Conference and workshops for clinical practitioners to introduce them to modern tools and an alternative approach to modern scientific research.
Purpose
1. Build a network of physicians across the country
2 Train physicians to analyse clinical data and restructure it to make it compatible with research standards
3. Introduce modern tools to understand the mechanism of actions of medicine
4. Introduce artificial intelligence and machine learning to clinical practitioners to support decision-making processes
Access to Science
Clinical experience and traditional knowledge are important sources of data that affect decision making processes in modern healthcare systems. This data should be made accessible for scientific evaluation and validation to improve healthcare worldwide. The Open Source Pharma Foundation believes that clinical practitioners from various disciplines should have the right to access research so that they can help identify problems, contribute their scientific knowledge, and support the discovery ecosystem.
Background
The majority of medical practitioners working on the ground level with patients do not take part in open clinical research worldwide. However, the data collected and owned by them plays an important role in establishing better discovery pathways. Through this workshop, we seek to open opportunities to enhance health care systems around the world and to overcome the following challenges faced by medical practitioners.
1. Regulatory limitations
2. Academic limitations
3. Time constraints
4. Lack of access to modern tools
5. Lack of access to research facilities
TreatmentMAP™
TreatmentMAP supports physicians in optimizing their treatment decisions, even for cancer patients in advanced stages of cancer, or when all of the standard treatment options for a patient have been exhausted.
New Publishers for New Scientists - PeerJ at MedicineXPeter Binfield
Slides and Video of the PeerJ presentation to the New Scientists session of MedicineX at Stanford - "New Publishers for New Scientists" Sept 30th, 2012. Event web site at: http://medicinex.stanford.edu/
The video is from: http://www.youtube.com/watch?v=e-NWG5iw4mI
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...Fundación Ramón Areces
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
The Pharma 2020 series
The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing. PwC believes that seven major trends are reshaping the marketplace:
Source of info:
http://www.pwc.com/gx/en/pharma-life-sciences/pharma2020/index.jhtml#
Healthcare, along with many other sectors, is facing increasing uncertainty driven by technology disruption and greater individual / patient empowerment. The barrier to entry into the sector is dropping fast enabling Asia entrepreneurs to significantly improve the Asia healthcare ecosystem
mHealth Israel_Dr. Marvin Slepian_ Innovation: A Vital Ingredient for the Ad...Levi Shapiro
To remain as an effective leading force in the US, world-wide and society in general, Medicine has to actively adopt Innovation in its teaching and culture, rather than letting it occur passively. Dr. Slepian discusses Innovation Thinking and Science for addressing the enormous healthcare challenges facing the US.
Innovation is needed to overcome the many stresses that exist
on Medicine today - increased prevention, better Dxics and Txics
cost-effectiveness, increased access to care
TreatmentMAP™
TreatmentMAP supports physicians in optimizing their treatment decisions, even for cancer patients in advanced stages of cancer, or when all of the standard treatment options for a patient have been exhausted.
New Publishers for New Scientists - PeerJ at MedicineXPeter Binfield
Slides and Video of the PeerJ presentation to the New Scientists session of MedicineX at Stanford - "New Publishers for New Scientists" Sept 30th, 2012. Event web site at: http://medicinex.stanford.edu/
The video is from: http://www.youtube.com/watch?v=e-NWG5iw4mI
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...Fundación Ramón Areces
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
The Pharma 2020 series
The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing. PwC believes that seven major trends are reshaping the marketplace:
Source of info:
http://www.pwc.com/gx/en/pharma-life-sciences/pharma2020/index.jhtml#
Healthcare, along with many other sectors, is facing increasing uncertainty driven by technology disruption and greater individual / patient empowerment. The barrier to entry into the sector is dropping fast enabling Asia entrepreneurs to significantly improve the Asia healthcare ecosystem
mHealth Israel_Dr. Marvin Slepian_ Innovation: A Vital Ingredient for the Ad...Levi Shapiro
To remain as an effective leading force in the US, world-wide and society in general, Medicine has to actively adopt Innovation in its teaching and culture, rather than letting it occur passively. Dr. Slepian discusses Innovation Thinking and Science for addressing the enormous healthcare challenges facing the US.
