This document provides information about the 12th Annual Conference and Exhibition on ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) taking place from June 12-14, 2017 in London. The conference will address early ADME application strategies and discuss the latest screening and testing models. It will feature talks from industry leaders on topics including predictive toxicity, PK optimization, preclinical testing, drug screening technologies, and physiologically-based PK modeling. A workshop on drug transporters will also be held on the third day.
In silico drug designing is the drug design which can be carried out in silicon chip,i.e., within computers. The slides are helpful to know a brief description about in silico drug designing.
High-throughput screening (HTS) is the name given to rapid semi-automated simultaneous primary screening of large numbers of compounds, mixtures or extracts for active compounds.
The process is based on the use of bio-microassays that are rapid to carry out and require very small quantities of the reagents and test compound.
These assays are carried out on 96- and bigger-well plates using specialised handling equipment.
In silico drug designing is the drug design which can be carried out in silicon chip,i.e., within computers. The slides are helpful to know a brief description about in silico drug designing.
High-throughput screening (HTS) is the name given to rapid semi-automated simultaneous primary screening of large numbers of compounds, mixtures or extracts for active compounds.
The process is based on the use of bio-microassays that are rapid to carry out and require very small quantities of the reagents and test compound.
These assays are carried out on 96- and bigger-well plates using specialised handling equipment.
High throughput screening is a type of assay. By this assay we can identified the target or binding site of drugs. Its mainly performed during the drug discovery process.
computational model of drug disposition.SaloniDalwadi
this presentation is about digitalization in pharmacy for prediction of parameter like pharmacokinetics and pharmacodynamics before drug dicovery process or formulation development process.
Back Rapid lead compounds discovery through high-throughput screeningrita martin
High-throughput screening process are used by today most of the drug discovery industries, this process helps pharmaceutical researches to make drug discovery process faster and also increase the quality and quantity of drugs production. This process in combination with robotics, data processing and control software, liquid handling devices and sensitive detectors allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests
Computational modeling of drug dispositionPV. Viji
Computational modeling of drug disposition , Modeling techniques , Drug absorption , solubility , intestinal permeation , Drug distribution , Drug excretion , Active Transport , P-gp , BCRP , Nucleoside transporters , hPEPT1 , ASBT , OCT , OATP , BBB-choline transporter
Computer-Aided Drug Designing (CADD) is a specialized discipline that uses computational methods to simulate drug-receptor interactions
CADD methods are heavily dependent on bioinformatics tools, applications, and databases
High throughput screening is a type of assay. By this assay we can identified the target or binding site of drugs. Its mainly performed during the drug discovery process.
computational model of drug disposition.SaloniDalwadi
this presentation is about digitalization in pharmacy for prediction of parameter like pharmacokinetics and pharmacodynamics before drug dicovery process or formulation development process.
Back Rapid lead compounds discovery through high-throughput screeningrita martin
High-throughput screening process are used by today most of the drug discovery industries, this process helps pharmaceutical researches to make drug discovery process faster and also increase the quality and quantity of drugs production. This process in combination with robotics, data processing and control software, liquid handling devices and sensitive detectors allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests
Computational modeling of drug dispositionPV. Viji
Computational modeling of drug disposition , Modeling techniques , Drug absorption , solubility , intestinal permeation , Drug distribution , Drug excretion , Active Transport , P-gp , BCRP , Nucleoside transporters , hPEPT1 , ASBT , OCT , OATP , BBB-choline transporter
Computer-Aided Drug Designing (CADD) is a specialized discipline that uses computational methods to simulate drug-receptor interactions
CADD methods are heavily dependent on bioinformatics tools, applications, and databases
In this seminar, I presented the concepts behind the theory, the basic interviewing method and an example of data analysis. The presentation is in Italian.
5th Annual Pre-Filled Syringes East CoastTeri Arri
Building on the success of previous sell-out shows, SMi Group is delighted to announce the return of the 5th annual conference and exhibition: Pre-Filled Syringes - East Coast, taking place on April 11th – 12th 2018 in Boston, Massachusetts, USA.
