05/17/2025
Tesloach James
PROLONGED PREGNANCY
TESLOACH JAMES, M.D.,
ASSISTANT PROFESSOR OF OBSTETRIC
AND GYNECOLOGY
Gambella University
College of Health Sciences
Department of Public Health
05/17/2025
Tesloach James
SOURCES
 RCOG 2003
 ACOG (SEPTEMBER 2004)
 COCHRANE LIBRARY 2006
 AFP (AMERICAN FAMILY PHYSICIAN) (May 15,
2005)
 PUBMED (MEDLINE)
05/17/2025
Tesloach James
Prolonged pregnancy(postterm
pregnancy ) It is one that has
lasted longer than 42 weeks or 294 days
beyond the first day of the last menstrual
period
DEFINITION
(
WHO & FIGO
)
05/17/2025
Tesloach James
Postdatism is pregnancy lasting beyond
the estimated due date at 40 weeks.
“Postmature” is reserved for the
pathologic syndrome in which the fetus
experiences placental insufficiency and
resultant IUGR .
DEFINITION
05/17/2025
Tesloach James
POST-MATURITY SYNDROME
 Representing 20 % cases of prolonged pregnancy and is
associated with :
1. Meconium -stained amniotic fluid,
2. Oligohydramnios
3. Fetal distress
4. Evidence of loss of subcutaneous fat and
5. Dry, cracked skin
Reflecting placental insufficiency.
05/17/2025
Tesloach James
ETIOLOGIC FACTORS
The most frequent cause is an error in
dating.
When truly exists, the cause usually is
unknown.
Primiparity and prior postterm pregnancy
are the most common identifiable risk
factors.
05/17/2025
Tesloach James
ETIOLOGIC FACTORS
Rarely, it may be associated with
placental sulfatase deficiency or fetal
anencephaly.
Male sex also has been associated.
Genetic predisposition may play a role .
05/17/2025
Tesloach James
Using the definition of 294 days,
the incidence of postterm
pregnancy is 9 - 10 %.
EPIDEMIOLOGY
05/17/2025
Tesloach James
RISKS TO THE FETUS
The perinatal mortality:
> 42 weeks twice that at term
> 43 weeks > 6-fold that at term
05/17/2025
Tesloach James
RISKS TO THE FETUS
 In some cases, the risks appear to be due to
uteroplacental insufficiency, resulting in fetal hypoxia ,
meconium aspiration, growth restriction, and
oligohydramnios .
 Fetal distress and meconium release were twice as
common (at or after 42 weeks) than at term.
 There was an eight-fold increase in meconium aspiration
05/17/2025
Tesloach James
- In other cases, continued growth of the fetus leads to
macrosomia, increasing the risk of labor
abnormalities, shoulder dystocia with resultant risks
of orthopedic or neurologic injury.
- Macrosomia is far more common in postterm than term
pregnancies .
Macrosomia
05/17/2025
Tesloach James
OLIGOHYDRAMNIOS
 It is a marker for fetal compromise and it puts the fetus
at risk for cord accidents.
 U/S diagnosis :
 No vertical pocket > 2 cm or
 Amniotic fluid index (AFI) 5 cm or less .
 It is considered an indication for delivery.
05/17/2025
Tesloach James
 Fetuses born postterm also are at increased risk
of :Sudden infant death syndrome
(death within the first year of life).
 Some of these deaths clearly result from peripartum
complications (such as
meconium aspiration syndrome), but most have no
known cause.
Risks to the Fetus
05/17/2025
Tesloach James
MATERNAL RISKS
1) Labor dystocia
2) Severe perineal injury
related to macrosomia
3) Doubling in the rate of cesarean
delivery.
4) A source of extreme anxiety for the
pregnant woman.
05/17/2025
Tesloach James
 Gest. age must be assessed carefully to avoid delivery
of a preterm infant.
 Women who attend late for ANC may be of uncertain
gestation and may be over-represented in populations of
postterm pregnancies.