Innovation is needed to overcome the many stresses that exist
on Medicine today - increased prevention, better Dxics and Txics
cost-effectiveness, increased access to care
Lustrumlezing paul stoffels de rol van innovatie voor de gezondheidszorg van ...Michiel Stoffels
Ter gelegenheid van het 40 jarig bestaan van de Universiteit werd een reeks lustrumlezingen georganiseerd. Voor de faculteit Gezondheid en Levenswetenschappen hadden we de eer Dr. Paul Stoffels - Worldwide Chairman , Janssen Pharmaceutical Chief Scientific Officer, Johnson & Johnson - te mogen ontvangen.
EuroBioForum 2013 - Day 2 | Mark PoznanskyEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Ontario Genomics Institute, Canada:
Innovative Research, Innovative Translation
Dr Mark Poznansky
President and CEO Ontario Genomics Institute
=======================================
http://www.eurobioforum.eu
For the 5th year, we culminated the best of the DayOne Healthcare Innovation initiative: hot topics, open debates, smart insights, bright ideas, high energy personalities and tangible expertise. This will include the Open Innovation Session that brings together the Health Hack and is a springboard for the Accelerator. The panel sessions included: The patient centric approach + four bright ideas; How to make it happen; + The healthcare innovation journey.
This year’s conference joined forces with BioData Congress 2020 in a virtual format. Thank you to the partners Arcondis and Innosuisse, as well as all the mentors, coaches and behind the scenes work to pull this all together in a great event wtih over 800 participants.
Presentation prepared for the AESIS webinar on “Measuring the Innovation Output of Science” in the series "Big Data Patterns & Signals for Science" More information at: http://aesisnet.com/event/webinar1017clar/
Asia HealthTech Investments by Julien de Salaberry (30 June 2015)KickstartPH
Kickstart Ventures' 2nd HealthTech Forum featured Julien de Salaberry, a globally-recognised expert on healthcare and technology.
Julien, the Chief Innovation Officer and Founder of The Propell Group (based in Singapore), talked about healthcare trends in Southeast Asia and how “frugal innovation" can be done in healthcare delivery.
And yeah, if you've got an interesting healthtech startup, message us at info@kickstart.ph. #startupPH
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Lustrumlezing paul stoffels de rol van innovatie voor de gezondheidszorg van ...Michiel Stoffels
Ter gelegenheid van het 40 jarig bestaan van de Universiteit werd een reeks lustrumlezingen georganiseerd. Voor de faculteit Gezondheid en Levenswetenschappen hadden we de eer Dr. Paul Stoffels - Worldwide Chairman , Janssen Pharmaceutical Chief Scientific Officer, Johnson & Johnson - te mogen ontvangen.
EuroBioForum 2013 - Day 2 | Mark PoznanskyEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Ontario Genomics Institute, Canada:
Innovative Research, Innovative Translation
Dr Mark Poznansky
President and CEO Ontario Genomics Institute
=======================================
http://www.eurobioforum.eu
For the 5th year, we culminated the best of the DayOne Healthcare Innovation initiative: hot topics, open debates, smart insights, bright ideas, high energy personalities and tangible expertise. This will include the Open Innovation Session that brings together the Health Hack and is a springboard for the Accelerator. The panel sessions included: The patient centric approach + four bright ideas; How to make it happen; + The healthcare innovation journey.
This year’s conference joined forces with BioData Congress 2020 in a virtual format. Thank you to the partners Arcondis and Innosuisse, as well as all the mentors, coaches and behind the scenes work to pull this all together in a great event wtih over 800 participants.
Presentation prepared for the AESIS webinar on “Measuring the Innovation Output of Science” in the series "Big Data Patterns & Signals for Science" More information at: http://aesisnet.com/event/webinar1017clar/
Asia HealthTech Investments by Julien de Salaberry (30 June 2015)KickstartPH
Kickstart Ventures' 2nd HealthTech Forum featured Julien de Salaberry, a globally-recognised expert on healthcare and technology.
Julien, the Chief Innovation Officer and Founder of The Propell Group (based in Singapore), talked about healthcare trends in Southeast Asia and how “frugal innovation" can be done in healthcare delivery.
And yeah, if you've got an interesting healthtech startup, message us at info@kickstart.ph. #startupPH
Similar to Access to Research Open Source Pharma Dr Bernard Munos (20)
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Preliminary findings _OECD field visits to ten regions in the TSI EU mining r...OECDregions
Preliminary findings from OECD field visits for the project: Enhancing EU Mining Regional Ecosystems to Support the Green Transition and Secure Mineral Raw Materials Supply.
