This document discusses how aflatoxin biocontrol plays an important role in achieving One Health. It summarizes that aflatoxins from crops negatively impact human, animal, and environmental health, increasing risks of liver cancer and diseases. The use of Aflasafe, which employs atoxigenic Aspergillus strains, can protect crops from aflatoxin contamination pre-harvest. This improves the health of people and animals through reduced dietary exposure to aflatoxins. Aflasafe also benefits environmental health by supporting a balanced population of non-toxigenic microbes in the environment. Its use presents a nature-based solution to achieving One Health by linking improved plant, human, and animal well-