 Dating by the last menstrual period (LMP) alone has a
tendency to overestimate the gestational age.
Gestational age calculation
05/17/2025
Tesloach James
GESTATIONAL AGE CALCULATION
 Because actual dates of conception are rarely
known,the LMP is used as the reference point.
 This can make the accuracy of gest. age determination
unreliable because of :
1. Irregular menses .
2. Recent cessation of birth control pills.
3. Inconsistent ovulation times.
05/17/2025
Tesloach James
Routine early pregnancy ultrasound
♣ Reduces the number of women who
require induction of labour for apparent
postterm pregnancy .
♣ It is recommended that all pregnant
ladies (and certainly those who do not
have regular menses),should have an
ultrasound examination for gestational
age determination, prior to 20 weeks
RCOG,COCHRANE
05/17/2025
Tesloach James
ULTRASOUND BIOMETRY MARGINS OF ERROR
 Crown-rump length (CRL) till 12 weeks is 3-5 days,
 Biparietal diameter (BPD) at 12-20 weeks is 1
week,
 BPD at 20-30 weeks is 2 weeks, and
 BPD after 30 weeks is 3 weeks.
 If there is more than a one week discrepancy between the
LMP and the ultrasound findings, the ultrasound data
should be used to determine the EDD .
05/17/2025
Tesloach James
TRANSCEREBELLAR DIAMETER
 When composite biometry is not consistent in all of the
parameters (i.e. BPD, head circumference,
abdominal circumference, femur length), using the
transcerebellar diameter is a way to more accurately
date a pregnancy
 The diameter in millimeters corresponds
to weeks of gestation up to 24 weeks.
05/17/2025
Tesloach James
Transcerebellar diameter
05/17/2025
Tesloach James
The available evidences are
strongly in support that dating
by Early ultrasonography alone
is the
most accurate method for
predicting EDD.
RCOG (GRADE A)
05/17/2025
Tesloach James
The use of early ultra­
sound alone to
calculate the rate of postterm pregnancy
in women who delivered spontaneously
significantly reduced the postterm rate
from 10 % to 1.5 %.
Routine early pregnancy ultrasound
RCOG (GRADE A)
05/17/2025
Tesloach James
ARE THERE INTERVENTIONS THAT DECREASE
THE RATE OF POSTTERM PREGNANCY?
 Accurate dating on the basis of ultrasonography
performed early in pregnancy .
 Breast and nipple stimulation at term have not been
shown to affect the incidence of postterm pregnancy.
 Sweeping of the membranes at term :
the data are still conflicting .
ACOG Guidelines 2004
05/17/2025
Tesloach James
1) Gestational age,
2) Absence/presence of maternal risk factors and / or
3) Evidence of fetal compromise, and
4) Maternal preferences .
 Successful management depends on effective
counseling of women and their full involvement in the
decision making process.
Management options depend on:
05/17/2025
Tesloach James
a. Inducing labour at 41-42 weeks gestation
or
b. Awaiting the onset of spontaneous labour, while
monitoring the fetal wellbeing .
 The decision is difficult and should not be taken
lightly.
Historically, prolonged pregnancy has
been managed in 2 ways , either :
05/17/2025
Tesloach James
ROUTINE INDUCTION OF LABOUR
AT 41 WEEKS
 Although postterm pregnancy is defined as a pregnancy of
42 weeks or more of gestation, several large multicenter
randomized studies reported favorable outcomes with
routine induction as early as the beginning of 41 weeks
of gestation.
Cochrane 2006
05/17/2025
Tesloach James
ROUTINE INDUCTION OF LABOUR
AT 41 WEEKS
 A recent review in the Cochrane Library concluded that
routine induction in low-risk
pregnancies at or after 41 weeks' gestation is associated
with :
1. A reduction in perinatal mortality,
2. No increase in the rate of instrumental or cesarean
delivery.
RCOG Grade A
05/17/2025
Tesloach James
 Contrary to what many obstetricians believe,
induction of labor for prolonged pregnancy does not
increase the rate of cesarean section, rather, it
decreases it.
