search ecosystem. - New developments in privacy and data regulation. - Emerging ad formats that are expected to make an impact next year. Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape. If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.

5 Public speaking tips from TED - Visualized summary

SpeakerHub

From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world. With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively. The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage. Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience. See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers See the original article on Forbes here: http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b

ChatGPT and the Future of Work - Clark Boyd

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Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world. Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance. For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age. Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.

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The document provides career advice for getting into the tech field, including: - Doing projects and internships in college to build a portfolio. - Learning about different roles and technologies through industry research. - Contributing to open source projects to build experience and network. - Developing a personal brand through a website and social media presence. - Networking through events, communities, and finding a mentor. - Practicing interviews through mock interviews and whiteboarding coding questions.

Google's Just Not That Into You: Understanding Core Updates & Search Intent

Lily Ray

1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework. 2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections. 3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.

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During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59 Key takeaways: • Learn how to use ChatGPT to add AI power to your testing and test automation • Understand the limitations of the technology and where human expertise is crucial • Gain insight into different AI-based tools • Adopt AI-based tools to stay relevant and optimize work for developers and testers * ChatGPT and OpenAI belong to OpenAI, L.L.C.

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2. SINGAPORE | MALAYSIA | PHILIPPINES | THAILAND | VIETNAM | SRI LANKA | INDONESIA | MYANMAR | CAMBODIA | CHINA What is Aging  Gradual decline in organ functionality with reduction in ability to maintain homeostasis under stress  Facial aging begins with surface and subsurface structural changes in multiple facial tissue layers, inducing skin, fat, muscle and bone.  As aging, Skin undergoes several changes - Wrinkle or sag - Reduction in collagen - Thinner(loss of fat and muscle) - Drier(loss of water) - Less elastic(loss of collagen)

23. SINGAPORE | MALAYSIA | PHILIPPINES | THAILAND | VIETNAM | SRI LANKA | INDONESIA | MYANMAR | CAMBODIA | CHINA THANK YOU (65) 68631808 Jinki.hong@mahachem.com www.mahachem.comMAHA CHEMICALS (ASIA) PTE LTD 51 TUAS WEST DRIVE SINGAPORE 638415 23 For more details on our anti-aging ingredients for personal care application, you may find more contents from our Facebook or LinkedIn. You may choose to subscribe our newsletter here as well.

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