RFP for Reno's Community Assistance CenterThis Is Reno
Property appraisals completed in May for downtown Reno’s Community Assistance and Triage Centers (CAC) reveal that repairing the buildings to bring them back into service would cost an estimated $10.1 million—nearly four times the amount previously reported by city staff.
Donate to charity during this holiday seasonSERUDS INDIA
For people who have money and are philanthropic, there are infinite opportunities to gift a needy person or child a Merry Christmas. Even if you are living on a shoestring budget, you will be surprised at how much you can do.
Donate Us
https://serudsindia.org/how-to-donate-to-charity-during-this-holiday-season/
#charityforchildren, #donateforchildren, #donateclothesforchildren, #donatebooksforchildren, #donatetoysforchildren, #sponsorforchildren, #sponsorclothesforchildren, #sponsorbooksforchildren, #sponsortoysforchildren, #seruds, #kurnool
Monitoring Health for the SDGs - Global Health Statistics 2024 - WHOChristina Parmionova
The 2024 World Health Statistics edition reviews more than 50 health-related indicators from the Sustainable Development Goals and WHO’s Thirteenth General Programme of Work. It also highlights the findings from the Global health estimates 2021, notably the impact of the COVID-19 pandemic on life expectancy and healthy life expectancy.
Working with data is a challenge for many organizations. Nonprofits in particular may need to collect and analyze sensitive, incomplete, and/or biased historical data about people. In this talk, Dr. Cori Faklaris of UNC Charlotte provides an overview of current AI capabilities and weaknesses to consider when integrating current AI technologies into the data workflow. The talk is organized around three takeaways: (1) For better or sometimes worse, AI provides you with “infinite interns.” (2) Give people permission & guardrails to learn what works with these “interns” and what doesn’t. (3) Create a roadmap for adding in more AI to assist nonprofit work, along with strategies for bias mitigation.
About Potato, The scientific name of the plant is Solanum tuberosum (L).Christina Parmionova
The potato is a starchy root vegetable native to the Americas that is consumed as a staple food in many parts of the world. Potatoes are tubers of the plant Solanum tuberosum, a perennial in the nightshade family Solanaceae. Wild potato species can be found from the southern United States to southern Chile
Synopsis (short abstract) In December 2023, the UN General Assembly proclaimed 30 May as the International Day of Potato.
About Potato, The scientific name of the plant is Solanum tuberosum (L).
Access to Research Open Source Pharma Dr Bernard Munos
1. Bernard Munos
Senior Fellow, FasterCures
Founder, InnoThink Center for Research in Biomedical Innovation
Bangalore, August 11, 2018
Rethinking The Pharmaceutical Business Model
InnoThink
4. R² = 0.9937
0
5
10
15
20
25
30
35
40
1/1/1980 6/23/1985 12/14/1990 6/5/1996 11/26/2001 5/19/2007 11/8/2012
Pfizer's cumulative number of NMEs
More Evidence That Innovation Does Not Scale With Size
Source: drugs@FDA
• Pfizer has produced new drugs at the same rate since at least 1980
• Similar charts can be drawn for every other company
Warner-Lambert ($90 bn)
Pharmacia ($60 bn)
Wyeth ($68 bn)
37 drugs over 38 years
InnoThink
5. 0
10
20
30
40
50
60
70
80
90
Large Pharmaceutical Companies*
NME approved R&D spending
NMEs or $ billion
More R&D Is Not Yielding More Drugs
*includes AbbVie, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, GSK, J&J, Lilly, MSD, Novartis, Pfizer, Roche,
Sanofi, and their predecessors
$78 billion
17 new drugs
$4.6 billion/NME
+8.4%
InnoThink
6. 0.0%
2.0%
4.0%
6.0%
8.0%
10.0%
12.0%
14.0%
16.0%
18.0%
20.0%
2010 2011 2012 2013 2014 2015 2016 2017
Return on R&D
large cap mid-large cap
Source: Measuring the return from pharmaceutical innovation 2017, Deloitte Center
for Health Solutions
Source: Pharma’s broken business model, Kelvin Stott
cost-of-capital
0%
20%
40%
60%
80%
100%
VRTX
REGN
BMY
GILD
BIIB
JNJ
BAY
BI
ASTE
BMRN
TAKE
NVO
NVS
OTSU
AMGN
CELG
LLY
EISA
AZN
MRK
ROC
GSK
PFE
SHP
SNY
ABBV