 The risk of fetal distress from uteroplacental
insufficiency due to prolonged pregnancy can be
reduced by induction of labor, even to the point of
preventing perinatal death from asphyxia.
Routine induction of labour
at 41 weeks
05/17/2025
Tesloach James
 There is insufficient evidence to indicate whether routine
antenatal surveillance of low-risk patients between 40
and 42 weeks of gestation improves perinatal outcome
but it is often
performed during this period.
ANTEPARTUM FETAL
SURVEILLANCE
05/17/2025
Tesloach James
ANTEPARTUM FETAL SURVEILLANCE
 The condition of the fetus can change quickly and thus,
monitoring should be at frequent intervals, and that none
of the tests are immune from false positives, false
negatives
 Boehm et al, demonstrated that twice-weekly testing of
patients at risk for fetal distress was superior to weekly
testing.
05/17/2025
Tesloach James
FETAL SURVEILLANCE
A modified biophysical profile consisting of
a:
 non stress test and an
 amniotic fluid index
have been shown to be as
sensitive as a full biophysical profile.
RCOG Grade A
05/17/2025
Tesloach James
INDUCTION OF LABOUR OR
EXPECTANT MANAGEMENT?
 Favorable cervix : Labor generally is induced because the
risk of failed induction and subsequent cesarean delivery
is low.
 Unfavorable cervix :a small advantage to labor induction
using cervical ripening agents (prostaglandins), when
indicated, regardless of parity or method
of induction.
ACOG 2004 (Level C)
05/17/2025
Tesloach James
A .Healthy, uncomplicated pregnancy and
fetal growth/ amniotic fluid normal:
 No evidence to support elective
induction of labour
 No evidence to support use of serial
antenatal monitoring :
non stress test (NST) or
amniotic fluid index (AFI) .
Management from 40-41 weeks gestation
05/17/2025
Tesloach James
B. Presence of maternal risk factors or
evidence of fetal compromise :
 Recommend cervical ripening
as necessary and
induction of labour
Management at 40 - 41 weeks gestation
05/17/2025
Tesloach James
A. Healthy, uncomplicated pregnancy
 Inform the woman of the options and
risks/ benefits of labour induction versus
expectant management, and
offer her labour induction.
 Establish the cervical (Bishop) Score
and ensure a ripening agent
(prostaglandin) prior to induction.
Management at 41 weeks gestation
05/17/2025
Tesloach James
B. If mother declines induction ,
then provide expectant management:
 Daily fetal movement counts
 Non stress test (NST) and Amniotic fluid index
(AFI) twice/ week to 42 weeks.
 If the NST or AFI is abnormal ,
then initiate induction immediately
Management at 41 weeks gestation
Induce at 42 weeks
even if NST and AFI are normal.
05/17/2025
Tesloach James
۞
Consider amniotomy to diagnose thick
meconium.
۞
If meconium is present then consider risk
of meconium aspiration , continuous fetal
assessment with electronic fetal monitoring
(EFM) is recommended.
۞
Be prepared for shoulder dystocia and
neonatal resuscitation at delivery.
Management during labour and delivery
05/17/2025
Tesloach James
 Labour induction at 41 weeks
gestation is recommended over
expectant management in women
with postterm pregnancy to reduce
the rate of cesarean delivery &
perinatal mortality .
Key Clinical Recommendations
(
RCOG Grade A
)
05/17/2025
Tesloach James
 If Expectant management (41- 42 weeks) is chosen,the
fetus should be monitored with twice weekly non-
stress test ,amniotic fluid index .
- However, evidence of benefit is lacking.
Key Clinical Recommendations
(RCOG Grade C )
05/17/2025
Tesloach James
 Prostaglandin can be used in postterm pregnancies to
promote cervical ripening and induce labor.
 Delivery should be effected if there is evidence of :
 fetal compromise or
 oligohydramnios.
ACOG 2004 (Level A)
Key Clinical Recommendations
05/17/2025
Tesloach James

Abnormal LabPROLONGED PREGNANCY (1).pptx

  • 1.