A rise in chronic diseases, improvements in technology and a growing demand for easy to use drug administration products has in recent years, created a booming Pre-Filled Syringes industry.
Some notable areas of increased attention have been the broader trends for combination products and biologics, as well as the move towards digital health and improving patient adherence due to increased self-administration figures. As well as these areas of lucrative opportunity, there are still several ongoing challenges that the key-thought leaders are battling to overcome such as chemical compatibility, user safety, high-volume and highly viscous formulation, and non-compliance.
Pre-Filled Syringes East Coast will once again play host to an international audience of drug delivery, medical device and PFS experts to discuss emerging trends and offer innovative solutions to the challenges facing the prefilled industry, helping attendees to secure global success for their PFS device.
ExL Pharma Clinical Trials Phase I and Phase IIa Conference Brochure: Phase 1...bryonmain
There is a pill or treatment for almost everything, or at least, that is how it seems. However, the amount of effort that goes into a pill or treatment before it is launched is extensive, expensive and often inefficient.
Efficiency and innovation go hand-in-hand with R&D and the development of clinical trials, however, FDA regulations and clinical trial standardization end up stifling these two key factors. This leads to drawn out processes that cost companies hundreds of millions of dollars before the drugs hit the market. Efforts have been made to increase efficiency in phase I/IIA with some companies changing their clinical trial manifestos to suit the available patient population at clinical sites, but more emphasis should be placed on creating more efficient processes for first in human studies by optimizing pharmacokinetics/pharmacodynamics, dosage selection, technological advancements to improve efficacy and structured patient mapping to increase successful trial and patient recruitment opportunities.
This program will give delegates the opportunity to share proven strategies between companies to help increase efficiency in this space and streamline processes to cut down costs. This event will bring together large and small companies and experts in this space to share best practices to decrease the financial drain theses phases have on the overall clinical trial budget. Life science corporations need the most up-to-date tools and practices to increase success by streamlining processes, sharing successful biomarker strategies, anticipating dosing quantities, and optimizing healthy or specialty patient recruitment and retention. Current strategies include patient mapping before organizing and setting up a clinical space, tailoring early phase clinical trials to patient populations, purchasing biological samples from collection companies, and trying to accelerate the process by submitting for breakthrough therapy designation.
Top Reasons To Attend
Identify Compound Development Strategies to Optimize Success in Clinical Trials
Learn Best Practices for Early Decision-Making Through Analysis of Biomarker Utility in Drug Development
Utilize Analytical Technology to Evaluate Multiple Configurations of a Small Molecule to Increase the Feasibility of Drug in Clinical Trials
Implement Adaptive Design in Proof of Concept Studies to Increase Efficiency, Decrease Time and Decrease Overall Cost
Explore the Seamless Development of Phase I to Phase II in Clinical Trials
NINE Case Studies and a Panel Session on Early Phase Clinical Trial Strategies
With the total size of the healthcare cold chain logistic services market expected to expand further from its current figures of £4.3 billion to nearly £6.9 billion by 2016*, we're even more excited to present SMi's 10th Annual Cold Chain Distribution Conference and Exhibition on Thursday 3rd and Friday 4th December 2015 at the Victoria Park Plaza Hotel, London, UK.
With the important advances in real time data logging to be assessed, in addition to compliance, GDP and best practices in the pharma distribution environment; these are only just a couple of sessions to be covered at this two-day conference
Helicopter technology eastern europe 2015.brochure.Alia Malick
Welcome to Sikorsky Aircraft who have just signed up as a sponsor to the SMi Group's Helicopter Technology Eastern Europe Conference and Exhibition to be held in Prague this June.
P 141 pre-filled syringes america revisedAlia Malick
The global prefilled syringe market is estimated to reach $6.9bn by 2018. This figure is reflective of manufacturers striving to improve their technologies to meet the increasing number of biologic drugs reaching the market. The rising demand for prefilled syringes is driving the manufacturers to introduce improvements in technology and with the focus still on the safety for the user, innovation improvements for device development and ease of use for the patient are key areas to be addressed.