10-year Freshness Index
(Percent of sales from drugs approved in last 10 years)
large companies
biotech & mid-sized
0.0
2.0
4.0
6.0
8.0
10.0
ASTE
SNY
PFE
TAKE
AZN
OTSU
LLY
GSK
BI
NVS
ROC
MRK
AMGN
REGN
EISA
CELG
BAY
VRTX
JNJ
NVO
ABBV
BMY
BIIB
SHP
GILD
BMRN
R&D spending/NME ($ billion)
calculated over 1990-2017
Source: EvaluatePharma ; drugs@FDASource: EvaluatePharma ; drugs@FDA
large companies
biotech & mid-sized
“Every $1 invested in R&D returns $0.70“
Chris Viehbacher, former CEO, Sanofi
7. • Old blockbusters (e.g., Lipitor) used to treat millions
• New targeted drugs treat thousands
• In the US…
90% of prescriptions are filled by generics for $30 billion
10% of prescriptions are filled by proprietary drugs for $250 billion
In 2000, only ~50% of prescriptions were filled by generics
Generics Are Crowding Out Proprietary Drugs
InnoThink
8. Yet, as the metrics deteriorate…
We cure cancer We restore vision
(Luxturna)
We change cystic
fibrosis patients’ lives
We cure hepatitis C We prevent Ebola
• All this would have been unthinkable 10 years ago
• Science is opening incredible new horizons
• How can we bring that promise to patients in an affordable way?
InnoThink
10. Data drives innovation
“If you think about the scientific revolutions that
have occurred in history, they’ve been driven by
one thing — the availability of data”
“From Copernicus to quantum mechanics,
it’s data that drives innovation”John Quackenbush
Harvard University
It Must Start With Data
InnoThink
11. Breakthrough Science Does Not Cost Much
R² = 0.9882
0
5
10
15
20
25
30
35
40
45
50
1944 1951 1958 1965 1972 1979 1986 1993 2000 2007 2014
Nobel prize Lasker prize
Source: Rockefeller University
Fostering a culture of innovation
on a shoestring
82 professors
200 students
325 postdocs
Research budget: $228 million
Rockefeller has predictably produced Nobel and Lasker prizes for 74 years. What’s the secret?
Not the size: only 82 professors
Not the money: only $228 million of annual research spending
It’s the talent and the culture
Rockefeller: 25 Nobel + 22 Lasker over 74 years
InnoThink
12. It is collected in clinical trials… the highest possible cost setting
Over $110 billion per year for human clinical trials!
It has limitations
Rare diseases, or rare mutations of common diseases
Diseases that progress slowly over many years (Alzheimer’s, cancers)
It is sparse — collected intermittently. Tells little about what’s
really happening. A snapshot, not a movie.
It does measure long-run outcomes. How is patient evolving
after treatment?
But Patient Data Is Expensive
InnoThink
13. Pulse oximeter
Blood pressure monitor
EKG monitor
Pill dispenser
Blood glucose monitor
Activity tracker
Smart car seat
Smart clothes
Smart toilet
Smart mattress
& sheets
Personal digital cloud
(Terabytes of data)
Smart phone
Smart
thermostat
genome
Xrays, lab results
eRx
and a lot more…
Digital Technologies Are Helping Overcome The Data Challenge
14. Digital Technologies Are Also Changing Science And Medicine
They enable open science and big science initiatives such as the “All of
Us” million-patient cohort
They allow data to be easily shared, aggregated, stored, and analyzed
in new ways
Increasingly, these open databases serve as starting points for many
research investigations. Exploratory research is less dependent upon
funding.
Collaborations are no longer hampered by geographic distance
InnoThink
15. These Collaborations Are Changing Innovation Dynamics
And Giving Rise To New Research Models
• They tap the global brain, facilitate access to top talent, and
foster cross-pollination
• They bring together competences that are seldom found
under one roof (e.g., AI, tissue engineering, biochips, etc)
• They broaden the locus of innovation by helping it flourish in
areas that have not traditionally participated in it (e.g., Africa)
• Examples:
• Public-Private Partnerships (e.g., MMV, GAVI, ADNI, SGC, AMP)
• Open-source collaboration platforms (e.g., OSDD)
• Crowdsourcing (e.g., Innocentive, drug repurposing)
• Partnerships (with academia, VCs, other pharma, e.g., Biden Cancer Initiative)
• Consortia (e.g., Critical Path Institute)
InnoThink