    05/17/2025 Tesloach James PROLONGED PREGNANCY TESLOACHJAMES, M.D., ASSISTANT PROFESSOR OF OBSTETRIC AND GYNECOLOGY Gambella University College of Health Sciences Department of Public Health
  • 2.
    05/17/2025 Tesloach James SOURCES  RCOG2003  ACOG (SEPTEMBER 2004)  COCHRANE LIBRARY 2006  AFP (AMERICAN FAMILY PHYSICIAN) (May 15, 2005)  PUBMED (MEDLINE)
  • 3.
    05/17/2025 Tesloach James Prolonged pregnancy(postterm pregnancy) It is one that has lasted longer than 42 weeks or 294 days beyond the first day of the last menstrual period DEFINITION ( WHO & FIGO )
  • 4.
    05/17/2025 Tesloach James Postdatism ispregnancy lasting beyond the estimated due date at 40 weeks. “Postmature” is reserved for the pathologic syndrome in which the fetus experiences placental insufficiency and resultant IUGR . DEFINITION
  • 5.
    05/17/2025 Tesloach James POST-MATURITY SYNDROME Representing 20 % cases of prolonged pregnancy and is associated with : 1. Meconium -stained amniotic fluid, 2. Oligohydramnios 3. Fetal distress 4. Evidence of loss of subcutaneous fat and 5. Dry, cracked skin Reflecting placental insufficiency.
  • 6.
    05/17/2025 Tesloach James ETIOLOGIC FACTORS Themost frequent cause is an error in dating. When truly exists, the cause usually is unknown. Primiparity and prior postterm pregnancy are the most common identifiable risk factors.
  • 7.
    05/17/2025 Tesloach James ETIOLOGIC FACTORS Rarely,it may be associated with placental sulfatase deficiency or fetal anencephaly. Male sex also has been associated. Genetic predisposition may play a role .
  • 8.
    05/17/2025 Tesloach James Using thedefinition of 294 days, the incidence of postterm pregnancy is 9 - 10 %. EPIDEMIOLOGY
  • 9.
    05/17/2025 Tesloach James RISKS TOTHE FETUS The perinatal mortality: > 42 weeks twice that at term > 43 weeks > 6-fold that at term
  • 10.
    05/17/2025 Tesloach James RISKS TOTHE FETUS  In some cases, the risks appear to be due to uteroplacental insufficiency, resulting in fetal hypoxia , meconium aspiration, growth restriction, and oligohydramnios .  Fetal distress and meconium release were twice as common (at or after 42 weeks) than at term.  There was an eight-fold increase in meconium aspiration
  • 11.
    05/17/2025 Tesloach James - Inother cases, continued growth of the fetus leads to macrosomia, increasing the risk of labor abnormalities, shoulder dystocia with resultant risks of orthopedic or neurologic injury. - Macrosomia is far more common in postterm than term pregnancies . Macrosomia
  • 12.
    05/17/2025 Tesloach James OLIGOHYDRAMNIOS  Itis a marker for fetal compromise and it puts the fetus at risk for cord accidents.  U/S diagnosis :  No vertical pocket > 2 cm or  Amniotic fluid index (AFI) 5 cm or less .  It is considered an indication for delivery.
  • 13.
    05/17/2025 Tesloach James  Fetusesborn postterm also are at increased risk of :Sudden infant death syndrome (death within the first year of life).  Some of these deaths clearly result from peripartum complications (such as meconium aspiration syndrome), but most have no known cause. Risks to the Fetus
  • 14.
    05/17/2025 Tesloach James MATERNAL RISKS 1)Labor dystocia 2) Severe perineal injury related to macrosomia 3) Doubling in the rate of cesarean delivery. 4) A source of extreme anxiety for the pregnant woman.
  • 15.