SMi’s leading prefilled syringes conference will focus on a number of hot talking points that will no doubt cause controversy and debate and on reflection open the floor to discussion in our breakout sessions. In addition, with a new competitive market just around the corner for biosimilars we look at this new session for 2015 in addition to the vision and benefit of lyophilisation in a prefilled syringe.
E 060 oil gas cyber security north americaAlia Malick
Building on 8 years developing conferences in the Cyber Security space the SMi Group are delighted to announce launch their 6th in the series Oil and Gas Cyber Security North America. This conference will provide delegates with an information packed two day agenda with representatives from across the industry, giving a comprehensive overview of the market, looking at insider threats, the latest technology, live demonstrations, current and future threats, APT and much more.
The event will present itself as the perfect platform for learning about the real issues currently being faced by the industry. Hear from leading experts who are currently facing cyber threats. This is a unique opportunity to hear about cyber security expressed from government personal and the operators as well as understanding key market challenges, regulations, human behaviour and technology available.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
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Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
admet
1. www.admet-event.com
Register online or fax your registration to +44 (0) 870 9090 712 or call +44 (0) 870 9090 711
@SMIPHARM
#smiADMET
CHAIR FOR 2017:
• Eric Blomme, Vice President Preclinical Safety, AbbVie
FEATURED SPEAKERS:
• Valeriu Damian, Director System Modeling &
Translational Biology, GSK
• Handan He, Director, Section Head, Nonclinical PK/
PD, Novartis
• Ben-Fillippo Krippendorff, Franchise Leader PK/PD
Immunology & Inflammation, Roche
• Andreas Reichel, VP, Head Research
Pharmacokinetics, Bayer
• Peter Littlewood, Senior Director Head of DMPK
Europe, Vertex Pharmaceuticals
• Timothy Schulz-Utermoehl, Director of DMPK,
Sygnature Discovery
HIGHLIGHTS IN 2017:
• Predictive Human Toxicity, Transporters and ADMET
Studies
• ADME/PK Optimisation for Drug Design and
Discovery
• Preclinical In Vivo Pharmacology Testing and
Translational PK/PD
• Developments in Drug Screening Technology
• In Vitro to Human In Vivo Translation
• Physiologically Based PK Modeling
CONFERENCE: 12TH -13TH
WORKSHOP: 14TH
JUNE
2017HOLIDAY INN KENSINGTON FORUM, LONDON, UK
SMi Presents the 12th Annual Conference and Exhibition on
ADMETAddressing early ADME application strategies and discussing the
latest technologically advanced screening and testing models
BOOK BY 31ST MARCH TO SAVE £200 • BOOK BY 28TH APRIL TO SAVE £100
Sponsored by
Drug Transporters Tool Kit
08.30am - 12.30pm
Workshop Leader:
Kunal Taskar, Associate GSK Fellow, GSK
PLUS AN INTERACTIVE HALF-DAY POST-CONFERENCE WORKSHOP | WEDNESDAY 14TH JUNE 2017, HOLIDAY INN KENSINGTON FORUM, LONDON, UK
2. ADMET
Day One 12th June 2017 www.admet-event.com
08.30 Registration & Coffee
09.00 Chairman’s Opening Remarks
Eric Blomme, Vice President, Preclinical Safety, AbbVie
DRUG DISCOVERY STRATEGIES
09.10 OPENING ADDRESS: Toxicology Strategies for Drug Discovery:
Personal Thoughts
• Issues with front-loading in vitro tox assays
• What type and how many in vitro assays are necessary to
identify problematic chemical matter
• Addressing secondary pharmacology and chemical promiscuity
Eric Blomme, Vice President, Preclinical Safety, AbbVie
09.45 Understanding CNS penetration – how far have we gotten?
• Current concept and methods to assess brain pharmacokinetics
• Unbound brain concentrations, Kpuu and PK/PD
• Case studies to illustrate both the potential and limitations of the
current concept
• Open issues and questions
Andreas Reichel, VP, Head Research Pharmacokinetics, Bayer
10.20 Morning Coffee & Networking Break
10.50 Understanding PK/PD during drug discovery
• Understanding drug exposure at the target site
• Free drug hypothesis revisited
• Which parameters determine the efficacious dose?
