This document summarizes a study that evaluated first-year pharmacy students' ability to construct clinical questions using the PICO (Population, Intervention, Comparison, Outcome) format and justify their choice of information resources. Students were asked to formulate three PICO questions and rationales for each of three clinical cases. Their responses were assessed using rubrics. Results showed students performed best at outlining the population component but struggled most with comparisons. When justifying resources, students did best using relevance criteria and worst using validity criteria. Performance varied across clinical topics. The authors conclude additional training is needed to improve students' skills in these areas.