    05/17/2025 Tesloach James  Gest.age must be assessed carefully to avoid delivery of a preterm infant.  Women who attend late for ANC may be of uncertain gestation and may be over-represented in populations of postterm pregnancies.  Dating by the last menstrual period (LMP) alone has a tendency to overestimate the gestational age. Gestational age calculation
  • 16.
    05/17/2025 Tesloach James GESTATIONAL AGECALCULATION  Because actual dates of conception are rarely known,the LMP is used as the reference point.  This can make the accuracy of gest. age determination unreliable because of : 1. Irregular menses . 2. Recent cessation of birth control pills. 3. Inconsistent ovulation times.
  • 17.
    05/17/2025 Tesloach James Routine earlypregnancy ultrasound ♣ Reduces the number of women who require induction of labour for apparent postterm pregnancy . ♣ It is recommended that all pregnant ladies (and certainly those who do not have regular menses),should have an ultrasound examination for gestational age determination, prior to 20 weeks RCOG,COCHRANE
  • 18.
    05/17/2025 Tesloach James ULTRASOUND BIOMETRYMARGINS OF ERROR  Crown-rump length (CRL) till 12 weeks is 3-5 days,  Biparietal diameter (BPD) at 12-20 weeks is 1 week,  BPD at 20-30 weeks is 2 weeks, and  BPD after 30 weeks is 3 weeks.  If there is more than a one week discrepancy between the LMP and the ultrasound findings, the ultrasound data should be used to determine the EDD .
  • 19.
    05/17/2025 Tesloach James TRANSCEREBELLAR DIAMETER When composite biometry is not consistent in all of the parameters (i.e. BPD, head circumference, abdominal circumference, femur length), using the transcerebellar diameter is a way to more accurately date a pregnancy  The diameter in millimeters corresponds to weeks of gestation up to 24 weeks.
  • 20.
  • 21.
    05/17/2025 Tesloach James The availableevidences are strongly in support that dating by Early ultrasonography alone is the most accurate method for predicting EDD. RCOG (GRADE A)
  • 22.
    05/17/2025 Tesloach James The useof early ultra­ sound alone to calculate the rate of postterm pregnancy in women who delivered spontaneously significantly reduced the postterm rate from 10 % to 1.5 %. Routine early pregnancy ultrasound RCOG (GRADE A)
  • 23.
    05/17/2025 Tesloach James ARE THEREINTERVENTIONS THAT DECREASE THE RATE OF POSTTERM PREGNANCY?  Accurate dating on the basis of ultrasonography performed early in pregnancy .  Breast and nipple stimulation at term have not been shown to affect the incidence of postterm pregnancy.  Sweeping of the membranes at term : the data are still conflicting . ACOG Guidelines 2004
  • 24.
    05/17/2025 Tesloach James 1) Gestationalage, 2) Absence/presence of maternal risk factors and / or 3) Evidence of fetal compromise, and 4) Maternal preferences .  Successful management depends on effective counseling of women and their full involvement in the decision making process. Management options depend on:
  • 25.
    05/17/2025 Tesloach James a. Inducinglabour at 41-42 weeks gestation or b. Awaiting the onset of spontaneous labour, while monitoring the fetal wellbeing .  The decision is difficult and should not be taken lightly. Historically, prolonged pregnancy has been managed in 2 ways , either :
  • 26.
    05/17/2025 Tesloach James ROUTINE INDUCTIONOF LABOUR AT 41 WEEKS  Although postterm pregnancy is defined as a pregnancy of 42 weeks or more of gestation, several large multicenter randomized studies reported favorable outcomes with routine induction as early as the beginning of 41 weeks of gestation. Cochrane 2006
  • 27.
    05/17/2025 Tesloach James ROUTINE INDUCTIONOF LABOUR AT 41 WEEKS  A recent review in the Cochrane Library concluded that routine induction in low-risk pregnancies at or after 41 weeks' gestation is associated with : 1. A reduction in perinatal mortality, 2. No increase in the rate of instrumental or cesarean delivery. RCOG Grade A
  • 28.