Robert van Waterschoot, Head of Pharmacokinetics, Dynamics &
Metabolism (PDM) Leaders, Roche
11.25 Advanced In vitro Models for Studying Drug Absorption,
Distribution, Metabolism and Elimination
• An overview of the current in vitro models for studying drug
metabolism and transport: pros and cons
• Introducing the advanced recombinant enzyme and
transporter models developed using mammalian expression
system
• Overview of the product characterization and
applications, including robust dynamic range, lot to
lot consistency and validation with known clinically
relevant substrates and inhibitors
Na Li, Senior Staff Scientist, Corning
12.05 Networking Lunch
PBPK MODELING – CHALLENGES AND DEVELOPMENTS
13.15 Mechanistic modeling and simulations of oral drug absorption/
food effect/PPI/PB IVIVC: opportunities and challenges
• An overview on Novartis applications of PBPK modeling of
formulation dependent exposure and BCS/BDDCS
• Case examples on PBPK applications including supersaturation
challenge, formulation dependent PBPK, positive/negative food
effect predictions, prediction on PPI effects, comparison of
IVIVC vs PBIVIVC
• Overall recommendations: opportunities and challenges of
PBPK modeling together with a collective and multi-disciplinary
paradigm approach
Handan He, Director, Section Head, PK Sciences, Novartis
13.50 PBPK modelling – Pragmatic application in drug development
• Physiologically based pharmacokinetic modelling is well
established as a clinical prediction tool
• PBPK models can be applied to impact mechanistic
understanding, clinical development plans and regulatory
communication
• Modelling approaches can be optimised depending on the
available data and the clinical question
• Case histories from GSK will illustrate how bespoke application of
PBPK modelling can influence decision making throughout drug
development
Jackie Bloomer, Director, GSK
14.25 Physiological Based Pharmacokinetic modeling – the road ahead
• PBPK modelling has evolved in the last two decades from a few
pioneering applications to regulatory acceptance. It may seem
that PBPK has reached its peak potential – but has it?
• EMA and the FDA have published draft PBPK guidance for
industry insuring an increase use of PBPK modelling in regulatory
submissions
• Next few years will bring significant developments in PBPK
science: from data integration to pure prediction from structure,
from oral and IV to dermal, inhaled, intramuscular, long acting,
intraocular, from drug alone to drug and metabolites, from
small molecules to large molecule constructs, from dissolution to
formulation design, from ODE’s to partial differential equations
• We will explore directions in which PBPK is likely to develop
providing examples and case studies
Valeriu Damian, Senior Director, System Modelling and
Translational Biology, GSK
15.00 Afternoon Tea & Networking Break
SPECTROMETRY, PHARMACOKINETICS AND INHIBITORS
15.30 Labelled free MS spectrometry for cellular drug concentrations
and stability
• Target engagement
• Cell permeability and drug delivery
• Small Molecules and New modalities
• Labelled free MS spectrometry
Elisabetta Chiarparin, Head of Oncology Analytical and Structural
Chemistry, AstraZeneca
16.05 Novel in vitro and in vivo models for the study of drug transporters
in discovery and development
• Descriptions of in vitro models applied to transporter studies
• Applications in Discovery and Development
• Case studies
Laurent Salphati, Principal Scientist, Genentech
16.40 Allosteric TrkA inhibitors, from data mining to clinical candidate
• Structure-based design to optimize potency
• Use of in-house ADME prediction tools in design
• Bioavailability and intestinal metabolism
• Efforts to design molecules with higher solubility
Kiyoyuki Omoto, Scientist, Associate Research Fellow, Pfizer
17.15 Chairman’s Closing Remarks and Close of Day One
Register online at www.admet-event.com
SPONSORSHIP AND EXHIBITION OPPORTUNITIES
SMi offer sponsorship, exhibition, advertising and branding packages, uniquely tailored to complement your company’s marketing strategy. Prime
networking opportunities exist to entertain, enhance and expand your client base within the context of an independent discussion specific to your
industry. Should you wish to join the increasing number of companies benefiting from sponsoring our conferences please call:
Alia Malick on +44 (0) 20 7827 6168 or email: amalick@smi-online.co.uk
Corning Incorporated offers integrated solutions to support life sciences and accelerate drug discovery and
development with reagents and contract research services for in vitro analysis of xenobiotic metabolism and
drug transport. Products include Corning® Gentest™ Hepatocytes, tissue fractions, various transporter models,
Corning Supersomes™ Enzymes, and Corning Gentest Contract Research Services.
