This document discusses types of medication effects on the body and allergic reactions. It explains that drugs can have local effects when applied topically or systemic effects when absorbed into bloodstream. Allergic reactions include anaphylaxis, skin rashes, pruritus, angioedema, rhinitis, lacrimal tearing, nausea, vomiting, diarrhea and shortness of breath. It also discusses drug tolerance occurring when decreased response requires higher dosages, and drug interactions including synergism, antagonism and incompatibility when drugs are mixed. The document will continue these topics in the next lecture.