    05/17/2025 Tesloach James  Contraryto what many obstetricians believe, induction of labor for prolonged pregnancy does not increase the rate of cesarean section, rather, it decreases it.  The risk of fetal distress from uteroplacental insufficiency due to prolonged pregnancy can be reduced by induction of labor, even to the point of preventing perinatal death from asphyxia. Routine induction of labour at 41 weeks
  • 29.
    05/17/2025 Tesloach James  Thereis insufficient evidence to indicate whether routine antenatal surveillance of low-risk patients between 40 and 42 weeks of gestation improves perinatal outcome but it is often performed during this period. ANTEPARTUM FETAL SURVEILLANCE
  • 30.
    05/17/2025 Tesloach James ANTEPARTUM FETALSURVEILLANCE  The condition of the fetus can change quickly and thus, monitoring should be at frequent intervals, and that none of the tests are immune from false positives, false negatives  Boehm et al, demonstrated that twice-weekly testing of patients at risk for fetal distress was superior to weekly testing.
  • 31.
    05/17/2025 Tesloach James FETAL SURVEILLANCE Amodified biophysical profile consisting of a:  non stress test and an  amniotic fluid index have been shown to be as sensitive as a full biophysical profile. RCOG Grade A
  • 32.
    05/17/2025 Tesloach James INDUCTION OFLABOUR OR EXPECTANT MANAGEMENT?  Favorable cervix : Labor generally is induced because the risk of failed induction and subsequent cesarean delivery is low.  Unfavorable cervix :a small advantage to labor induction using cervical ripening agents (prostaglandins), when indicated, regardless of parity or method of induction. ACOG 2004 (Level C)
  • 33.
    05/17/2025 Tesloach James A .Healthy,uncomplicated pregnancy and fetal growth/ amniotic fluid normal:  No evidence to support elective induction of labour  No evidence to support use of serial antenatal monitoring : non stress test (NST) or amniotic fluid index (AFI) . Management from 40-41 weeks gestation
  • 34.
    05/17/2025 Tesloach James B. Presenceof maternal risk factors or evidence of fetal compromise :  Recommend cervical ripening as necessary and induction of labour Management at 40 - 41 weeks gestation
  • 35.
    05/17/2025 Tesloach James A. Healthy,uncomplicated pregnancy  Inform the woman of the options and risks/ benefits of labour induction versus expectant management, and offer her labour induction.  Establish the cervical (Bishop) Score and ensure a ripening agent (prostaglandin) prior to induction. Management at 41 weeks gestation
  • 36.
    05/17/2025 Tesloach James B. Ifmother declines induction , then provide expectant management:  Daily fetal movement counts  Non stress test (NST) and Amniotic fluid index (AFI) twice/ week to 42 weeks.  If the NST or AFI is abnormal , then initiate induction immediately Management at 41 weeks gestation Induce at 42 weeks even if NST and AFI are normal.
  • 37.
    05/17/2025 Tesloach James ۞ Consider amniotomyto diagnose thick meconium. ۞ If meconium is present then consider risk of meconium aspiration , continuous fetal assessment with electronic fetal monitoring (EFM) is recommended. ۞ Be prepared for shoulder dystocia and neonatal resuscitation at delivery. Management during labour and delivery
  • 38.
    05/17/2025 Tesloach James  Labourinduction at 41 weeks gestation is recommended over expectant management in women with postterm pregnancy to reduce the rate of cesarean delivery & perinatal mortality . Key Clinical Recommendations ( RCOG Grade A )
  • 39.
    05/17/2025 Tesloach James  IfExpectant management (41- 42 weeks) is chosen,the fetus should be monitored with twice weekly non- stress test ,amniotic fluid index . - However, evidence of benefit is lacking. Key Clinical Recommendations (RCOG Grade C )
  • 40.
    05/17/2025 Tesloach James  Prostaglandincan be used in postterm pregnancies to promote cervical ripening and induce labor.  Delivery should be effected if there is evidence of :  fetal compromise or  oligohydramnios. ACOG 2004 (Level A) Key Clinical Recommendations
  • 41.