www.corning.com/lifesciences/
SOLVO Biotechnology is the leading provider of transporter assays Worldwide, since 1999. With over 100
solutions, we support your in-house or outsourced projects with high quality products or services, including FDA-,
EMA, PMDA-ready reports. Please visit www.solvobiotech.com
Sponsored by
3. ADMET
www.admet-event.com Day Two 13th June 2017
08.30 Registration & Coffee
09.00 Chairman’s Opening Remarks
Eric Blomme, Vice President, Preclinical Safety, AbbVie
ADME PROPERTIES AND PRECLINICAL IMPACT
09.10 OPENING ADDRESS: Physical Properties and their impact on ADMET
parameters and profiles
• How physical properties influence ADMET parameters,
compound progression and chances of success
• Better insight from new standards in measurements and
predictions of physical parameters
• Improving the effectiveness of predictive methods
• Influence of properties on toxicological outcomes
Rob Young, Senior Scientific Investigator & GSK Associate Fellow, GSK
09.45 Deciphering the mechanism of drug-induced liver injury (DILI) of
Cinchophen
• Introduction to cinchophen toxicity in patients
• In vitro ADME properties of cinchophen
• In vivo preclinical excretion profile of cinchophen
• Mechanistic studies using modern techniques to understand
cinchophen-induced liver injury
Timothy Schulz-Utermoehl, Director of DMPK, Sygnature Discovery
10.20 Morning Coffee & Networking Break
STRATEGIES FOR ACCURATE HUMAN DOSE PREDICTIONS
10.50 Addressing the continuing challenges of making accurate human
dose predictions
• Understanding the requirements
• Understanding how to use in vitro data
• Obtaining the right in vivo data in the right species
• IVIVC
• Dealing with non P450 clearance pathways
• Incorporating errors and variability into predictions
Peter Littlewood, Senior Director Head of DMPK Europe,
Vertex Pharmaceuticals
11.25 Estimation of human volume of distribution; methods, accuracy
and impact in human dose prediction
• Drivers of volume of distribution
• Impact of preclinical species used for extrapolation
• Method comparison of accuracy and statistical significance of
differences
• Application of Monte-Carlo simulations to visualize impact of
accuracy differences between methods
Carl Petersson, Associate Director Drug Disposition, Merck KGaA
12.00 Networking Lunch
DRUG-DRUG INTERACTIONS AND TRANSPORTERS
13.10 Impact of Drug-Excipient Interactions on Pharmacokinetics
• Overview of Pharmacokinetic Impact of Drug-Excipient
Interactions
• Case Study: Oral drug absorption impact of drug-croscarmellose
in a tablet
• Case Study: Intravenous pharmacokinetics of drug-cyclodextrin
interaction in solution
• Discussion: Role of drug self-association on pharmacokinetics
and influencing drug-excipient interactions
Ajit Narang, Senior Scientist, Genentech
13.45 Drug-Drug Interactions Involving Transporters – Theory and
Practice
• Short background on the subject
• Interesting examples from literature
• Bayer case-examples
Matthias Wittwer, Laboratory Head DMPK-BANP-NCPK, Bayer
14.20 Utility of endogenous probes for predicting transporter mediated
drug-drug interactions
• Endogenous transporter substrates
• Review of assessments to identify appropriate endogenous
markers for predicting transporter activity/modulations
• Relevance of transporter biomarkers in the clinic and
application in the predictions of transporter mediated DDIs
Kunal Taskar, Associate GSK Fellow, GSK
14.55 Afternoon Tea & Networking Break
LARGE MOLECULE PKPD, METABOLISM AND DISTRIBUTION
15.25 Assessment of therapeutic index: Moving beyond single point
estimate
• Inclusion of variability and uncertainty in the human PK
prediction and therapeutic indices
• Effective representation of therapeutic indices at various stage
of drug discovery for decision-making
Karelle Menochet, Principal Scientist, UCB
16.00 Large molecule PK/PD and new predictions of relevant tissue
concentrations
• Introduction to physiological processes driving large molecule PK
• New approaches to estimate the distribution and clearance of
large molecules
• How to quantitatively predict target mediated and unspecific
tissue uptake
Ben-Fillippo Krippendorff, Principal Scientist, Franchise Leader PK/
PD Immunology & Inflammation, Roche
16.35 Quantitative prediction of gut wall metabolism
• In vivo, in situ and in vitro models for the prediction of gut
metabolism
• Challenges in the establishment of good preclinical models
- species differences in the isoforms; regional abundances
and activities of drug metabolizing enzymes; the interplay of
enzyme-transporter proteins; and lack of knowledge on enzyme
abundances and availability of empirical scaling factors
• Focus on CYP3A
• Current gaps in the mechanistic understanding and the
prediction of gut metabolism and how they can be overcome
in the future
Sheila Annie Peters, Head, Translational Quantitative
Pharmacology, Merck KGaA
17.10 Chairman’s Closing Remarks and Close of Day Two
Alternatively fax your registration to +44 (0)870 9090 712 or call +44 (0)870 9090 711
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4. HALF DAY POST-CONFERENCE WORKSHOP
Wednesday 14th June 2017
Holiday Inn Kensington Forum, London, UK
8.30am – 12.30pm
Drug Transporters Tool Kit
Workshop Leader:
Kunal Taskar, Associate GSK Fellow, GSK
Workshop overview:
The workshop will focus on membrane transporters and
their application in drug discovery and development.
The workshop will introduce the clinically relevant
uptake and efflux transporters and their role in drug
pharmacokinetics and the important concept of
transporter mediated clinical drug-drug interactions.
The attendees will also learn about the various
transporter in vitro and in vivo tools and prediction
models as well as strategies.
Key Benefits of Attending:
The workshop will serve as a nice introductory course
to Pharmaceutical scientists to gain knowledge of drug
transporters as well as be a refresher to experienced
scientists in the field of drug development and research.
The workshop will be a nice platform to discuss any
case-studies or strategies related to the transporter
science.
Agenda
8.30 Registration & Coffee
9.00 Opening Remarks
9.10 Session 1: Introduction to Membrane
Transporters
9.50 Session 2: Clinically Relevant Drug Transporters
10.30 Morning Coffee
11.00 Session 3: How to study the Drug Transporters
and why to study Drug Transporters
11.40 Session 4: Regulatory Recommendations and
when to study the Drug Transporters
12.20 Closing Remarks
12.30 Close of workshop
About the Workshop Leader:
Kunal Taskar, Ph.D., is currently working as an Associate
GSK Fellow at GlaxoSmithKline, U.K. in Mechanistic
Safety and Disposition, IVIVT R&D department. He
is the transporter expert at the GSK UK site and
consults on drug transporter related project questions
from early drug discovery to post-marketing drug
development. His past experience includes working as
a drug transporter expert in the DMPK Pharmaceutical
Candidate Optimization department at Biocon Bristol-
Myers Squibb Research and Development. Kunal
completed his doctorate and postdoctoral research
at Texas Tech University Health Sciences department,
USA, in Quentin Smith’s lab with research focused on
drug delivery to central nervous system and role of
transporters in drug delivery across the blood-brain
barrier (BBB).
About the Organisation:
GlaxoSmithKline is a science-led global healthcare
company on a mission: GSK wants to help people
do more, feel better, live longer. Today there are still
millions of people without access to basic healthcare,
thousands of diseases without adequate treatments
and millions more people who suffer from everyday
ailments. At GSK we want to change this. GSK has three
world-leading businesses that research, develop and
manufacture innovative pharmaceutical medicines,
vaccines and consumer healthcare products. GSK
is committed to widening access to its products, so
more people can benefit, no matter where they live in
the world or what they can afford to pay.
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VENUE Holiday Inn Kensington Forum, London, SW7 4DN, UK
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